Investigation on an outbreak of acute hemorrhagic conjunctivitis at a boarding middle school in Guangdong Province

LUO Lixian; ZENG Biao; YI Yao; WENG Jiaxi; WAN Liwei; YE Zheng; TAN Chunrong; KANG Min; ZHANG Yingtao

doi:10.16835/j.cnki.1000-9817.2025158

Volume 46 Issue 6

Jun. 2025

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LUO Lixian, ZENG Biao, YI Yao, WENG Jiaxi, WAN Liwei, YE Zheng, TAN Chunrong, KANG Min, ZHANG Yingtao. Investigation on an outbreak of acute hemorrhagic conjunctivitis at a boarding middle school in Guangdong Province[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(6): 878-882. doi: 10.16835/j.cnki.1000-9817.2025158

Citation:

LUO Lixian, ZENG Biao, YI Yao, WENG Jiaxi, WAN Liwei, YE Zheng, TAN Chunrong, KANG Min, ZHANG Yingtao. Investigation on an outbreak of acute hemorrhagic conjunctivitis at a boarding middle school in Guangdong Province[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(6): 878-882. doi: 10.16835/j.cnki.1000-9817.2025158

Citation:

LUO Lixian, ZENG Biao, YI Yao, WENG Jiaxi, WAN Liwei, YE Zheng, TAN Chunrong, KANG Min, ZHANG Yingtao. Investigation on an outbreak of acute hemorrhagic conjunctivitis at a boarding middle school in Guangdong Province[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(6): 878-882. doi: 10.16835/j.cnki.1000-9817.2025158

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Investigation on an outbreak of acute hemorrhagic conjunctivitis at a boarding middle school in Guangdong Province

doi: 10.16835/j.cnki.1000-9817.2025158

LUO Lixian^{1, 2},
ZENG Biao³,
YI Yao³,
WENG Jiaxi^{1, 4},
WAN Liwei⁵,
YE Zheng^{1, 6},
TAN Chunrong⁶,
KANG Min³,
ZHANG Yingtao^{3
,
,}

1.
Guangdong Provincial Field Epidemiology Training Program, Guangzhou (510000), Guangdong Province, China

Received Date: 2025-01-20
Rev Recd Date: 2025-03-10

Available Online: 2025-07-04

Publish Date: 2025-06-25

Abstract

Abstract

Objective To investigate the characteristics and risk factors of an outbreak of acute hemorrhagic conjunctivitis (AHC) in a boarding middle school in Guangdong Province, in order to provide a scientific evidence for effective prevention and control of campus AHC outbreaks. Methods From September 1st to 28th 2023, case identification was conducted among 559 students and 60 faculty members using standardized definition. Descriptive analysis was conducted on the three distrubution patterns of the outbreak. Questionnaires were designed, and a case-control study was adopted to analyze the possible risk factors of the disease transmission. The propensity score matching (PSM) method was used to control the difference of baseline data. Results A total of 269 cases of AHC were identified, with an attack rate of 43.46%. The pathogen was confirmed as Coxsackie virus A24 variant (CA24v). Among these, 264 cases were students (attack rate of 47.23%) and 5 were staff (attack rate of 8.33%). A total of 153 pairs of PSM were successfully matched. After PSM matching, there were no statistically significant differences in gender, grade and class between the case group and the control group (χ²=0.12, 5.41, 11.24, P>0.05). The results of multivariate Logistic regression analysis showed that middle school students whose towels contacted with others (OR=1.81), and direct contact with other AHC cases recently (OR=4.89) were more likely to have AHC; while wearing glasses (OR=0.43) and frequent use of hand sanitizer (OR=0.37) were less likely to have AHC (P < 0.05). Conclusion The outbreak of AHC is caused by CA24v, demonstrating rapid spread and extensive impact within the school setting.
- Conjunctivitis, acute hemorrhagic,
- Disease outbreaks,
- Epidemiologic studies,
- Incidence,
- Students

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References(22)

