Association between age of life adversity and insulin resistance in girls with precocious puberty

WANG Ya; LI Jing; LI Ting; ZHOU Yan; ZHU Ruoping; SUN Ying

doi:10.16835/j.cnki.1000-9817.2024150

Volume 45 Issue 5

May 2024

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WANG Ya, LI Jing, LI Ting, ZHOU Yan, ZHU Ruoping, SUN Ying. Association between age of life adversity and insulin resistance in girls with precocious puberty[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(5): 714-718. doi: 10.16835/j.cnki.1000-9817.2024150

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WANG Ya, LI Jing, LI Ting, ZHOU Yan, ZHU Ruoping, SUN Ying. Association between age of life adversity and insulin resistance in girls with precocious puberty[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(5): 714-718. doi: 10.16835/j.cnki.1000-9817.2024150

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Association between age of life adversity and insulin resistance in girls with precocious puberty

doi: 10.16835/j.cnki.1000-9817.2024150

WANG Ya¹,
LI Jing²,
LI Ting¹,
ZHOU Yan¹,
ZHU Ruoping¹,
SUN Ying^{2, 3, 4
,
,}

1.
Department of Child health, Anhui Provinal Children's Hospital, Hefei (230032), Anhui Province, China

Received Date: 2024-02-21
Rev Recd Date: 2024-03-19

Available Online: 2024-05-30

Publish Date: 2024-05-25

Abstract

Abstract

Objective To investigate the association between early life adversity(ELA) and the triglyceride-glucose (TyG) index for an indicator of insulin resistance among girls with precocious puberty, so as to provide scientific basis for effective prevention and intervention measures. Methods From July 2020 to September 2021, girls with precocious puberty were recruited from the children's health clinic of Anhui Provincial Children's Hospital. Among them, 150 girls with complete blood indicators and questionnaire information were included. Both parental reports and child self-reports were combined to assess ELA exposure. Fasting blood samples were collected to evaluate thetyg index. According to the ELA score classification, girls were classified into 3 groups for 0, 1 and >2, multiple linear regression analysis were conducted to examine the association between ELA exposure and TyG index in girls with precocious puberty. Results Precocious pubertal girls subjectively reported high rates of ELA exposure, with an average ELA score of (1.07±1.17) and an average TyG level of (7.99±0.49). A single adverse association was found that the exposure of girls with precocious puberty to a lack of warm nurturing was significantly positively correlated with the TyG index (β=0.26, 95%CI=0.03-0.50, P<0.05). Multiple linear regression analysis showed that girls in the ELA≥2 group had a 0.24 increase in TyG levels compared to girls who did not experience ELA (β=0.24, 95%CI=0.04-0.43). After controlling for covariates such as child age, mother's age, father's age, physical activity, screen time, birth weight, birth method (including natural and cesarean sections), perceived stress, BMI standardized Z-score, and parental assessment SDQ score, The association remained significant after controlling for covariates and was independent of BMI (β=0.25, 95%CI=0.04-0.46)(P<0.05). Conclusions Cumulative early life adversity in girls with precocious puberty is significantly positively correlated with the TyG index. It should early identify the girls exposed to high ELA for precocious puberty and timely intervent to improve their glucose metabolism function.
- Puberty, precocious,
- Life change events,
- Insulin resistance,
- Growth and development,
- Regression analysis,
- Child,
- Female

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