Volume 43 Issue 12
Dec.  2022
Turn off MathJax
Article Contents
CUI Tingkai, CHE Yifan, ZHANG Xin. Association between inflammation and immunity with child autism spectrum disorder based on CiteSpace analysis[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(12): 1843-1846. doi: 10.16835/j.cnki.1000-9817.2022.12.020
Citation: CUI Tingkai, CHE Yifan, ZHANG Xin. Association between inflammation and immunity with child autism spectrum disorder based on CiteSpace analysis[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(12): 1843-1846. doi: 10.16835/j.cnki.1000-9817.2022.12.020

Association between inflammation and immunity with child autism spectrum disorder based on CiteSpace analysis

doi: 10.16835/j.cnki.1000-9817.2022.12.020
  • Received Date: 2022-09-01
  • Rev Recd Date: 2022-10-11
  • Available Online: 2022-12-30
  • Publish Date: 2022-12-25
  •   Objective  To summarize recent progress in the inflammation and immunity research on autism spectrum disorder (ASD) in children during 2002 to 2021, and to provide future directions.  Methods  Literature review was conducted in May 2022, with the literature source of core collection of the Web of Science database. CiteSpace software was used for bibliometric analysis. A total of 4 458 literature was included.  Results  In the past decade, the number of published articles increased rapidly, from 52 to 528. American has produced the highest number of articles (n=2 016), followed by China with 407 papers published. The high-frequency words included autism spectrum disorder, children, brain, autism, spectrum disorder. The high centrality keywords included schizophrenia, central nervous system, mental regression, multiple sclerosis, autoantibody. Recent researches in ASD primarily focused on the following three aspects: core symptoms and brain mechanism, gene-environment interaction, and epidemiological research. Maternal immune activation and gut-brain axis were gradually becoming research hotspots.  Conclusion  Research on inflammation and immunity of ASD in children increased rapidly in the past 20 years. Recent research hotspots included maternal immune activation and gut brain axis mechanisms, which could be integreted in future efforts to develop prevention and intervention programming on ASD in children.
  • loading
  • [1]
    American Psychiatry Association. Diagnostic and statistical manual of mental disorders[M]. 5th ed. Arlington, VA: American Psychiatric Association, 2013.
    MAENNER M J, SHAW K A, BAKIAN A V, et al. Prevalence and characteristics of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 sites, United States, 2018[J]. MMWR Surveill Summ, 2021, 70(11): 1-16. doi: 10.15585/mmwr.ss7011a1
    ROBINSON-AGRAMONTE M L A, NORIS G E, FRAGA G J, et al. Immune dysregulation in autism spectrum disorder: what do we know about it?[J]. Inter J Molecul Sci, 2022, 23(6): 3033. doi: 10.3390/ijms23063033
    VARGAS D L, NASCIMBENE C, KRISHNAN C, et al. Neuroglial activation and neuroinflammation in the brain of patients with autism[J]. Ann Neurol, 2005, 57(1): 67-81. doi: 10.1002/ana.20315
    ASHWOOD P, WILLS S, VAN DE WATER J. The immune response in autism: a new frontier for autism research[J]. J Leukoc Biol, 2006, 80(1): 1-15. doi: 10.1189/jlb.1205707
    SMITH S E, LI J, GARBETT K, et al. Maternal immune activation alters fetal brain development through interleukin-6[J]. J Neurosci, 2007, 27(40): 10695-10702. doi: 10.1523/JNEUROSCI.2178-07.2007
    LI X, CHAUHAN A, SHEIKH A M, et al. Elevated immune response in the brain of autistic patients[J]. J Neuroimmunol, 2009, 207(1/2): 111-116.
    ATLADÓTTIR H O, THORSEN P, ØSTERGAARD L, et al. Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders[J]. J Autism Dev Disord, 2010, 40(12): 1423-1430. doi: 10.1007/s10803-010-1006-y
    ASHWOOD P, KRAKOWIAK P, HERTZ-PICCIOTTO I, et al. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome[J]. Brain Behav Immun, 2011, 25(1): 40-45. doi: 10.1016/j.bbi.2010.08.003
    HALLMAYER J, CLEVELAND S, TORRES A, et al. Genetic heritability and shared environmental factors among twin pairs with autism[J]. Arch Gen Psychiatry, 2011, 68(11): 1095-1102. doi: 10.1001/archgenpsychiatry.2011.76
    VOINEAGU I, WANG X, JOHNSTON P, et al. Transcriptomic analysis of autistic brain reveals convergent molecular pathology[J]. Nature, 2011, 474(7351): 380-384. doi: 10.1038/nature10110
    ONORE C, CAREAGA M, ASHWOOD P. The role of immune dysfunction in the pathophysiology of autism[J]. Brain Behav Immun, 2012, 26(3): 383-392. doi: 10.1016/j.bbi.2011.08.007
