Epidemiological characteristics of clustering outbreak of hand foot and mouth disease in kindergartens in Pudong New Area of Shanghai

Objective To explore the relationship among indoor environment, meteorological factors with clustering outbreaks of hand-foot-mouth disease (HFMD) in kindergartens in Pudong New area of Shanghai.Methods Data of indoor environment, meteorological factors were analyzed with variance, multiple regression analysis and Pearson's correlation.Temporal and spatial characteristics were analyzed with Bayesian model Kriging interpolation method.Results The ultraviolet, high wind speed, high atmospheric pressure associated with lower risk while high indoor temperature, high average relative humidity and lowest temperature associated with higher risk of outbreaks of hand-foot-mouth disease.Indoor ultraviolet illumination and temperature entered into the final environment model, with regression coefficients-0.004 and 0.02, respectively.The average wind speed, atmospheric pressure and minimum temperature entered into the meteorological model, with regression coefficients of-11.68, -9.37 and-6.45, respectively.Conclusion Indoor environmental, meteorological factors and the regional characteristics are closely related to the clustering outbreak of hand, foot and mouth disease in kindergarten.Comprehensive measures should be taken to prevent hand, foot and mouth disease contemporaneously and efficiently.