Research progress on the relationship between adverse childhood experiences and cardiovascular diseases

LEI Wenqi; SUN Wenjie; SUN Jingyuan; WANG Yiru; SUN Xianghui; SHAO Jinang; MA Yanan

doi:10.16835/j.cnki.1000-9817.2025005

Volume 46 Issue 1

Jan. 2025

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LEI Wenqi, SUN Wenjie, SUN Jingyuan, WANG Yiru, SUN Xianghui, SHAO Jinang, MA Yanan. Research progress on the relationship between adverse childhood experiences and cardiovascular diseases[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(1): 148-152. doi: 10.16835/j.cnki.1000-9817.2025005

Citation:

LEI Wenqi, SUN Wenjie, SUN Jingyuan, WANG Yiru, SUN Xianghui, SHAO Jinang, MA Yanan. Research progress on the relationship between adverse childhood experiences and cardiovascular diseases[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(1): 148-152. doi: 10.16835/j.cnki.1000-9817.2025005

Citation:

LEI Wenqi, SUN Wenjie, SUN Jingyuan, WANG Yiru, SUN Xianghui, SHAO Jinang, MA Yanan. Research progress on the relationship between adverse childhood experiences and cardiovascular diseases[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2025, 46(1): 148-152. doi: 10.16835/j.cnki.1000-9817.2025005

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Research progress on the relationship between adverse childhood experiences and cardiovascular diseases

doi: 10.16835/j.cnki.1000-9817.2025005

School of Public Health, China Medical University, Shenyang (110122), Liaoning Province, China

Received Date: 2023-11-29
Rev Recd Date: 2023-12-13
Publish Date: 2025-01-25

Abstract

Abstract

To understand the relationship between cardiovascular disease (CVD) and adverse childhood experiences (ACEs), the present review aims to describe the burden and influencing factors of CVD, epidemiological characteristics and burden of ACEs, current research on the relationship between ACEs and CVD, and the mechanism of ACEs leading to CVD. It is proposed that further assessment of the relationship is warranted through identifying blood biomarkers, conducting prospective cohort studies and intervention studies. Such efforts would provide valuable scientific insights for primary prevention strategies for cardiovascular disease.
- Life change events,
- Cardiovascular diseases,
- Child,
- Research

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References(65)