References

[1]	任香, 陈梦想, 周楠, 等. 中国急性出血性结膜炎时空分布和社会环境影响因素分析[J]. 中华疾病控制杂志, 2022, 26(8): 953-960. REN X, CHEN M X, ZHOU N, et al. Spatio-temporal distribution and socioenvironmental factors of acute hemorrhagic conjunctivitis in China[J]. Chin J Dis Control Prev, 2022, 26(8): 953-960. (in Chinese)
[2]	MEDINA N H, HARO-MUÑOZ E, PELLINI A C, et al. Acute hemorrhagic conjunctivitis epidemic in São Paulo State, Brazil, 2011[J]. Rev Panam Salud Publica, 2016, 39(2): 137-141.
[3]	刘翠娟, 朱海城, 高淑萍, 等. 河源市2005—2019年急性出血性结膜炎流行特征[J]. 海峡预防医学杂志, 2021, 27(4): 39-40. LIU C J, ZHU H C, GAO S P, et al. Epidemiological characteristics of acute hemorrhagic conjunctivitis in Heyuan during 2005-2019[J]. Strait J Prev Med, 2021, 27(4): 39-40. (in Chinese)
[4]	龙亮, 肖锂琼. 1起新生军训期间急性出血性结膜炎流行的控制[J]. 中国校医, 2014, 28(9): 667. LONG L, XIAO L Q. Control of acute hemorrhagic conjunctivitis epidemic during freshman military training[J]. Chin J School Doctor, 2014, 28(9): 667. (in Chinese)
[5]	巴桑卓玛. 医院内急性出血性结膜炎暴发的现场流行病学调查分析[J]. 世界最新医学信息文摘, 2016, 16(77): 189. BA S Z A. Field epidemiological investigation and analysis of acute hemorrhagic conjunctivitis outbreak in hospital[J]. World Latest Med Inf, 2016, 16(77): 189. (in Chinese)
[6]	中华人民共和国卫生部. 急性出血性结膜炎诊断标准: WS 217—2008[S]. 2008-09-01. Ministry of Health of the PRC. Diagnostic criteria for acute hemorrhagic conjunctivitis: WS 217-2008[S]. 2008-09-01. (in Chinese)
[7]	黄福强, 杜春霖, 孙梦辉, 等. 倾向评分配比在SPSS软件上的实现[J]. 南方医科大学学报, 2015, 35(11): 1597-1601. HUANG F Q, DU C L, SUN M H, et al. Propensity score matching in SPSS[J]. J South Med Univ, 2015, 35(11): 1597-1601. (in Chinese)
[8]	黄明昭, 王雪玲, 陈婷. 基于PSM-Cox模型的老年人再就业对死亡风险的影响[J]. 现代预防医学, 2023, 50(19): 3457-3463. HUANG M Z, WANG X L, CHEN T. Effect of re-employment of the elderly on the mortality risk based on PSM-Cox model[J]. Mod Prev Med, 2023, 50(19): 3457-3463. (in Chinese)
[9]	田之魁, 孙璇, 王东军, 等. 基于倾向得分匹配的糖尿病足患者舌象研究[J]. 中华中医药杂志, 2023, 38(7): 3368-3371. TIAN Z K, SUN X, WANG D J, et al. Study on tongue distribution of diabetic foot patients based on tendency matching score[J]. China J Tradit Chin Med Pharm, 2023, 38(7): 3368-3371. (in Chinese)
[10]	孙立梅, 郑慧贞, 李灵辉, 等. 广东省2004—2007年急性出血性结膜炎疫情特征分析[J]. 现代预防医学, 2009, 36(8): 1548-1550. SUN L M, ZHENG H Z, LI L H, et al. Analysis on the epidemiologic characteristics of acute hemorrhagic conjunctivitis in Guangdong during 2004-2007[J]. Mod Prev Med, 2009, 36(8): 1548-1550. (in Chinese)
[11]	陈田木, 刘如春. 运用SIQR模型模拟学校急性出血性结膜炎暴发的隔离防控效果[J]. 中华流行病学杂志, 2013, 34(1): 75-79. CHEN T M, LIU R C. Study on the efficacy of quarantine during outbreaks of acute hemorrhagic conjunctivitis outbreaks at schools through the susceptive-infective-quarantine removal model[J]. Chin J Epidemiol, 2013, 34(1): 75-79. (in Chinese)
[12]	王晓芳, 赵俊伟, 张顺先, 等. 我国急性出血性结膜炎流行特征及暴发原因分析[J]. 疾病监测, 2014, 29(2): 92-97. WANG X F, ZHAO J W, ZHANG S X, et al. Acute hemorrhagic conjunctivitis outbreak in China[J]. Dis Surveill, 2014, 29(2): 92-97. (in Chinese)
