Effectiveness and associated factors of varicella vaccination on school outbreaks

MAI Weizhen; LI Jialing; XIE Xin; LIANG Wenjia; LI Weinan; LIN Daner; WU Xianbo; ZHU Qi; MA Wenjun

doi:10.16835/j.cnki.1000-9817.2023.02.027

Volume 44 Issue 2

Feb. 2023

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Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2023 > 44(2): 278-281

MAI Weizhen, LI Jialing, XIE Xin, LIANG Wenjia, LI Weinan, LIN Daner, WU Xianbo, ZHU Qi, MA Wenjun. Effectiveness and associated factors of varicella vaccination on school outbreaks[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(2): 278-281. doi: 10.16835/j.cnki.1000-9817.2023.02.027

Citation:

MAI Weizhen, LI Jialing, XIE Xin, LIANG Wenjia, LI Weinan, LIN Daner, WU Xianbo, ZHU Qi, MA Wenjun. Effectiveness and associated factors of varicella vaccination on school outbreaks[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(2): 278-281. doi: 10.16835/j.cnki.1000-9817.2023.02.027

Citation:

MAI Weizhen, LI Jialing, XIE Xin, LIANG Wenjia, LI Weinan, LIN Daner, WU Xianbo, ZHU Qi, MA Wenjun. Effectiveness and associated factors of varicella vaccination on school outbreaks[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(2): 278-281. doi: 10.16835/j.cnki.1000-9817.2023.02.027

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Effectiveness and associated factors of varicella vaccination on school outbreaks

doi: 10.16835/j.cnki.1000-9817.2023.02.027

MAI Weizhen^{1, 2},
LI Jialing³,
XIE Xin³,
LIANG Wenjia³,
LI Weinan⁴,
LIN Daner⁵,
WU Xianbo¹,
ZHU Qi^{3
,
,},
MA Wenjun^{1, 2
,
,}

1.
School of Public Health, Southern Medical University, Guangzhou(510515), China

Received Date: 2022-09-20
Rev Recd Date: 2022-11-30

Available Online: 2023-03-02

Publish Date: 2023-02-25

Abstract

Abstract

Objective To evaluate the effectiveness of varicella vaccine in varicella outbreaks and to analyze the influencing factors, and to provide a reference for making the targeted prevention and controlling measures. Methods A total of 3 888 students with no history of varicella were selected from 2 schools with varicella outbreak in Guangdong Province in 2021, a retrospective cohort study was conducted by using questionnaire survey, rate ratio (RR) and vaccine effectiveness (VE) values were calculated and Logistic regression was uses to analyze the factors influencing the protective effect of varicella. Results There were 138 confirmed cases of varicella among the participants. There was no significant sex difference in the vaccination rate(χ²=1.36, P=0.51), but there was significant difference in the vaccinattion rate of different age groups(χ²=555.82, P < 0.01). The overall protective effect of VarV was 66.94%(95%CI=56.17%-77.71%), and the protective effect of 2 doses of vaccine(VE=90.02%, 95%CI=83.13%-96.90%) was higher than that of 1 dose(VE=49.40%, 95%CI=32.36%-66.44%)(χ²=24.93, P < 0.01). The high fever rates in the vaccinated and unvaccinated groups were 7.69% and 25.81%, with significant difference(χ²=6.29, P < 0.05). The rates of moderate and severe skin lesions of vaccinated and unvaccinated groups was 20.00% and 50.00%, respectively, and the difference was statistically significant(χ²=11.32, P < 0.01). The protective effects of varicella vaccine against high fever and moderate to severe rash were 70.19%(95%CI=42.11%-98.27%) and 60.00%(95%CI=38.15%-81.85%). Stratified analysis showed that there were significant differences in different years of vaccination(χ²=37.87, P < 0.05), while there were no significant differences in age of vaccination and vaccine manufacturer (P>0.05). Conclusion Varicella vaccination can prevent chickenpox infection and reduce the severity of the disease. However, the efficacy of varicella vaccine was affected by vaccination years. It is recommended to improve the vaccination coverage of varicella vaccine to prevent the outbreak of the epidemic.
- Chickenpox vaccine,
- Vaccination,
- Disease outbreaks,
- Factor analysis, statistical,
- Students

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References(16)

