Research progress in mechanisms of neuromuscular system regulation in adolescent idiopathic scoliosis

ZHANG Chenjie; DONG Jingmei

doi:10.16835/j.cnki.1000-9817.2023.08.033

Volume 44 Issue 8

Aug. 2023

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ZHANG Chenjie, DONG Jingmei. Research progress in mechanisms of neuromuscular system regulation in adolescent idiopathic scoliosis[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(8): 1266-1271. doi: 10.16835/j.cnki.1000-9817.2023.08.033

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ZHANG Chenjie, DONG Jingmei. Research progress in mechanisms of neuromuscular system regulation in adolescent idiopathic scoliosis[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(8): 1266-1271. doi: 10.16835/j.cnki.1000-9817.2023.08.033

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Research progress in mechanisms of neuromuscular system regulation in adolescent idiopathic scoliosis

doi: 10.16835/j.cnki.1000-9817.2023.08.033

ZHANG Chenjie,
DONG Jingmei^,

Exercise and Health Research Centre, Tongji University, Shanghai(200090), China

Received Date: 2023-03-31
Rev Recd Date: 2023-07-20

Available Online: 2023-08-26

Publish Date: 2023-08-25

Abstract

Abstract

Adolescent idiopathic scoliosis (AIS) is a relatively common spinal health problem in the adolescents, whose pathogenesis remains unclear. AIS substantially affects the mind, intellect and body shape in children and adolescents. From a neurophysiological perspective, this article discusses progress in domestic and international research on the anatomical morphology, physiological function and neuromodulation of muscle metabolism in the nervous system in AIS, and analyses the dynamic balance in regulatory mechanisms of the neuromuscular system affecting spinal movement, which argues that an imbalance between the synergistic control of the central nervous system and the spinal neuromuscular system results in a series of kinetic compensatory responses of the spine, thus leading to AIS generation and/or development. This article is aimed at providing theoretical guidance for educational intervention approaches to address adolescent spinal health problems.
- Scoliosis,
- Central nervous system,
- Research,
- Adolescent

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References(49)