References

[1]	ROTH G A, MENSAH G A, JOHNSON C O, et al. Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 study[J]. J Am Coll Cardiol, 2020, 76(25): 2982-3021. doi: 10.1016/j.jacc.2020.11.010
[2]	ROTH G A, MENSAH G A, FUSTER V. The global burden of cardiovascular diseases and risks: a compass for global action[J]. J Am Coll Cardiol, 2020, 76(25): 2980-2981. doi: 10.1016/j.jacc.2020.11.021
[3]	OHIRA T, ISO H. Cardiovascular disease epidemiology in Asia: an overview[J]. Circ J, 2013, 77(7): 1646-1652. doi: 10.1253/circj.CJ-13-0702
[4]	National Center for Cardiovascular Diseases, the Writing Committee of the Report on Cardiovascular Health and Diseases in China. Report on cardiovascular health and diseases in China 2023: an updated summary[J]. Biomed Environ Sci, 2024, 37(9): 949-992.
[5]	TSAO C W, ADAY A W, ALMARZOOQ Z I, et al. Heart disease and stroke statistics-2023 update: a report from the American Heart Association[J]. Circulation, 2023, 147(8): e93-e621.
[6]	Blood Pressure Lowering Treatment Trialists' Collaboration. Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data Meta-analysis[J]. Lancet, 2021, 397(10285): 1625-1636. doi: 10.1016/S0140-6736(21)00590-0
[7]	FUCHS F D, WHELTON P K. High blood pressure and cardiovascular disease[J]. Hypertension, 2020, 75(2): 285-292. doi: 10.1161/HYPERTENSIONAHA.119.14240
[8]	CHENG Y J, IMPERATORE G, GEISS L S, et al. Trends and disparities in cardiovascular mortality among U.S. adults with and without self-reported diabetes, 1988-2015[J]. Diabetes Care, 2018, 41(11): 2306-2315. doi: 10.2337/dc18-0831
[9]	ZHANG Y, PLETCHER M J, VITTINGHOFF E, et al. Association between cumulative low-density lipoprotein cholesterol exposure during young adulthood and middle age and risk of cardiovascular events[J]. JAMA Cardiol, 2021, 6(12): 1406-1413. doi: 10.1001/jamacardio.2021.3508
[10]	KIM M S, KIM W J, KHERA A V, et al. Association between adiposity and cardiovascular outcomes: an umbrella review and Meta-analysis of observational and Mendelian randomization studies[J]. Eur Heart J, 2021, 42(34): 3388-3403. doi: 10.1093/eurheartj/ehab454
[11]	LACROIX A Z, BELLETTIERE J, RILLAMAS-SUN E, et al. Association of light physical activity measured by accelerometry and incidence of coronary heart disease and cardiovascular disease in older women[J]. JAMA Netw Open, 2019, 2(3): e190419. doi: 10.1001/jamanetworkopen.2019.0419
[12]	MONS U, MüEZZINLER A, GELLERT C, et al. Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: Meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium[J]. BMJ, 2015, 350: h1551. doi: 10.1136/bmj.h1551
[13]	BECERRA-TOMáS N, BLANCO MEJíA S, VIGUILIOUK E, et al. Mediterranean diet, cardiovascular disease and mortality in diabetes: a systematic review and Meta-analysis of prospective cohort studies and randomized clinical trials[J]. Crit Rev Food Sci Nutr, 2020, 60(7): 1207-1227. doi: 10.1080/10408398.2019.1565281
[14]	BENJAMIN E J, MUNTNER P, ALONSO A, et al. Heart disease and stroke statistics-2019 update: a report from the American Heart Association[J]. Circulation, 2019, 139(10): e56-e528.
[15]	BASU A, MCLAUGHLIN K A, MISRA S, et al. Childhood maltreatment and health impact: the examples of cardiovascular disease and type 2 diabetes mellitus in adults[J]. Clin Psychol (New York), 2017, 24(2): 125-139.
[16]	World Health Organization. Adverse childhood experiences international questionnaire(ACE-IQ)[EB/OL]. (2018-12-30)[2023-10-11]. http://www.who.int/violence_injury_prevention/violence/activities/adverse_childhood.
[17]	GERVIN D W, HOLLAND K M, OTTLEY P G, et al. Centers for disease control and prevention investments in adverse childhood experience prevention efforts[J]. Am J Prev Med, 2022, 62(6 Suppl 1): S1-S5.
