Analysis of influencing factors for maternal intentions to vaccinate age-appropriate girls against human papillomavirus

QIU Xiaofei*; KANG Xiao; ZHUANG Wenwen; GAO Riyue; ZHANG Delei; SHAO Yanyan; LI Xuedan; YANG Feng

doi:10.16835/j.cnki.1000-9817.2025097

Volume 46 Issue 4

Apr. 2025

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QIU Xiaofei*, KANG Xiao, ZHUANG Wenwen, GAO Riyue, ZHANG Delei, SHAO Yanyan, LI Xuedan, YANG Feng. Analysis of influencing factors for maternal intentions to vaccinate age-appropriate girls against human papillomavirus[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(4): 519-523. doi: 10.16835/j.cnki.1000-9817.2025097

Citation:

QIU Xiaofei*, KANG Xiao, ZHUANG Wenwen, GAO Riyue, ZHANG Delei, SHAO Yanyan, LI Xuedan, YANG Feng. Analysis of influencing factors for maternal intentions to vaccinate age-appropriate girls against human papillomavirus[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(4): 519-523. doi: 10.16835/j.cnki.1000-9817.2025097

Citation:

QIU Xiaofei*, KANG Xiao, ZHUANG Wenwen, GAO Riyue, ZHANG Delei, SHAO Yanyan, LI Xuedan, YANG Feng. Analysis of influencing factors for maternal intentions to vaccinate age-appropriate girls against human papillomavirus[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(4): 519-523. doi: 10.16835/j.cnki.1000-9817.2025097

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Analysis of influencing factors for maternal intentions to vaccinate age-appropriate girls against human papillomavirus

doi: 10.16835/j.cnki.1000-9817.2025097

1.
^*Qingdao Municipal Center for Disease Control and Prevention, Qingdao (266000), Shandong Province, China

Received Date: 2025-01-02
Rev Recd Date: 2025-02-12

Available Online: 2025-05-08

Publish Date: 2025-04-25

Abstract

Abstract

Objective To investigate the intentions of mothers of age-appropriate girls in Qingdao to vaccinate their daughters against human papillomavirus (HPV), so as to provide theoretical guidance for targeted health education in the future. Methods A multi-stage random sampling method was adopted to conduct a cross-sectional study among 2 244 mothers of girls aged 12-14 years in Qingdao from March to December 2023. The Mann-Whitney U test was used for group comparisons, and Logistic regression was performed to analyze the factors that influenced maternal intention to vaccinate their age-appropriate daughters against HPV. Results Among the surveyed mothers, 89.22% (n=2 002) intended to vaccinate their daughters against HPV, and 68.58% (n=1 539) had fully vaccinated or had plans to complete it for themselves. The knowledge score of mothers intended to vaccinate their daughters was 10 (8, 11). The multivariate Logistic regression analysis showed that mothers aged >45 years (OR=0.19), those with an annual family income of 60 000- < 150 000 yuan (OR=0.65), 150 000-<300 000 yuan (OR=0.58), 300 000-500 000 yuan (OR=0.22), and those with higher knowledge scores (OR=0.90) were more likely to vaccinate their daughters (P<0.05). Mothers with a junior college or undergraduate degree (OR=1.66), those who never or occasionally screened for HPV (OR=1.58), those who were intended to be vaccinated, not planning to complete the full-course vaccination, or over-aged and unvaccinated (OR=7.13), those who were not concerned about their daughters' HPV infection (OR=2.54), and those whose daughters were not in adolescence (OR=1.93) were less intended to vaccinate their daughters (P<0.05). The primary reasons for vaccine hesitancy were vaccine safety concerns (65.06%), followed by the belief of mothers that "the children is to young, and can be vaccinated when they are older" (13.25%). Conclusions Mothers of eligible girls in Qingdao have relatively higher intentions to vaccinate their daughters against HPV, and willingness is influenced by factors such as the mother's vaccination status, knowledge level, and daughter's development stage. It is recommended to strengthen targeted health education, improve the cognitive level and acceptance of mother, and increase the vaccination rate of HPV vaccines.
- Mothers,
- Papillomavirus vaccines,
- Attitude,
- Regression analysis,
- Students,
- Female

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References(28)

