维生素D缺乏与儿童肥胖关系的研究进展

王晓宁; 郭齐雅; 张倩; 许娟

doi:10.16835/j.cnki.1000-9817.2024170

维生素D缺乏与儿童肥胖关系的研究进展

doi: 10.16835/j.cnki.1000-9817.2024170

王晓宁¹,
郭齐雅¹,
张倩^{1, 2},
许娟^1, ,

1.
中国疾病预防控制中心营养与健康所，北京 100050
2.
国家卫生健康委员会微量元素与营养重点实验室

基金项目:

十四五国家重点研发计划项目 2021YFC2701902

详细信息

作者简介:
王晓宁(1999-)，女，河北省人，在读硕士，主要研究方向为学生营养与健康

通讯作者:
许娟，E-mail：xujuan@ninh.chinacdc.cn

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R179 R723.14 R591.44
计量
- 文章访问数: 97
- HTML全文浏览量: 39
- PDF下载量: 21
- 被引次数: 0
出版历程
- 收稿日期: 2023-11-13
- 修回日期: 2024-04-10
- 网络出版日期: 2024-07-27
- 刊出日期: 2024-07-25

Progress of research on the relationship between vitamin D deficiency and obesity among children

WANG Xiaoning¹,
GUO Qiya¹,
ZHANG Qian^{1, 2},
XU Juan^{1
, ,}

1.
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing (100050), China

摘要

摘要: 维生素D(Vit D)缺乏在全球普遍存在，儿童肥胖的患病率也呈全球增长趋势。多项研究证明Vit D缺乏可能是导致儿童肥胖发生发展的重要原因，同时肥胖儿童体内血清Vit D水平降低，二者间通过直接因素、分子机制以及环境因素等相互影响，但其作用机制尚未完全阐明。未来可开展循证医学级别更高的研究，以探明儿童肥胖与Vit D缺乏的联系及其相互作用的可能机制，为防控儿童Vit D缺乏和肥胖提供科学证据。
- 维生素D缺乏 /
- 肥胖症 /
- 儿童 /
- 研究
Abstract: Vitamin D (Vit D) deficiency is prevalent worldwide, and the prevalence of childhood obesity is increasing globally. Many studies have supported that Vit D deficiency may be an important cause of childhood obesity, and the level of serum Vit D among obese children decreases, simultaneously. Both Vit D deficiency and obesity among children interact through direct factors, molecular mechanisms and environmental factors, but the mechanism of interaction has not been fully elucidated. In the future, higher level research in evidence-based medicine could be conducted to explore the association between childhood obesity and Vit D deficiency and the possible mechanisms of their interaction, in order to provide scientific evidence for the prevention and control of Vit D deficiency and obesity among children.
- Vitamin D deficiency /
- Obesity /
- Child /
- Research
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

HTML全文

参考文献(56)

