Relationship between <i>SH</i>2<i>B</i> adaptor protein 1 gene and lifestyles with childhood obesity

SONG Jieyun; SONG Qiying; WANG Hui; WANG Haijun

doi:10.16835/j.cnki.1000-9817.2022.11.007

Volume 43 Issue 11

Nov. 2022

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SONG Jieyun, SONG Qiying, WANG Hui, WANG Haijun. Relationship between SH2B adaptor protein 1 gene and lifestyles with childhood obesity[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(11): 1626-1629. doi: 10.16835/j.cnki.1000-9817.2022.11.007

Citation:

SONG Jieyun, SONG Qiying, WANG Hui, WANG Haijun. Relationship between SH2B adaptor protein 1 gene and lifestyles with childhood obesity[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(11): 1626-1629. doi: 10.16835/j.cnki.1000-9817.2022.11.007

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Relationship between SH2B adaptor protein 1 gene and lifestyles with childhood obesity

doi: 10.16835/j.cnki.1000-9817.2022.11.007

1.
Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing (100191), China

Received Date: 2022-02-23
Rev Recd Date: 2022-03-20

Available Online: 2022-11-30

Publish Date: 2022-11-25

Abstract

Abstract

Objective To study the associations of rs7498665 polymorphism located in the SH2B adaptor protein 1 gene with obesity-related phenotypes in Chinese children and adolescents, and to explore the gene-lifestyles interactions. Methods Anthropometric measurements and lifestyles investigation were conducted in 3 305 children and adolescents aged 7-18 years old recruited from Beijing. The matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) was used to genotype rs7498665 polymorphism. Multiple Logistic and linear regressions were performed to analyze the associations of rs7498665 with obesity and obesity related phenotypes by different levels of physical activity and diet behavior. Results The G-allele of rs7498665 polymorphism showed 37%, 101%, 45% and 64% high risk of obesity in population groups with unhealthy dietary intake, not eating breakfast daily, high consumption of sugar-sweetened beverages or not daily moderate to vigorous physical activity (P < 0.05). In the further analysis, the G-allele of rs7498665 polymorphism was associated with obesity in population with unhealthy lifestyle score (OR=1.63, 95%CI=1.23-2.17, P < 0.01). There were similar results with obesity related phenotypes, with the gene-comprehensive lifestyle behaviors interactions were significant (P_{gene×lifestyle behaviors} < 0.05). Conclusion The present study suggests the interactive effect of rs7498665 polymorphism located in the SH2B1 and unhealth lifestyle on childhood obesity and related phenotypes.
- Genes,
- Behavior,
- Obesity,
- Regression analysis,
- Child

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References(25)

