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儿童1型糖尿病生命早期相关影响因素的病例对照研究

刘合作 孙琦 魏薇 翟玲玲 白英龙 贾丽红

刘合作, 孙琦, 魏薇, 翟玲玲, 白英龙, 贾丽红. 儿童1型糖尿病生命早期相关影响因素的病例对照研究[J]. 中国学校卫生, 2021, 42(1): 128-131. doi: 10.16835/j.cnki.1000-9817.2021.01.031
引用本文: 刘合作, 孙琦, 魏薇, 翟玲玲, 白英龙, 贾丽红. 儿童1型糖尿病生命早期相关影响因素的病例对照研究[J]. 中国学校卫生, 2021, 42(1): 128-131. doi: 10.16835/j.cnki.1000-9817.2021.01.031
LIU Hezuo, SUN Qi, WEI Wei, ZHAI Lingling, BAI Yinglong, JIA Lihong.. Case-control study of early life-related risk factors associated with type 1 diabetes mellitus in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(1): 128-131. doi: 10.16835/j.cnki.1000-9817.2021.01.031
Citation: LIU Hezuo, SUN Qi, WEI Wei, ZHAI Lingling, BAI Yinglong, JIA Lihong.. Case-control study of early life-related risk factors associated with type 1 diabetes mellitus in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(1): 128-131. doi: 10.16835/j.cnki.1000-9817.2021.01.031

儿童1型糖尿病生命早期相关影响因素的病例对照研究

doi: 10.16835/j.cnki.1000-9817.2021.01.031
基金项目: 

国家自然科学基金项目 81673190

详细信息
    作者简介:

    刘合作(1989-),男,湖北黄石人,在读硕士,主要研究方向为儿童糖尿病的影响因素

    通讯作者:

    贾丽红,E-mail: lhjia@cmu.edu.cn

  • 中图分类号: R 446 R 587.1 R 179

Case-control study of early life-related risk factors associated with type 1 diabetes mellitus in children

  • 摘要:   目的  探讨儿童1型糖尿病(T1DM)发生的影响因素,为有针对性采取防治措施提供参考。  方法  采用病例对照研究,选取沈阳市某医院106例确诊为T1DM的患儿为病例组,同期按照年龄、性别、居住地区1:1匹配的原则,选取106名健康儿童作为对照组,对两组生命早期可能影响T1DM发生发展的因素进行问卷调查。  结果  106例T1DM患儿平均确诊年龄为(8.02±3.49)岁; 女童占60.4%,男童占39.6%。多因素Logistic回归分析显示,家庭经济好、父亲文化程度高与T1DM的发生呈负相关; 而家庭成员吸烟(OR=2.51, 95%CI=1.19~5.29)、有糖尿病家族史(OR=2.56, 95%CI=1.18~5.55)、母亲肥胖(OR=5.42, 95%CI=2.49~11.83)和孕期感染(OR=3.45, 95%CI=1.04~11.46)与T1DM发生呈正相关(P值均 < 0.05)。  结论  儿童T1DM的发生受遗传、母孕期健康及家庭经济等多因素的影响,从生命早期开始预防儿童T1DM的发生具有重要意义。
  • 表  1  不同影响因素下两组儿童分布情况比较

    Table  1.   Comparison of the distribution of two groups children under different influencing factors

    变量 选项 病例组
    (n=106)
    对照组
    (n=106)
    χ2 P
    家庭经济 7(6.7) 26(24.8) 38.03 < 0.01
    一般 57(54.8) 73(69.5)
    40(38.5) 6(5.7)
    家庭成员吸烟 67(63.2) 49(46.2) 6.17 0.01
    39(36.8) 57(53.8)
    糖尿病家族史 47(44.3) 26(24.5) 9.21 < 0.01
    59(55.7) 80(75.5)
    父亲肥胖 68(64.2) 60(56.6) 1.26 0.26
    38(35.8) 46(43.4)
    母亲肥胖 52(49.1) 90(84.9) 30.79 < 0.01
    54(50.9) 16(15.1)
    父亲文化程度 大专以上 25(23.8) 55(51.9) 45.33 < 0.01
    高中 21(20.0) 38(35.8)
    初中及以下 59(56.2) 13(12.3)
    母亲文化程度 大专以上 29(27.6) 65(61.3) 35.83 < 0.01
    高中 24(22.9) 27(25.5)
    初中及以下 52(49.5) 14(13.2)
    孕期补充维生素D 41(38.7) 68(64.2) 13.77 < 0.01
    65(61.3) 38(35.8)
    孕期母亲感染 17(16.0) 6(5.7) 5.90 0.02
    89(84.0) 100(94.3)
    出生体重/kg <2.5 4(3.8) 4(3.8) 0.12 0.94
    2.5~ <4.0 80(75.5) 82(77.4)
    ≥4.0 22(20.8) 20(18.9)
    分娩方式 顺产 40(37.7) 47(44.3) 0.95 0.33
    剖腹产 66(62.3) 59(55.7)
    出生后0~4月母乳 76(71.7) 62(58.5) 4.07 0.04
    喂养 30(28.3) 44(41.5)
    目前儿童BMI 非超重肥胖 98(92.5) 91(85.8) 2.39 0.12
    超重肥胖 8(7.5) 15(14.2)
    注: ()内数字为构成比%; 表中数据存在缺失值。
    下载: 导出CSV

    表  2  儿童1型糖尿病影响因素的多因素Logistic回归分析(n=212)

    Table  2.   Analysis of multivariate Logistic regression of the influencing factors of type 1 diabetes mellitus in children (n=212)

    自变量 β 标准误 Wald χ2 P OR值(OR值95%CI)
    家庭经济
      一般 -1.50 0.61 6.06 0.01 0.22(0.06~0.73)
      好 -2.71 0.78 11.91 0.00 0.06(0.01~0.31)
    家庭成员吸烟 0.92 0.38 5.89 0.02 2.51(1.19~5.29)
    糖尿病家族史 0.94 0.39 5.68 0.02 2.56(1.18~5.55)
    母亲肥胖 1.69 0.39 18.10 < 0.01 5.42(2.49~11.83)
    父亲文化程度
      高中 -0.69 0.65 1.14 0.29 0.49(0.13~1.78)
      大专及以上 -1.74 0.58 3.92 < 0.05 0.35(0.12~0.98)
    母亲文化程度
      高中 -0.97 0.65 2.20 0.14 0.37(0.10~1.36)
      大专及以上 -0.38 0.63 0.36 0.55 0.68(0.19~2.35)
    孕期补充维生素D -0.50 0.37 1.80 0.18 0.60(0.28~1.26)
    孕期母亲感染 1.24 0.61 4.10 0.04 3.45(1.04~11.46)
    出生后0~4月母乳喂养 0.18 0.40 0.21 0.65 1.20(0.54~2.63)
    下载: 导出CSV
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出版历程
  • 收稿日期:  2020-05-07
  • 修回日期:  2020-06-30
  • 网络出版日期:  2021-04-01
  • 刊出日期:  2021-01-25

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