Effects of postnatal cadmium exposure on physical and pubertal development in children: a systematic review and Meta-analysis

HUANG Tianwenjing; PENG Zeqin; LIU Qin

doi:10.16835/j.cnki.1000-9817.2025088

Volume 46 Issue 3

Mar. 2025

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HUANG Tianwenjing, PENG Zeqin, LIU Qin. Effects of postnatal cadmium exposure on physical and pubertal development in children: a systematic review and Meta-analysis[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(3): 396-401. doi: 10.16835/j.cnki.1000-9817.2025088

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HUANG Tianwenjing, PENG Zeqin, LIU Qin. Effects of postnatal cadmium exposure on physical and pubertal development in children: a systematic review and Meta-analysis[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(3): 396-401. doi: 10.16835/j.cnki.1000-9817.2025088

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Effects of postnatal cadmium exposure on physical and pubertal development in children: a systematic review and Meta-analysis

doi: 10.16835/j.cnki.1000-9817.2025088

School of Public Health, Chongqing Medical University/Research Center for Environment and Human Health/Research Center for Medicine and Social Development, Chongqing (401331), China

Received Date: 2024-09-26
Rev Recd Date: 2025-02-05

Available Online: 2025-04-03

Publish Date: 2025-03-25

Abstract

Abstract

Objective To systematically evaluate the effects of postnatal cadmium exposure on children's pubertal and physical development, so as to provide reference for the latter research on cadmium exposure. Methods A computer search of PubMed, EBSCO, Web of Science, OVID, CNKI, WanFang, VIP and CBM database were conducted to collect relevant studies, and the search period was from the time of database construction to 27 February 2024. Two reviewers independently screened the literature, extracted data and evaluated the risk of bias of the included studies, and used GRADE to assess the certainty of the evidence for each outcome. Meta-analysis of the risk ratio (HR) for the occurrence of menarche was performed using Stata 17.0 software, and the results were summarized qualitatively for other indicators. Results A total of 6 cohort studies were included, comprising four pubertal development and two physical development studies with a total of 2 899 children. Studies of cadmium exposure and menarche in girls all found that late menarche in children with higher urinary cadmium concentrations (HR=0.86, 95%CI=0.74-0.99, P < 0.05; 3 studies; moderate-certainty evidence), and one of these studies found no statistically significant effect of cadmium exposure on breast and pubic hair development in children (aOR=0.90, 95%CI=0.72-1.14; aOR=0.85, 95%CI=0.64-1.13, P>0.05; low-quality evidence); the only study testicular volume, external genitalia and pubic hair development in boys found on effects of urinary cadmium exposure on pubertal development (aOR=0.76, 95%CI=0.50-1.15; aOR=1.07, 95%CI=0.79-1.45; aOR=0.79, 95%CI=0.51-1.23, P>0.05; low-certainty evidence). Regarding the effects of cadmium exposure on children's height and weight (2 studies, low-certainty evidence), the results of one study showed that cadmium exposure was negatively associated with children's physical growth (multivariable-adjusted attributable differences in height and weight study, being -1.60 cm, 95%CI=-2.40 to -0.77 cm; and -0.57 kg, 95%CI=-0.88 to -0.26 kg, P < 0.05), while the other showed no effect of cadmium exposure on children's height and weight (F=1.35, 1.76, P>0.05), but a negative effect on head and chest circumference (F=3.43, 4.50, P < 0.05; low-certainty evidence). Conclusion Cadmium exposure in childhood causes delayed menarche in girls and affects physical growth to some extent.
- Cadmium,
- Physical growth,
- Adolescent development,
- Meta-analysis,
- Child

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References(36)

