Research progress on the association between vitamin D and mental health among children and adolescents

WANG Lüyao; XU Baoyu; TANG Ting; WANG Jun; SU Puyu; WANG Gengfu

doi:10.16835/j.cnki.1000-9817.2024223

Volume 45 Issue 7

Jul. 2024

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2024 > 45(7): 1055-1058

WANG Lüyao, XU Baoyu, TANG Ting, WANG Jun, SU Puyu, WANG Gengfu. Research progress on the association between vitamin D and mental health among children and adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(7): 1055-1058. doi: 10.16835/j.cnki.1000-9817.2024223

Citation:

WANG Lüyao, XU Baoyu, TANG Ting, WANG Jun, SU Puyu, WANG Gengfu. Research progress on the association between vitamin D and mental health among children and adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(7): 1055-1058. doi: 10.16835/j.cnki.1000-9817.2024223

Citation:

PDF( 959 KB)

Research progress on the association between vitamin D and mental health among children and adolescents

doi: 10.16835/j.cnki.1000-9817.2024223

1.
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei (230032), Anhui Province, China

Received Date: 2024-03-14
Rev Recd Date: 2024-04-22

Available Online: 2024-07-27

Publish Date: 2024-07-25

Abstract

Abstract

Vitamin D, as an important nutrient, has been widely recognized for its significant role in the growth and development of children and adolescents, but its association with mental health is still under exploration. The article reviews and summarizes the related researches on vitamin D and common mental health problems of children and adolescents, including depression symptoms, anxiety symptoms, and suicidal ideation and behaviors, and possible biological mechanisms of vitamin D influencing mental health, to provide scientific evidence and ideas for improving the mental health of children and adolescents in China, as well as insights for future studies.
- Vitamin D,
- Mental health,
- Child,
- Adolescent

FullText(HTML)

References(54)

