Correlation between serum insulin-like growth factor-1 expression and characteristics of gut microbiota in children with cerebral palsy accompanied by growth retardation

HUANG Min; YU Xiaotang; ZHOU Ping; LU Zhensheng; ZHU Shihua; NIE Yun; LIANG Zhengzhong; WU Liqun; YANG Jiewen

doi:10.16835/j.cnki.1000-9817.2024290

Volume 45 Issue 9

Sep. 2024

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Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2024 > 45(9): 1246-1250

HUANG Min, YU Xiaotang, ZHOU Ping, LU Zhensheng, ZHU Shihua, NIE Yun, LIANG Zhengzhong, WU Liqun, YANG Jiewen. Correlation between serum insulin-like growth factor-1 expression and characteristics of gut microbiota in children with cerebral palsy accompanied by growth retardation[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(9): 1246-1250. doi: 10.16835/j.cnki.1000-9817.2024290

Citation:

HUANG Min, YU Xiaotang, ZHOU Ping, LU Zhensheng, ZHU Shihua, NIE Yun, LIANG Zhengzhong, WU Liqun, YANG Jiewen. Correlation between serum insulin-like growth factor-1 expression and characteristics of gut microbiota in children with cerebral palsy accompanied by growth retardation[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(9): 1246-1250. doi: 10.16835/j.cnki.1000-9817.2024290

Citation:

HUANG Min, YU Xiaotang, ZHOU Ping, LU Zhensheng, ZHU Shihua, NIE Yun, LIANG Zhengzhong, WU Liqun, YANG Jiewen. Correlation between serum insulin-like growth factor-1 expression and characteristics of gut microbiota in children with cerebral palsy accompanied by growth retardation[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(9): 1246-1250. doi: 10.16835/j.cnki.1000-9817.2024290

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Correlation between serum insulin-like growth factor-1 expression and characteristics of gut microbiota in children with cerebral palsy accompanied by growth retardation

doi: 10.16835/j.cnki.1000-9817.2024290

Guangzhou Social Welfare Institute, Guangzhou (510000), Guangdong Province, China

Received Date: 2024-05-20
Rev Recd Date: 2024-08-04

Available Online: 2024-10-08

Publish Date: 2024-09-25

Abstract

Abstract

Objective To explore expression of serum insulin-like growth factor-1 (IGF-1) and characteristics of gut microbiota in children with cerebral palsy accompanied by growth retardation, and the association between IGF-1 expression and gut microbiota characteristics, so as to provide the basis for promoting the overall health of children with cerebral palsy accompanied by growth retardation. Methods From June 2022 to June 2023, 112 children with cerebral palsy aged 3-14 years old were randomly selected from a welfare institution in Guangzhou. According to the WHO standard for growth and development delay, 112 children with cerebral palsy were divided into a cerebral palsy accompanied by growth and development delay group (80 cases) and a cerebral palsy accompanied by normal growth and development group (32 cases), and 32 healthy children living in the same institution were selected as the control group. Serum IGF-1 levels were measured in three groups of children, and the gut microbiota was determined using 16S rDNA sequencing technology. The expression characteristics, gut microbiota composition, differential features and correlation of IGF-1 in three groups of children were explored. Results The expression levels of serum IGF-1 in three groups of children were compared, and children with cerebral palsy accompanied by growth retardation[97.70(66.35, 139.50)ng/mL] and cerebral palsy accompanied by normal growth development[149.00(68.30, 233.00)ng/mL] were all lower than those in the healthy control group[169.90(118.75, 293.80)ng/mL], with statistical significance(H=20.13, P < 0.05). The Alpha diversity of gut microbiota in the cerebral palsy with growth retardation group and the cerebral palsy with normal growth group were higher than that in the healthy control group[Chao index(482.50, 489.90, 396.10), Shannon index(6.29, 6.44, 5.89), Simpson index(0.97, 0.97, 0.96)](H=17.20, 7.01, 6.41, P < 0.05). IGF-1 was positively correlated with the relative abundunce of Eubacterium coprostanogenes group and Subdoligranulum (r=0.38, 0.33, P < 0.05). Conclusions Cerebral palsy children with growth retardation show lower level in serum IGF-1, substantial variation in gastrointestinal tract community structure. The appropriate gut microbiota could be used as potential predictive markers of cerebral palsy associated with growth retardation, to provide new strategies for future intervention and treatment.
- Cerebral palsy,
- Developmental disabilities,
- Insulin-like growth factor I,
- Gastrointestinal tract,
- Bacteria,
- Child

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References(23)

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