Effects of different intensity of exercise combined with dietary intervention on body composition, lipid metabolism and gut microbiota in obese nonalcoholic fatty liver disease female college students
-
摘要:
目的 了解不同强度运动结合饮食干预对肥胖非酒精性脂肪肝(nonalcoholic fatty liver disease, NAFLD)女大学生身体成分、脂代谢及肠道菌群的影响, 为改善肥胖NAFLD女大学生的健康水平提供理论依据。 方法 2022年3—4月通过网上发布通知及选取体育保健班学生和至福建船政交通职业学院健康体检中心体检的43名肥胖NAFLD女大学生, 随机分为高等强度间歇训练(HIIT)组(n=22)及中等强度持续训练(MICT)组(n=21)。HIIT组实施8周HIIT结合饮食干预, MICT组实施8周MICT结合饮食干预, 对比干预前后肥胖NAFLD女大学生身体成分、脂代谢及肠道菌群指标的变化情况。 结果 干预8周后, HIIT和MICT结合饮食干预均能降低肥胖NAFLD女大学生体重、体质量指数(BMI)、体脂肪量、躯干脂肪量、腰臀比及内脏脂肪面积(t值分别为15.56, 15.48, 15.74, 13.92, 6.51, 11.55;13.64, 13.48, 15.82, 6.53, 4.40, 9.53), 血清胆固醇、三酰甘油及低密度脂蛋白水平及大肠杆菌和肠球菌指标均下降(t值分别为6.75, 2.16, 6.86, 3.06, 7.85;3.55, 2.36, 4.00, 3.32, 5.94), 有益菌乳酸杆菌及双歧杆菌指标增加(t值分别为6.64, 5.89;5.11, 4.71), 仅HIIT组高密度脂蛋白水平增加(t=5.08)(P值均 < 0.05);HIIT组除体脂肪量、躯干脂肪量、内脏脂肪面积及胆固醇水平低于MICT组外(t值分别为2.20, 2.10, 2.15, 2.26, P值均 < 0.05), 其他指标两组间差异均无统计学意义(P值均>0.05)。 结论 HIIT及MICT结合饮食干预均使肥胖NAFLD女大学生身体成分、脂代谢及肠道菌群产生有益的变化, 但HIIT结合饮食干预在减少体脂肪及内脏脂肪量和改善脂质代谢方面效果更优。 Abstract:Objective To understand the effects of different intensity of exercise combined with dietary intervention on body composition, lipid metabolism and gut microbiota in obese (nonalcoholic fatty liver disease, NAFLD) college students, so as to provide a theoretical reference for improving the health of the obese NAFLD female college students. Methods From March to Aprial 2022, 43 NAFLD female college students were recruited and randomly divided into HIIT group (n=22) and MICT group(n=21). Subsequently, HIIT group received HIIT combined with diet intervention for 8 weeks and MICT group received MICT combined with diet intervention for 8 weeks, the changes of body composition, lipid metabolism and gut microbiota in NAFLD female college students were compared before and after intervention. Results Compared with that before the experiment, after 8 weeks of HIIT and MICT combined with dietary intervention, the weight, BMI, body fat mass, trunk fat mass, waist hip ratio and visceral fat area significantly decreased (t=15.56, 15.48, 15.74, 13.92, 6.51, 11.55; 13.64, 13.48, 15.82, 6.53, 4.40, 9.53), the levels of cholesterol and triglyceride and low density lipoprotein, bacillus coli and enterococcus significantly decreased (t=6.75, 2.16, 6.86, 3.06, 7.85; 3.55, 2.36, 4.00, 3.32, 5.94); lactobacillus and bifidobacterium increased significantly (t=6.64, 5.89; 5.11, 4.71); however, only HIIT group had a significant increase in the level of high density lipoprotein(t=5.08)(P < 0.05). Compared with MICT group, body fat mass, trunk fat mass, visceral fat area and cholesterol level in HIIT group were significantly lower than those in MICT group (t=2.20, 2.10, 2.15, 2.26, P < 0.05). There were no significant differences in other indicators between the two groups (P > 0.05). Conclusion The results show that HIIT and MICT have benefical effects on body composition, lipid metabolism and gut microbiota in obese NAFLD female college students, but HIIT is superior to MICT intervention in reducing body fat mass, visceral fat and improving lipid metabolism. -
