Association between the ratio of dietary vitamin A to body weight and hypertension in children

CHENG Ping; REN Yanling; LIU Qin; CHEN Lanling; TONG Jishuang; XIAO Lun; QIN Jun; LI Xinggui; MA Jun; XU Lin; SHI Xiuzhen; WANG Li; WAN Lingjuan; LIANG Xiaohua

doi:10.16835/j.cnki.1000-9817.2024062

Volume 45 Issue 2

Feb. 2024

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Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2024 > 45(2): 267-272

CHENG Ping, REN Yanling, LIU Qin, CHEN Lanling, TONG Jishuang, XIAO Lun, QIN Jun, LI Xinggui, MA Jun, XU Lin, SHI Xiuzhen, WANG Li, WAN Lingjuan, LIANG Xiaohua. Association between the ratio of dietary vitamin A to body weight and hypertension in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(2): 267-272. doi: 10.16835/j.cnki.1000-9817.2024062

Citation:

CHENG Ping, REN Yanling, LIU Qin, CHEN Lanling, TONG Jishuang, XIAO Lun, QIN Jun, LI Xinggui, MA Jun, XU Lin, SHI Xiuzhen, WANG Li, WAN Lingjuan, LIANG Xiaohua. Association between the ratio of dietary vitamin A to body weight and hypertension in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(2): 267-272. doi: 10.16835/j.cnki.1000-9817.2024062

Citation:

CHENG Ping, REN Yanling, LIU Qin, CHEN Lanling, TONG Jishuang, XIAO Lun, QIN Jun, LI Xinggui, MA Jun, XU Lin, SHI Xiuzhen, WANG Li, WAN Lingjuan, LIANG Xiaohua. Association between the ratio of dietary vitamin A to body weight and hypertension in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(2): 267-272. doi: 10.16835/j.cnki.1000-9817.2024062

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Association between the ratio of dietary vitamin A to body weight and hypertension in children

doi: 10.16835/j.cnki.1000-9817.2024062

1.
Department of Pharmacy, People's Hospital of Shimian County, Yaan (625499), Sichuan Province, China

Received Date: 2023-08-12
Rev Recd Date: 2023-12-19

Available Online: 2024-03-02

Publish Date: 2024-02-25

Abstract

Abstract

Objective To explore the relationship between the ratio of dietary vitamin A (VitA) to body weight and hypertension among children, so as to provide a reference for blood pressure control through dietary nutritional interventions and childhood hypertension prevention. Methods Utilizing the baseline survey and follow-up sample data from the Healthy Children Cohort established in urban and rural areas of Chongqing from 2014 to 2019, structured quantitative dietary questionnaire and self-designed questionnaire were used to investigate the information of dietary intake and socioeconomic characteristics of 15 279 children, as well as blood pressure, height, weight measurement. The ratio of dietary VitA to body weight was divided into four groups based on quartiles [≤P₂₅(Q1), >P₂₅~P₅₀(Q2), >P₅₀~P₇₅(Q3), >P₇₅(Q4)]. Generalized linear regression models and Logistic regression models were used to analyze the correlation between ratio of dietary VitA to body weight with blood pressure levels and prevalence of hypertension. Results The results of the 2014 baseline survey indicated that, after adjusting for confounding factors such as demographic indicators and nutritional intake, significant differences were observed in systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) among different groups categorized by the ratio of dietary VitA to body weight (F=157.57, 44.71, 95.92, P < 0.01). The baseline ratio of dietary VitA to body weight in children exhibited a negative correlation with DBP, SBP and MAP at baseline and in 2019. Compared to Q1 group, the risk of hypertension decreased among children in Q4 at baseline and follow-up in 2019.[baseline: β(95%CI)=-0.65(-0.89--0.42), -0.22(-0.42--0.01), -0.36(-0.56--0.16); 2019: β(95%CI)=-0.77(-1.34--0.19), -0.62(-1.21--0.02), -0.77(-1.34--0.19), P < 0.05 ]. Compared to Q1 group, the risk of hypertension decreased among children in Q4 at baseline and follow-up in 2019 [OR(95%CI)=0.63(0.49-0.81), 0.18(0.08-0.42), P < 0.01 ]. Conclusions The ratio of dietary VitA to body weight is significantly negatively correlated with blood pressure levels among children, and dietary VitA deficiency is an independent risk factor for hypertension among children. Measures should be taken to actively adjust children's dietary nutrition and reduce the risk of childhood hypertension.
- Diet,
- Vitamin A,
- Body weight,
- Hypertension,
- Regression analysis,
- Child

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References(37)

