Temporal trend of tuberculosis burden among children under 5 years old in China from 1990 to 2021

TAO Luqiu; ZHANG Ziyu; TAN Gao; ZOU Yanzheng; PAN Li; ZHU Hongru; QIAN Yili; LIU Xiaoli; WANG Wei

doi:10.16835/j.cnki.1000-9817.2024358

Volume 45 Issue 12

Dec. 2024

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Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2024 > 45(12): 1792-1797

TAO Luqiu, ZHANG Ziyu, TAN Gao, ZOU Yanzheng, PAN Li, ZHU Hongru, QIAN Yili, LIU Xiaoli, WANG Wei. Temporal trend of tuberculosis burden among children under 5 years old in China from 1990 to 2021[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(12): 1792-1797. doi: 10.16835/j.cnki.1000-9817.2024358

Citation:

TAO Luqiu, ZHANG Ziyu, TAN Gao, ZOU Yanzheng, PAN Li, ZHU Hongru, QIAN Yili, LIU Xiaoli, WANG Wei. Temporal trend of tuberculosis burden among children under 5 years old in China from 1990 to 2021[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(12): 1792-1797. doi: 10.16835/j.cnki.1000-9817.2024358

Citation:

TAO Luqiu, ZHANG Ziyu, TAN Gao, ZOU Yanzheng, PAN Li, ZHU Hongru, QIAN Yili, LIU Xiaoli, WANG Wei. Temporal trend of tuberculosis burden among children under 5 years old in China from 1990 to 2021[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(12): 1792-1797. doi: 10.16835/j.cnki.1000-9817.2024358

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Temporal trend of tuberculosis burden among children under 5 years old in China from 1990 to 2021

doi: 10.16835/j.cnki.1000-9817.2024358

TAO Luqiu¹,
ZHANG Ziyu²,
TAN Gao³,
ZOU Yanzheng¹,
PAN Li¹,
ZHU Hongru¹,
QIAN Yili¹,
LIU Xiaoli^{3
,
,},
WANG Wei^{1
,
,}

1.
National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi (214064), Jiangsu Province, China

Received Date: 2024-10-31
Rev Recd Date: 2024-11-21
Publish Date: 2024-12-25

Abstract

Abstract

Objective To analyze the trends in disease burden of tuberculosis among children under 5 years of age in China from 1990 to 2021, so as to provide insights for future tuberculosis control measures among children in China. Methods Based on the Global Burden of Disease (GBD) 2021 datasets, the incidence, prevalence, mortality and disability-adjusted life year(DALY) of tuberculosis of children under 5 years of age in China and globally were collected from 1990 to 2021. The incidence, prevalence, mortality and DALY rate of tuberculosis were compared by genders and types. In addition, the annual percent change(APC) and the average annual percent change(AAPC) of children's tuberculosis burden in China and globally from 1990 to 2021 were calculated by using the Joinpoint regression model, and the changing trends were analyzed. Results The numbers of incident, prevalent and dead tuberculosis cases were 9 700, 8 477 800 and 200 among children under 5 years of age in China in 2021, and the DALY due to tuberculosis were 27 100 person-years. There were significant reductions in incidence, prevalence, mortality and DALY rate of tuberculosis among children under 5 years of age in China (AAPC=-5.45%, -1.14%, -12.37%, -11.34%) and globally(AAPC=-2.38%, -1.41%, -4.66%, -4.56%), and the reductions in the incidence, mortality and DALY rate were more significant in China than globally (P < 0.05).In 1992 and later, the numbers of incident, prevalent and dead tuberculosis cases and the DALY of tuberculosis were higher among male than among female. In addition, the disease burden of drug-susceptible tuberculosis appeared a tendency of downward in China from 1990 to 2021, while the incidence and prevalence of extensively drug-resistant tuberculosis rose since 2015. Conclusions The disease burden of tuberculosis remarkably reduced among children under 5 years of age in China from 1990 to 2021. However, the burden of disease due to multidrug-resistant tuberculosis appeared an upward trend recently. Increased attention is required to be paid to the prevention and control of tuberculosis among children and improved diagnosis and treatment of drug-resistant tuberculosis are recommended.
- Tuberculosis,
- Cost of illness,
- Regression analysis,
- Disability-adjusted life year,
- Child, preschool

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References(19)

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