References

[1]	LIBUDA L, TIMMESFELD N, ANTEL J, et al. Effect of vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients: results of a randomized controlled trial[J]. Eur J Nutr, 2020, 59(8): 3415-3424. doi: 10.1007/s00394-020-02176-6
[2]	YUAN M, LI Y, CHANG J, et al. Vitamin D and suicidality: a Chinese early adolescent cohort and Mendelian randomization study[J]. Epidemiol Psychiatr Sci, 2023, 32: e52. doi: 10.1017/S2045796023000665
[3]	赵梦雅, 许韶君, 李晓恒, 等. 深圳市中学生维生素D缺乏与焦虑抑郁症状的关联[J]. 中国学校卫生, 2023, 44(7): 1030-1033. doi: 10.16835/j.cnki.1000-9817.2023.07.016 ZHAO M Y, XU S J, LI X H, et al. Association of vitamin D deficiency with anxiety and depressive symptoms among middle school students in Shenzhen[J]. Chin J Sch Health, 2023, 44(7): 1030-1033. (in Chinese) doi: 10.16835/j.cnki.1000-9817.2023.07.016
[4]	BAKUNINA N, PARIANTE C M, ZUNSZAIN P A. Immune mechanisms linked to depression via oxidative stress and neuroprogression[J]. Immunology, 2015, 144(3): 365-373. doi: 10.1111/imm.12443
[5]	PARKER G B, BROTCHIE H, GRAHAM R K. Vitamin D and depression[J]. J Affect Disord, 2017, 208: 56-61. doi: 10.1016/j.jad.2016.08.082
[6]	MISRA M, PACAUD D, PETRYK A, et al. Vitamin D deficiency in children and its management: review of current knowledge and recommendations[J]. Pediatrics, 2008, 122(2): 398-417. doi: 10.1542/peds.2007-1894
[7]	PATSEADOU M, HALLER D M. Vitamin D in adolescents: a systematic review and narrative synthesis of available recommendations[J]. J Adolesc Health, 2020, 66(4): 388-407. doi: 10.1016/j.jadohealth.2019.08.025
[8]	BRAEGGER C, CAMPOY C, COLOMB V, et al. Vitamin D in the healthy European paediatric population[J]. J Pediatr Gastroenterol Nutr, 2013, 56(6): 692-701. doi: 10.1097/MPG.0b013e31828f3c05
[9]	SHROFF R, WAN M, NAGLER E V, et al. Clinical practice recommendations for native vitamin D therapy in children with chronic kidney disease Stages 2-5 and on dialysis[J]. Nephrol Dial Transplant, 2017, 32(7): 1098-1113. doi: 10.1093/ndt/gfx065
[10]	HOLICK M F, BINKLEY N C, BISCHOFF-FERRARI H A, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline[J]. J Clin Endocrinol Metab, 2011, 96(7): 1911-1930. doi: 10.1210/jc.2011-0385
[11]	中华人民共和国国家卫生健康委员会. 人群维生素D缺乏筛查方法: WS/T 677—2020[S]. 北京: 中国标准出版社, 2020. National Health Commission of the PRC. Screening method for population vitamin D deficiency: WS/T 677-2020[S]. Beijing: Standards Press of China, 2020. (in Chinese)
[12]	SMITH T J, LANHAM-NEW S A, HART K H. Vitamin D in adolescents: are current recommendations enough?[J]. J Steroid Biochem Mol Biol, 2017, 173: 265-272. doi: 10.1016/j.jsbmb.2017.02.010
[13]	JIANG Z, PU R, LI N, et al. High prevalence of vitamin D deficiency in Asia: a systematic review and Meta-analysis[J]. Crit Rev Food Sci Nutr, 2023, 63(19): 3602-3611. doi: 10.1080/10408398.2021.1990850
[14]	LIU W, HU J, FANG Y, et al. Vitamin D status in mainland of China: a systematic review and Meta-analysis[J]. E Clin Med, 2021, 38: 101017.
[15]	张浩, 董洋洋, 马萍, 等. 中国儿童青少年维生素D营养状况的Meta分析[J]. 中国循证医学杂志, 2021, 21(3): 284-289. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXZ202103006.htm ZHANG H, DONG Y Y, MA P, et al. Vitamin D nutritional status in Chinese children and adolescents: a Meta-analysis[J]. Chin J Evid Based Med, 2021, 21(3): 284-289. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXZ202103006.htm
[16]	National Institute for Health and Clinical Excellence. Vitamin D: supplement use in specific population groups[EB/OL]. (2014-11-26)[2024-04-13]. https://www.nice.org.uk/guidance/ph56.
[17]	CLEMENS T L, ADAMS J S, HENDERSON S L, et al. Increased skin pigment reduces the capacity of skin to synthesise vitamin D₃[J]. Lancet, 1982, 1(8263): 74-76.
[18]	HU Y, CHEN J, WANG R, et al. Vitamin D nutritional status and its related factors for Chinese children and adolescents in 2010-2012[J]. Nutrients, 2017, 9(9): 1024. doi: 10.3390/nu9091024