[1]	DI CESARE M, SORIC M, BOVET P, et al. The epidemiological burden of obesity in childhood: a worldwide epidemic requiring urgent action[J]. BMC Med, 2019, 17(1): 212. doi: 10.1186/s12916-019-1449-8
[2]	董彦会, 陈力, 刘婕妤, 等. 1985—2019年中国7~18岁儿童青少年超重与肥胖的流行趋势及预测研究[J]. 中华预防医学杂志, 2023, 57(4): 461-469. DONG Y H, CHEN L, LIU J Y, et al. Epidemiology and prediction of overweight and obesity among children and adolescents aged 7-18 years in China from 1985 to 2019[J]. Chin J Prev Med, 2023, 57(4): 461-469. (in Chinese)
[3]	HOLICK M F, CHEN T C. Vitamin D deficiency: a worldwide problem with health consequences[J]. Am J Clin Nutr, 2008, 87(4): 1080S-1086S. doi: 10.1093/ajcn/87.4.1080S
[4]	VELENTZAS C. Vitamin D metabolism in thyrotoxicosis. Therapeutic aspects derived from an old observation[J]. Int J Clin Pract, 2009, 63(8): 1265. doi: 10.1111/j.1742-1241.2009.02033.x
[5]	ROTH D E, ABRAMS S A, ALOIA J, et al. Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low- and middle-income countries[J]. Ann N Y Acad Sci, 2018, 1430 (1): 44-79. doi: 10.1111/nyas.13968
[6]	HU Y, CHEN J, WANG R, et al. Vitamin D nutritional status and its related factors for Chinese children and adolescents in 2010-2012[J]. Nutrients, 2017, 9(9): 1024. doi: 10.3390/nu9091024
[7]	HYPPÖNEN E, BOUCHER B J. Adiposity, vitamin D requirements, and clinical implications for obesity-related metabolic abnormalities[J]. Nutr Rev, 2018, 76(9): 678-692. doi: 10.1093/nutrit/nuy034
[8]	MARQUINA C, MOUSA A, SCRAGG R, et al. Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms[J]. Obes Rev, 2018, 20(2): 262-277.
[9]	BONNET L, KARKENI E, COUTURIER C, et al. Four days high fat diet modulates vitamin D metabolite levels and enzymes in mice[J]. J Endocrinol, 2021, 248(1): 87-93. doi: 10.1530/JOE-20-0198
[10]	MOORE E C, LIU Y. Low serum 25-hydroxy vitamin D concentrations are associated with total adiposity of children in the United States: national health and examination survey 2005 to 2006[J]. Nutr Res, 2016, 36(1): 72-79. doi: 10.1016/j.nutres.2015.11.003
[11]	朱莎, 钟燕, 康如彤, 等. 维生素D干预对单纯性肥胖合并维生素D缺乏儿童糖脂代谢的影响[J]. 中国医药, 2021, 16(1): 123-125. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYG202101029.htm ZHU S, ZHONG Y, KANG R T, et al. Effect of vitamin D intervention on glycolipid metabolism in children with simple obesity and vitamin D deficiency[J]. China Med, 2021, 16(1): 123-125. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYG202101029.htm
[12]	张益多, 于凡, 刘欢. 不同性别肥胖患儿维生素D水平与营养代谢的关系[J]. 山西医科大学学报, 2021, 52(6): 789-793. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYX202106023.htm ZHANG Y D, YU F, LIU H. Relationships of vitamin D level with nutrition metabolism in obese children of different gender[J]. J Shanxi Med Univ, 2021, 52(6): 789-793. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-SXYX202106023.htm
[13]	KESBY J P, EYLES D W, BURNE T H, et al. The effects of vitamin D on brain development and adult brain function[J]. Mol Cell Endocrinol, 2011, 347(1/2): 121-127.
[14]	JI S, DOUMIT M E, HILL R A. Regulation of adipogenesis and key adipogenic gene expression by 1, 25-dihydroxy vitamin D in 3T3-L1 cells[J]. PLoS One, 2015, 10(6): e0126142. doi: 10.1371/journal.pone.0126142
[15]	SHEN F, WANG Y, SUN H L, et al. Vitamin D receptor gene polymorphisms are associated with triceps skin fold thickness and body fat percentage but not with body mass index or waist circumference in Han Chinese[J]. Lipids Health Dis, 2019, 18(1): 97. doi: 10.1186/s12944-019-1027-2
[16]	NARVAEZ C J, MATTHEWS D, BROUN E, et al. Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue[J]. Endocrinology, 2009, 150(2): 651-661. doi: 10.1210/en.2008-1118
[17]	WANG D, SU K K, DING Z X, et al. Association of vitamin D receptor gene polymorphisms with metabolic syndrome in Chinese children[J]. Int J Gen Med, 2021, 14: 57-66, doi: 10.2147/IJGM.S287205
