The effect of <i>rs</i>12145833 polymorphism of <i>SDCCAG</i>8 gene on intervention of childhood obesity

WU Yahui; XIAO Wucai; CHEN Jing; SONG Jieyun; SHAN Rui; ZHANG Han; LIU Zheng

doi:10.16835/j.cnki.1000-9817.2023.07.009

Volume 44 Issue 7

Jul. 2023

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WU Yahui, XIAO Wucai, CHEN Jing, SONG Jieyun, SHAN Rui, ZHANG Han, LIU Zheng. The effect of rs12145833 polymorphism of SDCCAG8 gene on intervention of childhood obesity[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(7): 1000-1002. doi: 10.16835/j.cnki.1000-9817.2023.07.009

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WU Yahui, XIAO Wucai, CHEN Jing, SONG Jieyun, SHAN Rui, ZHANG Han, LIU Zheng. The effect of rs12145833 polymorphism of SDCCAG8 gene on intervention of childhood obesity[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(7): 1000-1002. doi: 10.16835/j.cnki.1000-9817.2023.07.009

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The effect of rs12145833 polymorphism of SDCCAG8 gene on intervention of childhood obesity

doi: 10.16835/j.cnki.1000-9817.2023.07.009

1.
Department of Maternal and Child Health, School of Public Health, Peking University, Beijing(100191), China

Received Date: 2023-04-10
Rev Recd Date: 2023-05-22

Available Online: 2023-07-25

Publish Date: 2023-07-25

Abstract

Abstract

Objective To study the role of rs12145833 polymorphism of SDCCAG8 gene in the intervention of childhood obesity, so as to provide scientific basis for formulating personalized intervention measures based on genetic background in children with obesity. Methods From September 2018 to June 2019, a total of 393 children aged 8-10 years in Beijing were enrolled in a cluster randomized controlled trial. Eight schools were randomly allocated into intervention group and control group at a ratio of 1∶1. Saliva DNA samples were collected to detect rs12145833 polymorphism of SDCCAG8 gene. The intervention group received a comprehensive intervention, while the control group received usual practice. Intervention measures included diet improvement, sports, school amd family sport. The obesity related indicators were measured at baseline and after the end of intervention 1 academic year. Multiple linear regression and Logistic regression were used to analyze the interaction between genes and intervention on obesity indicators. Results In the intervention group, children with TT genotype of rs12145833 of the SDCCAG8 gene had less increase in systolic(β=4.56, 95%CI=1.84-7.28, P < 0.01) and diastolic blood pressure(β=2.59, 95%CI=0.45-4.73, P < 0.05) than those with GT and GG genotypes. In the control group, the systolic blood pressure of children with TT genotype increased more than those with GT and GG genotype(β=-2.86, 95%CI=-5.63--0.83, P < 0.05). There was an interaction between rs12145833 polymorphism of SDCCAG8 gene and intervention on systolic blood pressure, diastolic blood pressure and body fat percentage in children(P < 0.05). Conclusion Children with TT genotype of rs12145833 in the SDCCAG8 gene are more sensitive to obesity intervention than those with GG and GT genotypes, especially in the improvement of systolic blood pressure, diastolic blood pressure and body fat percentage. Further trials to study the role of rs12145833 polymorphism of SDCCAG8 gene in the intervention of childhood obesity among different ethnic populations are needed.
- Genes,
- Obesity,
- Intervention studies,
- Child,
- Regression analysis

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References(14)

References

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