References

[1]	杨克敌. 环境卫生学[M]. 8版. 北京: 人民卫生出版社, 2017: 250. YANG K D. Environmental hygiene[M]. 8th ed. Beijing: People's Medical Publishing House, 2017: 250. (in Chinese)
[2]	LIU D, SHI Q, LIU C, et al. Effects of endocrine-disrupting heavy metals on human health[J]. Toxics, 2023, 11(4): 322.
[3]	VACCHI-SUZZI C, KRUSE D, HARRINGTON J, et al. Is urinary cadmium a biomarker of long-term exposure in humans? A review[J]. Curr Environ Health Rep, 2016, 3(4): 450-458.
[4]	LUCACCIONI L, TREVISANI V, MARROZZINI L, et al. Endocrine-disrupting chemicals and their effects during female puberty: a review of current evidence[J]. Int J Mol Sci, 2020, 21(6): 2078.
[5]	SUGHIS M, PENDERS J, HAUFROID V, et al. Bone resorption and environmental exposure to cadmium in children: a cross-sectional study[J]. Environ Health, 2011, 10(1): 104.
[6]	KHOSHHALI M, RAFIEI N, FARAJZADEGAN Z, et al. Maternal exposure to cadmium and fetal growth: a systematic review and Meta-analysis[J]. Biol Trace Elem Res, 2020, 195(1): 9-19.
[7]	ULDBJERG C, KOCH T, LIM Y H, et al. Prenatal and postnatal exposures to endocrine disrupting chemicals and timing of pubertal onset in girls and boys: a systematic review and Meta-analysis[J]. Hum Reprod Update, 2022, 28(5): 687-716.
[8]	李柄辉, 訾豪, 李路遥, 等. 医学领域一次研究和二次研究的方法学质量(偏倚风险)评价工具[J]. 医学新知, 2021, 31(1): 51-58. LI B H, ZI H, LI L Y, et al. Methodological quality(risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better?[J]. New Med, 2021, 31(1): 51-58. (in Chinese)
[9]	GUYATT G, OXMAN A D, AKL E A, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables[J]. J Clin Epidemiol, 2011, 64(4): 383-394. doi: 10.1016/j.jclinepi.2010.04.026
[10]	REYNOLDS P, CANCHOLA A J, DUFFY C N, et al. Urinary cadmium and timing of menarche and pubertal development in girls[J]. Environ Res, 2020, 183: 109224. doi: 10.1016/j.envres.2020.109224
[11]	ASHRAP P, SÁNCHEZ B N, TÉLLEZ-ROJO M M, et al. In utero and peripubertal metals exposure in relation to reproductive hormones and sexual maturation and progression among girls in Mexico City[J]. Environ Res, 2019, 177: 108630. doi: 10.1016/j.envres.2019.108630
[12]	ASHRAP P, MEEKER J D, SÁNCHEZ B N, et al. In utero and peripubertal metals exposure in relation to reproductive hormones and sexual maturation and progression among boys in Mexico City[J]. Environ Health, 2020, 19(1): 124. doi: 10.1186/s12940-020-00672-0
[13]	MALIN IGRA A, RAHMAN A, JOHANSSON A L V, et al. Early life environmental exposure to cadmium, lead, and arsenic and age at menarche: a longitudinal mother-child cohort study in Bangladesh[J]. Environ Health Perspect, 2023, 131(2): 27003.
[14]	GARDNER R M, KIPPLER M, TOFAIL F, et al. Environmental exposure to metals and children's growth to age 5 years: a prospective cohort study[J]. Am J Epidemiol, 2013, 177(12): 1356-1367.
[15]	姜帅. 儿童尿中重金属水平与生长发育关系[D]. 上海: 复旦大学, 2014. JIANG S. Urinary lead, mercury and cadmium level and the growth and development among children in rural area[D]. Shanghai: Fudan University, 2014. (in Chinese)
[16]	GALLAGHER J R. Growth at adolescence[J]. Pediatrics, 1956, 17(5): 800.
[17]	DE CRAEMER S, CROES K, VAN LAREBEKE N, et al. Metals, hormones and sexual maturation in Flemish adolescents in three cross-sectional studies(2002-2015)[J]. Environ Int, 2017, 102: 190-199.
[18]	SAMUEL J B, STANLEY J A, PRINCESS R A, et al. Gestational cadmium exposure-induced ovotoxicity delays puberty through oxidative stress and impaired steroid hormone levels[J]. J Med Toxicol, 2011, 7(3): 195-204.
[19]	SAEDI S, SHIRAZI M R J, ZAMIRI M J, et al. Impaired follicular development and endocrine disorders in female rats by prepubertal exposure to toxic doses of cadmium[J]. Toxicol Ind Health, 2020, 36(2): 63-75.