[18]	KAZEMIAN E, AMOUZEGAR A, AKBARI M E, et al. Vitamin D receptor gene polymorphisms affecting changes in visceral fat, waist circumference and lipid profile in breast cancer survivors supplemented with vitamin D₃[J]. Lipids Health Dis, 2019, 18(1): 161. doi: 10.1186/s12944-019-1100-x
[19]	PARK H K, AHIMA R S. Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism[J]. Metabolism, 2015, 64(1): 24-34. doi: 10.1016/j.metabol.2014.08.004
[20]	ADIYAMAN S C, OZER M, SAYDAM B O, et al. The role of adiponectin in maintaining metabolic homeostasis[J]. Curr Diabetes Rev, 2020, 16(2): 95-103.
[21]	MOUSA A, NADERPOOR N, WILSON K, et al. Vitamin D supplementation increases adipokine concentrations in overweight or obese adults[J]. Eur J Nutr, 2020, 59(1): 195-204. doi: 10.1007/s00394-019-01899-5
[22]	WALKER G E, FOLLENZI A, BRUSCAGGIN V, et al. Fetuin B links vitamin D deficiency and pediatric obesity: direct negative regulation by vitamin D[J]. Steroid Biochem Mol Biol, 2018, 182: 37-49. doi: 10.1016/j.jsbmb.2018.04.009
[23]	KHWANCHUEA R, PUNSAWAD C. Associations between body composition, leptin, and vitamin D varied by the body fat percentage in adolescents[J]. Front Endocrinol, 2022, 13: 876231. doi: 10.3389/fendo.2022.876231
[24]	RAFIQ R, EI HADDAOUI H, DE MUTSERT R, et al. Adiposity is a confounding factor which largely explains the association of serum vitamin D concentrations with C-reactive protein, leptin and adiponectin[J]. Cytokine, 2020, 131: 155104. doi: 10.1016/j.cyto.2020.155104
[25]	吕高峰, 唐仕华, 邹渝. 单纯性肥胖儿童血清25-羟维生素D水平及意义[J]. 中国妇幼健康研究, 2019, 30(2): 203-206. https://www.cnki.com.cn/Article/CJFDTOTAL-SANE201902018.htm LÜ G F, TANG S H, ZOU Y. Level and significance of serum 25-hydroxy vitamin D in children with simple obesity[J]. Chin J Woman Child Health Res, 2019, 30(2): 203-206. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-SANE201902018.htm
[26]	HALBERG N, KHAN T, TRUJILLO M E, et al. Hypoxia inducible factor 1 alpha induces fibrosis and insulin resistance in white adipose tissue[J]. Mol Cell Biol, 2009, 29(16): 4467-4483. doi: 10.1128/MCB.00192-09
[27]	PALANISWAMY S, GILL D, DE SILVA N M, et al. Could vitamin D reduce obesity-associated inflammation? Observational and Mendelian randomization study[J]. Am J Clin Nutr, 2020, 111(5): 1036-1047. doi: 10.1093/ajcn/nqaa056
[28]	ZAKHAROVA I, KLIMOV L, KURYANINOVA V, et al. Vitamin D insufficiency in overweight and obese children and adolescents[J]. Front Endocrinol, 2019, 10(1): 103.
[29]	PARK C Y, KIM T Y, YOO J S, et al. Effects of 1, 25-dihydroxy vitamin D₃ on the inflammatory responses of stromal vascular cells and adipocytes from lean and obese mice[J]. Nutrients, 2020, 12(2): 364. doi: 10.3390/nu12020364
[30]	MARZIOU A, PHILOUZE C, COUTURIER C, et al. Vitamin D supplementation improves adipose tissue inflammation and reduces hepatic steatosis in obese C57BL/6J mice[J]. Nutrients, 2020, 12(2): 342. doi: 10.3390/nu12020342
[31]	FARHANGI M A, MESGARI-ABBASI M, HAJILUIAN G, et al. Adipose tissue inflammation and oxidative stress: the ameliorative effects of vitamin D[J]. Inflammation, 2017, 40(5): 1688-1697. doi: 10.1007/s10753-017-0610-9
[32]	YU Y, TIAN L, XIAO Y, et al. Effect of vitamin D supplementation on some inflammatory biomarkers in type 2 diabetes mellitus subjects: a systematic review and Meta-analysis of randomized controlled trials[J]. Ann Nutr Metab, 2018, 73(1): 62-73. doi: 10.1159/000490358
[33]	CEDIEL G, CORVALÁN C, LÓPEZ DE ROMAÑA D, et al. Prepubertal adiposity, vitamin D status, and insulin resistance[J]. Pediatrics, 2016, 138(1): e20160076. doi: 10.1542/peds.2016-0076
[34]	CORICA D, ZUSI C, OLIVIERI F, et al. Vitamin D affects insulin sensitivity and β-cell function in obese non-diabetic youths[J]. Eur J Endocrinol, 2019, 181(4): 439-450. doi: 10.1530/EJE-19-0369
[35]	PRAMONO A, JOCKEN J W E, BLAAK E E. Vitamin D deficiency in the aetiology of obesity-related insulin resistance[J]. Diabetes Metab Res Rev, 2019, 35(5): e3146.
[36]	SZYMCZAK-PAJOR I, DRZEWOSKI J, SLIWINSKA A. The molecular mechanisms by which vitamin D prevents insulin resistance and associated disorders[J]. Int J Mol Sci, 2020, 21(18): 6644.