[18]	PIERCE J B, KERSHAW K N, KIEFE C I, et al. Association of childhood psychosocial environment with 30-year cardiovascular disease incidence and mortality in middle age[J]. J Am Heart Assoc, 2020, 9(9): e015326. doi: 10.1161/JAHA.119.015326
[19]	JACQUET-SMAILOVIC M, BRENNSTUHL M J, TARQUINIO C L, et al. Relationship between cumulative adverse childhood experiences and myocardial infarction in adulthood: a systematic review and Meta-analysis[J]. J Child Adolesc Trauma, 2022, 15(3): 701-714. doi: 10.1007/s40653-021-00404-7
[20]	WANG W, LIU Y, YANG Y, et al. Adverse childhood and adulthood experiences and risk of new-onset cardiovascular disease with consideration of social support: a prospective cohort study[J]. BMC Med, 2023, 21(1): 297. doi: 10.1186/s12916-023-03015-1
[21]	HUGHES K, BELLIS M A, HARDCASTLE K A, et al. The effect of multiple adverse childhood experiences on health: a systematic review and Meta-analysis[J]. Lancet Public Health, 2017, 2(8): e356-e366. doi: 10.1016/S2468-2667(17)30118-4
[22]	ANDA R F, DONG M, BROWN D W, et al. The relationship of adverse childhood experiences to a history of premature death of family members[J]. BMC Public Health, 2009, 9: 106. doi: 10.1186/1471-2458-9-106
[23]	CRONHOLM P F, FORKE C M, WADE R, et al. Adverse childhood experiences: expanding the concept of adversity[J]. Am J Prev Med, 2015, 49(3): 354-361. doi: 10.1016/j.amepre.2015.02.001
[24]	BELLIS M A, HUGHES K, FORD K, et al. Life course health consequences and associated annual costs of adverse childhood experiences across Europe and North America: a systematic review and Meta-analysis[J]. Lancet Public Health, 2019, 4(10): e517-e528. doi: 10.1016/S2468-2667(19)30145-8
[25]	LIN L, WANG H H, LU C, et al. Adverse childhood experiences and subsequent chronic diseases among middle-aged or older adults in China and associations with demographic and socioeconomic characteristics[J]. JAMA Netw Open, 2021, 4(10): e2130143. doi: 10.1001/jamanetworkopen.2021.30143
[26]	FLORES-TORRES M H, COMERFORD E, SIGNORELLO L, et al. Impact of adverse childhood experiences on cardiovascular disease risk factors in adulthood among Mexican women[J]. Child Abuse Negl, 2020, 99: 104175. doi: 10.1016/j.chiabu.2019.104175
[27]	TRIVEDI G Y, PILLAI N, TRIVEDI R G. Adverse childhood experiences and mental health: the urgent need for public health intervention in India[J]. J Prev Med Hyg, 2021, 62(3): E728-E735.
[28]	TUNG E L, WROBLEWSKI K E, MAKELARSKI J A, et al. Childhood parental incarceration and adult-onset hypertension and cardiovascular risk[J]. JAMA Cardiol, 2023, 8(10): 927-935. doi: 10.1001/jamacardio.2023.2672
[29]	HUGHES K, FORD K, KADEL R, et al. Health and financial burden of adverse childhood experiences in England and Wales: a combined primary data study of five surveys[J]. BMJ Open, 2020, 10(6): e036374. doi: 10.1136/bmjopen-2019-036374
[30]	QIN F Z, YUAN M Q, ZHOU Z, et al. Progress in research of association of adverse childhood experiences with prevalence of common chronic diseases in adulthood[J]. Chin J Epidemiol, 2020, 41(11): 1933-1937.
[31]	LI J J, LIN S Q, WU J L, et al. A retrospective cohort study of the effects of the adverse childhood experience on chronic diseases of middle-aged and elderly[J]. Chin J Epidemiol, 2021, 42(10): 1804-1808.
[32]	GODOY L C, FRANKFURTER C, COOPER M, et al. Association of adverse childhood experiences with cardiovascular disease later in life: a review[J]. JAMA Cardiol, 2021, 6(2): 228-235. doi: 10.1001/jamacardio.2020.6050