References

[1]	SINGH D, VIGNAT J, LORENZONI V, et al. Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO Global Cervical Cancer Elimination Initiative[J]. Lancet Glob Health, 2023, 11(2): e197-e206. doi: 10.1016/S2214-109X(22)00501-0
[2]	BRAY F, LAVERSANNE M, SUNG H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3): 229-263. doi: 10.3322/caac.21834
[3]	ARBYN M, XU L, SIMOENS C, et al. Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors[J]. Cochrane Database Syst Rev, 2018, 5(5): CD009069.
[4]	RAHANGDALE L, MUNGO C, O'CONNOR S, et al. Human papillomavirus vaccination and cervical cancer risk[J]. BMJ, 2022, 379: e070115. doi: 10.1097/01.ogx.0000931688.91347.0a
[5]	CROSBIE E J, EINSTEIN M H, FRANCESCHI S, et al. Human papillomavirus and cervical cancer[J]. Lancet, 2013, 382(9895): 889-899. doi: 10.1016/S0140-6736(13)60022-7
[6]	ZHANG J, CHENG K, WANG Z. Prevalence and distribution of human papillomavirus genotypes in cervical intraepithelial neoplasia in China: a Meta-analysis[J]. Arch Gynecol Obstet, 2020, 302(6): 1329-1337. doi: 10.1007/s00404-020-05787-w
[7]	SUNDARAM N, VOO T C, TAM C C. Adolescent HPV vaccination: empowerment, equity and ethics[J]. Hum Vaccin Immunother, 2020, 16(8): 1835-1840. doi: 10.1080/21645515.2019.1697596
[8]	HUGHES C C, JONES A L, FREEMSTER K A, et al. HPV vaccine decision making in pediatric primary care: a semi-structured interview study[J]. BMC Pediatr, 2011, 11: 74. doi: 10.1186/1471-2431-11-74
[9]	SUNDSTRÖM K, ELFSTRÖM K M. Advances in cervical cancer prevention: efficacy, effectiveness, elimination?[J]. PLoS Med, 2020, 17(1): e1003035. doi: 10.1371/journal.pmed.1003035
[10]	WHO Strategic Advisory Group of Experts (SAGE) on Immunization.Human papillomavirus vaccines: WHO position paper[EB/OL].(2022-12-16)[2024-10-28].https://www.who.int/publications/i/item/who-wer9750-645-672.
[11]	LVERSEN O E, MIRANDA M J, ULIED A, et al. Immunogenicity of the 9-valent HPV vaccine using 2-dose regimens in girls and boys vs a 3-dose regimen in women[J]. JAMA, 2016, 316(22): 2411-2421. doi: 10.1001/jama.2016.17615
[12]	LEHTINEN M, BRUNI L, ELFSTRÖM M, et al. Scientific approaches toward improving cervical cancer elimination strategies[J]. Int J Cancer, 2024, 154(9): 1537-1548. doi: 10.1002/ijc.34839
[13]	LI Y, QIN C, QIU S, et al. The effectiveness of pay-it-forward in addressing HPV vaccine delay and increasing uptake among 15-18-year-old adolescent girls compared to user-paid vaccination: a study protocol for a two-arm randomized controlled trial in China[J]. BMC Public Health, 2023, 23(1): 48. doi: 10.1186/s12889-022-14947-3
[14]	ZOU Z, FAIRLEY C K, ONG J J, et al. Domestic HPV vaccine price and economic returns for cervical cancer prevention in China: a cost-effectiveness analysis[J]. Lancet Glob Health, 2020, 8(10): e1335-e1344. doi: 10.1016/S2214-109X(20)30277-1
[15]	GLENN B A, TSUI J, SINGHAL R, et al. Factors associated with HPV awareness among mothers of low-income ethnic minority adolescent girls in Los Angeles[J]. Vaccine, 2015, 33(2): 289-293. doi: 10.1016/j.vaccine.2014.11.032
[16]	DERBIE A, MEKONNEN D, MISGAN E, et al. Acceptance of human papillomavirus vaccination and parents' willingness to vaccinate their adolescents in Ethiopia: a systematic review and Meta-analysis[J]. Infect Agent Cancer, 2023, 18(1): 59. doi: 10.1186/s13027-023-00535-6
