A longitudinal study on association between puberty development and thyroid function of school-aged girls in Minhang District, Shanghai

HE Dandan; LI Jinhong; XU Huilin; WANG Yingying; WEN Xiaosa; FU Ye; TANG Hongmei; SU Hualin; XU Dongli; WANG Na

doi:10.16835/j.cnki.1000-9817.2023.07.020

Volume 44 Issue 7

Jul. 2023

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HE Dandan, LI Jinhong, XU Huilin, WANG Yingying, WEN Xiaosa, FU Ye, TANG Hongmei, SU Hualin, XU Dongli, WANG Na. A longitudinal study on association between puberty development and thyroid function of school-aged girls in Minhang District, Shanghai[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(7): 1049-1053. doi: 10.16835/j.cnki.1000-9817.2023.07.020

Citation:

HE Dandan, LI Jinhong, XU Huilin, WANG Yingying, WEN Xiaosa, FU Ye, TANG Hongmei, SU Hualin, XU Dongli, WANG Na. A longitudinal study on association between puberty development and thyroid function of school-aged girls in Minhang District, Shanghai[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(7): 1049-1053. doi: 10.16835/j.cnki.1000-9817.2023.07.020

Citation:

HE Dandan, LI Jinhong, XU Huilin, WANG Yingying, WEN Xiaosa, FU Ye, TANG Hongmei, SU Hualin, XU Dongli, WANG Na. A longitudinal study on association between puberty development and thyroid function of school-aged girls in Minhang District, Shanghai[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(7): 1049-1053. doi: 10.16835/j.cnki.1000-9817.2023.07.020

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A longitudinal study on association between puberty development and thyroid function of school-aged girls in Minhang District, Shanghai

doi: 10.16835/j.cnki.1000-9817.2023.07.020

HE Dandan^{1, 2},
LI Jinhong^{1, 2},
XU Huilin^{1, 2},
WANG Yingying³,
WEN Xiaosa^{1, 2},
FU Ye^{1, 2},
TANG Hongmei^{1, 2},
SU Hualin^{1, 2},
XU Dongli^{1, 2
,
,},
WANG Na³

1.
Office of Integrated Control, Center for Disease Control and Prevention of Minhang District, Shanghai(201101), China

Received Date: 2023-01-03
Rev Recd Date: 2023-05-19

Available Online: 2023-07-25

Publish Date: 2023-07-25

Abstract

Abstract

Objective To observe the association between puberty development and thyroid function among school-aged girls in Minhang District of Shanghai, in order to explore the effect of puberty development on thyroid function. Methods The study was based on a cohort of adolescent girls recruited in iodine-suitable areas of Minhang District, and the baseline and follow-up survey have been carried out from January to March 2019.The method of phased cluster sampling was used to select one junior high school in the east, south, north and middle of Minhang District, Shanghai, respectively.Finally, 464 new junior high school girls were included in the Cohort study for physical examination, and girls were followed up from January to March 2021.The Puberty Development Scale (PDS) was used to assess the stage of puberty.Serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were determined for each participant.Thyroid homeostasis structure parameters (THSPs) was calculated.Changes of Thyroid hormones at baseline and follow-up were compared by Wilcoxon signed rank sum test.Multiple linear regression analyses were used to evaluate the associations of thyroid hormones (THs) and THSPs changes with pubertal develepment. Results Serum TSH levels of female studentds decreased significantly, while their FT3 and FT4 levels increased significantly during the study period (Z=-10.53, -4.71, -12.46, P < 0.01).In multiple linear regression analysis after adjustment for co-variables (including baseline age, change of BMI and waist circumference), FT4 and thyroid feedback quantile-based index (TFQI) in the higher puberty category scores changes (△PCS) group were further reduced compared with those in the low △PCS group (β=-0.66, -0.55).Compared to the late puberty at baseline and follow-up (BLFL) group, FT4 and TFQI showed higher decline in the pre-puberty at baseline and late puberty at follow-up (BPFL) group with the pre-puberty at baseline and end of puberty at follow-up (BPFT) group (β=-0.55, -0.44)(P < 0.05).There were no association of △TSH, △FT3, △FT4/FT3 and TSH index changes (△TSHI) with △PCS or the puberty pattern. Conclusion Serum TSH decreases while serum FT3 and FT4 increase among girls during puberty.Both the initial stage and the velocity of pubertal development are related to thyroid hormone fluctuations.
- Thyroid gland,
- Adolescent development,
- Growth and development,
- Cohort studies,
- Regression analysis,
- Students,
- Female

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References(22)