[37]	CEFALO C M A, CONTE C, SORICE G P, et al. Effect of vitamin D supplementation on obesity-induced insulin resistance: a double-blind, randomized, placebo-controlled trial[J]. Obesity, 2018, 26(4): 651-657.
[38]	LENDERS C M, FELDMAN H A, VON SCHEVEN E, et al. Relation of body fat indexes to vitamin D status and deficiency among obese adolescents[J]. Am J Clin Nutr, 2009, 90(3): 459-467.
[39]	PLESNER J L, DALAI M, FONVIG C E, et al. Obesity is associated with vitamin D deficiency in Danish children and adolescents[J]. JPEM, 2018, 31(1): 53-61.
[40]	陈星, 伍晋辉, 向韵, 等. 我国3~18岁超重或肥胖儿童维生素D水平的Meta分析[J]. 四川生理科学杂志, 2023, 45(1): 184-188, 181. CHEN X, WU J H, XIANG Y, et al. Meta-analysis of vitamin D levels in overweight or obese children aged 3 to 18 years in China[J]. Sichuan J Physiol Sci, 2023, 45(1): 184-188, 181. (in Chinese)
[41]	FIAMENGHI V I, MELLO E D. Vitamin D deficiency in children and adolescents with obesity: a Meta-analysis[J]. J Pediatr, 2021, 97(3): 273-279.
[42]	刘枫凤, 杨利琦. 不同程度肥胖儿童的代谢特征、维生素D、IGF-1水平及与肥胖的关系分析[J]. 中国现代医生, 2021, 59(33): 31-34. https://www.cnki.com.cn/Article/CJFDTOTAL-ZDYS202133010.htm LIU F F, YANG L Q. Metabolic characteristics, vitamin D and IGF-1 levels of children with different degrees of obesity and their relationship with obesity[J]. Mod Chin Doc, 2021, 59(33): 31-34. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZDYS202133010.htm
[43]	ROSENSTREICH S J, RICH C, VOLWILER W. Deposition in and release of vitamin D₃ from body fat: evidence for a storage site in the rat[J]. J Clin Investig, 1971, 50(3): 679-687.
[44]	CARRELLI A, BUCOVSKY M, HORST R, et al. Vitamin D storage in adipose tissue of obese and normal weight women[J]. J Bone Miner Res, 2017, 32(2): 237-242.
[45]	WORTSMAN J, MATSUOKA L Y, CHEN T C, et al. Decreased bioavailability of vitamin D in obesity[J]. Am J Clin Nutr, 2000, 72(3): 690-693.
[46]	ROIZEN J D, LONG C, CASELLA A, et al. Obesity decreases hepatic 25-hydroxylase activity causing low serum 25-hydroxy vitamin D[J]. J Bone Miner Res, 2019, 34(6): 1068-1073.
[47]	ZHU J, DELUCA H F. Vitamin D 25-hydroxylase-four decades of searching, are we there yet?[J]. Arch Biochem Biophys, 2012, 523(1): 30-36.
[48]	NASSAR M F, EMAM E K, ALLAM M. Is there a benefit of vitamin D supplementation in deficient children and adolescents suffering from obesity? A Meta-analysis[J]. Global Pediatr Health, 2021, 8: 2333794X211018352.
[49]	ELKHWANKY M S, KUMMU O, PILTONEN T T, et al. Obesity represses CYP2R1, the vitamin D 25-hydroxylase, in the liver and extrahepatic tissues[J]. JBMR Plus, 2020, 4(11): e10397.
[50]	WAMBERG L, CHRISTIANSEN T, PAULSEN S K, et al. Expression of vitamin D-metabolizing enzymes in human adipose tissue: the effect of obesity and diet-induced weight loss[J]. Int J Obes, 2013, 37(5): 651-657.
[51]	STEPAN M D, VINTILESCU S B, STREATA I, et al. The role of vitamin D in obese children with non-alcoholic fatty liver disease and associated metabolic syndrome[J]. Nutrients, 2023, 15(9): 2113.
[52]	EL AMROUSY D, ABDELHAI D, SHAWKY D. Vitamin D and nonalcoholic fatty liver disease in children: a randomized controlled clinical trial[J]. Eur J Pediatr, 2022, 181(2): 579-586.
[53]	SHULHAI A M, PAVLYSHYN H, SHULHAI O. Peculiarities of the prevalence and risk factors for vitamin D deficiency in overweight and obese adolescents in Ukraine[J]. Arch Balk Med Union, 2019, 54(1): 57-63.
[54]	GUO X F, WANG C, YANG T, et al. Vitamin D and non-alcoholic fatty liver disease: a Meta-analysis of randomized controlled trials[J]. Food funct, 2020, 11(9): 7389-7399.
[55]	BARREA L, SAVASTANO S, DI SOMMA C, et al. Low serum vitamin D-status, air pollution and obesity: a dangerous liaison[J]. Rev Endocr Metab Disord, 2017, 18(2): 207-214.
[56]	PRAMONO A, JOCKEN J W E, GOOSSENS G H, et al. Vitamin D release across abdominal adipose tissue in lean and obese men: the effect of β-adrenergic stimulation[J]. Physiol Rep, 2019, 7(24): e14308.