Research progress on the association between childhood sleep disorders and common oral diseases

ZHAO Binbin; SUN Ying; CHEN Xin

doi:10.16835/j.cnki.1000-9817.2025216

Volume 46 Issue 7

Jul. 2025

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2025 > 46(7): 1060-1064

ZHAO Binbin, SUN Ying, CHEN Xin. Research progress on the association between childhood sleep disorders and common oral diseases[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(7): 1060-1064. doi: 10.16835/j.cnki.1000-9817.2025216

Citation:

ZHAO Binbin, SUN Ying, CHEN Xin. Research progress on the association between childhood sleep disorders and common oral diseases[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(7): 1060-1064. doi: 10.16835/j.cnki.1000-9817.2025216

Citation:

PDF( 973 KB)

Research progress on the association between childhood sleep disorders and common oral diseases

doi: 10.16835/j.cnki.1000-9817.2025216

ZHAO Binbin¹,
SUN Ying²,
CHEN Xin^{1
,
,}

1.
College of Stomatology/Hospital of Stomatology, Anhui Medical University/Key Lab. of Oral Diseases Research of Anhui Province, Hefei 230032, Anhui Province, China

Received Date: 2025-04-27
Rev Recd Date: 2025-06-05

Available Online: 2025-08-02

Publish Date: 2025-07-25

Abstract

Abstract

The association of childhood sleep disorders and common oral diseases are increasingly recognized as public health challenges. The paper reviews epidemiological evidence on the bidirectional associations between multidimensional sleep indicators-including insufficient sleep duration, sleep-related disorders (sleep apnea and bruxism) and evening chronotype- and common oral diseases such as dental caries, periodontal diseases, and craniofacial developmental anomalies. It also explores potential neurobiological mechanisms underlying these associations. The review proposes that future research should employ longitudinal cohort studies and multi-omics technologies to further validate prospective causal relationships, thereby providing a theoretical foundation for developing childhood health interventions.
- Sleep,
- Mouth diseases,
- Mental health,
- Child

FullText(HTML)

References(45)