Key words:
- Motor activity /
- Diet /
- Intervention studies /
- Fatty liver /
- Body composition /
- Lipid metabolism /
- Students
1) 利益冲突声明 所有作者声明无利益冲突。 -
表 1 不同组别肥胖NAFLD女大学生干预前后身体成分指标比较(x±s)
Table 1. Comparison of the body composition in obese NAFLD female college students before and after interventions among different groups(x±s)
组别 干预前后 人数 统计值 体重/kg BMI/(kg·m-2) 体脂肪量/kg 躯干脂肪量/kg 腰臀比 内脏脂肪面积/cm2 HIIT组 干预前 22 76.92±2.78 29.59±1.15 29.20±1.71 16.08±1.39 0.89±0.05 115.32±4.30 干预后 22 72.32±3.04 27.82±1.25 25.24±2.28 13.07±1.65 0.83±0.04 106.50±5.06 t值 15.56 15.48 15.74 13.92 6.51 11.55 P值 <0.01 <0.01 <0.01 <0.01 <0.01 <0.01 MICT组 干预前 21 77.81±2.06 30.25±1.44 29.69±1.93 16.36±1.48 0.88±0.02 116.05±4.95 干预后 21 73.80±2.29 28.69±1.47 26.65±1.90 14.35±2.27 0.85±0.04 109.90±5.31 t值 13.64 13.48 15.82 6.53 4.40 9.53 P值 <0.01 <0.01 <0.01 <0.01 <0.01 <0.01 表 2 不同组别肥胖NAFLD女大学生干预前后脂代谢指标和肠道菌群指标比较(x±s)
Table 2. Comparison of the lipid metabolism and the gut microbiota in obese NAFLD female college students before and after the interventions among different groups(x±s)
组别 干预前后 人数 统计值 脂代谢指标/(mmol·L-1) 肠道菌群指标/(lg CFU·g-1) TC TG HDL LDL 肠球菌 大肠杆菌 乳酸杆菌 双歧杆菌 HIIT组 干预前 22 5.41±0.95 2.08±0.70 1.16±0.17 3.44±0.40 7.92±0.93 9.25±1.38 6.14±1.04 6.72±1.17 干预后 22 4.15±0.62 1.94±0.59 1.25±0.13 2.94±0.31 7.04±0.97 8.68±1.28 7.00±0.84 7.28±0.99 t值 6.75 2.16 -5.08 6.86 7.85 3.06 -6.64 -5.89 P值 <0.01 0.04 <0.01 <0.01 <0.01 <0.01 <0.01 <0.01 MICT组 干预前 21 5.24±1.01 2.11±0.50 1.14±0.26 3.39±0.51 7.73±0.85 9.09±1.48 6.44±0.89 6.65±1.18 干预后 21 4.60±0.69 2.02±0.46 1.20±0.28 3.02±0.55 7.26±1.06 8.60±1.32 7.01±0.81 7.01±1.03 t值 3.55 2.36 -2.02 4.00 -5.94 -3.32 -5.11 -4.71 P值 <0.01 0.03 0.06 <0.01 <0.01 <0.01 <0.01 <0.01 -
[1] 周鸣. 有氧运动对肥胖大学生部分心血管疾病危险因素的影响[D]. 南昌: 华东交通大学, 2017.ZHOU M. Effects of aerobic exercise on part of cardiovascular disease risk factors for obesity college students[D]. Nanchang: East China Jiaotong University, 2017. (in Chinese) [2] 刘云娜, 李帅广, 刘飞, 等. 肠道菌群代谢产物影响非酒精性脂肪肝的研究进展[J]. 食品与药品, 2022, 24(6): 583-588. https://www.cnki.com.cn/Article/CJFDTOTAL-SDPK202206013.htmLIU Y N, LI S G, LIU F, et al. Advances in effect of intestinal flora metabolites on nonalcoholic fatty liver disease[J]. Food Drug, 2022, 24(6): 583-588. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-SDPK202206013.htm [3] 吴明方, 陆阿明. 有氧运动及其联合饮食干预影响非酒精性脂肪肝患者血浆SREBP-1c、RBP4水平的研究[J]. 中国康复医学杂志, 2015, 30(2): 132-137. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGKF201502007.htmWU M F, LU A M. Effects of aerobic exercise combined with controlled diet on the serum level of SREBP-1c and RBP4 in patients with non-alcoholic fatty liver disease[J]. Chin J Rehabil Med, 2015, 30(2): 132-137. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZGKF201502007.htm [4] 于春霞, 傅力. 肠道菌群-运动干预防治代谢性疾病的新靶点[J]. 