[33]	DONG M, GILES W H, FELITTI V J, et al. Insights into causal pathways for ischemic heart disease: adverse childhood experiences study[J]. Circulation, 2004, 110(13): 1761-1766. doi: 10.1161/01.CIR.0000143074.54995.7F
[34]	BELLIS M A, HUGHES K, LECKENBY N, et al. Measuring mortality and the burden of adult disease associated with adverse childhood experiences in England: a national survey[J]. J Public Health (Oxf), 2015, 37(3): 445-454. doi: 10.1093/pubmed/fdu065
[35]	FOWLER C, HOMANDBERG L, STEELE C, et al. Adult correlates of adverse childhood experiences in Ukraine[J]. Child Abuse Negl, 2020, 107: 104617. doi: 10.1016/j.chiabu.2020.104617
[36]	O'LEARY E, MILLAR S R, PERRY I J, et al. Association of adverse childhood experiences with lipid profiles and atherogenic risk indices in a middle-to-older aged population[J]. SSM Popul Health, 2023, 22: 101393. doi: 10.1016/j.ssmph.2023.101393
[37]	LIANG Y Y, AI S, WENG F, et al. Associations of childhood maltreatment and genetic risks with incident heart failure in later life[J]. J Am Heart Assoc, 2022, 11(20): e026536. doi: 10.1161/JAHA.122.026536
[38]	LIU Y, WANG C, LIU Y. Association between adverse childhood experiences and later-life cardiovascular diseases among middle-aged and older Chinese adults: the mediation effect of depressive symptoms[J]. J Affect Disord, 2022, 319: 277-285. doi: 10.1016/j.jad.2022.09.080
[39]	LLABRE M M, SCHNEIDERMAN N, GALLO L C, et al. Childhood trauma and adult risk factors and disease in Hispanics/Latinos in the US: results from the Hispanic community health study/study of Latinos (HCHS/SOL) sociocultural ancillary study[J]. Psychosom Med, 2017, 79(2): 172-180. doi: 10.1097/PSY.0000000000000394
[40]	DESCHêNES S S, KIVIMAKI M, SCHMITZ N. Adverse childhood experiences and the risk of coronary heart disease in adulthood: examining potential psychological, biological, and behavioral mediators in the Whitehall Ⅱ cohort study[J]. J Am Heart Assoc, 2021, 10(10): e019013. doi: 10.1161/JAHA.120.019013
[41]	LEE T K, WICKRAMA K A S, O'NEAL C W. Early socioeconomic adversity and cardiometabolic risk in young adults: mediating roles of risky health lifestyle and depressive symptoms[J]. J Behav Med, 2019, 42(1): 150-161. doi: 10.1007/s10865-018-9952-5
[42]	RICH-EDWARDS J W, MASON S, REXRODE K, et al. Physical and sexual abuse in childhood as predictors of early-onset cardiovascular events in women[J]. Circulation, 2012, 126(8): 920-927. doi: 10.1161/CIRCULATIONAHA.111.076877
[43]	CROUCH E, RADCLIFF E, STROMPOLIS M, et al. Examining the association between adverse childhood experiences and smoking-exacerbated illnesses[J]. Public Health, 2018, 157: 62-68. doi: 10.1016/j.puhe.2018.01.021
[44]	CHARTIER M J, WALKER J R, NAIMARK B. Health risk behaviors and mental health problems as mediators of the relationship between childhood abuse and adult health[J]. Am J Public Health, 2009, 99(5): 847-854. doi: 10.2105/AJPH.2007.122408
[45]	DAS-MUNSHI J, LEAVEY G, STANSFELD S A, et al. Does social disadvantage over the life-course account for alcohol and tobacco use in Irish people? Birth cohort study[J]. Eur J Public Health, 2014, 24(4): 594-599. doi: 10.1093/eurpub/ckt122
[46]	DONG M, ANDA R F, FELITTI V J, et al. Childhood residential mobility and multiple health risks during adolescence and adulthood: the hidden role of adverse childhood experiences[J]. Arch Pediatr Adolesc Med, 2005, 159(12): 1104-1110. doi: 10.1001/archpedi.159.12.1104
[47]	DUBE S R, COOK M L, EDWARDS V J. Health-related outcomes of adverse childhood experiences in Texas, 2002[J]. Prev Chronic Dis, 2010, 7(3): A52.