[20]	INTERDONATO M, PIZZINO G, BITTO A, et al. Cadmium delays puberty onset and testis growth in adolescents[J]. Clin Endocrinol (Oxf), 2015, 83(3): 357-362. doi: 10.1111/cen.12704
[21]	SAEDI S, NAMAVAR M R, SHIRAZI M R J, et al. Exposure to cadmium alters the population of glial cell types and disrupts the regulatory mechanisms of the HPG axis in prepubertal female rats[J]. Neurotox Res, 2022, 40(4): 1029-1042. doi: 10.1007/s12640-022-00516-4
[22]	LAFUENTE A, MÁRQUEZ N, PÉREZ-LORENZO M, et al. Cadmium effects on hypothalamic-pituitary-testicular axis in male rats[J]. Exp Biol Med, 2001, 226(6): 605-611. doi: 10.1177/153537020122600615
[23]	ARTEAGA-SILVA M, ARENAS-RIOS E, BONILLA-JAIME H, et al. Neuroendocrine effects of cadmium exposure on male reproductive functions[J]. Front Biosci (Landmark Ed), 2021, 26(2): 286-326. doi: 10.2741/4895
[24]	SAEDI S, SHIRAZI M R J, ZAMIRI M J, et al. Impaired follicular development and endocrine disorders in female rats by prepubertal exposure to toxic doses of cadmium[J]. Toxicol Ind Health, 2020, 36(2): 63-75.
[25]	IAVICOLI I, FONTANA L, BERGAMASCHI A. The effects of metals as endocrine disruptors[J]. J Toxicol Environ Health B Crit Rev, 2009, 12(3): 206-223.
[26]	LEITE G A A, ROSA J DE L, SANABRIA M, et al. Delayed reproductive development in pubertal male rats exposed to the hypolipemiant agent rosuvastatin since prepuberty[J]. Reprod Toxicol, 2014, 44: 93-103.
[27]	WANG Q C, HUANG N X, PSALTIS J B, et al. Activation of estrogen-related receptor γ by calcium and cadmium[J]. Front Endocrinol (Lausanne), 2024, 15: 1400022.
[28]	GOLLENBERG A L, HEDIGER M L, LEE P A, et al. Association between lead and cadmium and reproductive hormones in peripubertal U.S. girls[J]. Environ Health Perspect, 2010, 118(12): 1782-1787.
[29]	MA Y G, RAN D, SHI X N, et al. Cadmium toxicity: a role in bone cell function and teeth development[J]. Sci Total Environ, 2021, 15: 144646.
[30]	TURGUT S, KAPTANOGLU B, TURGUT G, et al. Effects of cadmium and zinc on plasma levels of growth hormone, insulin-like growth factor I, and insulin-like growth factor-binding protein 3[J]. Biol Trace Elem Res, 2005, 108(1/3): 197-204.
[31]	FAULDS M H, ZHAO C, DAHLMAN-WRIGHT K, et al. The diversity of sex steroid action: regulation of metabolism by estrogen signaling[J]. J Endocrinol, 2012, 212(1): 3-12.
[32]	ARTEAGA-SILVA M, LIMÓN-MORALES O, BONILLA-JAIME H, et al. Effects of postnatal exposure to cadmium on male sexual incentive motivation and copulatory behavior: estrogen and androgen receptors expression in adult brain rat[J]. Reprod Toxicol, 2023, 120: 108445.
[33]	葛丽平. 张家口市3~6岁儿童头发中部分微量元素分析及其对生长发育的影响[D]. 石家庄: 河北医科大学, 2011. GE L P. Analysis of some trace element in the hair of children aged 3 to 6 in Zhangjiakou and its effect on their growing development[D]. Shijiazhuang: Hebei Medical University, 2011. (in Chinese)
[34]	曲英莉, 张淼, 丁亮, 等. 广西壮族自治区某矿区学龄儿童血铅和血镉水平与体格发育的相关性研究[J]. 环境卫生学杂志, 2021, 11(3): 223-229. QU Y L, ZHANG M, DING L, et al. Correlation of blood lead and cadmium levels with physical development in school-aged children in a mining area of Guangxi Zhuang Autonomous Region, China[J]. J Environ Hyg, 2021, 11(3): 223-229. (in Chinese)
[35]	ASHLEY-MARTIN J, IANNOTTI L, LESOROGOL C, et al. Heavy metal blood concentrations in association with sociocultural characteristics, anthropometry and anemia among Kenyan adolescents[J]. Int J Environ Health Res, 2022, 32(9): 1935-1949.
[36]	刘子婧. 长期污染地区重金属暴露对学龄前儿童生长发育和肾脏的早期影响[D]. 兰州: 兰州大学, 2022. LIU Z J. Early effects on growth and development and kidney of preschoolers to heavy metals exposure in a long-term polluted area[D]. Lanzhou: Lanzhou University, 2022. (in Chinese)