References

[1]	张晓颖. 水痘的流行特征与防控策略研究进展[J]. 中国城乡企业卫生, 2020, 35(4): 48-50. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCXW202004019.htm ZHANG X Y. Research progress on epidemiological characteristics and prevention and control strategies of varicella[J]. Chin J Urban Rural Enterp Hyg, 2020, 35(4): 48-50. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZCXW202004019.htm
[2]	李媛, 孔东锋, 唐秀娟, 等. 广东省深圳市2013—2017年水痘疫情流行特征及免疫接种情况分析[J]. 医学动物防制, 2019, 35(5): 438-441. https://www.cnki.com.cn/Article/CJFDTOTAL-YXDZ201905008.htm LI Y, KONG D F, TANG X J, et al. Analysis on epidemiological characteristics and vaccination of varicella in Shenzhen of Guangdong Province from 2013 to 2017[J]. J Med Pest Control, 2019, 35(5): 438-441. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-YXDZ201905008.htm
[3]	李瑞平, 高彩红, 吴芳, 等. 2005—2018年上海市奉贤区水痘流行病学特征分析[J]. 现代预防医学, 2020, 47(11): 1929-1932. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF202011003.htm LI R P, GAO C H, WU F, et al. Epidemiological characteristics of varicella in Fengxian District of Shanghai, 2005-2018[J]. Mod Prev Med, 2020, 47(11): 1929-1932. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF202011003.htm
[4]	董蒲梅, 王淼, 刘燕敏. 2016—2019年中国水痘流行病学特征[J]. 中国疫苗和免疫, 2020, 26(4): 403-406. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGJM202004011.htm DONG P M, WANG M, LIU Y M. Epidemiological characteristics of varicella in China, 2016-2019[J]. Chin J Vaccin Immun, 2020, 26(4): 403-406. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZGJM202004011.htm
[5]	ZHANG M, GUI G P, GUO F, et al. A centralized outbreak of varicella among children attending preschool in Suzhou, China[J]. Biomed Res Int, 2020, 2020: 6183936.
[6]	GERSHON A A, GERSHON M D, SHAPIRO E D. Live attenuated varicella vaccine: prevention of varicella and of zoster[J]. J Infect Dis, 2021, 224(12 Suppl 2): S387-S397.
[7]	曾四清, 孙立梅, 何剑峰, 等. 水痘突发公共卫生事件中疫苗接种史的保护效果分析[J]. 预防医学情报杂志, 2019, 35(3): 297-302. https://www.cnki.com.cn/Article/CJFDTOTAL-YFYX201903020.htm ZENG S Q, SUN L M, HE J F, et al. Analysis of vaccine effectiveness in public health emergency of varicella[J]. J Prev Med Inf, 2019, 35(3): 297-302. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-YFYX201903020.htm
[8]	ZHANG Z, SUO L, PAN J, et al. Two-dose varicella vaccine effectiveness in China: a Meta-analysis and evidence quality assessment[J]. BMC Infect Dis, 2021, 21(1): 543.
[9]	QIN W, MENG X, ZHANG L, et al. The impact of long-term moderate level of vaccination coverage for epidemiology of varicella in Lu'an, China: should we change immunisation strategy now?[J]. Epidemiol Infect, 2020, 148: e74.
[10]	ZHAO D, SUO L, LU L, et al. Effect of earlier vaccination and a two-dose varicella vaccine schedule on varicella incidence Beijing municipality, 2007-2018[J]. China CDC Wkly, 2021, 3(15): 311-315.
[11]	WANG Y, ZHANG L, SUN X, et al. Effectiveness and failure rate of the varicella vaccine in an outbreak in Jiangsu, China: a 1: 2 matched case-control study[J]. Hum Vaccin Immunother, 2020, 16(3): 506-512.
[12]	WU Q, LIU J, WANG Y, et al. Effectiveness of second-dose varicella vaccination as post-exposure prophylaxis: a prospective cohort study[J]. Clin Microbiol Infect, 2019, 25(7): 872-877.
[13]	XU Y, LIU Y, ZHANG X, et al. Epidemiology of varicella and effectiveness of varicella vaccine in Hangzhou, China, 2019[J]. Hum Vaccin Immunother, 2021, 17(1): 211-216.
[14]	ZHANG Y, WANG L, WANG Y, et al. Immunogenicity and safety of a booster dose of live attenuated varicella vaccine, and immune persistence of a primary dose for children aged 2 to 6 years[J]. Vaccines (Basel), 2022, 10(5): 660.
[15]	董晓春, 李琳. 接种2剂次水痘疫苗的突破病例前瞻性观察及抗体动态变化分析[J]. 中华预防医学杂志, 2022, 56(2): 114-118. DONG X C, LI L. Prospective observation of breakthrough cases and analysis of antibody dynamic changes after two doses of varicella[J]. Chin J Prev Med, 2022, 56(2): 114-118. (in Chinese)
[16]	RIECK T, FEIG M, AN D H M, et al. Assessing varicella vaccine effectiveness and its influencing factors using health insurance claims data, Germany, 2006 to 2015[J]. Eur Surv, 2017, 22(17): 30521.

