Relationship between polycyclic aromatic hydrocarbons internal exposure and lung function change among healthy college students

CHEN Junjie; LIU Siqiao; LI Miao; HAO Kelu; ZHANG Yanli; LI Weihong; XU Houjun; HAO Yulan; WANG Manman; WANG Xuesheng; WANG Qian.

doi:10.16835/j.cnki.1000-9817.2023.09.029

Volume 44 Issue 9

Sep. 2023

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Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2023 > 44(9): 1409-1413

CHEN Junjie, LIU Siqiao, LI Miao, HAO Kelu, ZHANG Yanli, LI Weihong, XU Houjun, HAO Yulan, WANG Manman, WANG Xuesheng, WANG Qian.. Relationship between polycyclic aromatic hydrocarbons internal exposure and lung function change among healthy college students[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(9): 1409-1413. doi: 10.16835/j.cnki.1000-9817.2023.09.029

Citation:

CHEN Junjie, LIU Siqiao, LI Miao, HAO Kelu, ZHANG Yanli, LI Weihong, XU Houjun, HAO Yulan, WANG Manman, WANG Xuesheng, WANG Qian.. Relationship between polycyclic aromatic hydrocarbons internal exposure and lung function change among healthy college students[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(9): 1409-1413. doi: 10.16835/j.cnki.1000-9817.2023.09.029

Citation:

CHEN Junjie, LIU Siqiao, LI Miao, HAO Kelu, ZHANG Yanli, LI Weihong, XU Houjun, HAO Yulan, WANG Manman, WANG Xuesheng, WANG Qian.. Relationship between polycyclic aromatic hydrocarbons internal exposure and lung function change among healthy college students[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(9): 1409-1413. doi: 10.16835/j.cnki.1000-9817.2023.09.029

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Relationship between polycyclic aromatic hydrocarbons internal exposure and lung function change among healthy college students

doi: 10.16835/j.cnki.1000-9817.2023.09.029

1.
School of Public Health, North China University of Science and Technology, Tangshan (063000), Hebei Province, China

Received Date: 2023-06-14
Rev Recd Date: 2023-06-27

Available Online: 2023-09-28

Publish Date: 2023-09-25

Abstract

Abstract

Objective To investigate the relationship between urinary monohydroxylated metabolites of hydroxyl polycyclic aromatic hydrocarbons (OH-PAHs) and lung function, as well as the role of oxidative stress in these associations, so as to provide a scientific basis for air pollution control and policy formulation. Methods A panel study was carried out among 45 young healthy adults. Four follow-up surveys and health examinations were conducted from November 2017 to October 2018 to measure lung function parameters [forced vital capacity (FVC), second forced expiratory volume in one second (FEV1), peak expiratory flow (PEF), FEV1/FVC, and forced expiratory flow between 25% and 75% vital capacity (FEF_25%~75%)], markers of exposure to 7OH-PAHs [∑₇OH-PAHs], and markers of oxidative stress[8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-isoprostaglandin-F_2α (8-iso-PGF_2α)]. The relationship between urinary PAH metabolites and lung function was quantified by linear mixed effects models. Mediation analysis was performed to assess the role of oxidative stress in the relationship between OH-PAHs and lung function. Results The median values of FVC, FEV1, FEVI/FVC, PEF, and FEF_25%-75% were 4.37 L, 3.58 L, 83.00%, 4.38 L/s, and 3.32 L/s, respectively. The results showed that each 1-unit increase in log-transformed value of 2-Hydroxyfluorene (2-OHFlu) was associated with a 5.05% decrease (β%=-5.05%, 95%CI=-8.85%--1.09%) in FVC, 4.15% decrease (β%=-4.15%, 95%CI=-7.94%--0.22%) in FEV1 and 5.87% decrease (β%=-5.87%, 95%CI=-11.35%--0.05%) in FEF_25%-75%, respectively. Each 1-unit increase in log-transformed values of 2-OHFlu and 9-Phenanthrol (9-OHPhe) was associated with a 7.03% decrease (β%=-7.03%, 95%CI=-12.60%--1.11%) and a 7.08% decrease (β%=-7.08%, 95%CI=-13.50%--0.17%) in PEF, respectively. Additionally, urinary ∑₇OH-PAHs had a positive correlation with the levels of urinary 8-OHdG and 8-iso-PGF_2α (r=0.64, 0.69, P < 0.01). Meanwhile, the levels of 8-OHdG mediated 17.06% and 15.71% of the association between 2-OHFlu with FVC and FEV1. Conclusion The finding reveales a negative relationship between urinary OH-PAHs and lung function among young healthy adults. The 8-OHdG plays a mediated role in the correlation of 2-OHFlu with FVC and FEV1. Active relevant policies are needed to control air pollution and maintain the healthy living conditions of young people.
- Polycyclic aromatic hydrocarbons,
- Lung,
- Oxidative stress,
- Students,
- Linear models

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References(30)

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