Mediating effects of metabolic-related indicators on the association between childhood overweight/obesity and left ventricular hypertrophy

LI Huiping; YANG Lili; ZHAO Min; XI Bo

doi:10.16835/j.cnki.1000-9817.2024033

Volume 45 Issue 1

Jan. 2024

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LI Huiping, YANG Lili, ZHAO Min, XI Bo. Mediating effects of metabolic-related indicators on the association between childhood overweight/obesity and left ventricular hypertrophy[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(1): 41-45. doi: 10.16835/j.cnki.1000-9817.2024033

Citation:

LI Huiping, YANG Lili, ZHAO Min, XI Bo. Mediating effects of metabolic-related indicators on the association between childhood overweight/obesity and left ventricular hypertrophy[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(1): 41-45. doi: 10.16835/j.cnki.1000-9817.2024033

Citation:

LI Huiping, YANG Lili, ZHAO Min, XI Bo. Mediating effects of metabolic-related indicators on the association between childhood overweight/obesity and left ventricular hypertrophy[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2024, 45(1): 41-45. doi: 10.16835/j.cnki.1000-9817.2024033

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Mediating effects of metabolic-related indicators on the association between childhood overweight/obesity and left ventricular hypertrophy

doi: 10.16835/j.cnki.1000-9817.2024033

LI Huiping¹,
YANG Lili¹,
ZHAO Min²,
XI Bo^{1
,
,}

1.
Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University/Children Cardiovascular Research Center of Shandong University, Jinan (250012), Shandong Province, China

Received Date: 2023-11-08
Rev Recd Date: 2024-01-10

Available Online: 2024-02-01

Publish Date: 2024-01-25

Abstract

Abstract

Objective To examine the mediating effects of blood pressure, glucose, lipids, and serum uric acid on the association between childhood overweight/obesity and left ventricular hypertrophy (LVH), and to provide scientific evidence for the prevention and control of cardiovascular diseases during childhood. Methods One public school in Huantai County, Zibo City was selected to conduct the baseline survey from November 2017 to January 2018 using a convenient cluster sampling method. A total of 1 400 children aged 6 to 11 were included in the study. According to the classification criteria based on body mass index (BMI), participants were divided into the non-overweight/obese group (n=787) and the overweight/obese group (n=613). The mediating effects of metabolic variables on the association between childhood overweight/obesity and left ventricular hypertrophy (LVH) were analyzed using the "mediation" package in R software. Results Children who were overweight/obese had higher levels of BMI-Z score (2.0±0.8), systolic blood pressure (SBP) (109.1±8.9 mmHg), diastolic blood pressure (DBP) (65.4±6.8 mmHg), fasting plasma glucose (FPG) (4.8±0.5 mmol/L), insulin (INS) (11.3±7.6 μU/mL), apolipoprotein B (ApoB) (0.7±0.2 g/L), low-density lipoprotein cholesterol (LDL-C) (2.4±0.7 mmol/L), total cholesterol (TC) (4.2±0.9 mmol/L), triglycerides (TG) (0.9±0.4 mmol/L), and serum uric acid (SUA) (321.2±91.4 μmol/L) compared to those who were non-overweight/obese [the corresponding values were (-0.2±0.7), (104.3±8.8) mmHg, (62.2±6.2) mmHg, (4.7±0.6) mmol/L, (6.1±4.2) μU/mL, (0.6±0.2) g/L, (2.2±0.6) mmol/L, (4.1±0.7) mmol/L, (0.7±0.2) mmol/L, and (278.6±74.7) μmol/L, respectively], whereas the levels of high-density lipoprotein cholesterol (HDL-C) were lower in overweight/obese children (1.5±0.3 mmol/L) than in non-overweight/obese children (1.7±0.4 mmol/L). All differences were statistically significant (t=53.66, 9.88, 9.19, 3.60, 16.32, 7.36, 5.11, 2.55, 11.08, 9.58, -10.31, P < 0.05). After adjusting for potential covariates, overweight/obese children had 8.72 times increased risk of developing LVH compared to the non-overweight/obese children (OR=8.72, 95%CI=5.45-14.66, P < 0.01). Mediation analysis showed that INS, HDL-C, LDL-C, TG, ApoB, and SUA partially mediated the association between childhood overweight/obesity and LVH, and among these, INS and TG had relatively strong mediating effects, accounting for 28.05% and 13.71% of the total effects, respectively. Conclusions INS, HDL-C, LDL-C, TG, ApoB, and SUA are intermediate risk factors on the association between childhood overweight/obesity and LVH. Keeping metabolic indicators (especially INS and TG) at healthy levels is particularly important for reducing the burden of cardiovascular diseases in overweight/obese children.
- Metabolism,
- Overweight,
- Obesity,
- Hypertrophy, left ventricular,
- Regression analysis,
- Child

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References(29)

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