[48]	FULLER-THOMSON E, FILIPPELLI J, LUE-CRISOSTOMO C A. Gender-specific association between childhood adversities and smoking in adulthood: findings from a population-based study[J]. Public Health, 2013, 127(5): 449-460. doi: 10.1016/j.puhe.2013.01.006
[49]	MORTON P M, MUSTILLO S A, FERRARO K F. Does childhood misfortune raise the risk of acute myocardial infarction in adulthood?[J]. Soc Sci Med, 2014, 104: 133-141. doi: 10.1016/j.socscimed.2013.11.026
[50]	LOUCKS E B, ALMEIDA N D, TAYLOR S E, et al. Childhood family psychosocial environment and coronary heart disease risk[J]. Psychosom Med, 2011, 73(7): 563-571. doi: 10.1097/PSY.0b013e318228c820
[51]	HAZZARD V M, YOON C, EMERY R L, et al. Adverse childhood experiences in relation to mood-, weight-, and eating-related outcomes in emerging adulthood: does self-compassion play a buffering role?[J]. Child Abuse Negl, 2021, 122: 105307. doi: 10.1016/j.chiabu.2021.105307
[52]	SCHULER B R, VAZQUEZ C, KOBULSKY J M, et al. The early effects of cumulative and individual adverse childhood experiences on child diet: examining the role of socioeconomic status[J]. Prev Med, 2021, 145: 106447. doi: 10.1016/j.ypmed.2021.106447
[53]	JACKSON D B, VAUGHN M G. Parental incarceration and child sleep and eating behaviors[J]. J Pediatr, 2017, 185: 211-217. doi: 10.1016/j.jpeds.2017.03.026
[54]	FANG Y, XIA J, LIAN Y, et al. The burden of cardiovascular disease attributable to dietary risk factors in the provinces of China, 2002-2018: a nationwide population-based study[J]. Lancet Reg Health West Pac, 2023, 37: 100784.
[55]	SHIVAPPA N, GODOS J, HéBERT J R, et al. Dietary Inflammatory Index and cardiovascular risk and mortality: a Meta-analysis[J]. Nutrients, 2018, 10(2): 200. doi: 10.3390/nu10020200
[56]	KAJEEPETA S, GELAYE B, JACKSON C L, et al. Adverse childhood experiences are associated with adult sleep disorders: a systematic review[J]. Sleep Med, 2015, 16(3): 320-330. doi: 10.1016/j.sleep.2014.12.013
[57]	BAIDEN P, FALLON B, DEN DUNNEN W, et al. The enduring effects of early-childhood adversities and troubled sleep among Canadian adults: a population-based study[J]. Sleep Med, 2015, 16(6): 760-767. doi: 10.1016/j.sleep.2015.02.527
[58]	GANGWISCH J E. A review of evidence for the link between sleep duration and hypertension[J]. Am J Hypertens, 2014, 27(10): 1235-1242. doi: 10.1093/ajh/hpu071
[59]	JAVAHERI S, STORFER-ISSER A, ROSEN C L, et al. Sleep quality and elevated blood pressure in adolescents[J]. Circulation, 2008, 118(10): 1034-1040. doi: 10.1161/CIRCULATIONAHA.108.766410
[60]	BADRAN M, YASSIN B A, FOX N, et al. Epidemiology of sleep disturbances and cardiovascular consequences[J]. Can J Cardiol, 2015, 31(7): 873-879. doi: 10.1016/j.cjca.2015.03.011
[61]	TOTTENHAM N, HARE T A, MILLNER A, et al. Elevated amygdala response to faces following early deprivation[J]. Dev Sci, 2011, 14(2): 190-204. doi: 10.1111/j.1467-7687.2010.00971.x
[62]	POWELL N D, SLOAN E K, BAILEY M T, et al. Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis[J]. Proc Natl Acad Sci USA, 2013, 110(41): 16574-16579. doi: 10.1073/pnas.1310655110
[63]	HOSTINAR C E, LACHMAN M E, MROCZEK D K, et al. Additive contributions of childhood adversity and recent stressors to inflammation at midlife: findings from the MIDUS study[J]. Dev Psychol, 2015, 51(11): 1630-1644. doi: 10.1037/dev0000049
[64]	PFEFFER C R, ALTEMUS M, HEO M, et al. Salivary cortisol and psychopathology in children bereaved by the September 11, 2001 Terror Attacks[J]. Biol Psychiatry, 2007, 61(8): 957-965. doi: 10.1016/j.biopsych.2006.07.037
[65]	MILLER G E, CHEN E, FOK A K, et al. Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling[J]. Proc Natl Acad Sci USA, 2009, 106(34): 14716-14721. doi: 10.1073/pnas.0902971106