Association between body mass index during pre-pregnancy and maternal lipid levels during early pregnancy with the risk of overweight and obesity in preschool children

GUO Xiru; LÜ Jinlang; SU Tao; HAN Na; WANG Lu; JI Yuelong; WANG Haijun

doi:10.16835/j.cnki.1000-9817.2025239

Volume 46 Issue 8

Aug. 2025

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GUO Xiru, LÜ Jinlang, SU Tao, HAN Na, WANG Lu, JI Yuelong, WANG Haijun. Association between body mass index during pre-pregnancy and maternal lipid levels during early pregnancy with the risk of overweight and obesity in preschool children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(8): 1084-1087. doi: 10.16835/j.cnki.1000-9817.2025239

Citation:

GUO Xiru, LÜ Jinlang, SU Tao, HAN Na, WANG Lu, JI Yuelong, WANG Haijun. Association between body mass index during pre-pregnancy and maternal lipid levels during early pregnancy with the risk of overweight and obesity in preschool children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(8): 1084-1087. doi: 10.16835/j.cnki.1000-9817.2025239

Citation:

GUO Xiru, LÜ Jinlang, SU Tao, HAN Na, WANG Lu, JI Yuelong, WANG Haijun. Association between body mass index during pre-pregnancy and maternal lipid levels during early pregnancy with the risk of overweight and obesity in preschool children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(8): 1084-1087. doi: 10.16835/j.cnki.1000-9817.2025239

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Association between body mass index during pre-pregnancy and maternal lipid levels during early pregnancy with the risk of overweight and obesity in preschool children

doi: 10.16835/j.cnki.1000-9817.2025239

1.
Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China

Received Date: 2025-02-18
Rev Recd Date: 2025-04-01

Available Online: 2025-08-30

Publish Date: 2025-08-25

Abstract

Abstract

Objective To analyze the relationship between body mass index(BMI) during pre-pregnancy, maternal lipid levels during early pregnancy and childhood overweight and obesity, as well as the mediating role of maternal lipid levels during early pregnancy in pre-pregnancy BMI and childhood overweight and obesity, providing scientific evidence for developing obesity prevention strategies in preschool children. Methods Using data from Peking University Birth Cohort in Tongzhou (PKUBC-T) collected between June 2018 and September 2022, the study included 1 292 mother-child pairs. Participants were stratified into two groups based on children's BMI-Z scores at age 3: an overweight/obesity risk group (BMI-Z>1, n=173) and a non-overweight/obesity risk group (BMI-Z≤1, n=1 119).Multivariate Logistic regression was conducted to analyze the associations between pre-pregnancy BMI, maternal lipid levels[total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), TC/HDL-C, TG/HDL-C, LDL-C/HDL-C] during early pregnancy and childhood overweight and obesity. The mediating effect of maternal lipid levels during early pregnancy on pre-pregnancy BMI and childhood overweight and obesity was further explored. Results There were statistically significant differences in pregnancy BMI levels, early pregnancy blood LDL-C, TC/HDL-C, LDL-C/HDL-C levels between the overweight and obesity risk group and the non overweight and obesity risk group (χ²/Z=19.01, 2.48, 2.48, 2.71, all P < 0.05). Multivariate Logistic regression analysis showed that pre-pregnancy BMI, LDL-C, TC/HDL-C and LDL-C/HDL-C in early pregnancy were significantly associated with childhood overweight and obesity (OR=1.09, 1.42, 1.49, 1.60, all P < 0.05). LDL-C, TC/HDL-C and LDL-C/HDL-C in early pregnancy played a significant mediating role on pre-pregnancy BMI and childhood obesity and the mediating effects accounted for 7.3%, 10.2%, 23.5% of the total effects, respectively (all P < 0.05). Conclusions Maternal hyperlipidemia during early pregnancy partially mediated the association between pre-pregnancy obesity and childhood obesity. Both pre-pregnancy obesity and maternal hyperlipidemia during early pregnancy are risk factors for obesity in preschool children.
- Mothers,
- Body mass index,
- Dyslipidemias,
- Overweight,
- Obeysity,
- Regression analysis,
- Child, preschool

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References(25)