    MALKOVAN V, YU C Z, HSIAO E Y, et al. Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism[J]. Brain Behav Immun, 2012, 26(4): 607-616. doi: 10.1016/j.bbi.2012.01.011
    HSIAO E Y, MCBRIDE S W, HSIEN S, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders[J]. Cell, 2013, 155(7): 1451-1463. doi: 10.1016/j.cell.2013.11.024
    KNUESEL I, CHICHA L, BRITSCHGI M, et al. Maternal immune activation and abnormal brain development across CNS disorders[J]. Nat Rev Neurol, 2014, 10(11): 643-660. doi: 10.1038/nrneurol.2014.187
    ESTES M L, MCALLISTER K A. Immune mediators in the brain and peripheral tissues in autism spectrum disorder[J]. Nat Rev Neurosci, 2015, 16(8): 469-486. doi: 10.1038/nrn3978
    CHOI G B, YIM Y S, WONG H, et al. The maternal interleukin-17 a pathway in mice promotes autism-like phenotypes in offspring[J]. Science, 2016, 351(6276): 933-939. doi: 10.1126/science.aad0314
    ESTES M L, MCALLISTER A K. Maternal immune activation: implications for neuropsychiatric disorders[J]. Science, 2016, 353(6301): 772-777. doi: 10.1126/science.aag3194
    KANG D W, ADAMS J B, GREGORY A C, et al. Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study[J]. Microbiome, 2017, 5(1): 10. doi: 10.1186/s40168-016-0225-7
    MELTZER A, VAN DE WATER J. The role of the immune system in autism spectrum disorder[J]. Neuropsychopharmacology, 2017, 42(1): 284-298. doi: 10.1038/npp.2016.158
    KIM S, KIM H, YIM Y S, et al. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring[J]. Nature, 2017, 549(7673): 528-532. doi: 10.1038/nature23910
    BAIO J, WIGGINS L, CHRISTENSEN D L, et al. Prevalence of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 sites, United States, 2014[J]. MMWR Surveill Summ, 2018, 67(6): 1-23. doi: 10.15585/mmwr.ss6706a1
    GALEA I. The blood-brain barrier in systemic infection and inflammation[J]. Cell Mol Immunol, 2021, 18(11): 2489-2501. doi: 10.1038/s41423-021-00757-x
    PAKHATHIRATHIEN P, JANJINDAMAI W, DISSANEEVATE S, et al. Neonatal outcomes in pregnant women with systemic lupus erythematosus: a 13-year experience in Southern Thailand[J]. J Trop Pediatr, 2021, 67(3): fmab058. doi: 10.1093/tropej/fmab058
    SAUNDERS N R, LIDDELOW S A, DZIEGIELEWSKA K M. Barrier mechanisms in the developing brain[J]. Front Pharmacol, 2012, 3: 46.
    KRAKOWIAK P, GOINES P E, TANCREDI D J, et al. Neonatal cytokine profiles associated with autism spectrum disorder[J]. Biol Psychiatry, 2017, 81(5): 442-451. doi: 10.1016/j.biopsych.2015.08.007
    SHUID A N, JAYUSMAN P A, SHUID N, et al. Association between viral infections and risk of autistic disorder: an overview[J]. Int J Environ Res Public Health, 2021, 18(6): 2817. doi: 10.3390/ijerph18062817
    IVANOV Ⅱ, MCKENZIE B S, ZHOU L, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells[J]. Cell, 2006, 126(6): 1121-1133. doi: 10.1016/j.cell.2006.07.035
    PRINS J R, ESKANDAR S, EGGEN B J L, et al. Microglia, the missing link in maternal immune activation and fetal neurodevelopment; and a possible link in preeclampsia and disturbed neurodevelopment?[J]. J Reprod Immunol, 2018, 126: 18-22. doi: 10.1016/j.jri.2018.01.004
    HAN X V, PATEL S, JONES H F, et al. Maternal immune activation and neuroinflammation in human neurodevelopmental disorders[J]. Nat Rev Neurol, 2021, 17(9): 564-579. doi: 10.1038/s41582-021-00530-8
    CRYAN J F, O'RIORDAN K J, COWAN C S M, et al. The microbiota-gut-brain axis[J]. Physiol Rev, 2019, 99(4): 1877-2013. doi: 10.1152/physrev.00018.2018
    ZHU S, JIANG Y, XU K, et al. The progress of gut microbiome research related to brain disorders[J]. J Neur, 2020, 17(1): 25.
    PROFACI C P, MUNJI R N, PULIDO R S, et al. The blood-brain barrier in health and disease: important unanswered questions[J]. J Exp Med, 2020, 217(4): e20190062. doi: 10.1084/jem.20190062
    ALAMOUDI M U, HOSIE S, SHINDLER A E, et al. Comparing the gut microbiome in autism and preclinical models: a systematic review[J]. Front Cell Infect Microbiol, 2022, 12: 905841. doi: 10.3389/fcimb.2022.905841
    VALENZUELA-ZAMORA A F, RAMÍREZ G-VALENZUELA D G, RAMOS-JIMÉNEZ A. Food selectivity and its implications associated with gastrointestinal disorders in children with autism spectrum disorders[J]. Nutrients, 2022, 14(13): 2660. doi: 10.3390/nu14132660
  • 加载中


    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(5)

    Article Metrics

    Article views (81) PDF downloads(46) Cited by()
    Proportional views


    DownLoad:  Full-Size Img  PowerPoint