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健康大学生多环芳烃内暴露与肺功能变化的关系

陈俊杰 刘思巧 李淼 郝珂璐 张艳丽 李卫红 徐厚君 郝玉兰 王曼曼 王学生 王茜

陈俊杰, 刘思巧, 李淼, 郝珂璐, 张艳丽, 李卫红, 徐厚君, 郝玉兰, 王曼曼, 王学生, 王茜. 健康大学生多环芳烃内暴露与肺功能变化的关系[J]. 中国学校卫生, 2023, 44(9): 1409-1413. doi: 10.16835/j.cnki.1000-9817.2023.09.029
引用本文: 陈俊杰, 刘思巧, 李淼, 郝珂璐, 张艳丽, 李卫红, 徐厚君, 郝玉兰, 王曼曼, 王学生, 王茜. 健康大学生多环芳烃内暴露与肺功能变化的关系[J]. 中国学校卫生, 2023, 44(9): 1409-1413. doi: 10.16835/j.cnki.1000-9817.2023.09.029
CHEN Junjie, LIU Siqiao, LI Miao, HAO Kelu, ZHANG Yanli, LI Weihong, XU Houjun, HAO Yulan, WANG Manman, WANG Xuesheng, WANG Qian.. Relationship between polycyclic aromatic hydrocarbons internal exposure and lung function change among healthy college students[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(9): 1409-1413. doi: 10.16835/j.cnki.1000-9817.2023.09.029
Citation: CHEN Junjie, LIU Siqiao, LI Miao, HAO Kelu, ZHANG Yanli, LI Weihong, XU Houjun, HAO Yulan, WANG Manman, WANG Xuesheng, WANG Qian.. Relationship between polycyclic aromatic hydrocarbons internal exposure and lung function change among healthy college students[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(9): 1409-1413. doi: 10.16835/j.cnki.1000-9817.2023.09.029

健康大学生多环芳烃内暴露与肺功能变化的关系

doi: 10.16835/j.cnki.1000-9817.2023.09.029
基金项目: 

河北省自然科学基金面上项目 H2021209054

河北省自然科学基金面上项目 H2022209025

唐山市科技计划项目 19130209g

详细信息
    作者简介:

    陈俊杰(1998-), 男, 广东汕尾人, 在读硕士, 主要研究方向为环境有害因素与健康

    通讯作者:

    王茜, E-mail: wwqq517@aliyun.com

  • 利益冲突声明  所有作者声明无利益冲突。
  • 中图分类号: R816.41  R179  R193

Relationship between polycyclic aromatic hydrocarbons internal exposure and lung function change among healthy college students

  • 摘要:   目的  研究尿中单羟基多环芳烃代谢物(OH-PAHs)与肺功能之间的关系以及氧化应激在其中的中介作用,为空气污染治理与政策制定提供科学依据。  方法  招募华北理工大学45名健康大学生为研究对象,分别于2017年11月至2018年10月进行4次随访调查和健康体检,测量肺功能参数[用力肺活量(FVC)、1 s用力呼气量(FEV1)、呼气峰值流速(PEF)、FEV1/FVC和用力呼气流量(FEF25%~75%)]和尿液中7种暴露标志物OH-PAHs(∑7OH-PAHs)、氧化应激标志物8-羟基-2'-脱氧鸟苷(8-OHdG)、8-异前列腺素F(8-iso-PGF)。利用线性混合效应模型分析尿多环芳烃代谢物与肺功能之间的关系,并用中介模型评估氧化应激在OH-PAHs与肺功能之间关系中的中介效应。  结果  研究对象FVC、FEV1、FEV1/FVC、PEF和FEF25%~75%的中位数分别为4.37 L,3.58 L,83.00%,4.38 L/s和3.32 L/s。2-羟基芴(2-OHFlu)的对数转换值每增加1个(ln)单位,FVC下降5.05%(β%=-5.05%,95%CI=-8.85%~-1.09%),FEV1下降4.15%(β%=-4.15%,95%CI=-7.94%~-0.22%),FEF25%~75%下降5.87%(β%=-5.87%,95%CI=-11.35%~-0.05%)。2-OHFlu和9-羟基菲(9-OHPhe)的对数转换值每增加1个(ln)单位,PEF分别降低7.03%(β%=-7.03%,95%CI=-12.60%~-1.11%)和7.08%(β%=-7.08%,95%CI=-13.50%~-0.17%)。此外,尿∑7OH-PAHs与尿8-OHdG和8-iso-PGF水平呈正相关(r值分别为0.64,0.69,P值均<0.01)。同时,8-OHdG介导2-OHFlu与FVC和FEV1的相关性分别为17.06%和15.71%。  结论  健康大学生尿中OH-PAHs与肺功能呈负相关,8-OHdG在2-OHFlu与FVC和FEV1之间的关系中起介导作用。应积极制定相关政策治理空气污染,维护青年人的健康生活状态。
    1)  利益冲突声明  所有作者声明无利益冲突。
  • 表  1  不同季节肺功能参数、尿中OH-PAHs及氧化应激标志物水平比较[M(IQR),n=45]