References

[1]	KUZNIA A L, HERNANDEZ A K, LEE L U. Adolescent idiopathic scoliosis: common questions and answers[J]. Am Fam Physician, 2020, 101(1): 19-23.
[2]	赵树山. 特发性脊柱侧凸流行病学、遗传易感性及治疗的系统评价[D]. 长沙: 中南大学, 2014. ZHAO S S. Systematic review of the epidemiology, genetic predisposition and treatment of idiopathic scoliosis[D]. Changsha: Central South University, 2014. (in Chinese)
[3]	SAVVIDES P, GERDHEM P, GRAUERS A, et al. Self-experienced trunk appearance in individuals with and without idiopathic scoliosis[J]. Spine, 2020, 45(8): 522-527. doi: 10.1097/BRS.0000000000003308
[4]	ERWIN J, CARLSON B B, BUNCH J, et al. Impact of unoperated adolescent idiopathic scoliosis in adulthood: a 10-year analysis[J]. Spine Deform, 2020, 8(5): 1009-1016. doi: 10.1007/s43390-020-00142-0
[5]	GIAMPIETRO P F, HADLEY-MILLER N, RAGGIO C L. Overview of gene special issue "genetic conditions affecting the skeleton: congenital, idiopathic scoliosis and arthrogryposis"[J]. Genes, 2022, 13(7): 1194. doi: 10.3390/genes13071194
[6]	PENG Y, WANG S R, QIU G X, et al. Research progress on the etiology and pathogenesis of adolescent idiopathic scoliosis[J]. Chin Med J, 2020, 133(4): 483-493. doi: 10.1097/CM9.0000000000000652
[7]	LIANG Z T, GUO C F, LI J, et al. The role of endocrine hormones in the pathogenesis of adolescent idiopathic scoliosis[J]. Faseb J, 2021, 35(9): e21839. doi: 10.1096/fj.202100759R
[8]	BARBA N, IGNASIAK D, VILLA T M T, et al. Assessment of trunk muscle activation and intervertebral load in adolescent idiopathic scoliosis by musculoskeletal modelling approach[J]. J Biomech, 2021, 114: 110154. doi: 10.1016/j.jbiomech.2020.110154
[9]	KAMAL Z, ROUHI G, ARJMAND N, et al. A stability-based model of a growing spine with adolescent idiopathic scoliosis: a combination of musculoskeletal and finite element approaches[J]. Med Eng Phys, 2019, 64: 46-55. doi: 10.1016/j.medengphy.2018.12.015
[10]	WATANABE K, MICHIKAWA T, YONEZAWA I, et al. Physical activities and lifestyle factors related to adolescent idiopathic scoliosis[J]. J Bone Joint Surg Am, 2017, 99(4): 284-294. doi: 10.2106/JBJS.16.00459
[11]	LIU T, CHU W C, YOUNG G, et al. MR analysis of regional brain volume in adolescent idiopathic scoliosis: neurological manifestation of a systemic disease[J]. J Magn Reson Imag, 2008, 27(4): 732-736. doi: 10.1002/jmri.21321
[12]	JOLY O, ROUSIE D, JISSENDI P, et al. A new approach to corpus callosum anomalies in idiopathic scoliosis using diffusion tensor magnetic resonance imaging[J]. Eur Spine J, 2014, 23(12): 2643-2649. doi: 10.1007/s00586-014-3435-3
[13]	XUE C, SHI L, HUI S C N, et al. Altered white matter microstructure in the corpus callosum and its cerebral interhemispheric tracts in adolescent idiopathic scoliosis: diffusion tensor imaging analysis[J]. Am J Neuroradiol, 2018, 39(6): 1177-1184. doi: 10.3174/ajnr.A5634
[14]	FORMAGGIO E, BERTUCCELLI M, RUBEGA M, et al. Brain oscillatory activity in adolescent idiopathic scoliosis[J]. Sci Rep, 2022, 12(1): 17266. doi: 10.1038/s41598-022-19449-1
[15]	BOCEK V, KRBEC M, VASKO P, et al. Alteration of cortical but not spinal inhibitory circuits in idiopathic scoliosis[J]. J Spinal Cord Med, 2022, 45(2): 186-193. doi: 10.1080/10790268.2020.1739893
[16]	DOMENECH J, GARCIA-MARTI G, MARTI-BONMATI L, et al. Abnormal activation of the motor cortical network in idiopathic scoliosis demonstrated by functional MRI[J]. Eur Spine J, 2011, 20(7): 1069-1078. doi: 10.1007/s00586-011-1776-8
[17]	LEE R K, GRIFFITH J F, LEUNG J H, et al. Effect of upright position on tonsillar level in adolescent idiopathic scoliosis[J]. Eur Radiol, 2015, 25(8): 2397-2402. doi: 10.1007/s00330-015-3597-3
[18]	SHI L, WANG D, HUI S C, et al. Volumetric changes in cerebellar regions in adolescent idiopathic scoliosis compared with healthy controls[J]. Spine J, 2013, 13(12): 1904-1911. doi: 10.1016/j.spinee.2013.06.045