References

[1]	NORRIS T, MANSUKOSKI L, GILTHORPE M S, et al. Early childhood weight gain: latent patterns and body composition outcomes[J]. Paediatr Perinat Epidemiol, 2021, 35(5): 557-568. doi: 10.1111/ppe.12754
[2]	MANNINO A, SARAPIS K, MOSCHONIS G. The effect of maternal overweight and obesity pre-pregnancy and during childhood in the development of obesity in children and adolescents: a systematic literature review[J]. Nutrients, 2022, 14(23): 5125. doi: 10.3390/nu14235125
[3]	JANJUA N Z, MAHMOOD B, ISLAM M A, et al. Maternal and early childhood risk factors for overweight and obesity among low-income predominantly black children at age five years: a prospective cohort study[J]. J Obes, 2012, 2012: 457173.
[4]	OOSTVOGELS A J, STRONKS K, ROSEBOOM T J, et al. Maternal prepregnancy BMI, offspring's early postnatal growth, and metabolic profile at age 5-6 years: the ABCD study[J]. J Clin Endocrinol Metab, 2014, 99(10): 3845-3854. doi: 10.1210/jc.2014-1561
[5]	MARTIN C L, VLADUTIU C J, ZIKRY T M, et al. Maternal lipid levels during pregnancy and child weight status at 3 years of age[J]. Pediatr Obes, 2019, 14(4): e12485. doi: 10.1111/ijpo.12485
[6]	YUAN S, LI L, PU T, et al. The relationship between NLR, LDL-C/HDL-C, NHR and coronary artery disease[J]. PLoS One, 2024, 19(7): e0290805. doi: 10.1371/journal.pone.0290805
[7]	YUGE H, OKADA H, HAMAGUCHI M, et al. Triglycerides/HDL cholesterol ratio and type 2 diabetes incidence: Panasonic Cohort Study 10[J]. Cardiovasc Diabetol, 2023, 22(1): 308. doi: 10.1186/s12933-023-02046-5
[8]	王超, 张萍. 血脂比值预测心血管疾病的临床研究进展[J]. 山东医药, 2015, 55(36): 99-102. WANG C, ZHANG P. Clinical research progress of lipid ratio in predicting cardiovascular diseases[J]. Shandong Med, 2015, 55(36): 99-102. (in Chinese)
[9]	JIN C, LIN L, HAN N, et al. Effects of dynamic change in fetuin: a levels from the first to the second trimester on insulin resistance and gestational diabetes mellitus: a nested case-control study[J]. BMJ Open Diabetes Res Care, 2020, 8(1): e000802. doi: 10.1136/bmjdrc-2019-000802
[10]	中华人民共和国国家卫生和计划生育委员会. 成人体重判定: WS/T 428—2013[S]. 北京: 中国标准出版社, 2013. National Health and Family Planning Commission of the PRC. Criteria of weight for adults : WS/T 428-2013[S]. Beijing: China Standards Press, 2013. (in Chinese)
[11]	BRÄMER G R. International statistical classification of diseases and related health problems. Tenth revision[J]. World Health Stat Q, 1988, 41(1): 32-36.
[12]	World Health Organization. Child growth standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development[EB/OL]. (2006-11-11)[2025-02-01]. https://www.who.int/publications/i/item/924154693X.
[13]	TINGLEY D, YAMAMOTO T, HIROSE K, et al. Mediation: R package for causal mediation analysis[J]. J Stat Softw, 2014, 59(5): 1-38.
[14]	BAAS R E, HUTTEN B A, HENRICHS J, et al. Associations between maternal lipid blood levels at the 13th week of pregnancy and offspring's adiposity at age 11-12 years[J]. J Clin Endocrinol Metab, 2022, 107(10): e4048-e4057. doi: 10.1210/clinem/dgac442
[15]	GARCÍA A I, NIÑO-SILVA L A, GONZÁLEZ-RUÍZ K, et al. Body adiposity index as marker of obesity and cardiovascular risk in adults from Bogotá, Colombia[J]. Endocrinol Nutr, 2015, 62(3): 130-137. doi: 10.1016/j.endonu.2014.11.007
[16]	WEINSTEIN S, MAOR E, KAPLAN A, et al. Non-interventional weight changes are associated with alterations in lipid profiles and in the triglyceride-to-HDL cholesterol ratio[J]. Nutrients, 2024, 16(4): 486. doi: 10.3390/nu16040486
[17]	XU X, LUO S, LIN J, et al. Association between maternal lipid profiles and lipid ratios in early to middle pregnancy as well as their dynamic changes and gestational diabetes mellitus[J]. BMC Preg Childbirth, 2024, 24(1): 510. doi: 10.1186/s12884-024-06692-9
[18]	ZENG S, LIU Q, WU Y, et al. Reduced low-density lipoprotein cholesterol levels are associated with increased risk of gestational diabetes mellitus in Chinese women[J]. Sci Rep, 2025, 15(1): 6435. doi: 10.1038/s41598-025-91258-8
[19]	MOON J H, JANG H C. Gestational diabetes mellitus: diagnostic approaches and maternal-offspring complications[J]. Diabetes Metab J, 2022, 46(1): 3-14. doi: 10.4093/dmj.2021.0335
[20]	WAHAB R J, JADDOE V W V, VOERMAN E, et al. Maternal body mass index, early-pregnancy metabolite profile, and birthweight[J]. J Clin Endocrinol Metab, 2022, 107(1): e315-e327. doi: 10.1210/clinem/dgab596
[21]	DESOYE G, HERRERA E. Adipose tissue development and lipid metabolism in the human fetus: the 2020 perspective focusing on maternal diabetes and obesity[J]. Prog Lipid Res, 2021, 81: 101082. doi: 10.1016/j.plipres.2020.101082
[22]	周玉博, 李宏田, 刘建蒙. 孕前肥胖、孕期增重过度与子代健康[J]. 中国生育健康杂志, 2022, 33(4): 386-390. ZHOU Y B, LI H T, LIU J M. Pre-pregnancy obesity, excessive weight gain during pregnancy and offspring health[J]. Chin J Reprod Health, 2022, 33(4): 386-390. (in Chinese)
[23]	MULDER J W C M, KUSTERS D M, ROETERS VAN LENNEP J E, et al. Lipid metabolism during pregnancy: consequences for mother and child[J]. Curr Opin Lipidol, 2024, 35(3): 133-140. doi: 10.1097/MOL.0000000000000927
[24]	GUAY S P, HOUDE A A, BRETON E, et al. DNA methylation at LRP1 gene locus mediates the association between maternal total cholesterol changes in pregnancy and cord blood leptin levels[J]. J Dev Orig Health Dis, 2020, 11(4): 369-378. doi: 10.1017/S204017441900076X
[25]	ACHARI A E, JAIN S K. Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction[J]. Int J Mol Sci, 2017, 18(6): 1321. doi: 10.3390/ijms18061321