Tuberculin skin test in close contacts in case of school tuberculosis outbreak

DONG Xiaowei; LIN Peixin; HE Junlei; LI Jianwei; YU Meiling; WEN Wenpei

doi:10.16835/j.cnki.1000-9817.2021.12.007

Volume 42 Issue 12

Dec. 2021

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Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2021 > 42(12): 1785-1788, 1792

DONG Xiaowei, LIN Peixin, HE Junlei, LI Jianwei, YU Meiling, WEN Wenpei. Tuberculin skin test in close contacts in case of school tuberculosis outbreak[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(12): 1785-1788, 1792. doi: 10.16835/j.cnki.1000-9817.2021.12.007

Citation:

DONG Xiaowei, LIN Peixin, HE Junlei, LI Jianwei, YU Meiling, WEN Wenpei. Tuberculin skin test in close contacts in case of school tuberculosis outbreak[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(12): 1785-1788, 1792. doi: 10.16835/j.cnki.1000-9817.2021.12.007

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Tuberculin skin test in close contacts in case of school tuberculosis outbreak

doi: 10.16835/j.cnki.1000-9817.2021.12.007

Epidemiological Survenlance Unit, Centre for Tuberculosis Control of Guangdong Province, Guangzhou(610630), China

Received Date: 2021-03-17
Rev Recd Date: 2021-05-24

Available Online: 2021-12-23

Publish Date: 2021-12-25

Abstract

Abstract

Objective To evaluate the role of tuberculin skin test prified-protein derivative (PPD) in defining the screening scope of close contacts of tuberculosis cases in disposal of tuberculosis outbreak in schools. Methods In a senior middle school in August 2019, 1 553 students of the grade two were tested by PPD because of a school tuberculosis outbreak. PPD results were compared to grade one students without any association with this tuberculosis epidemic, who were also tested by PPD when beginning school. Potential association between PPD distribution characteristics and tuberculosis case distribution were analyzed. Results Twenty-nine grade two students were diagnozed as tuberculosis infection, seven of which were PPD-positive, and with the same MIRU-VNTR genotype. In grade one, 0.1% (1/796) student showed strong PPD-positive, 34.3% (273/796) student showed positive. For grade two students, significant higher rate of strong PPD-positive [5.9% (45/757)], and PPD-positive [52.0% (394/757)] were observed (χ²=45.71, 49.90, P < 0.01). Proportion of strong PPD-positive in the first floor of the teaching building (19.4%), where tuberculosis cases clustered, was significantly higher than that in other floors (χ²=89.81, P < 0.01); Number of strong PPD-positive students increased with TB cases in each floor of the teaching building (r=0.99, P < 0.01). Proportion of strong PPD-positive and PPD-positive in floors of the dormitory, where TB cases lived, was significantly higher than in other floors (χ²=49.4, 64.9, P < 0.01). Number of strong PPD-positive and PPD-positive students increased with TB cases in each floor of the teaching building (r=0.84, 0.56, P < 0.01). Conclusion Strong PPD-positive rate well reflects tuberculosis infection of close contacts, and is recommended for defining the scope of screening.
- Tuberculosis, pulmonary,
- Tuberculin test,
- Disease outbreaks,
- Students,
- Contact tracing

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References(23)

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