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超重肥胖对PM2.5短期暴露与儿童青少年肺活量关联的修饰效应

马涛 霍家康 吴立娟 李伟铭 刘相佟 温勃 陈力 董彦会 郭秀花 马军

马涛, 霍家康, 吴立娟, 李伟铭, 刘相佟, 温勃, 陈力, 董彦会, 郭秀花, 马军. 超重肥胖对PM2.5短期暴露与儿童青少年肺活量关联的修饰效应[J]. 中国学校卫生, 2021, 42(11): 1740-1743. doi: 10.16835/j.cnki.1000-9817.2021.11.032
引用本文: 马涛, 霍家康, 吴立娟, 李伟铭, 刘相佟, 温勃, 陈力, 董彦会, 郭秀花, 马军. 超重肥胖对PM2.5短期暴露与儿童青少年肺活量关联的修饰效应[J]. 中国学校卫生, 2021, 42(11): 1740-1743. doi: 10.16835/j.cnki.1000-9817.2021.11.032
MA Tao, HUO Jiakang, WU Lijuan, LI Weiming, LIU Xiangtong, WEN Bo, CHEN Li, DONG Yanhui, GUO Xiuhua, MA Jun. Effect modification of overweight and obesity on the relationship between short-term PM2.5 exposure and vital capacity in children and adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(11): 1740-1743. doi: 10.16835/j.cnki.1000-9817.2021.11.032
Citation: MA Tao, HUO Jiakang, WU Lijuan, LI Weiming, LIU Xiangtong, WEN Bo, CHEN Li, DONG Yanhui, GUO Xiuhua, MA Jun. Effect modification of overweight and obesity on the relationship between short-term PM2.5 exposure and vital capacity in children and adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(11): 1740-1743. doi: 10.16835/j.cnki.1000-9817.2021.11.032

超重肥胖对PM2.5短期暴露与儿童青少年肺活量关联的修饰效应

doi: 10.16835/j.cnki.1000-9817.2021.11.032
基金项目: 

博士后科学基金 2020M680266

博士后科学基金 BX20200019

详细信息
    作者简介:

    马涛(1997-),男,宁夏人,在读硕士,主要研究方向为儿童青少年生长发育及其影响因素

    通讯作者:

    董彦会,E-mail:dongyanhui@bjmu.edu.cn

  • 中图分类号: R723.14  R179  R122

Effect modification of overweight and obesity on the relationship between short-term PM2.5 exposure and vital capacity in children and adolescents

  • 摘要:   目的  分析PM2.5短期暴露与儿童青少年肺活量关联及其超重肥胖修饰效应,为中小学生合理安排室外活动和加强空气污染防护提供科学依据。  方法  选取2017—2018年北京市中小学生年度健康体检数据中数据合格的学生1 036 273名为研究对象;采用反距离加权插值法得出研究对象所处区域的气象要素与空气质量;采用线性混合效应模型估计PM2.5短期暴露对肺活量7 d内的单独滞后效应与平均滞后效应,分析超重肥胖对PM2.5的短期暴露与儿童青少年肺活量关联的修饰效应。  结果  2017年9月1日至2018年6月30日,北京市PM2.5平均质量体积浓度为66.36 μg/m3;研究对象超重肥胖检出率为33.38%,平均肺活量为(2 286.72±956.77)mL。PM2.5对肺活量的单独滞后效应lag6时最大,即PM2.5日均浓度每增长10 μg/m3与儿童青少年肺活量降低2.81(95%CI=2.60~3.03) mL显著相关。PM2.5对肺活量的平均滞后效应lag07时最大,即PM2.5滑动平均质量体积浓度每增长10 μg/m3与儿童青少年肺活量降低5.82(95%CI=5.37~6.27) mL显著相关。超重肥胖的儿童青少年对PM2.5短期暴露引起的肺活量下降易感性更高(P<0.01)。  结论  PM2.5短期暴露与儿童青少年肺活量呈负相关,且存在滞后效应,超重肥胖的儿童青少年在PM2.5短期暴露后肺活量下降更显著。
  • 表  1  是否超重肥胖儿童青少年基本指标比较(x±s)

    Table  1.   Basic information of subjects comparison between overweight and obesity groups (x±s)

    是否超重肥胖 人数 年龄/岁 BMI/(kg·m-2) 身高/cm 人均GDP/万元 体育场地数量/个 肺活量/mL
    345 941 11.14±2.87 23.99±3.98 153.17±15.05 13.75±8.71 1 671.72±770.41 2 476.25±1 032.74
    690 332 11.14±2.99 17.26±2.40 149.06±16.03 14.68±8.86 1 701.36±775.01 2 191.74±901.46
    t 0.76 914.54 128.28 -51.08 -18.43 137.84
    P 0.45 <0.01 <0.01 <0.01 <0.01 <0.01
    下载: 导出CSV

    表  2  PM2.5短期暴露与儿童青少年肺活量的关联[β值(β值95%CI),n=1 036 273]

    Table  2.   Correlation between short-term PM2.5 exposure and vital capacity of children and adolescents [β(β 95%CI), n=1 036 273]

    污染物 单独滞后效应(lag6) 平均滞后效应(lag07) P
    NO2 -4.14(-4.43~-3.85) -13.76(-14.32~-13.20) <0.01
    O3 -1.93(-2.15~-1.71) -4.12(-4.58~-3.70) <0.01
    SO2 -2.81(-3.08~-2.58) -6.41(-7.00~-5.83) <0.01
    CO -3.91(-4.29~-3.53) -7.16(-7.81~-6.50) <0.01
    下载: 导出CSV
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出版历程
  • 收稿日期:  2021-03-30
  • 修回日期:  2021-08-01
  • 网络出版日期:  2021-12-01
  • 刊出日期:  2021-11-25

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