[17]	HUANG Z, JI M, REN J, et al. Effect of the framing of HPV vaccination on parents' willingness to accept an HPV vaccine[J]. Vaccine, 2022, 40(6): 897-903. doi: 10.1016/j.vaccine.2021.12.051
[18]	赵春艳, 石晶, 张国峰, 等. 北京市通州区中小学女生母亲接受女儿接种HPV疫苗情况及其影响因素[J]. 中国学校卫生, 2020, 41(4): 597-600. doi: 10.16835/j.cnki.1000-9817.2020.04.031 ZHAO C Y, SHI J, ZHANG G F, et al. Mothers of primary and secondary school girls in Tongzhou District of Beijing received HPV vaccination for their daughters vaccine status and its influencing factors[J]. Chin J Sch Health, 2020, 41(4): 597-600. (in Chinese) doi: 10.16835/j.cnki.1000-9817.2020.04.031
[19]	SUZUKI Y, SUKEGAWA A, UEDA Y, et al. The effect of a web-based cervical cancer survivor's story on parents' behavior and willingness to consider human papillomavirus vaccination for daughters: randomized controlled trial[J]. JMIR Public Health Surveill, 2022, 8(5): e34715. doi: 10.2196/34715
[20]	MIHRETIE G N, LIYEH T M, AYELE A D, et al. Knowledge and willingness of parents towards child girl HPV vaccination in Debre Tabor Town, Ethiopia: a community-based cross-sectional study[J]. Rep Health, 2022, 19(1): 136. doi: 10.1186/s12978-022-01444-4
[21]	ALSANAFI M, SALIM N A, SALLAM M. Willingness to get HPV vaccination among female university students in Kuwait and its relation to vaccine conspiracy beliefs[J]. Hum Vaccin Immunother, 2023, 19(1): 2194772. doi: 10.1080/21645515.2023.2194772
[22]	LEADER A E, WEINER J L, KELLY B J, et al. Effects of information framing on human papillomavirus vaccination[J]. J Womens Health (Larchmt), 2009, 18(2): 225-233. doi: 10.1089/jwh.2007.0711
[23]	DUNDAR Y, ELDEM I, SCHWARTZ C, et al. Screening awareness of HPV-related oropharyngeal cancers and attitudes and concerns towards HPV vaccination among parents: HPV and oropharyngeal cancer[J]. J Cancer Educ, 2022, 37(4): 1152-1160. doi: 10.1007/s13187-020-01932-w
[24]	郗思琪, 肖冰冰, 尹玲, 等. 女童和青春期女性阴道菌群相关研究进展[J]. 中国微生态学杂志, 2024, 36(1): 105-109, 114. XI S Q, XIAO B B, YIN L, et al. Research progress on vaginal flora in children and adolescent girls[J]. Chin J Microecol, 2024, 36(1): 105-109, 114. (in Chinese)
[25]	陈亚昕, 苏丹. 中国女大学生人乳头瘤病毒疫苗接种意愿与接种率及影响因素研究进展[J]. 中国学校卫生, 2023, 44(11): 1756-1760. doi: 10.16835/j.cnki.1000-9817.2023.11.011 CHEN Y X, SU D. Research progress on HPV vaccination willingness, vaccination rate and influencing factors of female college students in China[J]. Chin J Sch Health, 2023, 44(11): 1756-1760. (in Chinese) doi: 10.16835/j.cnki.1000-9817.2023.11.011
[26]	高士锐, 所佳宁, 焦阳, 等. 2024年黑龙江省9-18岁女孩父母人乳头瘤病毒及其疫苗相关知识和为女孩接种疫苗意愿调查[J]. 中国疫苗和免疫, 2024, 30(6): 703-707. GAO S R, SUO J N, JIAO Y, et al. Parents' knowledge about human papillomavirus (HPV)/HPV vaccine and their willingness for HPV vaccination of 9-18-year-old girls in Heilongjiang Province in 2024[J]. Chin J Vaccines Immun, 2024, 30(6): 703-707. (in Chinese)
[27]	THOMPSON E L, ROSEN B L, VAMOS C A, et al. Human papillomavirus vaccination: what are the reasons for nonvaccination among U.S. adolescents?[J]. J Adolesc Health, 2017, 61(3): 288-293.
[28]	PERKINS R B, CLARK J A. Providers' perceptions of parental concerns about HPV vaccination[J]. J Health Care Poor Underserved, 2013, 24(2): 828-839. http://www.xueshufan.com/publication/2071496811