Association between <i>SIK</i>3 SNP <i>rs</i>12225230 with obese phenotype in children

LI Xueying; LI Chenxiong; SONG Jieyun; WANG Hui; WANG Haijun

doi:10.16835/j.cnki.1000-9817.2022.11.009

Volume 43 Issue 11

Nov. 2022

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Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2022 > 43(11): 1634-1637

LI Xueying, LI Chenxiong, SONG Jieyun, WANG Hui, WANG Haijun. Association between SIK3 SNP rs12225230 with obese phenotype in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(11): 1634-1637. doi: 10.16835/j.cnki.1000-9817.2022.11.009

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LI Xueying, LI Chenxiong, SONG Jieyun, WANG Hui, WANG Haijun. Association between SIK3 SNP rs12225230 with obese phenotype in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(11): 1634-1637. doi: 10.16835/j.cnki.1000-9817.2022.11.009

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Association between SIK3 SNP rs12225230 with obese phenotype in children

doi: 10.16835/j.cnki.1000-9817.2022.11.009

1.
Department of Maternal and Child Health, School of Public Health, Peking University, Beijing (100191), China

Received Date: 2022-02-22
Rev Recd Date: 2022-03-08

Available Online: 2022-11-30

Publish Date: 2022-11-25

Abstract

Abstract

Objective To assess the associations between the single-nucleotide polymorphism (SNP) rs12225230 of salt inducible kinase 3 (SIK3) and obesity/central obesity in children, and to provide evidence for screening intervention for obesity in children and adolescents. Methods A cluster sampling of 2 030 children aged 7-18 years in Beijing were enrolled and height, weight and waist circumference were measured according to the manufacturer. The genotype frequency of SNP rs12225230 was detected by matrix-assisted laser analysis/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Logistic regression and multiple linear regression were applied to analyze the associations between SNP rs12225230 and overweight/obesity and central obesity. Polyphen2 database was used to predict the effect of SNP rs12225230 on the protein function of SIK3. GTEx database was used to explore expression quantitative trait loci (eQTL) of SNP rs12225230. Results C allele of SNP rs12225230 was a risk allele for obesity and severe obesity in children (OR_obesity=1.50, 95%CI=1.10-2.04, P=0.01; OR_{severe obesity}=1.72, 95%CI=1.23-2.39, P < 0.01). The SNP rs12225230 was positively associated with waist circumference and waist height ratio (β_{waist circumference}=1.40, 95%CI=0.28-2.52, P=0.01; β_{waist height ratio}=0.01, 95%CI=0.00-0.02, P=0.01). C allele of SNP rs12225230 may be harmful to the function of the protein encoded by the SIK3, and was positively related to the expression of the APOA1 in the heart tissue. Conclusion SNP rs12225230 is associated with obesity and central obesity in children, and SNP rs12225230 may affect the expression of the APOA1 in children, but its association with lipid metabolism needs to be verified.
- Genes,
- Obesity,
- Regression analysis,
- Child

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References(29)

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