孤独症谱系障碍儿童青少年情绪面孔眼动特征的系统评价

李鑫雨; 熊文娟; 崔庭凯; 曲之毅; 张欣

doi:10.16835/j.cnki.1000-9817.2024267

孤独症谱系障碍儿童青少年情绪面孔眼动特征的系统评价

doi: 10.16835/j.cnki.1000-9817.2024267

天津医科大学公共卫生学院, 天津 300070

基金项目:

国家自然科学基金项目 82273655

详细信息

作者简介:
李鑫雨(1998-)，女，河北交河县人，在读硕士，主要研究方向为儿少卫生与妇幼保健

通讯作者:
张欣, E-mail: zhangxin@tmu.edu.cn

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R179 R748 B844 R322.9⁺¹
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- 被引次数: 0
出版历程
- 收稿日期: 2024-04-26
- 修回日期: 2024-05-30
- 网络出版日期: 2024-10-08
- 刊出日期: 2024-09-25

Systematic evaluation of eye tracking characteristics of emotional face in children and adolescents with autism spectrum disorder

School of Public Health, Tianjin Medical University, Tianjin (300070), China

摘要

摘要: 目的应用眼动技术测量孤独症谱系障碍(ASD)儿童青少年对情绪面孔的注视时间，为ASD的诊断及干预提供潜在的客观指标。方法以PubMed、Web of Science、中国知网、万方数据为检索数据库，检索时间为建库至2024年4月1日，根据检索策略，检索3~18岁儿童青少年ASD的情绪面孔相关病例-对照研究，采用纽卡斯尔-渥太华量表(NOS)评估文献质量，使用State 17.0软件进行Meta分析。结果共纳入18篇文献，研究样本包括ASD组361例，对照组413例，NOS评分均≥6分，研究质量较高。与对照组相比，ASD组对某些情绪面孔的注视时间更短(P值均＜0.01)，包括自制情绪面孔及同人种情绪面孔范式下高兴面孔的注视时间(SMD值分别为-1.05，-1.16)，国内文献条件下中性面孔的注视时间(SMD=-1.00)，临床诊断标准下生气面孔(SMD=-1.73)和悲伤面孔的注视时间(SMD=-1.29)及中国精神障碍分类与诊断标准第3版(CCMD-Ⅲ)标准下恐惧面孔的注视时间(SMD=-1.51)。结论 ASD儿童青少年对某些情绪面孔的眼动指标存在异常，提示这些眼动指标可能是ASD诊断的预警指标。
- 孤独性障碍 /
- 情绪 /
- 面部 /
- 精神卫生 /
- Meta分析 /
- 儿童 /
- 青少年
Abstract: Objective To apply eye-tracking technology to measure the fixation duration of children and adolescents with autism spectrum disorder (ASD) towards emotional faces, so as to provide potential objective indicators for the diagnosis and intervention of ASD. Methods Case-control studies related to emotional faces in ASD children and adolescents aged 3-18 years were searched in PubMed, Web of Science, CNKI and Wanfang, with a search period spanning from the inception of the databases to April 1, 2024. The Newcastle-Ottawa Scale (NOS) was employed to assess the quality of the retrieved articles, and a Meta-analysis was conducted by Stata 17.0 software. Results A total of 18 articles were included, encompassing 361 participants in the ASD group and 413 in the control group. All studies scored ≥6 on the NOS, indicating high research quality. Compared to the control group, the ASD group demonstrated significantly shorter fixation duration (P < 0.01) towards specific emotional faces, including happy faces under the paradigm of self-made and same-ethnicity emotional faces (SMD=-1.05, -1.16), neutral faces in domestic literature (SMD= -1.00), angry and sad faces under clinical diagnosis criteria (SMD=-1.73, -1.29), and fearful faces under Chinese Classification and Diagnostic Criteria of Mental Disorders, Version 3 (CCMD-Ⅲ) (SMD=-1.51). Conclusion Children and adolescents with ASD exhibit abnormal eye-tracking indicators towards certain emotional faces, which may serve as early warning indicators for the diagnosis of ASD.
- Autistic disorder /
- Emotions /
- Face /
- Mental health /
- Meta-analysis /
- Child /
- Adolescent
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

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图 1 文献筛选流程

Figure 1. Flow chart of literature retrieval

下载: 全尺寸图片幻灯片

图 2 ASD儿童青少年不同情绪面孔注视时间比较的Meta分析

Figure 2. Meta-analysis for comparing the fixation duration for different emotional face in children and adolescents with ASD