References

[1]	REN D, LI M, DUAN C, et al. Identification of SH2B as a key regulator of leptin sensitivity, energy balance, and body weight in mice[J]. Cell Metab, 2005, 2(2): 95-104. doi: 10.1016/j.cmet.2005.07.004
[2]	DUAN C, YANG H, WHITE M F, et al. Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance[J]. Mol Cell Biol, 2004, 24(17): 7435-7443. doi: 10.1128/MCB.24.17.7435-7443.2004
[3]	REN D, ZHOU Y, MORRIS D, et al. Neuronal SH2B1 is essential for controlling energy and glucose homeostasis[J]. J Clin Invest, 2007, 117(2): 397-406. doi: 10.1172/JCI29417
[4]	RUI L. SH2B1 regulation of energy balance, body weight, and glucose metabolism[J]. World J Diabet, 2014, 5(4): 511-526. doi: 10.4239/wjd.v5.i4.511
[5]	MORRIS D L, CHO K W, ZHOU Y, et al. SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins[J]. Diabetes, 2009, 58(9): 2039-2047. doi: 10.2337/db08-1388
[6]	GUO Y, LANKTREE M B, TAYLOR K C, et al. Gene-centric Meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals[J]. Hum Mol Genet, 2013, 22(1): 184-201. doi: 10.1093/hmg/dds396
[7]	GRAFF M, SCOTT R A, JUSTICE A E, et al. Genome-wide physical activity interactions in adiposity-A Meta-analysis of 200, 452 adults[J]. PLoS Genet, 2017, 13(4): e1006528. doi: 10.1371/journal.pgen.1006528
[8]	SHUNGIN D, WINKLER T W, CROTEAU-CHONKA D C, et al. New genetic loci link adipose and insulin biology to body fat distribution[J]. Nature, 2015, 518(7538): 187-196. doi: 10.1038/nature14132
[9]	WILLER C J, SPELIOTES E K, LOOS R J, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation[J]. Nat Genet, 2009, 41(1): 25-34. doi: 10.1038/ng.287
[10]	SPELIOTES E K, WILLER C J, BERNDT S I, et al. Association analyses of 249 796 individuals reveal 18 new loci associated with body mass index[J]. Nat Genet, 2010, 42(11): 937-948. doi: 10.1038/ng.686
[11]	PATERNOSTER L, EVANS D M, NOHR E A, et al. Genome-wide population-based association study of extremely overweight young adults: the GOYA study[J]. PLoS One, 2011, 6(9): e24303. doi: 10.1371/journal.pone.0024303
[12]	XI B, SHEN Y, REILLY K H, et al. Sex-dependent associations of genetic variants identified by GWAS with indices of adiposity and obesity risk in a Chinese children population[J]. Clin Endocrinol (Oxf), 2013, 79(4): 523-528. doi: 10.1111/cen.12091
[13]	SHI J, LONG J, GAO Y T, et al. Evaluation of genetic susceptibility loci for obesity in Chinese women[J]. Am J Epidemiol, 2010, 172(3): 244-254. doi: 10.1093/aje/kwq129
[14]	HONG J, SHI J, QI L, et al. Genetic susceptibility, birth weight and obesity risk in young Chinese[J]. Int J Obes (Lond), 2013, 37(5): 673-677. doi: 10.1038/ijo.2012.87
[15]	ZHU J, LOOS R J, LU L, et al. Associations of genetic risk score with obesity and related traits and the modifying effect of physical activity in a Chinese Han population[J]. PLoS One, 2014, 9(3): e91442. doi: 10.1371/journal.pone.0091442
[16]	张美仙, 赵小元, 席波, 等. 基因多态性对儿童肥胖和代谢异常的影响[J]. 中华预防医学杂志, 2014, 48(9): 776-783. ZHANG M X, ZHAO X Y, XI B, et al. Impact of obesity-related gene polymorphism on risk of obesity and metabolic disorder in childhood[J]. Chin J Prev Med, 2014, 48(9): 776-783. (in Chinese)
[17]	KRISHNAN M, SHELLING A N, WALL C R, et al. Gene-by-activity interactions on obesity traits of 6-year-old New Zealand European children: a children of SCOPE Study[J]. Pediatr Exerc Sci, 2018, 30(1): 69-80. doi: 10.1123/pes.2017-0077
[18]	RICHARDSON A S, NORTH K E, GRAFF M, et al. Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort[J]. Pediatr Obes, 2014, 9(2): e35-e46. doi: 10.1111/j.2047-6310.2013.00152.x
[19]	JI C Y. Report on childhood obesity in China(1): body mass index reference for screening overweight and obesity in Chinese school-age children[J]. Biomed Environ Sci, 2005, 18(6): 390-400.
[20]	中国营养学会. 中国学龄儿童膳食指南(2016)[M]. 北京: 人民卫生出版社, 2016. Chinese Nutrition Society. Dietary guidelines for school-age children in China(2016)[M]. Beijing: People's Medical Publishing House, 2016. (in Chinese)
[21]	张云婷, 马生霞, 陈畅, 等. 中国儿童青少年身体活动指南[J]. 中国循证儿科杂志, 2017, 12(6): 401-409. https://www.cnki.com.cn/Article/CJFDTOTAL-XZEK201706001.htm ZHANG Y T, MA S X, CHEN C, et al. Guidelines of physical activity for chinese children and adolescents[J]. Chin J Evidence-Based Pediatr, 2017, 12(6): 401-409. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-XZEK201706001.htm
[22]	JAMSHIDI Y, SNIEDER H, GE D, et al. The SH2B gene is associated with serum leptin and body fat in normal female twins[J]. Obesity(Silver Spring), 2007, 15(1): 5-9.
[23]	VOLCKMAR A L, BOLZE F, JARICK I, et al. Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants[J]. BMC Med Genom, 2012, 5: 65.
[24]	ZHAO J, BRADFIELD J P, LI M, et al. The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI[J]. Obesity(Silver Spring), 2009, 17(12): 2254-2257.
[25]	HEBEBRAND J, VOLCKMAR A L, KNOLL N, et al. Chipping away the "missing heritability": GIANT steps forward in the molecular elucidation of obesity-but still lots to go[J]. Obes Facts, 2010, 3(5): 294-303.