[19]	DENG M, HUI S C N, YU F W P, et al. MRI-based morphological evidence of spinal cord tethering predicts curve progression in adolescent idiopathic scoliosis[J]. Spine J, 2015, 15(6): 1391-401. doi: 10.1016/j.spinee.2015.02.033
[20]	KONG Y, SHI L, HUI S C, et al. Variation in anisotropy and diffusivity along the medulla oblongata and the whole spinal cord in adolescent idiopathic scoliosis: a pilot study using diffusion tensor imaging[J]. Am J Neuroradiol, 2014, 35(8): 1621-1627. doi: 10.3174/ajnr.A3912
[21]	CHU W C, MAN G C, LAM W W, et al. Morphological and functional electrophysiological evidence of relative spinal cord tethering in adolescent idiopathic scoliosis[J]. Spine (Phila Pa 1976), 2008, 33(6): 673-680. doi: 10.1097/BRS.0b013e318166aa58
[22]	SHI L, WANG D, CHU W C, et al. Automatic MRI segmentation and morphoanatomy analysis of the vestibular system in adolescent idiopathic scoliosis[J]. Neuroimage, 2011, 54(Suppl 1): S180-S188.
[23]	CARRY P M, DUKE V R, BRAZELL C J, et al. Lateral semi-circular canal asymmetry in females with idiopathic scoliosis[J]. PLoS One, 2020, 15(4): e0232417. doi: 10.1371/journal.pone.0232417
[24]	HITIER M, HAMON M, DENISE P, et al. Lateral semicircular canal asymmetry in idiopathic scoliosis: an early link between biomechanical, hormonal and neurosensory theories?[J]. PLoS One, 2015, 10(7): e0131120. doi: 10.1371/journal.pone.0131120
[25]	白婧媛, 冯金升, 王健. 基于移动平台的姿势干扰及其神经生理调节研究进展[J]. 航天医学与医学工程, 2020, 33(6): 549-555. https://www.cnki.com.cn/Article/CJFDTOTAL-HYXB202006012.htm BAI J Y, FENG J S, WANG J. Research progress of postural interference based on movable platform and its neurophysiological adjustments[J]. Space Med Med Eng, 2020, 33(6): 549-555. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-HYXB202006012.htm
[26]	PIALASSE J P, MERCIER P, DESCARREAUX M, et al. A procedure to detect abnormal sensorimotor control in adolescents with idiopathic scoliosis[J]. Gait Posture, 2017, 57: 124-129. doi: 10.1016/j.gaitpost.2017.05.032
[27]	WIERNICKA M, KOTWICKI T, KAMINSKA E, et al. Postural stability in adolescent girls with progressive idiopathic scoliosis[J]. Biomed Res Int, 2019, 2019: 7103546.
[28]	DOMENECH J, BARRIOS C, TORMOS J M, et al. Somatosensory cortectomy induces motor cortical hyperexcitability and scoliosis: an experimental study in developing rats[J]. Spine J, 2013, 13(8): 938-946. doi: 10.1016/j.spinee.2013.03.002
[29]	LAMBERT F M, MALINVAUD D, GRATACAP M, et al. Restricted neural plasticity in vestibulospinal pathways after unilateral labyrinthectomy as the origin for scoliotic deformations[J]. J Neurosci, 2013, 33(16): 6845-6856. doi: 10.1523/JNEUROSCI.4842-12.2013
[30]	BARRIOS C, ARROTEGUI J I. Experimental kyphoscoliosis induced in rats by selective brain stem damage[J]. Int Orthop, 1992, 16(2): 146-151. doi: 10.1007/BF00180206
[31]	DOMENECH J, TORMOS J M, BARRIOS C, et al. Motor cortical hyperexcitability in idiopathic scoliosis: could focal dystonia be a subclinical etiological factor?[J]. Eur Spine J, 2010, 19(2): 223-230. doi: 10.1007/s00586-009-1243-y
[32]	SCHNEIDER E, NIETHARD F U, SCHIEK H, et al. How idiopathic is idiopathic scoliosis? Results of neurological studies with somatosensory evoked potentials (SSEP) in children and adolescents[J]. Z Orthop Ihre Grenzgeb, 1991, 129(4): 355-361.
[33]	GUO X, CHAU W W, HUI-CHAN C W, et al. Balance control in adolescents with idiopathic scoliosis and disturbed somatosensory function[J]. Spine (Phila Pa 1976), 2006, 31(14): E437-E440. doi: 10.1097/01.brs.0000222048.47010.bf
[34]	CHAU W W, CHU W C W, LAM T P, et al. Anatomical origin of abnormal somatosensory-evoked potential (SEP) in adolescent idiopathic scoliosis with different curve severity and correlation with cerebellar tonsillar level determined by MRI[J]. Spine, 2016, 41(10): E598-E604. doi: 10.1097/BRS.0000000000001345
