Epidemiological characteristics of children's Hand, Foot and Mouth Disease and its association with temperature in Nanjing from 2011-2016

ZHAO Hui; HONG Lei; CHEN Jiaping; ZHOU Yimin; MIN Ji; XU Fei; SHAO Fang; LIU Sijun

doi:10.16835/j.cnki.1000-9817.2021.04.033

Volume 42 Issue 4

Apr. 2021

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Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2021 > 42(4): 623-626, 630

ZHAO Hui, HONG Lei, CHEN Jiaping, ZHOU Yimin, MIN Ji, XU Fei, SHAO Fang, LIU Sijun. Epidemiological characteristics of children's Hand, Foot and Mouth Disease and its association with temperature in Nanjing from 2011-2016[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(4): 623-626, 630. doi: 10.16835/j.cnki.1000-9817.2021.04.033

Citation:

ZHAO Hui, HONG Lei, CHEN Jiaping, ZHOU Yimin, MIN Ji, XU Fei, SHAO Fang, LIU Sijun. Epidemiological characteristics of children's Hand, Foot and Mouth Disease and its association with temperature in Nanjing from 2011-2016[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(4): 623-626, 630. doi: 10.16835/j.cnki.1000-9817.2021.04.033

Citation:

ZHAO Hui, HONG Lei, CHEN Jiaping, ZHOU Yimin, MIN Ji, XU Fei, SHAO Fang, LIU Sijun. Epidemiological characteristics of children's Hand, Foot and Mouth Disease and its association with temperature in Nanjing from 2011-2016[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(4): 623-626, 630. doi: 10.16835/j.cnki.1000-9817.2021.04.033

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Epidemiological characteristics of children's Hand, Foot and Mouth Disease and its association with temperature in Nanjing from 2011-2016

doi: 10.16835/j.cnki.1000-9817.2021.04.033

1.
College of Public Health, Nanjing Medical University, Nanjing (211166), China

Received Date: 2020-11-04
Rev Recd Date: 2020-12-20

Available Online: 2021-04-16

Publish Date: 2021-04-25

Abstract

Abstract

Objective This study aims to investigate the epidemiological distribution of HFMD and quantify the association of temperature with the incidence of children's HFMD in Nanjing, China. Methods Daily counts of HFMD in children under 5 years and daily meteorological variables during 2011-2016 were obtained. Descriptive statistics were used to describe the epidemiological characteristics and distributed lag non-linear model (DLNM) was used to assess the associations of temperature on HFMD cases. Results A total of 104 977 HFMD cases aged 0-5 years were reported in Nanjing during the study period and the male-to-female sex ratio was 1.49∶1. The average annual incidence was 213.5 per 100 000. A bimodal seasonal pattern was observed and the south and west were found to be the high-incidence areas in the city. Of these laboratory-confirmed enteroviruses positive cases, 32.5% cases were positive for EV-A71 infections, 29.1% cases were positive for CV-A16 infections and 38.4% cases were positive of other enteroviruses infections. The temperature-HFMD relationships were non-linear and showed obvious lag effects. The cumulative relative risk presented as an approximately inverted U-shape over 14 days and peaked at 25.7 ℃ with value of 2.71(95%CI=1.93-3.81). Subgroup analyses revealed that males and children aged < 1 year were more vulnerable to temperature variations. Conclusion Epidemiological characteristics of HFMD among children aged 0-5 years old in Nanjing presented temporal and regional distribution. The temperature has significant impact on children's HFMD occurrence.
- Hand, foot and nouth disease,
- Incidence,
- Epidemiologic studies,
- Temperature,
- Child

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References

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