Correlations between levels of thyroid hormone-related indicators and the status of physical development of children aged 6 years old in Pudong New Area, Shanghai

HU Hui; REN Yaping; WU Tianfeng; SHEN Huiping; BAI Pinqing

doi:10.16835/j.cnki.1000-9817.2023.08.023

Volume 44 Issue 8

Aug. 2023

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Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2023 > 44(8): 1221-1225

HU Hui, REN Yaping, WU Tianfeng, SHEN Huiping, BAI Pinqing. Correlations between levels of thyroid hormone-related indicators and the status of physical development of children aged 6 years old in Pudong New Area, Shanghai[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(8): 1221-1225. doi: 10.16835/j.cnki.1000-9817.2023.08.023

Citation:

HU Hui, REN Yaping, WU Tianfeng, SHEN Huiping, BAI Pinqing. Correlations between levels of thyroid hormone-related indicators and the status of physical development of children aged 6 years old in Pudong New Area, Shanghai[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(8): 1221-1225. doi: 10.16835/j.cnki.1000-9817.2023.08.023

Citation:

HU Hui, REN Yaping, WU Tianfeng, SHEN Huiping, BAI Pinqing. Correlations between levels of thyroid hormone-related indicators and the status of physical development of children aged 6 years old in Pudong New Area, Shanghai[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(8): 1221-1225. doi: 10.16835/j.cnki.1000-9817.2023.08.023

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Correlations between levels of thyroid hormone-related indicators and the status of physical development of children aged 6 years old in Pudong New Area, Shanghai

doi: 10.16835/j.cnki.1000-9817.2023.08.023

Department of School Health and Nutrition Food, Pudong Center for Disease Control and Prevention/Pudong Institute of Preventive Medicine, Fudan University, Shanghai (200136), China

Received Date: 2023-05-30
Rev Recd Date: 2023-06-16

Available Online: 2023-08-26

Publish Date: 2023-08-25

Abstract

Abstract

Objective To explore the correlations among serum thyroid stimulating hormone (TSH), total triiodothyronne (TT3) and total thyroxine (TT4) and the status of physical development of school-age children in Pudong New Area, Shanghai, so as to provide a basis for health guidance and clinical intervention for school-age children. Methods From October to November 2020, stratified cluster sampling method was used to select 2 088 students aged 6 years old from 13 primary schools in Pudong New Area. Test of the level of serum thyroid hormone, physical examination and questionnaire investigation were performed. Height for age Z score (HAZ), Weight for age Z score (WAZ) and BMI for age Z score (BAZ) were used to evaluate child's status of physical development. The correlations among the level of thyroid hormone and the status of physical development of school-age children was analyzed. Results The median (P₂₅, P₇₅) values of TSH, TT3 and TT4 of school-age children in Pudong New Area were 3.09 (2.27, 3.87)μIU/mL, 2.06 (1.88, 2.25) nmol/L and 110.30 (99.80, 120.00) nmol/L. Height, weight, body mass index (BMI), HAZ, WAZ and BAZ were (122.34±5.22)cm, (24.72±4.90)kg, (16.42±2.40)kg/m², (0.64±0.94) (0.71±1.69) and (0.50±1.30), respectively. There were statistically significant differences in BMI, WAZ and BAZ with different TSH levels (F=3.61, 3.39, 3.18, P < 0.05), and there were statistically significant differences in height, weight, BMI, HAZ, WAZ and BAZ (F=15.28, 53.79, 54.77, 15.78, 27.57, 52.78, P < 0.01) with different TT3 levels. Compared with the normal group, high TSH group was positively correlated with BAZ grading [OR(95%CI) =1.27 (1.03-1.57)], low TT3 group was negatively correlated with HAZ grading, WAZ grading, and BAZ grading [OR(95%CI) =0.68(0.54-0.85), 0.61(0.49-0.76), 0.63(0.51-0.79)], high TT3 group was positively correlated with WAZ grading and BAZ grading [OR(95%CI) =1.90(1.55-2.33), 1.89(1.54-2.33)], high TT4 group was positively correlated with BAZ grading [OR(95%CI)=1.26(1.02-1.56)] (P < 0.05). Conclusion The serum levels of thyroid hormone, Shanghai were correlated with physical development among 6-year-old Children in Pudong New Area, Shanghai. Keep normal thyroid hormone level is of great significance for children's health.
- Thyroid hormones,
- Growth and development,
- Regression analysis,
- Child

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References(26)

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