生物节律紊乱与青少年心血管代谢风险关联及其机制的研究进展

韩菲菲; 谢阳; 陶芳标

doi:10.16835/j.cnki.1000-9817.2024130

生物节律紊乱与青少年心血管代谢风险关联及其机制的研究进展

doi: 10.16835/j.cnki.1000-9817.2024130

安徽医科大学公共卫生学院儿少卫生与妇幼保健学系/出生人口健康教育部重点实验室/环境与人口健康安徽省重点实验室，合肥 230032

基金项目:

国家自然科学基金重点项目 82073578

详细信息

作者简介:
韩菲菲(1998-)，女，安徽合肥人，在读硕士，主要研究方向为环境暴露与母婴健康

通讯作者:
陶芳标，E-mail: fbtao@ahmu.edu.cn

利益冲突声明 所有作者声明无利益冲突。
中图分类号: R179 R714.252 R825.6 G479
计量
- 文章访问数: 25
- HTML全文浏览量: 9
- PDF下载量: 9
- 被引次数: 0
出版历程
- 收稿日期: 2024-02-18
- 修回日期: 2024-03-30
- 网络出版日期: 2024-04-25
- 刊出日期: 2024-04-25

Research progress on the association between biorhythm disorders and cardiovascular metabolic risk in adolescents and possible mechanisms

Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University/MOE Key Laboratory of Population Health across Life Cycle/Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Hefei(230032), Anhui Province, China

摘要

摘要: 青少年处于由儿童向成人角色转变的重要过渡时期，该时期青少年的行为习惯和生理周期变化显著，生物节律易出现紊乱；同时由于青少年时期超重和肥胖率增加，心血管代谢风险显著上升。研究就生物节律紊乱、青少年心血管代谢健康的流行现状和关联以及潜在的表观遗传调控机制进行综述，为调控生物节律促进青少年心血管代谢健康提供理论依据。
- 生物节律 /
- 心血管系统 /
- 基因 /
- 青少年
Abstract: Adolescence is a unique transitional period from childhood to adulthood, during which behavioral habits and physiological cycles undergo significant changes, and biorhythms are vulnerable to be disrupted. Meanwhile, due to increased rates of overweight and obesity, cardiovascular metabolic risk significantly increases during adolescence. The article reviews the prevalence, correlation, and potential epigenetic regulatory mechanisms of biorhythm disorders and adolescent cardiovascular metabolic health, providing a theoretical basis for regulating biorhythm to promote adolescent cardiovascular metabolic health.
- Biological rhythm /
- Cardiovascular system /
- Genes /
- Adolescent
注释:

1) 利益冲突声明 所有作者声明无利益冲突。

HTML全文

表 1 不同生物节律紊乱表型与心血管代谢风险关联的相关研究

Table 1. Correlation studies on the association between different phenotypes of circadian rhythm disorders and cardiovascular metabolic risk

第一作者	年份	国家	研究方法	生物节律紊乱表型	主要发现
Lo^[5]	2019	中国	临床试验	睡眠-觉醒周期不规律	上学日和周末就寝时间相差>2 h与超重肥胖风险增加相关
Morales-Ghinaglia^[6]	2023	美国	队列研究	睡眠-觉醒周期不规律	上学日与周末睡眠-觉醒周期失调可能会导致向心性肥胖和血压升高
Chang^[14]	2021	韩国	临床试验	周末入睡时间延迟	周末入睡时间延迟与青少年舒张压升高显著相关
Dos Santos^[17]	2020	巴西	临床试验	睡眠时长不足	睡眠时长增加与男生收缩压降低和女生的收缩压升高有关
Widjaja^[18]	2023	印度	临床试验	睡眠时长不足	睡眠时长与空腹胰岛素水平和HOMA-IR值呈负相关
Zakrzewski-Fruer^[7]	2023	英国	临床试验	不吃早餐	不吃早餐对青春期女生的心脏代谢风险标志物产生不利影响
Liang^[22]	2024	中国	临床试验	饮食和睡眠节律紊乱	儿童饮食和睡眠节律紊乱可能与血压水平升高有关
Yang^[27]	2016	美国	实验研究	生物钟基因bmal1缺失	敲除核心生物钟基因bmal1后，小鼠心率和血压的正常昼夜节律均完全消失
Harfmann^[28]	2016	美国	实验研究	生物钟基因bmal1缺失	小鼠骨骼肌中生物钟基因bmal1的缺失导致糖代谢紊乱
Lin^[31]	2022	中国	临床试验	MEL分泌紊乱	暴露于较高ALAN水平下的儿童青少年超重肥胖等心血管代谢风险因素增加40%
Overberg^[32]	2022	德国	临床试验	MEL分泌紊乱	具有胰岛素抵抗的肥胖青少年夜间MEL水平显著降低
Agil^[34]	2011	西班牙	实验研究	MEL分泌减少	MEL可以改变年轻雄性肥胖2型糖尿病大鼠的体重和血脂水平
Bouzas^[35]	2014	巴西	临床试验	月经周期紊乱	月经周期不规律的青春期女生腰围、口服葡萄糖后2 h血糖、空腹和2 h胰岛素、HOMA-IR和TG显著增加
Glueck^[37]	2015	美国	临床试验	月经周期延迟	青春期月经延迟模式是年轻成人血糖受损、2型糖尿病、代谢综合征和多囊卵巢综合征发生和发展的重要危险因素

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