References

[1]	CHEN X, KE Z, CHEN Y, et al. The prevalence of sleep problems among children in mainland China: a Meta-analysis and systemic-analysis[J]. Sleep Med, 2021, 83: 248-255.
[2]	王兴. 第四次全国口腔健康流行病学调查报告[M]. 北京: 人民卫生出版社, 2018. WANG X. The fourth national oral health epidemiological survey[M]. Beijing: People's Medical Publishing House, 2018. (in Chinese)
[3]	SARDANA D, GALLAND B, WHEELER B J, et al. Effect of sleep on development of early childhood caries: a systematic review[J]. Eur Arch Paediatr Dent, 2023, 24: 1-14.
[4]	ZHOU N, ZHU H, CHEN Y, et al. Dental caries and associated factors in 3- to 5-year-old children in Zhejiang Province, China: an epidemiological survey[J]. BMC Oral Health, 2019, 19(1): 9.
[5]	OGAWA M, OGI H, NAKAMURA D, et al. Association between insufficient sleep and dental caries among preschoolers in Japan: a cross-sectional multicentre study[J]. Eur J Investig Health Psychol Educ, 2021, 12(1): 1-10.
[6]	MEHDIPOUR A, ABBASI R, KEYKHA E, et al. The association between dental caries, periodontal status, and sleep patterns in children[J]. Int J Clin Pediatr Dent, 2024, 17(8): 925-932.
[7]	AROUCHA L M C, AGUIAR D, PAIVA M, et al. Prevalence of sleep-disordered breathing and associations with malocclusion in children[J]. J Clin Sleep Med, 2020, 16(7): 1007-1012.
[8]	KIM K A, KIM S J, YOON A. Craniofacial anatomical determinants of pediatric sleep-disordered breathing: a comprehensive review[J]. J Prosthodont, 2025, 34(S1): 26-34.
[9]	ARROYO B A, RIBAS-PÉREZ D. Early childhood car-ies and sleep disorders[J]. J Clin Med, 2023, 12(4): 1378.
[10]	TAMASAS B, NELSON T, CHEN M. Oral health and oral health-related quality of life in children with obstructive sleep apnea[J]. J Clin Sleep Med, 2019, 15(3): 445-452.
[11]	DAVIDOVICH E, HEVRONI A, GADASSI L T, et al. Dental, oral pH, orthodontic and salivary values in children with obstructive sleep apnea[J]. Clin Oral Investig, 2022, 26(3): 2503-2511.
[12]	TOPALOGLU-AK A, KURTULMUS H, BASA S, et al. Can sleeping habits be associated with sleep bruxism, temporomandibular disorders and dental caries among children?[J]. Dent Med Probl, 2022, 59(4): 517-522.
[13]	LEE D W, KIM J G, YANG Y M. Influence of mouth breathing on atopic dermatitis risk and oral health in children: a population-based cross-sectional study[J]. J Dent Sci, 2021, 16(1): 178-185.
[14]	GENTRY N W, ASHBROOK L H, FU Y H, et al. Human circadian variations[J]. J Clin Invest, 2021, 131(16): e148282.
[15]	MAJEWSKA K, SEREMAK M, PODHORODECKA K, et al. New insights into health conditions related to malfunctions in clock genes[J]. Biomolecules, 2024, 14(10): 1282.
[16]	KURTOVIC A, TALAPKO J, BEKIC S, et al. The relationship between sleep, chronotype, and dental caries: a narrative review[J]. Clocks Sleep, 2023, 5(2): 295-312.
[17]	DA SILVEIRA K S R, PRADO I M, ABREU L G, et al. Association among chronotype, dietary behaviours, and caries experience in Brazilian adolescents: is there a behavioural pattern?[J]. Int J Paediatr Dent, 2018, 28: 608-615.
[18]	ALQADERI H, TAVARES M, AL-MULLA F, et al. Late bedtime and dental caries incidence in Kuwaiti children: a longitudinal multilevel analysis[J]. Commun Dent Oral Epidemiol, 2020, 48(3): 181-187.
[19]	FOLAYAN M O, EL TANTAWI M, OGINNI O, et al. Is chronotype profile a risk indicator for caries in children and adolescents in sub-urban Nigeria?[J]. Int J Paediatr Dent, 2021, 31(5): 627-633.
[20]	QUADRI M F A, ALWADANI M A, TALBI K M, et al. Exploring associations between oral health measures and oral health-impacted daily performances in 12-14-year-old schoolchildren[J]. BMC Oral Health, 2022, 22(1): 304.
[21]	ANGELHOFF C, FARESJÖ T, SUNDELL A L. Measuring hair cortisol concentration, insomnia symptoms and quality of life in preschool children with severe early childhood caries: a case-control pilot study[J]. Acta Odontol Scand, 2023, 81(7): 508-516.
