Association between plasma Irisin concentrations and changes in blood pressure among children: a cohort study

TAN Minyi; HU Yan; SONG Yanyan; ZENG Xia; GUI Zhaohuan; WU Shengchi; CHEN Yajun; CAI Li

doi:10.16835/j.cnki.1000-9817.2023.03.023

Volume 44 Issue 3

Mar. 2023

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TAN Minyi, HU Yan, SONG Yanyan, ZENG Xia, GUI Zhaohuan, WU Shengchi, CHEN Yajun, CAI Li. Association between plasma Irisin concentrations and changes in blood pressure among children: a cohort study[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(3): 419-422. doi: 10.16835/j.cnki.1000-9817.2023.03.023

Citation:

TAN Minyi, HU Yan, SONG Yanyan, ZENG Xia, GUI Zhaohuan, WU Shengchi, CHEN Yajun, CAI Li. Association between plasma Irisin concentrations and changes in blood pressure among children: a cohort study[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(3): 419-422. doi: 10.16835/j.cnki.1000-9817.2023.03.023

Citation:

TAN Minyi, HU Yan, SONG Yanyan, ZENG Xia, GUI Zhaohuan, WU Shengchi, CHEN Yajun, CAI Li. Association between plasma Irisin concentrations and changes in blood pressure among children: a cohort study[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(3): 419-422. doi: 10.16835/j.cnki.1000-9817.2023.03.023

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Association between plasma Irisin concentrations and changes in blood pressure among children: a cohort study

doi: 10.16835/j.cnki.1000-9817.2023.03.023

1.
Department of Children Healthcare, Guangzhou Women and Children's Medical Center/Guangdong Provincial Clinical Research Center for Child Health, Guangzhou(510623), China

Received Date: 2022-10-16
Rev Recd Date: 2023-01-13
Publish Date: 2023-03-25

Abstract

Abstract

Objective To investigate the longitudinal association of plasma Irisin concentrations with changes in blood pressure (BP) levels among children, and to assess the moderating effect of physical activity (PA) or sedentary behavior (SB) on the relationship between Irisin levels and BP. Methods Based on a cohort study, a cluster sampling method was used to select 3 651 school-aged children from five schools in Guangzhou in 2017 at the baseline survey and follow-up in 2019. Both at baseline and during follow-up, PA and SB were assessed by validated questionnaires, and BP levels were measured by an electronic sphygmomanometer. A final sample of 521 children were enrolled based on the PA and SB at baseline. Plasma Irisin concentrations were measured by ELISA at baseline. Logistic regression analysis was recruited for exploring the associations of plasma Irisin concentrations with changes in BP. Moderating effects of PA and SB on the relationship between Irisin concentrations and BP were estimated using stratified analysis. Results Logistic regression analysis indicated that there was no significant association between Irisin concentrations and changes in BP levels among children (OR=0.98, P>0.05). After stratification for SB, Irisin levels in the low SB subgroup were inversely associated with changes in diastolic blood pressure (OR=0.87, 95%CI=0.77-0.98, P=0.02). In addition, SB level had a moderating effect on the relationship between Irisin levels and the DBP changes (P=0.01). Conclusion Increased Irisin concentration is associated with the decrease of DBP level among low SB children. Furthermore, SB level shows moderating role in the relationship between Irisin concentrations and changes in DBP levels.
- Irisin,
- Plasma,
- Blood pressure,
- Cohort studies,
- Regression analysis,
- Child

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References(23)

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