Epidemiological evaluation for vaccine effectiveness of varicella attenuated live vaccine among students in collective institutions in Jing'an District, Shanghai from 2017 to 2019

ZHANG Xiaojuan; AO Jianjun; YU Ping; QUAN Li; BEI Weihui; HUA Ruijue; HUANG Jin

doi:10.16835/j.cnki.1000-9817.2023.01.031

Volume 44 Issue 1

Jan. 2023

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Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2023 > 44(1): 139-142

ZHANG Xiaojuan, AO Jianjun, YU Ping, QUAN Li, BEI Weihui, HUA Ruijue, HUANG Jin. Epidemiological evaluation for vaccine effectiveness of varicella attenuated live vaccine among students in collective institutions in Jing'an District, Shanghai from 2017 to 2019[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(1): 139-142. doi: 10.16835/j.cnki.1000-9817.2023.01.031

Citation:

ZHANG Xiaojuan, AO Jianjun, YU Ping, QUAN Li, BEI Weihui, HUA Ruijue, HUANG Jin. Epidemiological evaluation for vaccine effectiveness of varicella attenuated live vaccine among students in collective institutions in Jing'an District, Shanghai from 2017 to 2019[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(1): 139-142. doi: 10.16835/j.cnki.1000-9817.2023.01.031

Citation:

ZHANG Xiaojuan, AO Jianjun, YU Ping, QUAN Li, BEI Weihui, HUA Ruijue, HUANG Jin. Epidemiological evaluation for vaccine effectiveness of varicella attenuated live vaccine among students in collective institutions in Jing'an District, Shanghai from 2017 to 2019[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2023, 44(1): 139-142. doi: 10.16835/j.cnki.1000-9817.2023.01.031

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Epidemiological evaluation for vaccine effectiveness of varicella attenuated live vaccine among students in collective institutions in Jing'an District, Shanghai from 2017 to 2019

doi: 10.16835/j.cnki.1000-9817.2023.01.031

Immunization Planning Department, Center for Disease Control and Prevention, Jing'an District, Shanghai(200072), China

Received Date: 2022-06-09
Rev Recd Date: 2022-07-10

Available Online: 2023-02-06

Publish Date: 2023-01-25

Abstract

Abstract

Objective To understand the vaccination of varicella attenuated live vaccine (VarV) among students in collective institutions, to provide a basis for analying the protective effect of vaccination. Methods All collective institutions with chickenpox epidemic and post-exposure vaccination in Jing'an District from 2017 to 2019 were investigated. All students(n=6 473) in the affected class were included. Vaccination status and the incidence information of disease were collected to analyze vaccine effectiveness (VE). Results The proportion of study subjects without an immunization history decreased year by year, and 7.5% in 2017, 7.2% in 2018, and 4.9% in 2019. The proportion with a history of one dose prior to exposure in cases was 90.0%, it was lower than 93.5% in the non cases (χ²=6.53, P < 0.05). The proportion with one dose as post-exposure prophylaxis in cases was 8.3%, it was much lower than 44.1% in the non cases (χ²=179.06, P < 0.01). The proportion with one dose as post-exposure prophylaxis in secondary cases was 28.6%, much lower than 44.1% in the non cases (χ²=9.44, P < 0.01).Unvaccinated ones and the second dose as post-exposure prophylaxis ones in cases had the highest rate of varicella development (11.0%), a history of one dose prior to exposure and one dose as post-exposure prophylaxis in cases had the lowest varicella rate (1.0%).There was a clear protective effect within two years after one dose of VarV inoculation, VE was 63.1%(95%CI=11.0%-84.7%). Conclusion The vaccine effectiveness of one-dose VarV was limited. Post-exposure prophylaxis as early as possible was highly effective in decreasing secondary attack rate.
- Chickenpox vaccine,
- Vaccination,
- Prevalence,
- Students

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References(17)

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