Research update on the effect of adverse childhood experience on telomere morphology

XIAO Wan; WAN Yuhui

doi:10.16835/j.cnki.1000-9817.2022.08.034

Volume 43 Issue 8

Aug. 2022

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2022 > 43(8): 1272-1275

XIAO Wan, WAN Yuhui. Research update on the effect of adverse childhood experience on telomere morphology[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(8): 1272-1275. doi: 10.16835/j.cnki.1000-9817.2022.08.034

Citation:

XIAO Wan, WAN Yuhui. Research update on the effect of adverse childhood experience on telomere morphology[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(8): 1272-1275. doi: 10.16835/j.cnki.1000-9817.2022.08.034

Citation:

PDF( 391 KB)

Research update on the effect of adverse childhood experience on telomere morphology

doi: 10.16835/j.cnki.1000-9817.2022.08.034

XIAO Wan,
WAN Yuhui^,

Department of Maternal, Child & Adolescent Health, School of Public Health/MOE Key Laboratory of Population Health across Life Cycle/Anhui Provincial Key Laboratory of Population Health & Aristogenics, Anhui Medical University, Hefei(230032), China

Received Date: 2022-05-05
Rev Recd Date: 2022-06-13

Available Online: 2022-08-24

Publish Date: 2022-08-25

Abstract

Abstract

Adverse childhood experiences (ACEs) not only affect individual's physical and mental health but also have adverse intergenerational effects. A growing body of researches focused on biological mechanism of ACEs, among which the emerging role of telomere has gained much attention. This article reviews the association between ACEs and telomere morphology during different developmental stages and the role of telomere in adverse health effects of ACEs. It aims to summarize possible mechanisms underlying negative effects of ACEs.
- Life change events,
- Telomere,
- Child,
- Adolescent,
- Life cycle stages,
- Mental health

FullText(HTML)

References(46)