[19]	HU Y, JIANG S, LU J, et al. Vitamin D status for Chinese children and adolescents in CNNHS 2016-2017[J]. Nutrients, 2022, 14(22): 4928. doi: 10.3390/nu14224928
[20]	吴琼辉, 陈倩, 杨亭, 等. 中国20个城市2~ < 7岁儿童血清维生素A和维生素D水平现况调查[J]. 中华儿科杂志, 2024, 62(3): 231-238. doi: 10.3760/cma.j.cn112140-20230923-00216 WU Q H, CHEN Q, YANG T, et al. A survey on the current situation of serum vitamin A and vitamin D levels among children aged 2- < 7 years of 20 cities in China[J]. Chin J Pediatr, 2024, 62(3): 231-238. (in Chinese) doi: 10.3760/cma.j.cn112140-20230923-00216
[21]	COLAPINTO C K, ROSSITER M, KHAN M K, et al. Obesity, lifestyle and socio-economic determinants of vitamin D intake: a population-based study of Canadian children[J]. Can J Public Health, 2014, 105(6): e418-e424. doi: 10.17269/cjph.105.4608
[22]	KARAMPELA I, SAKELLIOU A, VALLIANOU N, et al. Vitamin D and obesity: current evidence and controversies[J]. Curr Obes Rep, 2021, 10(2): 162-180. doi: 10.1007/s13679-021-00433-1
[23]	BATER J, BROMAGE S, JAMBAL T, et al. Prevalence and determinants of vitamin D deficiency in 9 595 Mongolian schoolchildren: a cross-sectional study[J]. Nutrients, 2021, 13(11): 4175. doi: 10.3390/nu13114175
[24]	ESNAFOGLU E, OZTURAN D D. The relationship of severity of depression with homocysteine, folate, vitamin B₁₂, and vitamin D levels in children and adolescents[J]. Child Adolesc Ment Health, 2020, 25(4): 249-255. doi: 10.1111/camh.12387
[25]	HUSMANN C, FRANK M, SCHMIDT B, et al. Low 25(OH)-vitamin D concentrations are associated with emotional and behavioral problems in German children and adolescents[J]. PLoS One, 2017, 12(8): e0183091. doi: 10.1371/journal.pone.0183091
[26]	ROBINSON S L, MARÍN C, OLIVEROS H, et al. Vitamin D deficiency in middle childhood is related to behavior problems in adolescence[J]. J Nutr, 2020, 150(1): 140-148. doi: 10.1093/jn/nxz185
[27]	TARIKERE S P, SURYANARAYANA R, THEOPHILUS Y S, et al. Is sunshine vitamin related to adolescent depression? A cross-sectional study of vitamin D status and depression among rural adolescents[J]. Cureus, 2023, 15(2): e34639.
[28]	AL-SABAH R, AL-TAIAR A, SHABAN L, et al. Vitamin D level in relation to depression symptoms during adolescence[J]. Child Adolesc Psychiatry Ment Health, 2022, 16(1): 53. doi: 10.1186/s13034-022-00489-4
[29]	WANG G, YUAN M, CHANG J, et al. Vitamin D and depressive symptoms in an early adolescent cohort[J]. Psychol Med, 2023, 53(12): 5852-5860. doi: 10.1017/S0033291722003117
[30]	ATAIE-JAFARI A, QORBANI M, HESHMAT R, et al. The association of vitamin D deficiency with psychiatric distress and violence behaviors in Iranian adolescents: the CASPIAN-Ⅲ study[J]. J Diabetes Metab Disord, 2015, 14: 62. doi: 10.1186/s40200-015-0191-9
[31]	NAMAZI N, QORBANI M, SHAFIEE G, et al. Association of vitamin D concentrations with subjective health complaints in children and adolescents: the CASPIAN-V study[J]. BMC Public Health, 2021, 21(1): 3. doi: 10.1186/s12889-020-10020-z
[32]	KELLEY L, SANDERS A F, BEATON E A. Vitamin D deficiency, behavioral atypicality, anxiety and depression in children with chromosome 22q11.2 deletion syndrome[J]. J Dev Orig Health Dis, 2016, 7(6): 616-625. doi: 10.1017/S2040174416000428
[33]	HAN B, ZHU F X, YU H F, et al. Low serum levels of vitamin D are associated with anxiety in children and adolescents with dialysis[J]. Sci Rep, 2018, 8(1): 5956. doi: 10.1038/s41598-018-24451-7
[34]	FEDOTOVA J, PIVINA S, SUSHKO A. Effects of chronic vitamin D₃-hormone administration on anxiety-like behavior in adult female rats after long-term ovariectomy[J]. Nutrients, 2017, 9(1): 28. doi: 10.3390/nu9010028
[35]	ZHANG Z, YANG X, JIA Y, et al. Vitamin D and the risks of depression and anxiety: an observational analysis and genome-wide environment interaction study[J]. Nutrients, 2021, 13(10): 3343. doi: 10.3390/nu13103343
