Association between serum alanine transaminase levels and carotid intima-media thickness in adolescents

HUANG Sisi; ZHAO Min; SUN Jiahong; XI Bo

doi:10.16835/j.cnki.1000-9817.2025193

Volume 46 Issue 7

Jul. 2025

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HUANG Sisi, ZHAO Min, SUN Jiahong, XI Bo. Association between serum alanine transaminase levels and carotid intima-media thickness in adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(7): 1042-1045. doi: 10.16835/j.cnki.1000-9817.2025193

Citation:

HUANG Sisi, ZHAO Min, SUN Jiahong, XI Bo. Association between serum alanine transaminase levels and carotid intima-media thickness in adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(7): 1042-1045. doi: 10.16835/j.cnki.1000-9817.2025193

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Association between serum alanine transaminase levels and carotid intima-media thickness in adolescents

doi: 10.16835/j.cnki.1000-9817.2025193

HUANG Sisi¹,
ZHAO Min²,
SUN Jiahong^{3
,
,},
XI Bo^{1
,
,}

1.
Department of Epidemiology/Maternal and Child Health/Children's Cardiovascular Research Centre, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, China

Received Date: 2025-05-07
Rev Recd Date: 2025-06-17

Available Online: 2025-08-02

Publish Date: 2025-07-25

Abstract

Abstract

Objective To investigate the relationship between serum alanine transaminase (ALT) and carotid intima-media thickness (cIMT) in adolescents, providing evidence for early prevention and control strategies for cardiovascular structural abnormalities in adolescents. Methods Data were obtained from the third follow-up survey (from October to November 2023) of the "Huantai Children Cardiovascular Health Cohort", including 1 153 healthy adolescents with complete information. Analysis of variance (ANOVA) was used to compare cIMT across different ALT level groups, and multiple linear regression was employed to analyze the relationship between serum ALT levels and cIMT. Results Significant differences in cIMT were observed among Q1, Q2, and Q3 ALT level groups [(0.56±0.04) (0.57±0.04) (0.59±0.04)mm, respectively; F=3.61, P < 0.01]. After adjusting for covariates, multiple linear regression revealed a positive correlation between ALT levels and cIMT (β=0.18, P < 0.01). Gender subgroup analysis showed similar results in males (β=0.19, P < 0.01), but no statistically significant association was found in females (β=0.07, P=0.54). Conclusions Elevated serum ALT levels are associated with an increased risk of vascular structural damage in adolescents, especially in boys. Early detection and control of abnormal serum ALT levels can help to reduce early vascular structural damage and further reduce the risk of adverse cardiovascular events.
- Alanine transaminase,
- Carotid arteries,
- Tunica media,
- Regression analysis,
- Adolescent

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References(32)

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