References

[1]	ZHANG Y, LIU M, ZHOU C, et al. Inverse association between dietary vitamin A intake and new-onset hypertension[J]. Clin Nutr, 2021, 40(5): 2868-2875. doi: 10.1016/j.clnu.2021.04.004
[2]	ZHANG Y, NIE J, ZHANG Y, et al. Degree of blood pressure control and incident diabetes mellitus in Chinese adults with hypertension[J]. J Am Heart Assoc, 2020, 9(16): e017015. doi: 10.1161/JAHA.120.017015
[3]	ZHANG Y X, WANG S R. Comparison of blood pressure levels among children and adolescents with different body mass index and waist circumference: study in a large sample in Shandong, China[J]. Eur J Nutr, 2014, 53(2): 627-634. doi: 10.1007/s00394-013-0571-1
[4]	MOYER V A, FORCE U S P S T. Screening for primary hypertension in children and adolescents: U.S. preventive services task force recommendation statement[J]. Pediatrics, 2013, 132(5): 907-914. doi: 10.1542/peds.2013-2864
[5]	HILL D C, MOSS R H, SYKES-MUSKETT B, et al. Stress and eating behaviors in children and adolescents: systematic review and Meta-analysis[J]. Appetite, 2018, 123: 14-22. doi: 10.1016/j.appet.2017.11.109
[6]	RENNINGER M, HANSEN B H, STEENE-JOHANNESSEN J, et al. Associations between accelerometry measured physical activity and sedentary time and the metabolic syndrome: a Meta-analysis of more than 6 000 children and adolescents[J]. Pediatr Obes, 2020, 15(1): e12578. doi: 10.1111/ijpo.12578
[7]	KATSA M E, IOANNIDIS A, ZYGA S, et al. The effect of nutrition and sleep habits on predisposition for metabolic syndrome in Greek children[J]. J Pediatr Nurs, 2018, 40: e2-e8. doi: 10.1016/j.pedn.2018.01.012
[8]	BORGHI C, TSIOUFIS K, AGABITI-ROSEI E, et al. Nutraceuticals and blood pressure control: a European society of hypertension position document[J]. J Hypertens, 2020, 38(5): 799-812. doi: 10.1097/HJH.0000000000002353
[9]	VON LINTIG J. Provitamin A metabolism and functions in mammalian biology[J]. Am J Clin Nutr, 2012, 96(5): 1234S-1244S. doi: 10.3945/ajcn.112.034629
[10]	FREY S K, VOGEL S. Vitamin A metabolism and adipose tissue biology[J]. Nutrients, 2011, 3(1): 27-39. doi: 10.3390/nu3010027
[11]	SOMMER A. Vitamin A deficiency and childhood mortality[J]. Lancet, 1992, 340(8817): 488-489.
[12]	SONG P, WANG J, WEI W, et al. The prevalence of vitamin A deficiency in Chinese children: a systematic review and Bayesian Meta-analysis[J]. Nutrients, 2017, 9(12): 1285. doi: 10.3390/nu9121285
[13]	SURI S, KUMAR D, DAS R. Dietary deficiency of vitamin A among rural children: a community-based survey using a food-frequency questionnaire[J]. Natl Med J India, 2017, 30(2): 61-64.
[14]	ACHAN V, TRAN C T, ARRIGONI F, et al. All-trans-retinoic acid increases nitric oxide synthesis by endothelial cells: a role for the induction of dimethylarginine dimethylaminohydrolase[J]. Circ Res, 2002, 90(7): 764-769. doi: 10.1161/01.RES.0000014450.40853.2B
[15]	OLSON J A. Benefits and liabilities of vitamin A and carotenoids[J]. J Nutr, 1996, 126(4 Suppl): 1208S-1212S.
[16]	MCCARRON D A, MORRIS C D, HENRY H J, et al. Blood pressure and nutrient intake in the United States[J]. Science, 1984, 224(4656): 1392-1398. doi: 10.1126/science.6729459
[17]	LLOPIS-GONZALEZ A, RUBIO-LOPEZ N, PINEDA-ALONSO M, et al. Hypertension and the fat-soluble vitamins A, D and E[J]. Int J Environ Res Public Health, 2015, 12(3): 2793-2809. doi: 10.3390/ijerph120302793
[18]	ZHENG M, HUO Y, WANG X, et al. A prospective study on pulse wave velocity (PWV) and response to anti-hypertensive treatments: PWV determines BP control[J]. Int J Cardiol, 2015, 178: 226-231. doi: 10.1016/j.ijcard.2014.10.049