[36]	CALLEGARI E T, REAVLEY N, GORELIK A, et al. Serum 25-hydroxy vitamin D and mental health in young Australian women: results from the Safe-D study[J]. J Affect Disord, 2017, 224: 48-55. doi: 10.1016/j.jad.2016.10.002
[37]	EYLES D W, SMITH S, KINOBE R, et al. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain[J]. J Chem Neuroanat, 2005, 29(1): 21-30. doi: 10.1016/j.jchemneu.2004.08.006
[38]	GRUDET C, LINDQVIST D, MALM J, et al. 25(OH)D levels are decreased in patients with difficult-to-treat depression[J]. Compr Psychoneuroendocrinol, 2022, 10: 100126. doi: 10.1016/j.cpnec.2022.100126
[39]	KHAIRY E Y, ATTIA M M. Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF)[J]. Nutr Neurosci, 2021, 24(8): 650-659. doi: 10.1080/1028415X.2019.1665854
[40]	SHIRAZI H A, RASOULI J, CIRIC B, et al. 1, 25-dihydroxy vitamin D₃ enhances neural stem cell proliferation and oligodendrocyte differentiation[J]. Exp Mol Pathol, 2015, 98(2): 240-245. doi: 10.1016/j.yexmp.2015.02.004
[41]	CHEN J, LI C R, YANG H, et al. proBDNF attenuates hippocampal neurogenesis and induces learning and memory deficits in aged mice[J]. Neurotox Res, 2016, 29(1): 47-53. doi: 10.1007/s12640-015-9568-2
[42]	POPOVA N K, ILCHIBAEVA T V, NAUMENKO V S. Neurotrophic factors (BDNF and GDNF) and the serotonergic system of the brain[J]. Biochemistry (Mosc), 2017, 82(3): 308-317. doi: 10.1134/S0006297917030099
[43]	YEH M L, SELVAM R, LEVINE E S. BDNF-induced endocannabinoid release modulates neocortical glutamatergic neurotransmission[J]. Synapse, 2017, 71(5): e21962. doi: 10.1002/syn.21962
[44]	SANCHEZ B, LOPEZ-MARTIN E, SEGURA C, et al. 1, 25-Dihydroxy vitamin D(3) increases striatal GDNF mRNA and protein expression in adult rats[J]. Brain Res Mol Brain Res, 2002, 108(1/2): 143-146.
[45]	RUHÉ H G, MASON N S, SCHENE A H. Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a Meta-analysis of monoamine depletion studies[J]. Mol Psychiatry, 2007, 12(4): 331-359. doi: 10.1038/sj.mp.4001949
[46]	CALCIA M A, BONSALL D R, BLOOMFIELD P S, et al. Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness[J]. Psychopharmacology (Berl), 2016, 233(9): 1637-1650. doi: 10.1007/s00213-016-4218-9
[47]	GABBAY V, KLEIN R G, ALONSO C M, et al. Immune system dysregulation in adolescent major depressive disorder[J]. J Affect Disord, 2009, 115(1/2): 177-182.
[48]	MUSAZADEH V, KERAMATI M, GHALICHI F, et al. Vitamin D protects against depression: evidence from an umbrella Meta-analysis on interventional and observational Meta-analyses[J]. Pharmacol Res, 2023, 187: 106605. doi: 10.1016/j.phrs.2022.106605
[49]	MIRARCHI A, ALBI E, BECCARI T, et al. Microglia and brain disorders: the role of vitamin D and its receptor[J]. Int J Mol Sci, 2023, 24(15): 11892. doi: 10.3390/ijms241511892
[50]	ZHANG Y, LEUNG D Y M, GOLEVA E. Vitamin D enhances glucocorticoid action in human monocytes: involvement of granulocyte-macrophage colony-stimulating factor and mediator complex subunit 14[J]. J Biol Chem, 2013, 288(20): 14544-14553. doi: 10.1074/jbc.M112.427054
[51]	GOWDA U, MUTOWO M P, SMITH B J, et al. Vitamin D supplementation to reduce depression in adults: Meta-analysis of randomized controlled trials[J]. Nutrition, 2015, 31(3): 421-429. doi: 10.1016/j.nut.2014.06.017
[52]	OBRADOVIC D, GRONEMEYER H, LUTZ B, et al. Cross-talk of vitamin D and glucocorticoids in hippocampal cells[J]. J Neurochem, 2006, 96(2): 500-509. doi: 10.1111/j.1471-4159.2005.03579.x
[53]	HÖGBERG G, GUSTAFSSON S A, HÄLLSTRÖM T, et al. Depressed adolescents in a case-series were low in vitamin D and depression was ameliorated by vitamin D supplementation[J]. Acta Paediatr, 2012, 101(7): 779-783. doi: 10.1111/j.1651-2227.2012.02655.x
[54]	FÖCKER M, ANTEL J, GRASEMANN C, et al. Effect of an vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients: a randomized controlled trial: study protocol[J]. BMC Psychiatry, 2018, 18(1): 57. doi: 10.1186/s12888-018-1637-7