[35]	CHEN Z, QIU Y, MA W, et al. Comparison of somatosensory evoked potentials between adolescent idiopathic scoliosis and congenital scoliosis without neural axis abnormalities[J]. Spine J, 2014, 14(7): 1095-1098. doi: 10.1016/j.spinee.2013.07.465
[36]	ANTONIADOU N, HATZITAKI V, STAVRIDIS S, et al. Verticality perception reveals a vestibular deficit in adolescents with idiopathic scoliosis[J]. Exp Brain Res, 2018, 236(6): 1725-1734. doi: 10.1007/s00221-018-5256-9
[37]	WOO E J, SIEGMUND G P, REILLY C W, et al. Asymmetric unilateral vestibular perception in adolescents with idiopathic scoliosis[J]. Front Neurol, 2019, 10: 1270. doi: 10.3389/fneur.2019.01270
[38]	LAU K K L, LAW K K P, KWAN K Y H, et al. Timely revisit of proprioceptive deficits in adolescent idiopathic scoliosis: a systematic review and Meta-analysis[J]. Global Spine J, 2022, 12(8): 1852-1861. doi: 10.1177/21925682211066824
[39]	ASSAIANTE C, MALLAU S, JOUVE J L, et al. Do adolescent idiopathic scoliosis (AIS) neglect proprioceptive information in sensory integration of postural control?[J]. PLoS One, 2012, 7(7): e40646. doi: 10.1371/journal.pone.0040646
[40]	陈楠. 青少年特发性脊柱侧凸的本体感觉与功能性动作特征[D]. 上海: 上海体育学院, 2018. CHEN N. The features of spinal proprioception and functional movement in adolescent idiopathic scoliosis[D]. Shanghai: Shanghai University of Sport, 2018. (in Chinese)
[41]	HADERSPECK K, SCHULTZ A. Progression of idiopathic scoliosis: an analysis of muscle actions and body weight influences[J]. Spine (Phila Pa 1976), 1981, 6(5): 447-455. doi: 10.1097/00007632-198109000-00005
[42]	HU Z S, ZHAO Z H, TSENG C C, et al. Abnormal activity of sympathetic nervous system in girls with adolescent idiopathic scoliosis: a cross-sectional study[J]. Biomed Environ Sci, 2018, 31(9): 700-704.
[43]	BURWELL R G, AUJLA R K, GREVITT M P, et al. Pathogenesis of adolescent idiopathic scoliosis in girls-a double neuro-osseous theory involving disharmony between two nervous systems, somatic and autonomic expressed in the spine and trunk: possible dependency on sympathetic nervous system and hormones with implications for medical therapy[J]. Scoliosis, 2009, 4: 24. doi: 10.1186/1748-7161-4-24
[44]	BURWELL R G, DANGERFIELD P H, FREEMAN B J. Etiologic theories of idiopathic scoliosis.somatic nervous system and the NOTOM escalator concept as one component in the pathogenesis of adolescent idiopathic scoliosis[J]. Stud Health Technol Inform, 2008, 140: 208-217.
[45]	CZUPRYNA K, NOWOTNY-CZUPRYNA O, NOWOTNY J. Neuropathological aspects of conservative treatment of scoliosis.a theoretical view point[J]. Ortop Traumatol Rehabil, 2012, 14(2): 103-114. doi: 10.5604/15093492.992293
[46]	KIM K, KIM Y H. Role of trunk muscles in generating follower load in the lumbar spine of neutral standing posture[J]. J Biomech Eng, 2008, 130(4): 041005. doi: 10.1115/1.2907739
[47]	HATZILAZARIDIS I, HATZITAKI V, ANTONIADOU N, et al. Postural and muscle responses to galvanic vestibular stimulation reveal a vestibular deficit in adolescents with idiopathic scoliosis[J]. Eur J Neurosci, 2019, 50(10): 3614-3626. doi: 10.1111/ejn.14525
[48]	MAGUIRE J, MADIGAN R, WALLACE S, et al. Intraoperative long-latency reflex activity in idiopathic scoliosis demonstrates abnormal central processing: a possible cause of idiopathic scoliosis[J]. Spine (Phila Pa 1976), 1993, 18(12): 1621-1626. doi: 10.1097/00007632-199309000-00009
[49]	NG P T T, CLAUS A, IZATT M T, et al. Is spinal neuromuscular function asymmetrical in adolescents with idiopathic scoliosis compared to those without scoliosis? a narrative review of surface EMG studies[J]. J Electromyogr Kinesiol, 2022, 63: 102640. doi: 10.1016/j.jelekin.2022.102640