[22]	VILLA M P, EVANGELISTI M, BARRETO M, et al. Short lingual frenulum as a risk factor for sleep-disordered breathing in school-age children[J]. Sleep Med, 2020, 66: 119-122.
[23]	HANSEN C, MARKSTRÖM A, SONNESEN L. Specific dento-crani-ofacial characteristics in non-syndromic children can predispose to sleep-disordered breathing[J]. Acta Paediatr, 2022, 111(3): 473-477.
[24]	LI Y, TONG X, WANG S, et al. Pediatric sleep-disordered breathing in Shanghai: characteristics, independent risk factors and its association with malocclusion[J]. BMC Oral Health, 2023, 23(1): 130.
[25]	BRUUN S N, HANSEN C, SONNESEN L. Sleepiness in children with severe malocclusion compared with in children with neutral occlusion[J]. Am J Orthod Dentofac Orthop, 2024, 165(5): 593-601.
[26]	SCHRADER L A, RONNEKLEIV-KELLY S M, HOGENESCH J B, et al. Circadian disruption, clock genes, and metabolic health[J]. J Clin Invest, 2024, 134(14): e170998.
[27]	FENG G, ZHAO J, PENG J, et al. Circadian clock: a promising scientific target in oral science[J]. Front Physiol, 2022, 13: 2388.
[28]	YU S, TANG Q, CHEN G, et al. Circadian rhythm modulates endochondral bone formation via MTR1/AMPKβ1/BMAL1 signaling axis[J]. Cell Death Differ, 2022, 29(4): 874-887.
[29]	LUO B, SONG J, ZHANG J, et al. The contribution of circadian clock to the biological processes[J]. Front Mol Biosci, 2024(11): 1387576.
[30]	HUANG W, HUANG Q, HE H, et al. PER2 promotes odontoblastic/osteogenic differentiation of dental pulp stem cells by modulating mitochondrial metabolism[J]. Int J Mol Sci, 2023, 24(13): 10661.
[31]	WU K, LI X, BAI Y, et al. The circadian clock in enamel development[J]. Int J Oral Sci, 2024, 16(1): 56.
[32]	SHANG Y F, SHEN Y Y, ZHANG M C, et al. Progress in salivary glands: endocrine glands with immune functions[J]. Front Endocrinol (Lausanne), 2023, 14: 1061235.
[33]	CIURLI A, MOHAMMED Y, AMMON C, et al. Spatially and temporally resolved metabolome of the human oral cavity[J]. iScience, 2024, 27(2): 108884.
[34]	GONZÁLEZ-GONZÁLEZ J M. Circadian rhythms and dental caries[J]. Int J Curr Res, 2018(10): 71616-71618.
[35]	MEHDIPOUR A, FATEH R, FULADVAND F, et al. Association between sleep pattern, salivary cariogenic bacteria and fungi populations, pH and buffering capacity in children: a comparative study[J]. Dent Med Probl, 2024, 61(2): 217-224.
[36]	TAKAYASU L, SUDA W, TAKANASHI K, et al. Circadian oscillations of microbial and functional composition in the human salivary microbiome[J]. DNA Res, 2017, 24(3): 261-270.
[37]	CHELLAPPA SL, ENGEN PA, NAQIB A, et al. Proof-of-principle demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota[J]. Faseb J, 2022, 36(1): e22043.
[38]	XUE Y, XU P, HU Y, et al. Stress systems exacerbate the inflammatory response after corneal abrasion in sleep-deprived mice via the IL-17 signaling pathway[J]. Mucosal Immunol, 2024, 17(3): 323-345.
[39]	CHEN P, WU H, YAO H, et al. Multi-omics analysis reveals the systematic relationship between oral homeostasis and chronic sleep deprivation in rats[J]. Front Immunol, 2022, 13: 847132.
[40]	ALARCÓN-SÁNCHEZ M A, BECERRA-RUIZ J S, AVETISYAN A, et al. Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and Meta-analysis[J]. BMC Oral Health, 2024, 24(1): 816.
[41]	NIE L, PAN X L, ZHANG X B, et al. Research on the correlation of immunity in patients with chronic insomnia[J]. Front Psychiatry, 2022, 13: 1034405.
[42]	YU X, JIANG H, CHENG G, et al. High levels of HIF-1α in hypoxic dental pulps associated with teeth with severe periodontitis[J]. J Mol Histol, 2020, 51(3): 265-275.
[43]	STANEK A, BRO YNA-TKACZYK K, MYSLINSKI W. Oxidative stress markers among obstructive sleep apnea patients[J]. Oxid Med Cell Longev, 2021, 2021: 9681595.
[44]	SEHIRLI A, CHUKWUNYERE U, AKSOY U, et al. The circadian clock gene Bmal1: role in COVID-19 and periodontitis[J]. Chronobiol Int, 2021, 38(6): 779-784.
[45]	ZHU R, MI X, LI Y. Effects of hypoxic environment on periodontal tissue through the ROS/TXNIP/NLRP3 inflammasome pathway[J]. Biomed Res Int, 2022, 2022: 7690960.