Interaction of ATP2B1-eNOS pathway gene polymorphisms and lifestyle factors on high blood pressure among adolescents

HUANG Zehua; XIE Ming; XIAO Tianli; ZENG Yuan; YUAN Shuqian; GONG Yue; MAO Bin; ZHENG Chanjuan; YANG Yide

doi:10.16835/j.cnki.1000-9817.2022.09.031

Volume 43 Issue 9

Sep. 2022

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Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2022 > 43(9): 1407-1411

HUANG Zehua, XIE Ming, XIAO Tianli, ZENG Yuan, YUAN Shuqian, GONG Yue, MAO Bin, ZHENG Chanjuan, YANG Yide. Interaction of ATP2B1-eNOS pathway gene polymorphisms and lifestyle factors on high blood pressure among adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(9): 1407-1411. doi: 10.16835/j.cnki.1000-9817.2022.09.031

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HUANG Zehua, XIE Ming, XIAO Tianli, ZENG Yuan, YUAN Shuqian, GONG Yue, MAO Bin, ZHENG Chanjuan, YANG Yide. Interaction of ATP2B1-eNOS pathway gene polymorphisms and lifestyle factors on high blood pressure among adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(9): 1407-1411. doi: 10.16835/j.cnki.1000-9817.2022.09.031

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Interaction of ATP2B1-eNOS pathway gene polymorphisms and lifestyle factors on high blood pressure among adolescents

doi: 10.16835/j.cnki.1000-9817.2022.09.031

1.
Department of Child and Adolescent Health, School of Medicine, Hunan Normal University, Changsha (410013), China

Received Date: 2022-05-16
Rev Recd Date: 2022-06-20

Available Online: 2022-09-23

Publish Date: 2022-09-25

Abstract

Abstract

Objective To explore the gene-lifestyle interaction of ATP2B1-eNOS pathway gene polymorphisms on blood pressure. Methods Using the convenient cluster sampling method, a total of 872 junior middle school students from 3 school in July to August 2019, were included in the final analysis.The survey included questionnaire investigation, anthropometry measurement and blood sample collection.After DNA was extracted from peripheral blood samples, the gene polymorphisms (ATP2B1 gene rs17249754 and rs2070759, eNOS gene rs1799983 and rs2070744) were genotyped.Logistic regression model was used to analyze the association between gene polymorphism and blood pressure phenotypes. Results The prevalence of high blood pressure was 9.52% in adolescents (9.15% in boys and 9.87% in girls), with no significant sex difference (χ²=0.13, P=0.72).There were statistically significant differences between boys and girls in age, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI) classification, birth weight, daily school physical exercise time and daily playing video games time (P < 0.05).Logistic regression analysis showed that, eNOS gene rs2070744 polymorphism was associated with high blood pressure (HBP) under the recessive model, and the risk of HBP in CC genotype carriers were higher than that TT/TC genotype carriers (OR=3.88, 95%CI=1.00-15.02, P < 0.05).The results of gene-lifestyle interaction showed that ATP2B1 gene rs2070759 polymorphism gene had an interaction with the time of physical exercise in school (P_interaction=0.05).In the subgroup with daily physical exercise time at school < 1 hour, the TT/TG genotype carriers were associated with increased risk of HBP compared with GG genotype carriers (OR=2.65, 95%CI=1.11-6.30, P < 0.05).But in the subgroup with daily physical exercise time in school ≥1 hour, rs2070759 was not significantly associated with HBP. Conclusion eNOS/rs2070744 polymorphisms are associated with risk of HBP among adolescents.There is significant interaction between ATP2B1 gene rs2070759 polymorphism and physical exercise time in school on HBP.Adolescents should spend more time on physical activity in school, which will help to maintain normal blood pressure level.
- Genes, Blood pressure,
- Regression analysis,
- Adolescent

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References(21)

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