Association of joint effect of overweight and obesity with dyslipidemia on left ventricular hypertrophy in children

AN Silian; LIU Ziqi; ZHANG Qian; ZHAO Min; XI Bo

doi:10.16835/j.cnki.1000-9817.2025110

Volume 46 Issue 4

Apr. 2025

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AN Silian, LIU Ziqi, ZHANG Qian, ZHAO Min, XI Bo. Association of joint effect of overweight and obesity with dyslipidemia on left ventricular hypertrophy in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(4): 474-478. doi: 10.16835/j.cnki.1000-9817.2025110

Citation:

AN Silian, LIU Ziqi, ZHANG Qian, ZHAO Min, XI Bo. Association of joint effect of overweight and obesity with dyslipidemia on left ventricular hypertrophy in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(4): 474-478. doi: 10.16835/j.cnki.1000-9817.2025110

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Association of joint effect of overweight and obesity with dyslipidemia on left ventricular hypertrophy in children

doi: 10.16835/j.cnki.1000-9817.2025110

AN Silian^{1, 2},
LIU Ziqi^{1, 2},
ZHANG Qian³,
ZHAO Min⁴,
XI Bo^{1, 2
,
,}

1.
Department of Epidemiology/Department of Maternal, Child and Adolescent Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Ji'nan (250012), Shandong Province, China

Received Date: 2024-08-07
Rev Recd Date: 2024-09-19

Available Online: 2025-05-08

Publish Date: 2025-04-25

Abstract

Abstract

Objective To examine the association of joint effect of overweight and obesity with dyslipidemia on left ventricular hypertrophy (LVH) in children, so as to provide scientific evidence for the prevention of early cardiovascular damage in children. Methods Data were obtained from the second follow-up cross-sectional survey of Huantai Childhood Cardiovascular Health Cohort study in 2021, comprising 1 047 children aged 10-15 years with complete information. Based on overweight and obesity status and dyslipidemia status, all participants were divided into four groups: normal weight with normal lipid levels, normal weight with dyslipidemia, overweight and obesity with normal lipid levels, and overweight and obesity with dyslipidemia. Left ventricular mass index (LVMI) levels and prevalence of LVH across four groups were compared. Multivariate Logistic regression model was used to examine the association of joint effect of overweight and obesity with dyslipidemia on LVH in children. Results There were significant differences in LVMI levels [(28.66±7.10, 29.63±4.71, 31.49±5.86, 32.65±4.80)g/m^2.7] and prevalence of LVH (4.28%, 12.50%, 22.74%, 31.30%) across four groups (F/χ²=50.76, 90.92, P<0.05). After adjustment for confounding variables such as gender, age, screen time, sleep duration, fruit and vegetable intake, carbonated beverage consumption, physical activity and elevated blood pressure, compared to children with both normal weight and normal lipid levels, the risk of LVH in children with dyslipidemia alone increased (OR=3.27, 95%CI=1.57-6.82, P<0.05). Children with overweight and obesity alone also had a significantly increased risk of LVH (OR=6.33, 95%CI=3.76-10.66), and the highest risk was observed in those with both overweight and obesity with dyslipidemia (OR=9.66, 95%CI=5.35-17.43) (P<0.05). Conclusions The joint effect of overweight and obesity with dyslipidemia is positively correlated with LVH in children. To prevent LVH in children, both overweight and obesity with dyslipidemia should be paid attention to.
- Overweight,
- Obesity,
- Dyslipidemias,
- Cardiomyopathy,
- hypertrophic,
- Regression analysis,
- Child

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References(29)