References

[1]	TARQUINIO C. A focus on adverse childhood experiences (ACEs)[J]. Eur J Truma Dissoc, 2020, 4(4): 100181. doi: 10.1016/j.ejtd.2020.100181
[2]	TURNEY K. Cumulative adverse childhood experiences and children's health[J]. Child Youth Serv Rev, 2020, 119: 105538. doi: 10.1016/j.childyouth.2020.105538
[3]	HALL A, PEREZ A, WEST X, et al. The association of adverse childhood experiences and resilience with health outcomes in adolescents: an observational study[J]. Glob Pediatr Health, 2021, 8: 2333794X20982433.
[4]	LEE H, SLACK K S, BERGER L M, et al. Childhood poverty, adverse childhood experiences, and adult health outcomes[J]. Health Soc Work, 2021, 46(3): 159-170.
[5]	WAEHRER G M, MILLER T R, SILVERIO MARQUES S C, et al. Disease burden of adverse childhood experiences across 14 states[J]. PLoS One, 2020, 15(1): e0226134. doi: 10.1371/journal.pone.0226134
[6]	DOIS, FUJIWARA T, ISUMI A. Association between maternal adverse childhood experiences and mental health problems in offspring: an intergenerational study[J]. Dev Psychopathol, 2021, 33(3): 1041-1058. doi: 10.1017/S0954579420000334
[7]	KANG N R, KWACK Y S, SONG J K, et al. The Impact of maternal adverse childhood experiences on offspring's internalizing and externalizing problems[J]. Psychiatry Investig, 2021, 18(11): 1050-1057. doi: 10.30773/pi.2021.0343
[8]	GEHRED M Z, KNODT A R, AMBLER A, et al. Long-term neural embedding of childhood adversity in a population-representative birth cohort followed for 5 Decades[J]. Biol Psychiatry, 2021, 90(3): 182-193. doi: 10.1016/j.biopsych.2021.02.971
[9]	METCALF C A, JOHNSON R L, FREEMAN E W, et al. Influences of the menopause transition and adverse childhood experiences on peripheral basal inflammatory markers[J]. Brain Behav Immun Health, 2021, 15: 100280. doi: 10.1016/j.bbih.2021.100280
[10]	APPELMANN H M, MANIGAULT A W, SHOREY R C, et al. Childhood adversity and cortisol habituation to repeated stress in adulthood[J]. Psychoneuroendocrinology, 2021, 125: 105118. doi: 10.1016/j.psyneuen.2020.105118
[11]	TYRKA A R, PRICE L H, KAO H T, et al. Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging[J]. Biol Psychiatry, 2010, 67(6): 531-534. doi: 10.1016/j.biopsych.2009.08.014
[12]	MCFARLAND M J, TAYLOR J, HILL T D, et al. Stressful life events in early life and leukocyte telomere length in adulthood[J]. Adv Life Course Res, 2018, 35: 37-45. doi: 10.1016/j.alcr.2017.12.002
[13]	BELSKY J, SHALEV I. Contextual adversity, telomere erosion, pubertal development, and health: two models of accelerated aging, or one?[J]. Dev Psychopathol, 2016, 28(4pt2): 1367-1383. doi: 10.1017/S0954579416000900
[14]	SFEIR A, DE LANGE T. Removal of shelterin reveals the telomere end-protection problem[J]. Science, 2012, 336(6081): 593-597. doi: 10.1126/science.1218498
[15]	TURNER K J, VASU V, GRIFFIN D K. Telomere biology and human phenotype[J]. Cells, 2019, 8(1): 73. doi: 10.3390/cells8010073
[16]	SMITH E M, PENDLEBURY D F, NANDAKUMAR J. Structural biology of telomeres and telomerase[J]. Cell Mol Life Sci, 2020, 77(1): 61-79. doi: 10.1007/s00018-019-03369-x
[17]	GUARNERI-WHITE M E, ARANA A A, BOYD E Q, et al. It's more than skin-deep: the relationship between social victimization and telomere length in adolescence[J]. Aggress Behav, 2018, 44(4): 337-347. doi: 10.1002/ab.21755
[18]	KLIEWER W, ROBINS J L. Adverse childhood experiences are associated with cardiometabolic risk indicators and telomere length in low-income African-American adolescents[J]. Int J Behav Med, 2022, 29(1): 131-135. doi: 10.1007/s12529-021-09978-w
[19]	SOSNOWSKI D W, KLIEWER W, VALRIE C R, et al. The association between adverse childhood experiences and child telomere length: examining self-regulation as a behavioral mediator[J]. Child Dev, 2021, 92(2): 746-759. doi: 10.1111/cdev.13441
[20]	SUN Y, FANG J, WAN Y, et al. Association of early-life adversity with measures of accelerated biological aging among children in China[J]. JAMA Netw Open, 2020, 3(9): e2013588. doi: 10.1001/jamanetworkopen.2020.13588
[21]	MITCHELL C, MCLANAHAN S, SCHNEPER L, et al. Father loss and child telomere length[J]. Pediatrics, 2017, 140(2): e20163245. doi: 10.1542/peds.2016-3245
[22]	CHEN X, ZENG C, GONG C, et al. Associations between early life parent child separation and shortened telomere length and psychopathological outcomes during adolescence[J]. Psychoneuroendocrinology, 2019, 103: 195-202. doi: 10.1016/j.psyneuen.2019.01.021
[23]	RIDOUT K K, PARADE S H, KAO H T, et al. Childhood maltreatment, behavioral adjustment, and molecular markers of cellular aging in preschool-aged children: a cohort study[J]. Psychoneuroendocrinology, 2019, 107: 261-269. doi: 10.1016/j.psyneuen.2019.05.015
[24]	WARNER E T, ZHANG Y, GU Y, et al. Physical and sexual abuse in childhood and adolescence and leukocyte telomere length: a pooled analysis of the study on psychosocial stress, spirituality, and health[J]. PLoS One, 2020, 15(10): e0241363. doi: 10.1371/journal.pone.0241363
