Longitudinal association between vitamin D supplementation in infancy and overweight or obesity among first-grade primary school pupils

YE Peiqi; LIN Dan; CHEN Didi; LI Yun; WEN Xiaosa; HUANG Jun; SHI Huijing

doi:10.16835/j.cnki.1000-9817.2022.06.005

Volume 43 Issue 6

Jun. 2022

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2022 > 43(6): 817-821

YE Peiqi, LIN Dan, CHEN Didi, LI Yun, WEN Xiaosa, HUANG Jun, SHI Huijing. Longitudinal association between vitamin D supplementation in infancy and overweight or obesity among first-grade primary school pupils[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(6): 817-821. doi: 10.16835/j.cnki.1000-9817.2022.06.005

Citation:

YE Peiqi, LIN Dan, CHEN Didi, LI Yun, WEN Xiaosa, HUANG Jun, SHI Huijing. Longitudinal association between vitamin D supplementation in infancy and overweight or obesity among first-grade primary school pupils[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(6): 817-821. doi: 10.16835/j.cnki.1000-9817.2022.06.005

Citation:

YE Peiqi, LIN Dan, CHEN Didi, LI Yun, WEN Xiaosa, HUANG Jun, SHI Huijing. Longitudinal association between vitamin D supplementation in infancy and overweight or obesity among first-grade primary school pupils[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(6): 817-821. doi: 10.16835/j.cnki.1000-9817.2022.06.005

PDF( 383 KB)

Longitudinal association between vitamin D supplementation in infancy and overweight or obesity among first-grade primary school pupils

doi: 10.16835/j.cnki.1000-9817.2022.06.005

YE Peiqi¹,
LIN Dan¹,
CHEN Didi^{2, 3},
LI Yun⁴,
WEN Xiaosa^{2, 3},
HUANG Jun⁴,
SHI Huijing^{1
,
,}

1.
Department of Maternal, Child and Adolescent Health, School of Public Health, Fudan University, Shanghai (200032), China

Received Date: 2021-12-16
Rev Recd Date: 2022-02-02

Available Online: 2022-06-23

Publish Date: 2022-06-25

Abstract

Abstract

Objective To investigate the current status of vitamin D supplementation in infancy and to explore the effect of vitamin D supplementation in infancy and overweight or obesity in early school years. Methods Tollay 8 744 first-grade elementary school students in Minhang District, Shanghai, who entered school on September 1st, 2019, and had a routine physical examination in that year, were enrolled in the study. Children's height and weight were measured by medical professionals according to standard methods and instruments, and overweight or obesity was defined by BMI. Birth records, vitamin D supplementation during infancy, and feeding records during infancy were collected retrospectively. An unconditional Logistic regression model was used to evalute the effect of vitamin D supplementation in infancy on overweight or obesity in early school age. Stratified analysis was performed according to whether they were exclusively breastfed within 1, 4, 6 month of birth or not. Results The overweight or obesity rate of first grade students in Minhang District, Shanghai was 32.5%(2 843/8 744). Retracing their vitamin D supplementation during infancy, the vitamin D supplementation rates were 20.2%, 49.7%, 66.3%, and 72.7% for infants 1, 2, 4, and 6 months of age after birth, respectively, and 83.2% of infants and toddlers were supplemented within 3 years of birth. Infants who were supplemented with vitamin D within 1 month of birth had a reduced risk of overweight and obesity in early school age (OR=0.82, 95%CI=0.68-0.98), and stratified analysis showed that this protective effect was only present in infants who were exclusively breastfed at 1, 4, and 6 months of age [OR(95%CI)=0.76(0.61-0.97), 0.76(0.59-0.99), 0.69(0.49-0.98), P < 0.05]. Conclusion The rate of vitamin D supplementation in infancy needs to be improved, and vitamin D supplementation in infancy may have a protective effect on the development of overweight and obesity in exclusively breastfed children in early school years.
- Vitamin D,
- Overweight,
- Obesity,
- Regression analysis,
- Students

FullText(HTML)

References(22)