[13]	赵宏, 刘燕, 李斌, 等. 青海藏区寄宿制学校中小学生卫生习惯状况[J]. 中国学校卫生, 2015, 36(3): 340-342. http://www.cjsh.org.cn/article/id/zgxxws201503007 ZHAO H, LIU Y, LI B, et al. Personal hygiene habit survey of the Tibetan primary and middle boarding school students in Qinghai Province[J]. Chin J Sch Health, 2015, 36(3): 340-342. (in Chinese) http://www.cjsh.org.cn/article/id/zgxxws201503007
[14]	俞慧芳, 陈中文, 罗建勇, 等. 嘉兴市中小学生手卫生知识和行为影响因素调查分析[J]. 中国农村卫生事业管理, 2013, 33(6): 651-653. YU H F, CHEN Z W, LUO J Y, et al. Investigation and analysis of influencing factors of hand hygiene knowledge and behavior among primary and middle school students in Jiaxing[J]. Chin Rural Health Serv Adm, 2013, 33(6): 651-653. (in Chinese)
[15]	邢彦, 江初, 华伟玉, 等. 一起诺如病毒感染引起的学校突发公共卫生事件调查[J]. 中华流行病学杂志, 2017, 38(9): 1174-1178. XING Y, JIANG C, HUA W Y, et al. Survey on a school public health emergency caused by norovirus[J]. Chin J Epidemiol, 2017, 38(9): 1174-1178. (in Chinese)
[16]	谭昆, 韩颖, 谭莉, 等. 集束化干预急性出血性结膜炎聚集性事件的效果[J]. 中国感染控制杂志, 2018, 17(8): 660-664. TAN K, HAN Y, TAN L, et al. Efficacy of bunld intervention in cluster events of acute hemorrhagic conjunctivitis[J]. Chin J Infect Control, 2018, 17(8): 660-664. (in Chinese)
[17]	中华人民共和国卫生部. 中国居民的正确洗手率仅为4%[J]. 护理管理杂志, 2011, 11(11): 834. Ministry of the Health of the PRC. The correct hand-washing rate among Chinese residents is only 4%[J]. J Nurs Administr, 2011, 11 (11): 834. (in Chinese)
[18]	陈静. 寄宿制初中住宿管理现状的调查研究[D]. 石家庄: 河北师范大学, 2021. CHEN J. Research on the current situation of boarding management in boarding junior middle school[D]. Shijiazhuang: Hebei Normal University, 2021. (in Chinese)
[19]	胡艳丹, 谭育林, 余畅, 等. 湘潭市城区中小学校卫生室及校医配备现状分析[J]. 中国卫生监督杂志, 2020, 27(1): 53-57. HU Y D, TAN Y L, YU C, et al. Analysis on the current situation of clinics and school physicians equipped in primary and secondary schools in the urban area of Xiangtan City[J]. Chin J Health Inspect, 2020, 27(1): 53-57. (in Chinese)
[20]	姚海舟, 朱广荣, 张芯, 等. 中国16省中小学校校医配备现状分析[J]. 中国学校卫生, 2018, 39(10): 1455-1458. doi: 10.16835/j.cnki.1000-9817.2018.10.005 YAO H Z, ZHU G R, ZHANG X, et al. Current situation and analysis of school physicians in primary and secondary schools in 16 provinces in China[J]. Chin J Sch Health, 2018, 39(10): 1455-1458. (in Chinese) doi: 10.16835/j.cnki.1000-9817.2018.10.005
[21]	夏明娟, 吕宜临, 王泽强. 重庆市部分寄宿制中小学校医工作现状分析[J]. 中国校医, 2022, 36(2): 154-155. XIA M J, LÜ Y L, WANG Z Q. Analysis of the current situation of school doctors in some boarding primary and secondary schools in Chongqing[J]. Chin J School Doctor, 2022, 36(2): 154-155. (in Chinese)
[22]	肖伟华, 杨仁东, 徐晓敏, 等. 珠海市中小学校校医和保健教师配置现状[J]. 中国校医, 2021, 35(7): 487-489. XIAO W H, YANG R D, XU X M, et al. Investigation of current situation of school doctors and health teachers in primary and secondary schools in Zhuhai City[J]. Chin J School Doctor, 2021, 35(7): 487-489. (in Chinese)