References

[1]	张娜, 马冠生. 《中国儿童肥胖报告》解读[J]. 营养学报, 2017, 39(6): 530-534. doi: 10.3969/j.issn.0512-7955.2017.06.003 ZHANG N, MA G S. Interpretation of report on childhood obesity in China[J]. Acta Nutr Sinca, 2017, 39(6): 530-534. (in Chinese) doi: 10.3969/j.issn.0512-7955.2017.06.003
[2]	董彦会, 陈力, 刘婕妤, 等. 1985-2019年中国7~18岁儿童青少年超重与肥胖的流行趋势及预测研究[J]. 中华预防医学杂志, 2023, 57(4): 461-469. DONG Y H, CHEN L, LIU J Y, et al. Epidemiology and prediction of overweight and obesity among children and adolescents aged 7-18 years in China from 1985 to 2019[J]. Chin J Prev Med, 2023, 57(4): 461-469. (in Chinese)
[3]	PIOTROWICZ K, GASOWSKI J. Risk factors for frailty and cardiovascular diseases: are they the same?[J]. Adv Exp Med Biol, 2020, 1216: 39-50.
[4]	王增武, 刘静, 李建军, 等. 中国血脂管理指南(2023年)[J]. 中国循环杂志, 2023, 38(3): 237-271. doi: 10.3969/j.issn.1000-3614.2023.03.001 WANG Z W, LIU J, LI J J, et al. Chinese guidelines for lipid management (2023)[J]. Chin Circul J, 2023, 38(3): 237-271. (in Chinese) doi: 10.3969/j.issn.1000-3614.2023.03.001
[5]	LAVIE C J, PATEL D A, MILANI R V, et al. Impact of echocardiographic left ventricular geometry on clinical prognosis[J]. Progress Cardiovas Dis, 2014, 57(1): 3-9. doi: 10.1016/j.pcad.2014.05.003
[6]	ANTIKAINEN R L, PETERS R, BECKETT N S, et al. Left ventricular hypertrophy is a predictor of cardiovascular events in elderly hypertensive patients: hypertension in the Very Elderly Trial[J]. J Hypertens, 2016, 34(11): 2280-2286. doi: 10.1097/HJH.0000000000001073
[7]	JING L, NEVIUS C D, FRIDAY C M, et al. Ambulatory systolic blood pressure and obesity are independently associated with left ventricular hypertrophic remodeling in children[J]. J Cardiovas Magnetic Reson, 2017, 19(1): 86.
[8]	BRADY T M. The role of obesity in the development of left ventricular hypertrophy among children and adolescents[J]. Curr Hypertens Rep, 2016, 18(1): 3. doi: 10.1007/s11906-015-0608-3
[9]	BJELAKOVIC B, STEFANUTTI C, VUKOVIC V, et al. Lipid profile and left ventricular geometry pattern in obese children[J]. Lipids Health Dis, 2020, 19(1): 109. doi: 10.1186/s12944-020-01285-9
[10]	TANG Y, YANG G B, CHEN J, et al. Association between left ventricular remodeling and lipid profiles in obese children: an observational study[J]. Front Pediatr, 2024, 12: 1308887. doi: 10.3389/fped.2024.1308887
[11]	中华人民共和国国家卫生和计划生育委员会. 学龄儿童青少年超重与肥胖筛查: WS/T 586-2018[S]. 北京: 中国标准出版社, 2018. National Health and Family Planning Commission of the PRC. Screening for overweight and obesity among school-age children and adolescents: WS/T 586-2018[S]. Beijing: Standards Press of China, 2018. (in Chinese)
[12]	MENG L, ZHAO D, PAN Y, et al. Validation of Omron HBP-1300 professional blood pressure monitor based on auscultation in children and adults[J]. BMC Cardiovasc Disord, 2016, 16: 9. doi: 10.1186/s12872-015-0177-z
[13]	LANG R M, BIERIG M, DEVEREUX R B, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology[J]. J Am Soc Echocard, 2005, 18(12): 1440-1463. doi: 10.1016/j.echo.2005.10.005
[14]	DEVEREUX R B, ALONSO D R, LUTAS E M, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings[J]. Am J Cardiol, 1986, 57(6): 450-458. doi: 10.1016/0002-9149(86)90771-X
[15]	DE SIMONE G, DANIELS S R, DEVEREUX R B, et al. Left ventricular mass and body size in normotensive children and adults: assessment of allometric relations and impact of overweight[J]. J Am Coll Cardiol, 1992, 20(5): 1251-1260. doi: 10.1016/0735-1097(92)90385-Z