[25]	CEVIK B, MANCE-CALISIR O, ATBASOGLU E C, et al. Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: a study on schizophrenia patients, unaffected siblings, and nonclinical controls[J]. J Psychiatr Res, 2019, 111: 169-185. doi: 10.1016/j.jpsychires.2019.01.022
[26]	JIMENEZ K M, PEREIRA-MORALES A J, ADAN A, et al. Telomere length and childhood trauma in Colombians with depressive symptoms[J]. Braz J Psychiatry, 2019, 41(3): 194-198. doi: 10.1590/1516-4446-2018-0027
[27]	KEMP B R, FERRARO K F. Are biological consequences of childhood exposures detectable in telomere length decades later?[J]. J Gerontol A Biol Sci Med Sci, 2021, 76(1): 7-14. doi: 10.1093/gerona/glaa019
[28]	PUTERMAN E, GEMMILL A, KARASEK D, et al. Lifespan adversity and later adulthood telomere length in the nationally representative US health and retirement study[J]. Proc Natl Acad Sci USA, 2016, 113(42): E6335-E6342.
[29]	MAYER S E, PRATHER A A, PUTERMAN E, et al. Cumulative lifetime stress exposure and leukocyte telomere length attrition: the unique role of stressor duration and exposure timing[J]. Psychoneuroendocrinology, 2019, 104: 210-218. doi: 10.1016/j.psyneuen.2019.03.002
[30]	MITCHELL A M, KOWALSKY J M, EPEL E S, et al. Childhood adversity, social support, and telomere length among perinatal women[J]. Psychoneuroendocrinology, 2018, 87: 43-52. doi: 10.1016/j.psyneuen.2017.10.003
[31]	SOSNOWSKI D W, KLIEWER W, YORK T P, et al. Familial support following childhood sexual abuse is associated with longer telomere length in adult females[J]. J Behav Med, 2019, 42(5): 911-923. doi: 10.1007/s10865-019-00014-7
[32]	OLIVEIRA B S, ZUNZUNEGUI M V, QUINLAN J, et al. Lifecourse adversity and telomere length in older women from northeast Brazil[J]. Rejuven Res, 2018, 21(4): 294-303. doi: 10.1089/rej.2017.1937
[33]	DEMPSTER K S, O'LEARY D D, MACNEIL A J, et al. Linking the hemodynamic consequences of adverse childhood experiences to an altered HPA axis and acute stress response[J]. Brain Behav Immun, 2021, 93: 254-263. doi: 10.1016/j.bbi.2020.12.018
[34]	MORRIS G, BERK M, MAES M, et al. Socioeconomic deprivation, adverse childhood experiences and medical disorders in adulthood: mechanisms and associations[J]. Mol Neurobiol, 2019, 56(8): 5866-5890. doi: 10.1007/s12035-019-1498-1
[35]	JENKINS N D M, ROGERS E M, BANKS N F, et al. Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood[J]. Am J Physiol Heart Circ Physiol, 2021, 321(3): H532-H541. doi: 10.1152/ajpheart.00123.2021
[36]	SCORZA P, DUARTE C S, LEE S, et al. Epigenetic intergenerational transmission: mothers'dverse childhood experiences and DNA methylation[J]. J Am Acad Child Adolesc Psychiatry, 2020, 59(7): 900-901. doi: 10.1016/j.jaac.2020.03.008
[37]	MERRILL S M, MOORE S R, GLADISH N, et al. Paternal adverse childhood experiences: associations with infant DNA methylation[J]. Dev Psychobiol, 2021, 63(6): e22174.
[38]	Lê-SCHERBAN F, WANG X, BOYLE-STEED K H, et al. Intergenerational associations of parent adverse childhood experiences and child health outcomes[J]. Pediatrics, 2018, 141(6): e20174274. doi: 10.1542/peds.2017-4274
[39]	MADIGAN S, WADE M, PLAMONDON A, et al. Maternal adverse childhood experience and infant health: biomedical and psychosocial risks as intermediary mechanisms[J]. J Pediatr, 2017, 187: 282-289. doi: 10.1016/j.jpeds.2017.04.052
[40]	ESTEVES K C, JONES C W, WADE M, et al. Adverse childhood experiences: implications for offspring telomere length and psychopathology[J]. Am J Psychiatry, 2020, 177(1): 47-57. doi: 10.1176/appi.ajp.2019.18030335
[41]	ETZEL L, HASTINGS W J, MATTERN B C, et al. Intergenerational transmission of childhood trauma?Testing cellular aging in mothers exposed to sexual abuse and their children[J]. Psychoneuroendocrinology, 2020, 120: 104781. doi: 10.1016/j.psyneuen.2020.104781
[42]	BOSQUET-ENLOW M, BOLLATI V, SIDERIDIS G, et al. Sex differences in effects of maternal risk and protective factors in childhood and pregnancy on newborn telomere length[J]. Psychoneuroendocrinology, 2018, 95: 74-85. doi: 10.1016/j.psyneuen.2018.05.025
[43]	ROUBINOV D S, LUECKEN L J, CURCI S G, et al. A prenatal programming perspective on the intergenerational transmission of maternal adverse childhood experiences to offspring health problems[J]. Am Psychol, 2021, 76(2): 337-349. doi: 10.1037/amp0000762
[44]	EISENBERG D T, HAYES M G, KUZAWA C W. Delayed paternal age of reproduction in humans is associated with longer telomeres across two generations of descendants[J]. Proc Natl Acad Sci USA, 2012, 109(26): 10251-10256. doi: 10.1073/pnas.1202092109
[45]	ZIV Y, SOFRI I, CAPPS UMPHLET K L, et al. Children and caregivers' exposure to adverse childhood experiences (ACES): association with children's and caregivers' psychological outcomes in a therapeutic preschool program[J]. Int J Environ Res Public Health, 2018, 15(4): 646. doi: 10.3390/ijerph15040646
[46]	COE J L, HUFFHINES L, CONTENTE C A, et al. Intergenerational effects of maternal childhood experiences on maternal parenting and infant developmental progress[J]. J Dev Behav Pediatr, 2020, 41(8): 619-627. doi: 10.1097/DBP.0000000000000835