下载: 全尺寸图片幻灯片

表 1 纳入文献的基本特征

Table 1. Basic characteristics of included literature

第一作者及年份	国家	人数		年龄/岁		ASD诊断方法	眼动追踪装置	刺激材料	情绪面孔	NOS评分
第一作者及年份	国家	病例组	对照组	病例组	对照组	ASD诊断方法	眼动追踪装置	刺激材料	情绪面孔	NOS评分
Wieckowski(2017)^[8]	美国	20	20	14.65±1.79	13.75±1.59	临床诊断/ADOS-2	Tobii T60 XL	VT-KFER数据集	生气、厌恶、恐惧、悲伤、高兴、惊喜	8
Sahuquillo-Leal(2022)^[9]	西班牙	27	25	12.81±2.79	13.05±4.41	DSM-IV	SMI RED250	IAPS	高兴、悲伤、中性	8
Chien(2022)^[10]	中国	3	14	4.75±1.76	4.89±1.24	DSM-V/ICD-10	Tobii X2-30	自制情绪识别游戏	悲伤、高兴、惊喜	7
Van Der Donck(2021)^[11]	比利时	20	20	10.40±1.40	10.50±1.50	DSM-IV-TR/DSM-V	Tobii X3-120	情绪识别任务	生气、厌恶、恐惧、悲伤、高兴、惊喜	9
Van Der Geest(2002)^[12]	荷兰	17	17	12.60±2.10	10.10±1.30	DSM-IV/ADI-R	SensoMotoric	JAC-Fee和JACNeuf数据集	生气、高兴、惊喜、中性	9
马伟娜(2014)^[13]	中国	15	15	13.80±1.42	12.90±0.46	临床诊断	Tobii 120	中国化情绪图片系统	生气、恐惧、悲伤、高兴	7
李丹丹(2021)^[14]	中国	27	36	7.60±0.49	7.50±1.45	临床诊断	SMI iView X	中国化情绪图片系统	生气、悲伤、高兴、中性	6
李琳(2020)^[15]	中国	30	30	4.98±1.17	5.20±0.50	DSM-V	Tobii 4C	自制情绪视频	悲伤、高兴	7
林云强(2022)^[16]	中国	15	15	11.07±1.83	5.50±0.82	DSM-V	Tobii Pro X3-120 EPU	自制情绪面孔	生气、悲伤、高兴	8
余宥依(2019)^[17]	中国	22	25	8.14±1.07	8.11±0.71	临床诊断/CARS	SMI Iview X	自制情绪面孔	生气、恐惧、高兴	7
王广帅(2018)^[18]	中国	31	51	4.37±2.00	5.02±0.63	DSM-V	Tobii Eye Tracker 4C	BU-3DFE数据库	恐惧、高兴	8
林云强(2014)^[19]	中国	28	28	12.15±1.89	5.39±0.43	临床诊断	Tobii X120	自制情绪面孔	生气、高兴	7
陈晖(2012)^[20]	中国	35	35	11.91±2.10	5.33±0.46	DSM-IV	Tobii X120	自制情绪面孔	生气、高兴、中性	8
魏玲(2023)^[21]	中国	21	23	8.11±1.03	8.19±0.69	临床诊断	SMI Iview X	自制情绪面孔	生气、恐惧、高兴	7
龙细连(2015)^[22]	中国	6	6	一至四年级	一至四年级	临床诊断	Tobii 120	CFAPS	生气、厌恶、恐惧、悲伤、惊喜	6
胡清莹(2013)^[23]	中国	25	27	9.16±2.90	8.41±1.42	CCMD-Ⅲ	Tobii 120	自制情绪面孔	恐惧、高兴、中性	7
龙细连(2012)^[24]	中国	6	6	8.83±1.72	7.83±1.17	CCMD-Ⅲ	Tobii 120	CFAPS	中性	8
陈顺森(2011)^[25]	中国	13	20	8.69±0.97	8.45±0.97	CCMD-Ⅲ	Tobii 120	CFAPS	恐惧、高兴、中性	7
注： ADOS-2为第2版孤独症诊断观察时间表，DSM-IV为《诊断和统计手册》第4版，DSM-IV-TR为《诊断和统计手册》第4版修订版，DSM-V为《诊断和统计手册》第5版，ICD-10为《国际疾病分类》第10版，ADI-R为孤独症诊断访谈量表(修订版)，CARS为儿童孤独症评定量表，CCMD-Ⅲ为中国精神障碍分类与诊断标准第3版。

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