    Table  1.   Comparison of levels of lung function parameters, OH-PAHs and oxidative stress markers in urine in different seasons[M(IQR), n=45]

    季节 FVC/L FEV1/L FEV1/FVC/(%) PEF/(L·s-1) FEF25%~75%/(L·s-1) 2-OHNapa 1-OHNapa 2-OHFlua
    4.15(2.01) 1.04(0.67) 88.00(6.00) 1.18(0.79) 0.91(0.76) 0.94(1.25) 2.41(2.70) 0.44(0.68)
    5.00(1.43) 3.74(1.06) 80.00(9.00) 5.16(1.67) 3.79(1.24) 0.45(0.97) 2.36(2.46) 0.35(0.65)
    3.14(1.33) 3.52(1.20) 86.00(9.00) 2.97(1.47) 2.42(1.29) 0.32(0.94) 2.36(2.33) 0.53(0.61)
    4.79(0.83) 3.64(0.89) 80.00(7.00) 4.38(1.62) 3.34(1.08) 0.35(0.66) 2.16(2.42) 0.41(0.58)
    H 61.72 45.30 25.47 47.61 35.15 19.35 3.58 4.70
    P <0.01 <0.01 <0.01 <0.01 <0.01 <0.01 0.31 0.20
    季节 3-OHPhea 9-OHPhea 1-OHPhea 1-OHPyra 7OH-PAHsa 8-OHdGa 8-iso-PGFa
    0.11(0.12) 0.47(0.56) 0.34(0.43) 4.70(4.55) 11.04(10.80) 20.27(22.02) 0.18(0.13)
    0.08(0.11) 0.29(0.45) 0.20(0.25) 4.88(4.62) 8.60(10.66) 20.29(23.36) 0.16(0.26)
    0.09(0.09) 0.51(0.57) 0.27(0.42) 5.71(4.48) 10.61(10.09) 15.18(22.84) 0.08(0.11)
    0.08(0.13) 0.41(0.58) 0.22(0.46) 5.21(8.64) 10.61(13.17) 11.08(15.03) 0.06(0.07)
    H 2.67 6.72 7.75 2.49 1.15 12.63 50.70
    P 0.45 0.08 0.05 0.48 0.77 0.01 <0.01
    注:a单位为μg/g Cr。
    下载: 导出CSV

    表  2  氧化应激在尿多环芳烃代谢物与肺功能关系中的介导作用

    Table  2.   Mediating effect of oxidative stress(8-OHd Gand 8-iso-PGF) on the associations between urinary OH-PAHs and lung function parameters

    OH-PAHs 中介变量 因变量 总效应(95%CI) 介导效应(95%CI)
    2-OHFlu 8-OHdG FVC -0.05(-0.09~-0.01)* -0.01(-0.02~0.00)
    8-OHdG FEV1 -0.04(-0.08~0.00)* -0.01(-0.03~0.00)
    8-OHdG PEF -0.07(-0.12~-0.02)* -0.00(-0.02~0.01)
    8-OHdG FEF25%~75% -0.05(-0.10~0.00)* -0.01(-0.02~0.01)
    8-iso-PGF FVC -0.08(-0.12~-0.03)* 0.00(-0.01~0.01)
    8-iso-PGF FEV1 -0.07(-0.12~-0.02)* 0.00(-0.01~0.01)
    8-iso-PGF PEF -0.09(-0.14~-0.04)* 0.00(-0.01~0.01)
    8-iso-PGF FEF25%~75% -0.07(-0.15~0.00)* 0.00(-0.01~0.01)
    9-OHPhe 8-OHdG FVC -0.03(-0.07~0.01) -0.01(-0.03~0.00)
    8-OHdG FEV1 -0.02(-0.06~0.03) -0.01(-0.03~0.00)
    8-OHdG PEF -0.06(-0.11~0.01) -0.01(-0.03~0.02)
    8-OHdG FEF25%~75% -0.02(-0.08~0.04) -0.01(-0.03~0.01)
    8-iso-PGF FVC -0.03(-0.08~0.02) 0.00(-0.02~0.01)
    8-iso-PGF FEV1 -0.02(-0.07~0.03) 0.00(-0.01~0.01)
    PEF -0.03(-0.11~0.04) -0.01(-0.03~0.01)
    8-iso-PGF FEF25%~75% 0.00(-0.07~0.07) -0.01(-0.03~0.00)
    注:*P<0.05。
    下载: 导出CSV
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  • 收稿日期:  2023-06-14
  • 修回日期:  2023-06-27
  • 网络出版日期:  2023-09-28
  • 刊出日期:  2023-09-25

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