Evaluation of the correlation between the fractional amplitude of low frequency fluctuation and sleep belief in adolescents with drug-naive first-episode insomnia disorder

HUANG Yiyang; LYU Chuang; LYU Lanlan; ZHOU Yang; XIE Shiping

doi:10.16835/j.cnki.1000-9817.2022.03.018

Volume 43 Issue 3

Mar. 2022

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HUANG Yiyang, LYU Chuang, LYU Lanlan, ZHOU Yang, XIE Shiping. Evaluation of the correlation between the fractional amplitude of low frequency fluctuation and sleep belief in adolescents with drug-naive first-episode insomnia disorder[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(3): 395-398. doi: 10.16835/j.cnki.1000-9817.2022.03.018

Citation:

HUANG Yiyang, LYU Chuang, LYU Lanlan, ZHOU Yang, XIE Shiping. Evaluation of the correlation between the fractional amplitude of low frequency fluctuation and sleep belief in adolescents with drug-naive first-episode insomnia disorder[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(3): 395-398. doi: 10.16835/j.cnki.1000-9817.2022.03.018

Citation:

HUANG Yiyang, LYU Chuang, LYU Lanlan, ZHOU Yang, XIE Shiping. Evaluation of the correlation between the fractional amplitude of low frequency fluctuation and sleep belief in adolescents with drug-naive first-episode insomnia disorder[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2022, 43(3): 395-398. doi: 10.16835/j.cnki.1000-9817.2022.03.018

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Evaluation of the correlation between the fractional amplitude of low frequency fluctuation and sleep belief in adolescents with drug-naive first-episode insomnia disorder

doi: 10.16835/j.cnki.1000-9817.2022.03.018

1.
Children's Hospital of Nanjing Medical University, Nanjing (210029), China

Received Date: 2021-09-09
Rev Recd Date: 2021-12-13

Available Online: 2022-03-29

Publish Date: 2022-03-25

Abstract

Abstract

Objective To investigate the brain function and their correlation with sleep beliefs and attitudes in adolescents with drug-naive insomnia by using fractional amplitude of low frequency fluctuation, so as to provide a reference for the mechanism and treatment of insomnia. Methods An insomnia group (n=21) recruited first-episode, drug-naive, adolescents with insomnia who met the diagnostic criteria of the American Diagnostic and Statistical Manual of Mental Disorders(DSM-V). Healthy subjects matched with age, gender, and educational background were selected as the control group (n=20). Pittsburgh Sleep Quality Index Scale (PSQI), Brief Version of Dysfunctional Beliefs and Attitudes about Sleep (DBAS-16), 24 Items-Hamilton Depression Scale (HAMD-24), 14 Items-Hamilton Anxiety Scale (HAMA-14) were evaluated. Fractional amplitude of low-frequency fluctuation was used for analysis, and Pearson correlation analysis was employed to quantify the correlation between peak values of brain regions with significant differences and the clinical scale scores of the two groups. Results Compared with the control group, ractional amplitude of low frequency fluctuation(fALFF) values in the insomnia group were significantly decreased (P < 0.01, Alphaism corrected) in the left dorsolateral prefrontal lobe (L-DLPFC, MNI coordinates: -12, 60, 21, t=-3.85, K=495) and the left precuneus (MNI coordinates: -3, -54, 51, t=-4.29, K=417). The fALFF value of L-DLPFC in the insomnia group was positively correlated with DBAS-16 score (r=0.47, P=0.04). Conclusion Abnormalities in the L-DLPFC region suggest that adolescents with insomnia may suffer from impaired regulation of emotional and cognitive activities related to sleep.
- Puberty,
- Sleep disorders,
- Mental health,
- Brain,
- Students

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References(25)

References

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