创伤大学生言语流畅性任务的功能性近红外成像研究

郑敏晓; 朱冬梅; 魏强; 向念; 邱敏; 肖强; 李晓南; 张妍

doi:10.16835/j.cnki.1000-9817.2024068

创伤大学生言语流畅性任务的功能性近红外成像研究

doi: 10.16835/j.cnki.1000-9817.2024068

郑敏晓^{1, 2},
朱冬梅²,
魏强²,
向念³,
邱敏³,
肖强³,
李晓南³,
张妍^1, ,

1.
华中科技大学教育科学研究院，湖北武汉 430074
2.
江汉大学教育学院
3.
华中科技大学医院心理科

基金项目:

江汉大学校级科研专项第三批立项项目 2023XYB21

华中科技大学自主创新研究基金资助项目 2023WKFZZX109

详细信息

作者简介:
郑敏晓(1990-)，女，河南南阳人，在读博士，讲师，主要研究方向为大学生心理健康

朱冬梅(1981-)，女，江苏太仓人，博士，副教授，主要研究方向为儿童青少年心理健康

通讯作者:
张妍，E-mail: zhangyan1981@hust.edu.cn

利益冲突声明 所有作者声明无利益冲突。
中图分类号: B844.2 R179 R445
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出版历程
- 收稿日期: 2023-08-23
- 修回日期: 2023-12-25
- 网络出版日期: 2024-03-29
- 刊出日期: 2024-03-25

Functional near infrared imaging of college students on speech fluency tasks in traumatized

1.
School of Education Science, Huazhong University of Science and Technology, Wuhan (430074), Hubei Province, China

摘要

摘要: 目的利用近红外脑功能成像技术(fNIRS)探究不同创伤大学生在言语流畅性任务中认知功能差异的大脑神经机制，为创伤后应激障碍(PTSD)的评估和诊断提供神经影像学支持。方法于2020年9—11月，根据创伤后应激障碍症状自评量表(平民版)(PCL-C)得分，从华中科技大学入学新生中抽取51名完成言语流畅性任务，根据PCL-C≥38分选取创伤组21名，根据PCL-C＜38分选取对照组30名，同时用53通道的近红外光谱设备(fNIRS)收集其大脑血氧信号。采用Mann-Whitney U检验和t检验比较创伤组和对照组的氧合血红蛋白含量和PCL-C评分差异，采用Spearman相关分析大学生PTSD和氧合血红蛋白的相关性。结果创伤组和对照组被试在PCL-C量表上的总平均分(46.38±6.96，25.57±6.09)差异有统计学意义(t=11.33，P＜0.05)。大学生个体左侧背外侧前额叶的氧合血红蛋白信号变化与PCL-C量表得分呈负相关(r=-0.37，P＜0.05)。创伤组左侧背外侧前额叶通道6的氧合血红蛋白含量[0.19(-0.09，0.86)mmol/(L·mm)]低于对照组[0.79(0.37，1.47)mmol/(L·mm)](Z=2.16，P＜0.05)。结论大学生创伤程度与左侧背外侧前额叶氧合血红蛋白指标有相关性。未来或可利用fNIRS收集认知任务中左侧背外侧前额叶血氧信号，为大学生PTSD的鉴别提供影像学依据。
- 言语 /
- 谱学，近红外线 /
- 精神卫生 /
- 应激障碍，创伤后 /
- 学生
Abstract: Objective The study aims to explore the neural mechanism of cognitive differences in college students with posttraumatic stress disorder under verbal fluency task based on functional near-infrared spectroscopy (fNIRS), so as to provide neuroimaging support for the evaluation, diagnosis and treatment of posttraumatic stress disorder(PTSD). Methods Posttaumatic Stress Disorder Checklist-Combat(PCL-C) was used to screen the subjects, including 21 students in PTSD group (PCL-C≥38) and 30 students in control group from September to Novenber in 2020. A 53-channel near-infrared spectroscopy device was used to collect cerebral blood oxygen signals under the verbal fluency task, and correlation analysis, Mann-Whitney U test and independent sample t test were performed on the results. Results The difference in the total average score of PCL-C Scale between PTSD group and the control group(46.38±6.96, 25.57±6.09) was statistically significant (t=11.33, P < 0.05). Correlation analysis showed that Avg-HbO in left dorsolateral prefrontal lobe was negatively correlated with PCL-C Score (r=-0.37, P < 0.05). Mann-Whitney U test showed that in the left dorsolateral prefrontal lobe (Ch6), the Avg-HbO change in PTSD group [0.19(-0.09, 0.86)mmol/(L ·mm)] was significantly lower than the control group [0.79(0.37, 1.47)mmol/(L ·mm)] (Z=2.16, P < 0.05), which was statistically significant. Conclusions The degree of PTSD was negatively correlated with the index of oxygenated hemoglobin in the left dorsolateral prefrontal lobe, and the oxygenated hemoglobin content in the PTSD group was lower than that in the normal group. In the future, fNIRS may be used to collect blood oxygen signals from the left dorsolateral prefrontal lobe in cognitive tasks to provide imaging evidence for the identification of PTSD.
- Speech /
- Spectroscopy, near-infrared /
- Mental health /
- Stress disorders, post-traumatic /
- Students
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1) 利益冲突声明 所有作者声明无利益冲突。

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参考文献(20)

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创伤大学生言语流畅性任务的功能性近红外成像研究

doi: 10.16835/j.cnki.1000-9817.2024068

作者简介:
郑敏晓(1990-)，女，河南南阳人，在读博士，讲师，主要研究方向为大学生心理健康

朱冬梅(1981-)，女，江苏太仓人，博士，副教授，主要研究方向为儿童青少年心理健康

通讯作者:
张妍，E-mail: zhangyan1981@hust.edu.cn

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Functional near infrared imaging of college students on speech fluency tasks in traumatized

计量

目录

留言板

创伤大学生言语流畅性任务的功能性近红外成像研究

doi: 10.16835/j.cnki.1000-9817.2024068

作者简介: 郑敏晓(1990-)，女，河南南阳人，在读博士，讲师，主要研究方向为大学生心理健康 朱冬梅(1981-)，女，江苏太仓人，博士，副教授，主要研究方向为儿童青少年心理健康

通讯作者: 张妍，E-mail: zhangyan1981@hust.edu.cn

计量

出版历程

Functional near infrared imaging of college students on speech fluency tasks in traumatized

计量

出版历程

目录

作者简介:
郑敏晓(1990-)，女，河南南阳人，在读博士，讲师，主要研究方向为大学生心理健康

朱冬梅(1981-)，女，江苏太仓人，博士，副教授，主要研究方向为儿童青少年心理健康

通讯作者:
张妍，E-mail: zhangyan1981@hust.edu.cn