中国运动医学杂志, 2017, 36(5): 443-447. https://www.cnki.com.cn/Article/CJFDTOTAL-YDYX201705012.htmYU C X, FU L. Intestinal flora: a new target for exercise intervention against metabolic diseases[J]. Chin J Sports Med, 2017, 36(5): 443-447. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-YDYX201705012.htm [5] KEATING S E, HACKETT D A, PARKER H M, et al. Effect of aerobic exercise training dose on liver fat and visceral adiposity[J]. J Hepatol, 2015, 63(1): 174-182. doi: 10.1016/j.jhep.2015.02.022 [6] 梁晋裕, 郝亮. 高强度间歇运动对肥胖儿童身体成分血压及血清Chemerin的影响[J]. 中国学校卫生, 2018, 39(11): 1729-1732. doi: 10.16835/j.cnki.1000-9817.2018.11.039LIANG J Y, HAO L. Effects of high intensity intermittent exercise on body composition, blood pressure and serum Chemerin in obese children[J]. Chin J Sch Health, 2018, 39(11): 1729-1732. (in Chinese) doi: 10.16835/j.cnki.1000-9817.2018.11.039 [7] 王健, 马军, 王翔. 健康教育学[M]. 北京: 高等教育出版社, 2020: 239.WANG J, MA J, WANG X. Health education[M]. Beijing: Higher Education Press, 2020: 239. (in Chinese) [8] 中华医学会肝病学分会脂肪肝和酒精性肝病学组. 非酒精性脂肪性肝病防治指南(2018更新版)[J]. 传染病信息, 2018, 31(5): 393-402, 420. https://www.cnki.com.cn/Article/CJFDTOTAL-CRBX201805002.htmFatty Liver and Alcoholic Liver Disease Group, Chinese Society of Hepatology. Guidelines of prevention and treatment for nonalcoholic fatty liver disease: a 2018 update[J]. Infect Dis Info, 2018, 31(5): 393-402, 420. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-CRBX201805002.htm [9] ABDELBASSET W K, TANTAWY S A, KAMEL D M, et al. Effects of high-intensity interval and moderate-intensity continuous aerobic exercise on diabetic obese patients with nonalcoholic fatty liver disease: a comparative randomized controlled trial[J]. Medicine(Baltimore), 2020, 99(10): e19471. [10] 中国营养学会《中国居民膳食指南(2016)》修订专家委员会. 6大秘诀助你健康饮食——最新《中国居民膳食指南》营养推荐[J]. 健康世界, 2016(8): 56-59.Expert Member of the Revision of the Dietary Guidelines for Chinese Residents (2016), Chinese Nutrition Society. 6 tips to help you eat healthy-the latest "Dietary Guidelines for Chinese residents" nutrition recommendations[J]. Healthy World, 2016(8): 56-59. (in Chinese) [11] 周青松. 10周HⅡT对扬州大学在校肥胖女大学生BMI、体脂率和腰臀比的影响研究[D]. 扬州: 扬州大学, 2022.ZHOU Q S. Effects of 10-week HⅡT on BMI, body fat percentage and waist-to-hip ratio of obese female college students in Yangzhou University[D]. Yangzhou: Yangzhou University, 2022. (in Chinese) [12] 陆佳萍, 叶晓梅, 韩辰宇, 等. 2型糖尿病合并非酒精性脂肪肝的危险因素及其与中国人内脏脂肪指数的相关性研究[J]. 中国实用内科杂志, 2022, 42(11): 925-929. https://www.cnki.com.cn/Article/CJFDTOTAL-SYNK202211011.htmLU J P, YE X M, HAN C Y, et al. Risk factors of non-alcoholic fatty liver disease in type 2 diabetes mellitus and its correlation with Chinese visceral adipose index[J]. Chin J Pract Int Med, 2022, 42(11): 925-929. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-SYNK202211011.htm [13] KOLNES K J, PETERSEN M H, LIEN-IVERSEN T, et al. Effect of exercise training on fat loss-energetic perspectives and the role of improved adipose tissue function and body fat distribution[J]. Front Physiol, 2021, 12: 737709. [14] WEWEGE M, VAN DEN BERG R, WARD R E, et al. The effects of high-intensity interval training and moderate-intensity continuous training on body composition in overweight and obese adults: a systematic review and Meta-analysis[J]. Obes Rev, 2017, 18(6): 635-646. [15] SHENG G, LU S, XIE Q, et al. The usefulness of obesity and lipid-related indices to predict the presence of non-alcoholic fatty liver disease[J]. Lipids Health Dis, 2021, 20(1): 134. [16] 曲静, 林小晶, 王业玲, 等. 4周结合饮食控制的有氧运动降低肥胖青年血清炎症因子chemerin水平及其应用价值[J]. 中国体育科技, 2022, 58(7): 76-82. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGTY202207007.htmQU J, LIN X J, WANG Y L, et al. Decrease of serum inflammatory cytokine chemerin by four-week aerobic exercise combined with dieting in obese youth and its application value[J]. Chin Sport Sci Technol, 2022, 58(7): 76-82. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZGTY202207007.htm [17] ADALBERTO L J, MOTADA-SILVA J, FURTADODA-SILVA V, et al. Multimodal HⅡT is more efficient than moderate continuous training for management of body composition, lipid profile and glucose metabolism in the diabetic elderly[J]. Int J Morphol, 2020, 38(2): 392-399. [18] RUIZ A, CERDÓ T, JÁUREGUI R, et al. One-year calorie restriction impacts gut microbial composition but not its metabolic performance in obese adolescents[J]. Environ Microbiol, 2017, 19(4): 1536-1551. [19] DONG T S, LUU K, LAGISHETTY V, et al. A high protein calorie restriction diet alters the gut microbiome in obesity[J]. Nutrients, 2020, 12(10): 3221. [20] CAMPBELL S C, WISNIEWSKI P J. Exercise is a novel promoter of intestinal health and microbial diversity[J]. Exerc Sport Sci Rev, 2017, 45(1): 41-47. [21] 邓海林. 运动结合饮食干预对肥胖青少年心血管功能及肠道菌群的影响[D]. 广州: 广州体育学院, 2019.DENG H L. Effects of exercise combined with diet intervention on cardiovascular function and intestinal flora in obese adolescents[D]. Guangzhou: Guangzhou Sport University, 2019. (in Chinese) [22] 雷岱. HⅡT和MICT对高脂膳食大鼠肠道菌群与TLR4蛋白的影响[D]. 石家庄: 河北师范大学, 2021.LEI D. The effects of HⅡT and MICT on gut microbiota and TLR4 in high-fat diet rats[J]. Shijiazhuang: Hebei Normal University, 2021. (in Chinese) [23] 李东海, 李永攀, 王雪. 针刺联合中药对肥胖型多囊卵巢综合征患者肠道菌群、糖脂代谢及炎症因子水平的影响[J]. 川北医学院学报, 2021, 36(10): 1280-1285. https://www.cnki.com.cn/Article/CJFDTOTAL-NOTH202110004.htmLI D H, LI Y P, WANG X. Effect of acupuncture combined with traditional Chinese medicine on intestinal flora, glycolipid metabolism and inflammatory factor levels in patients with obese polycystic ovary syndrome[J]. J North Sichuan Med Coll, 2021, 36(10): 1280-1285. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-NOTH202110004.htm [24] 张黎雯, 任明星, 薛国昌, 等. 肠道菌群失调对肥胖儿童非酒精性脂肪肝发生的影响[J]. 肝脏, 2020, 25(7): 755-758. https://www.cnki.com.cn/Article/CJFDTOTAL-ZUAN202007030.htmZHANG L W, REN M X, XUE G C, et al. Effects of alteration of intestinal flora on the incidence of non-alcoholic fatty liver disease in obese children[J]. Chin Hepatol, 2020, 25(7): 755-758. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZUAN202007030.htm
计量
- 文章访问数: 371
- HTML全文浏览量: 188
- PDF下载量: 45
- 被引次数: 0