References

[1]	NG M, FLEMING T, ROBINSON M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013[J]. Lancet, 2014, 384(9945): 766-781. doi: 10.1016/S0140-6736(14)60460-8
[2]	张娜, 马冠生. 《中国儿童肥胖报告》解读[J]. 营养学报, 2017, 39(6): 530-534. doi: 10.3969/j.issn.0512-7955.2017.06.003 ZHANG N, MA G S. Interpretation of Report on Childhood Obesity in China[J]. Acta Nutr Sinica, 2017, 39(6): 530-534. doi: 10.3969/j.issn.0512-7955.2017.06.003
[3]	马冠生. 中国肥胖报告[R]. 北京: 人民卫生出版社, 2017. MA G S. China obesity report[R]. Beijing: People's Medical Publishing House, 2017.
[4]	PLESNER J L, DAHL M, FONVIG C E, et al. Obesity is associated with vitamin D deficiency in Danish children and adolescents[J]. J Pediatr Endocrinol Metab, 2018, 31(1): 53-61. doi: 10.1515/jpem-2017-0246
[5]	金骥翔. 356例儿童维生素D营养状况及其与肥胖的相关性研究[J]. 中国妇幼健康研究, 2020, 31(12): 1673-1676. https://www.cnki.com.cn/Article/CJFDTOTAL-SANE202012019.htm JIN J X. Nutritional status of vitamin D in 356 children and its correlation with obesity[J]. Chin J Woman Child Health Res, 2020, 31(12): 1673-1676. https://www.cnki.com.cn/Article/CJFDTOTAL-SANE202012019.htm
[6]	MOTLAGHZADEH Y, SAYARIFARD F, ALLAHVERDI B, et al. Assessment of vitamin D status and response to vitamin D3 in obese and non-obese iranian children[J]. J Trop Pediatr, 2016, 62(4): 69-275. https://academic.oup.com/tropej/article/62/4/269/2223569
[7]	李琳珊, 苏芊, 常波. 儿童肥胖与维生素D关系的研究进展[J]. 大连医科大学学报, 2019, 41(5): 463-467. https://www.cnki.com.cn/Article/CJFDTOTAL-DLYK201905021.htm LI L S, SU Q, CHANG B. Research progress on the relationship between childhood obesity and vitamin D[J]. J Dalian Med Univ, 2019, 41(5): 463-467. https://www.cnki.com.cn/Article/CJFDTOTAL-DLYK201905021.htm
[8]	中国营养学会膳食指南修订专家委员会妇幼人群指南修订专家工作组. 6月龄内婴儿母乳喂养指南[J]. 临床儿科杂志, 2016, 34(4): 287-291. doi: 10.3969/j.issn.1000-3606.2016.04.011 Expert Committee on Revision of Dietary Guidelines of the Chinese Society of Nutrition, Revision of Guidelines for Women and Children. Breastfeeding guidelines for infants up to 6 months of age[J]. J Clin Pediatr, 2016, 34(4): 287-291. doi: 10.3969/j.issn.1000-3606.2016.04.011
[9]	洪淼. 婴儿0~6月龄维生素D补充对其生长发育影响的研究[D]. 武汉: 华中科技大学, 2017. HONG M. The influence of vitamin D supplementation within the first 6 months on infant growth[D]. Wuhan: Huazhong University of Science and Technology, 2017.
[10]	KUMAR G T, SACHDEV H S, CHELLANI H, et al. Effect of weekly vitamin D supplements on mortality, morbidity, and growth of low birthweight term infants in India up to age 6 months: randomised controlled trial[J]. BMJ, 2011, 342: d2975. doi: 10.1136/bmj.d2975
[11]	TRILOK-KUMAR G, KAUR M, REHMAN A M, et al. Effects of vitamin D supplementation in infancy on growth, bone parameters, body composition and gross motor development at age 3-6 years: follow-up of a randomized controlled trial[J]. Int J Epidemiol, 2015, 44(3): 894-905. doi: 10.1093/ije/dyv116
[12]	国家卫生和计划生育委员会. 学龄儿童青少年超重与肥胖筛查: WS/T 586—2018[S]. 2018-08-01. National Health and Family Planning Commission of the PRC. Screening for overweight and obesity among school-age children and adolescents: WS/T 586-2018[S]. 2018-08-01.
[13]	MAILHOT G, WHITE J H. Vitamin D and immunity in infants and children[J]. Nutrients, 2020, 12(5): 1233. doi: 10.3390/nu12051233
[14]	ZITTERMANN A, PILZ S, BERTHOLD H K. Serum 25-hydroxy vitamin D response to vitamin D supplementation in infants: a systematic review and Meta-analysis of clinical intervention trials[J]. Eur J Nutr, 2020, 59(1): 359-369. doi: 10.1007/s00394-019-01912-x
[15]	Health Canada, Canada Paediatric Society, Dietitians of Canada, et al. Nutrition for healthy term infants: recommendations from birth to six months[J]. Can J Diet Pract Res, 2012, 73(4): 204. doi: 10.3148/73.4.2012.204
[16]	PERRINE C G, SHARMA A J, JEFFERDS M E, et al. Adherence to vitamin D recommendations among US infants[J]. Pediatrics, 2010, 125(4): 627-632. doi: 10.1542/peds.2009-2571
[17]	LEHTONEN E, ORMISSON A, NUCCI A, et al. Use of vitamin D supplements during infancy in an international feeding trial[J]. Public Health Nutr, 2014, 17(4): 810-822. doi: 10.1017/S1368980013001122
[18]	李苹, 昌雪莲, 尚煜, 等. 婴儿早期维生素D补充对生长发育及肠道菌群的影响[J]. 公共卫生与预防医学, 2018, 29(1): 12-16. https://www.cnki.com.cn/Article/CJFDTOTAL-FBYF201801005.htm LI P, CHANG X L, SHANG Y, et al. Effects of vitamin D supplementation during early infancy on the growth and gutmicrobiota in infants[J]. J Public Health Prev Med, 2018, 29(1): 12-16. https://www.cnki.com.cn/Article/CJFDTOTAL-FBYF201801005.htm
[19]	TRILOK-KUMAR G, KAUR M, REHMAN A M, et al. Effects of vitamin D supplementation in infancy on growth, bone parameters, body composition and gross motor development at age 3-6 years: follow-up of a randomized controlled trial[J]. Int J Epidemiol, 2015, 44(3): 894-905. doi: 10.1093/ije/dyv116
[20]	ZHENG M, LAMB K E, GRIMES C, et al. Rapid weight gain during infancy and subsequent adiposity: a systematic review and Meta-analysis of evidence[J]. Obes Rev, 2018, 19(3): 321-332. doi: 10.1111/obr.12632
[21]	SAVASTANO S, BARREA L, SAVANELLI M C, et al. Low vitamin D status and obesity: role of nutritionist[J]. Rev Endocr Metab Disord, 2017, 18(2): 215-225. doi: 10.1007/s11154-017-9410-7
[22]	中华预防医学会儿童保健分会. 中国儿童维生素A、维生素D临床应用专家共识[J]. 中国儿童保健杂志, 2021, 29(1): 110-116. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO202101029.htm China Preventive Medicine Association, Society of Child Health. Expert consensus on clinical application of vitamin A and vitamin D in children in China[J]. Chin J Child Health Care, 2021, 29(1): 110-116. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO202101029.htm