[16]	《中华儿科杂志》编辑委员会, 中华医学会儿科学分会儿童保健学组, 中华医学会儿科学分会心血管学组, 等. 儿童青少年血脂异常防治专家共识[J]. 中华儿科杂志, 2009, 47(6): 426-428. The Editorial Board of Chinese Journal of Pediatrics, the Subspecialty Group of Child Health Care, the Society of Pediatrics, Chinese Medical Association, the Subspecialty Group of Cardiovascular Disease, the Society of Pediatrics, Chinese Medical Association, et al. Experts consensus for prevention and treatment of dyslipidemia in children and adolescents[J]. Chin J Pediatr, 2009, 47(6): 426-428. (in Chinese)
[17]	郭腾, 羊柳, 张茜, 等. 儿童超重肥胖和血压偏高联合作用与左心室肥厚的关联研究[J]. 中华预防医学杂志, 2019, 53(7): 686-691. GUO T, YANG L, ZHANG Q, et al. Association of joint effect of overweight/obesity and elevated blood pressure with left ventricular hypertrophy in children[J]. Chin J Prev Med, 2019, 53(7): 686-691. (in Chinese)
[18]	范晖, 闫银坤, 米杰. 中国3~17岁儿童性别、年龄别和身高别血压参照标准[J]. 中华高血压杂志, 2017, 25(5): 428-435. FAN H, YAN Y K, MI J. Updating blood pressure references for Chinese children aged 3-17 years[J]. Chin J Hypertens, 2017, 25(5): 428-435. (in Chinese)
[19]	WHO Guidelines Approved by the Guidelines Review Committee. Glo-bal recommendations on physical activity for health[M]. Geneva: World Health Organization, 2010.
[20]	LOCK K, POMERLEAU J, KNAI C, et al. Effectiveness of interventions and programmes promoting fruit and vegetable intake[J]. Eur J Public Health, 2004, 14(4): 93.
[21]	DHUPER S, ABDULLAH R A, WEICHBROD L, et al. Association of obesity and hypertension with left ventricular geometry and function in children and adolescents[J]. Obesity (Silver Spring), 2011, 19(1): 128-133. doi: 10.1038/oby.2010.134
[22]	FALKNER B, DELOACH S, KEITH S W, et al. High risk blood pressure and obesity increase the risk for left ventricular hypertrophy in African-American adolescents[J]. J Pediatr, 2013, 162(1): 94-100. doi: 10.1016/j.jpeds.2012.06.009
[23]	ALP H, KARAARSLAN S, EKLIOGLU B S, et al. The effect of hypertension and obesity on left ventricular geometry and cardiac functions in children and adolescents[J]. J Hypertens, 2014, 32(6): 1283-1292.
[24]	PIERUZZI F, ANTOLINI L, SALERNO F R, et al. The role of blood pressure, body weight and fat distribution on left ventricular mass, diastolic function and cardiac geometry in children[J]. J Hypertens, 2015, 33(6): 1182-1192.
[25]	张茜, 马传伟, 席波. 超重肥胖对高血压学龄儿童左心室肥厚的影响[J]. 中国学校卫生, 2019, 40(6): 815-817. doi: 10.16835/j.cnki.1000-9817.2019.06.007 ZHANG X, MA C W, XI B. Effects of overweight and obesity on left ventricular hypertrophy in school-aged children with hypertension[J]. Chin J Sch Health, 2019, 40(6): 815-817. (in Chinese) doi: 10.16835/j.cnki.1000-9817.2019.06.007
[26]	曹亚船, 豆吉娟, 马亚萍, 等. 肥胖儿童脂质代谢与左心室肥厚及左心室重构的相关性[J]. 中国儿童保健杂志, 2023, 31(7): 809-812. CAO Y C, DOU J J, MA Y P, et al. Correlation of lipid metabolism with left ventricular hypertrophy and leftventricular remodeling in obese children[J]. Chin J Child Health Care, 2023, 31(7): 809-812. (in Chinese)
[27]	ALPERT M A, LAVIE C J, AGRAWAL H, et al. Obesity and heart failure: epidemiology, pathophysiology, clinical manifestations, and management[J]. Transl Res, 2014, 164(4): 345-356.
[28]	DROZDZ M, MOCZULSKA A, RUDZINSKI A, et al. Metabolic syndrome as risk factor for left ventricular hypertrophy in children with chronic kidney disease[J]. Front Endocrinol (Lausanne), 2023, 14: 1215527.
[29]	YAO Y S, LI T D, ZENG Z H. Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review[J]. Lipids Health Dis, 2020, 19(1): 23.