[19]	LIANG X, CHEN M, QU P, et al. The association of vitamin A and vitamin D with hypertension in children: a case-control study[J]. Int J Hypertens, 2018, 2018: 9295147.
[20]	LIANG X, XIAO L, LUO Y, et al. Prevalence and risk factors of childhood hypertension from birth through childhood: a retrospective cohort study[J]. J Hum Hypertens, 2020, 34(2): 151-164. doi: 10.1038/s41371-019-0282-z
[21]	ELMENHORST J, HULPKE-WETTE M, BARTA C, et al. Percentiles for central blood pressure and pulse wave velocity in children and adolescents recorded with an oscillometric device[J]. Atherosclerosis, 2015, 238(1): 9-16. doi: 10.1016/j.atherosclerosis.2014.11.005
[22]	杨月欣. 中国食物成分表(2004版)[M]. 2版. 北京: 北京大学医学出版社, 2004. YANG Y X. China food composition (2004)[M]. 2 ed. Beijing: Peking University Medical Press, 2004. (in Chinese)
[23]	杨月欣, 王光亚, 潘兴昌. 中国食物成分表[M]. 北京: 北京大学医学出版社, 2002. YANG Y X, WANG G Y, PAN X C. China food composition[M]. Beijing: Peking University Medical Press, 2002. (in Chinese)
[24]	范晖, 闫银坤, 米杰. 中国3~17岁儿童性别、年龄别和身高别血压参照标准[J]. 中华高血压杂志, 2017, 25(5): 428-435. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGZ201705010.htm FAN H, YAN Y K, MI J. Updating blood pressure references for Chinese children aged 3-17 years[J]. Chin J Hypertens, 2017, 25(5): 428-435. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGZ201705010.htm
[25]	TRASINO S E, TANG X H, JESSURUN J, et al. Obesity leads to tissue, but not serum vitamin A deficiency[J]. Sci Rep, 2015, 5: 15893. doi: 10.1038/srep15893
[26]	LI Z, CHEN J, ZHANG D. Association between dietary carotenoid intakes and hypertension in adults: national health and nutrition examination survey 2007-2014[J]. J Hypertens, 2019, 37(12): 2371-2379. doi: 10.1097/HJH.0000000000002200
[27]	WOO J, HO S C, DONNAN S, et al. Nutritional correlates of blood pressure in elderly Chinese[J]. J Hum Hypertens, 1988, 1(4): 287-291.
[28]	ALBUQUERQUE M N, DINIZ ADA S, ARRUDA I K. Retinolemia, vitamin A intake, and blood pressure in the elderly[J]. Arch Latinoam Nutr, 2009, 59(4): 396-401.
[29]	O'BYRNE S M, WONGSIRIROJ N, LIBIEN J, et al. Retinoid absorption and storage is impaired in mice lacking lecithin: retinol acyltransferase (LRAT)[J]. J Biol Chem, 2005, 280(42): 35647-3557. doi: 10.1074/jbc.M507924200
[30]	PIETRI P, VLACHOPOULOS C, TERENTES-PRINTZIOS D, et al. Beneficial effects of low-dose aspirin on aortic stiffness in hypertensive patients[J]. Vasc Med, 2014, 19(6): 452-457. doi: 10.1177/1358863X14556695
[31]	LIANG X, CHEN M, WANG D, et al. Vitamin A deficiency indicating as low expression of LRAT may be a novel biomarker of primary hypertension[J]. Clin Exp Hypertens, 2021, 43(2): 151-163. doi: 10.1080/10641963.2020.1833023
[32]	SERAVALLE G, GRASSI G. Obesity and hypertension[J]. Pharmacol Res, 2017, 122: 1-7. doi: 10.1016/j.phrs.2017.05.013
[33]	NARKIEWICZ K. Diagnosis and management of hypertension in obesity[J]. Obes Rev, 2006, 7(2): 155-162. doi: 10.1111/j.1467-789X.2006.00226.x
[34]	WUHL E. Hypertension in childhood obesity[J]. Acta Paediatr, 20 19, 108(1): 37-43. doi: 10.1111/apa.14551
[35]	BANCALARI R, DIAZ C, MARTINEZ-AGUAYO A, et al. Prevalence of hypertension in school age children and its association with obesity[J]. Rev Med Chil, 2011, 139(7): 872-879. doi: 10.4067/S0034-98872011000700007
[36]	SAEED S, WAJE-ANDREASSEN U, FROMM A, et al. Early vascular aging in young and middle-aged ischemic stroke patients: the Norwegian Stroke in the young study[J]. PLoS One, 2014, 9(11): e112814. doi: 10.1371/journal.pone.0112814
[37]	MUNAKATA M. Brachial-ankle pulse wave velocity in the measurement of arterial stiffness: recent evidence and clinical applications[J]. Curr Hypertens Rev, 2014, 10(1): 49-57. doi: 10.2174/157340211001141111160957