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[19]	Effects of influenza vaccination among high school students: Two-year follow-up study[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2014, 35(3): 413-415.
[20]	Coverage and protective effects of varicella vaccination for students in Xuhui District of Shanghai[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2013, 34(4): 465-467.

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Periodical cited type(18)

1.	孙坤，胡伟红，周银柱，陈水连，邱劲松. 2012—2022年长沙市水痘暴发疫情流行特征与处置情况分析. 热带病与寄生虫学. 2024(01): 37-41 .
2.	张传云，蒋薇薇. 2020—2021年合肥市蜀山区儿童水痘突破病例流行特征及疫苗保护效果分析. 实用预防医学. 2024(05): 608-611 .
3.	陈文花，沈金花，朱祺，姚红岑，陆红梅. 2022年上海市松江区1～30岁健康人群水痘-带状疱疹病毒抗体水平分析. 上海预防医学. 2024(04): 337-341 .
4.	李思杰，王跃会，杨慧. 2009—2022年重庆市某地区法定呼吸道传染病流行特征及基于Joinpoint回归模型的流行趋势. 职业与健康. 2024(08): 1061-1066 .
5.	李思杰，王跃会，邵宇，曹蕾，郑晖，陈磊. 2008—2022年重庆市渝中区疫苗针对法定呼吸道传染病流行趋势分析. 医学动物防制. 2024(08): 774-778+783 .
6.	郑杰，黄东升，李国辉，赵永，屈尚亮. 2022年云南省某中学一起水痘暴发疫情调查分析. 疾病预防控制通报. 2024(03): 21-24+28 .
7.	蒋雪飞，王亚，张晓燕，曾凡娜，吴欢. 2005—2022年重庆市永川区突发公共卫生事件流行特征及发展趋势分析. 保健医学研究与实践. 2024(04): 26-32 .
8.	周路平，张颖，刘玮，周莉薇. 2005-2023年宁夏回族自治区水痘流行病学特征. 中国疫苗和免疫. 2024(05): 583-589 .
9.	陈甦. 某高校大学生水痘流行病学分析及防控措施. 中国医药指南. 2024(31): 137-139 .
10.	高桂玲，薛青，王超，姚春霞. 2018—2022年上海市松江区中小学生传染病流行特征. 上海预防医学. 2024(10): 958-962 .
11.	李霞，吴美丽，左羚，荣利萍，王静，王峰. 2015—2022年新疆克拉玛依市水痘流行病学特征分析. 上海预防医学. 2024(10): 954-957+962 .
12.	王宝龙，赵秀娟. 水痘疫苗对儿童突破病例保护情况调查分析. 名医. 2024(19): 48-50 .
13.	张洋，田鑫，翟前前，田蕊，姚来顺. 2013—2022年吉林省突发公共卫生事件流行特征分析. 热带病与寄生虫学. 2023(03): 126-129+159 .
14.	储开稳. 2017—2022年海安市水痘流行病学特征分析和防控体会探讨. 口岸卫生控制. 2023(03): 32-35 .
15.	余鹏飞，钟梦婷，许荣全，杜哲群，沈国初，胡洁. 嘉兴市2021年1起高中水痘暴发疫情调查和水痘疫苗保护效果评价. 中国疫苗和免疫. 2023(04): 417-421 .
16.	张荣瑜，蒋智，高岚. 贵阳市2010—2022年水痘流行病学特征分析. 现代预防医学. 2023(23): 4386-4391 .
17.	罗健斌，杨燕君，吴少敏，谢丹. 2013—2022年广州市番禺区突发公共卫生事件流行病学特征分析. 国际医药卫生导报. 2023(23): 3515-3519 .
18.	罗卓珊，黎燕君，黄韵诗. 广州市番禺区社区儿童水痘疫苗接种现况调查及影响因素分析. 妇儿健康导刊. 2023(24): 41-43+46 .