Relationship between sensory characteristics and gray matter volumes in children with autism spectrum disorders

ZHU Ting; WANG Longlong; WANG Yarong; WANG Lei; QIAO Letian; ZHANG Xinyue; LIU Zhanhui; QIAO Xiangyang; WANG Yanping; YANG Shuhan

doi:10.16835/j.cnki.1000-9817.2023.04.024

Volume 44 Issue 4

Apr. 2023

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ZHU Ting, WANG Longlong, WANG Yarong, WANG Lei, QIAO Letian, ZHANG Xinyue, LIU Zhanhui, QIAO Xiangyang, WANG Yanping, YANG Shuhan. Relationship between sensory characteristics and gray matter volumes in children with autism spectrum disorders[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(4): 582-585. doi: 10.16835/j.cnki.1000-9817.2023.04.024

Citation:

ZHU Ting, WANG Longlong, WANG Yarong, WANG Lei, QIAO Letian, ZHANG Xinyue, LIU Zhanhui, QIAO Xiangyang, WANG Yanping, YANG Shuhan. Relationship between sensory characteristics and gray matter volumes in children with autism spectrum disorders[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(4): 582-585. doi: 10.16835/j.cnki.1000-9817.2023.04.024

Citation:

ZHU Ting, WANG Longlong, WANG Yarong, WANG Lei, QIAO Letian, ZHANG Xinyue, LIU Zhanhui, QIAO Xiangyang, WANG Yanping, YANG Shuhan. Relationship between sensory characteristics and gray matter volumes in children with autism spectrum disorders[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(4): 582-585. doi: 10.16835/j.cnki.1000-9817.2023.04.024

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Relationship between sensory characteristics and gray matter volumes in children with autism spectrum disorders

doi: 10.16835/j.cnki.1000-9817.2023.04.024

1.
Xi'an Ninth Hospital, Xi'an(710054), China

Received Date: 2023-01-28
Rev Recd Date: 2023-03-07

Available Online: 2023-04-26

Publish Date: 2023-04-25

Abstract

Abstract

Objective To investigate the potential relationship between sensory characteristics and gray matter volumes in children with autism spectrum disorders (ASD), to provide a basis for the diagnosis and treatment of children with ASD. Methods A total of 40 ASD children who were treated or recovered in Xi'an medical institutions and 16 typically developing (TD) children who were from several kindergatens in Xi'an were invited for participation. Sensory characteristics were evaluated by the sensory processing and self-regulation checklist, 3D structural brain images were obtained with TIWI, and gray matter volumes were analyzed by voxel-based morphometry. Sensory characteristics and gray matter volumes were compared between groups and the relationship between sensory characteristics and different gray matter volumes were analyzed. Results The scores of auditory, visual, tactile, sensory processing ability and sensory under-responsivity in the ASD group were lower than those in the TD group (Z/t=-2.63, -2.57, -3.11, -2.19, -3.83, P < 0.05). Gray matter volumes in nine brain regions increased in the ASD group compared to the TD group, including the left and right posterior inferior lobe, right parahippocamal gyrus, left insula, left media frontal gyrus, left superion occipital gyrus, right superion occipital gyrus, right superion parietal lobe, and right posterion central gyrus (t=3.53, 3.69, 3.37, 3.86, 3.61, 3.37, 4.04, 3.38, 3.16, P < 0.01). In the ASD group, the scores of visual, vestibular, proprioceptive, sensory processing ability, sensory-seeking behavior and sensory over-responsivity were negatively correlated with gray matter volumes of left superior occipital gyrus (r=-0.36, -0.40, -0.39, -0.36, -0.40, -0.36), and the scores of visual, vestibular, and sensory over-responsivity were negatively correlated with gray matter volumes of the right superior parietal lobule (r=-0.36, -0.50, -0.42)(P < 0.05). Conclusion The presence of paresthesia in children with ASD is associated with gray matter volumes of the left superior occipital gyrus and right superior parietal lobule.
- Autistic disorder,
- Cerebral cortex,
- Mental health,
- Child, preschool

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References(24)

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