References

[1]	LARSEN P R, DAVIS T F, HAY I D. The thyroid gland[M]//WILSON J D, FOSTER D W, KRONENBERG H M, et al. Williams Textbook of Endocrinology. 9th ed. Philadelphia: WB Saunders, 1998: 389-515.
[2]	ZHU S, PANG Y, XU J, et al. Endocrine regulation on bone by thyroid[J]. Front Endocrinol (Lausanne), 2022, 13: 873820. doi: 10.3389/fendo.2022.873820
[3]	BIANCO A C, DUMITRESCU A, GEREBEN B, et al. Paradigms of dynamic control of thyroid hormone signaling[J]. Endocr Rev, 2019, 40(4): 1000-1047. doi: 10.1210/er.2018-00275
[4]	BROWN S J, BREMNER A P, HADLOW N C, et al. The log TSH-free T4 relationship in a community-based cohort is nonlinear and is influenced by age, smoking and thyroid peroxidase antibody status[J]. Clin Endocrinol, 2016, 85(5): 789-796. doi: 10.1111/cen.13107
[5]	NARELLE C, HADLO W, WARDROP R, et al. The relationship between TSH and free T? In a large population is complex and nonlinear and differs by age and sex[J]. J Clin Endocrinol Metabol, 2013, 98(7): 2936-2943. doi: 10.1210/jc.2012-4223
[6]	GNOCCHI D, STEFFENSEN K R, BRUSCALUPI G, et al. Emerging role of thyroid hormone metabolites[J]. Acta Physiol, 2016, 217(3): 184-216. doi: 10.1111/apha.12648
[7]	JOHANNES W, DIETRICH GABI, FOTIADOU E H. TSH and thyrotropic agonists: key actors in thyroid homeostasis[J]. J Thyroid Res, 2012, 2012: 351864.
[8]	LACLAUSTRA M, MORENO-FRANCO B, LOU-BONAFONTE J M, et al. Impaired sensitivity to thyroid hormones is associated with diabetes and metabolic syndrome[J]. Diabetes Care, 2019, 42(2): 303-310. doi: 10.2337/dc18-1410
[9]	ŠTěPÁNEK L, HORÁKOVÁ D, ŠTěPÁNEK L, et al. Free triiodothyronine/free thyroxine (FT3/FT4) ratio is strongly associated with insulin resistance in euthyroid and hypothyroid adults: a cross-sectional study[J]. Endokrynol Pol, 2020, 72(3): 8-13.
[10]	李红娟, 邢文化. 女性青春期发育的内分泌调控[J]. 北京体育大学学报, 2008, 32(4): 466-470. doi: 10.3969/j.issn.1007-3612.2008.04.011 LI H J, XING W H. Endocrine regulation of female in puberty[J]. J Beijing Sport Univ, 2008, 32(4): 466-470. (in Chinese) doi: 10.3969/j.issn.1007-3612.2008.04.011
[11]	RAPA A, CHIORBOLI E, SARTORIO A, et al. Puberty and urinary iodine excretion[J]. J Pediatr Endocrinol Metab, 1999, 12(4): 583-584.
[12]	李丹, 史慧静, 张越, 等. 青春发育事件自我评定量表在城市青少年人群中的适用性研究[J]. 中华流行病学杂志, 2012, 33(6): 580-582. doi: 10.3760/cma.j.issn.0254-6450.2012.06.008 LI D, SHI H J, ZHANG Y, et al. Applicability of self-rated pubertal development scale among urban Chinese adolescents[J]. Chin J Epidemiol, 2012, 33(6): 580-582. (in Chinese) doi: 10.3760/cma.j.issn.0254-6450.2012.06.008
[13]	RADICIONI A F, TAHANI N, SPAZIANI M, et al. Reference ranges for thyroid hormones in normal Italian children and adolescents and overweight adolescents[J]. J Endocrinol Invest, 2013, 36(5): 326-330.
[14]	MARWAHA R K, TANDON N, DESAI A K, et al. The evolution of thyroid function with puberty[J]. Clin Endocrinol, 2012, 76(6): 899-904. doi: 10.1111/j.1365-2265.2011.04305.x
[15]	ABREU A P, KAISER U B. Pubertal development and regulation[J]. Lancet Diabetes Endocrinol, 2016, 4(3): 254-264. doi: 10.1016/S2213-8587(15)00418-0
[16]	KARAPANOU O, PAPADIMITRIOU A. Determinants of menarche[J]. Reprod Biol Endocrinol, 2010, 8: 115. doi: 10.1186/1477-7827-8-115
[17]	GUNAPALASINGHAM G, FRITHIOFF-BOJSOE C, LUND MAV, et al. Reference values for fasting serum concentrations of thyroidstimulating hormone and thyroid hormones in healthy Danish/North European white children and adolescents[J]. Scand J Clin Lab Invest, 2019, 79(1/2): 129-135.
[18]	ELMLINGER M W, KUHNEL W, LAMBRECHT H G, et al. Reference intervals from birth to adulthood for serum thyroxine (T-4), triiodothyronine (T-3), free T-3, free T-4, thyroxine binding globulin (TBG) and thyrotropin (TSH)[J]. Clin Chem Lab Med, 2001, 39(10): 973-979.
[19]	PARRA A, VILLALPANDO S, JUNCO E, et al. Thyroid gland function during childhood and adolescence. Changes in serum TSH, T4, T3, thyroxine-binding globulin, reverse T3 and free T4 and T3 concentrations[J]. Acta Endocrinol (Copenh), 1980, 93(3): 306-341.
[20]	MICHAUD P, FORADORI A, RODRIGUEZ-PORTALES J A, et al. Prepubertal surge of thyrotropin precedes an increase in thyroxine and 3, 5, 3-triiodothyronine in normal children[J]. J Clin Endocrinol Metab, 1991, 72(5): 976-981. doi: 10.1210/jcem-72-5-976
[21]	TAYLOR P N, SAYERS A, OKOSIEME O, et al. Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study[J]. J Clin Endocrinol Metab, 2017, 102(7): 2508-2515. doi: 10.1210/jc.2016-3605
[22]	PETER N T, ADRIAN S, ONYEBUCHI O, et al. Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study[J]. J Clin Endocrinol Metab, 2017, 102(7): 2508-2515. doi: 10.1210/jc.2016-3605