Effect of comprehensive intervention on ANGPTL2 and vascular endothelial function in obese male adolescents

YAO Meng; TANG Donghui; BAI Shuang

doi:10.16835/j.cnki.1000-9817.2021.12.031

Volume 42 Issue 12

Dec. 2021

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2021 > 42(12): 1888-1891

YAO Meng, TANG Donghui, BAI Shuang. Effect of comprehensive intervention on ANGPTL2 and vascular endothelial function in obese male adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(12): 1888-1891. doi: 10.16835/j.cnki.1000-9817.2021.12.031

Citation:

YAO Meng, TANG Donghui, BAI Shuang. Effect of comprehensive intervention on ANGPTL2 and vascular endothelial function in obese male adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(12): 1888-1891. doi: 10.16835/j.cnki.1000-9817.2021.12.031

Citation:

PDF( 352 KB)

Effect of comprehensive intervention on ANGPTL2 and vascular endothelial function in obese male adolescents

doi: 10.16835/j.cnki.1000-9817.2021.12.031

YAO Meng^{1, 2},
TANG Donghui^{1
,
,},
BAI Shuang¹

1.
College of P.E. and Sports Science, Beijing Normal University, Beijing (100875), China

Received Date: 2021-02-04
Rev Recd Date: 2021-06-29

Available Online: 2021-12-23

Publish Date: 2021-12-25

Abstract

Abstract

Objective To investigate the effect of a comprehensive exercise intervention program combined with diet control on ANGPTL2 and vascular endothelial function in obese male adolescents, and to provide theoretual basis for exercise to reduce the risk of cardiovascular disease in obese male adolescents. Methods Forty-two obese male adolescents and 10 healthy male adolescents were selected, a comprehensive intervention of 6 weeks of exercise combined with diet control was carried out on obese male adolescents, and changes in morphological function, glucose and lipid metabolism, inflammation level and vascular endothelial function were measured before and after the intervention. Results After 6 weeks of comprehensive intervention, the morphological and functional indicators of obese adolescents were significantly reduced: weight, BMI, waist circumference, waist-to-hip ratio, systolic blood pressure, diastolic blood pressure (P < 0.05); blood lipid levels significantly decreased, including TC, TG and LDL-C (P < 0.05); inflammation levels significantly decreased, including TNF-α and ANGPTL2 (P < 0.05); Vascular endothelial function significantly improved: RHI, NO/ET-1, NO, AI(P < 0.05). Before and after 6 weeks of comprehensive intervention, the ANGPTL2 of obese adolescents was significantly correlated with weight (r=0.37), BMI (r=0.45), RHI (r=-0.46), NO/ET-1 (r=-0.41), NO(r=-0.45), and AI (r=0.33)(P < 0.05). Conclusion The comprehensive intervention can effectively improve the morphological function, blood lipid level and vascular endothelial function of obese male adolescents, and reduce the circulating level of ANGPTL2. ANGPTL2 may be involved in the process of comprehensive intervention to improve the vascular endothelial function of obese adolescents.
- Obesity,
- Angiopoietin-2,
- Cardiovascular system,
- Adolescent,
- Male

FullText(HTML)

References(16)

References

[1]	ROBERT H E, SCOTT M G, PAUL Z Z. The metabolic syndrome[J]. Lancet, 2005, 365: 1415-1428. doi: 10.1016/S0140-6736(05)66378-7
[2]	CABALLERO A E. Endothelial dysfunction in obesity and insulin resistance: a road to diabetes and heart disease[J]. Obes Res, 2003, 11(11): 1278-1289. doi: 10.1038/oby.2003.174
[3]	IANTORNO M, CAMPIA U, DI DANIELE N, et al. Obesity, inflammation and endothelial dysfunction[J]. J Biol Regul Homeost Agents, 2014, 28(2): 169-176.
[4]	GAETANO S. Angiopoietin-like proteins: a comprehensive look[J]. Front Endocrinol, 2014, 5: 4.
[5]	JUNG C H, LEE W J, LEE M J, et al. Association of serum angiopoietin-like protein 2 with carotid intima-media thickness in subjects with type 2 diabetes[J]. Cardiovasc Diabetol, 2015, 14(1): 35. doi: 10.1186/s12933-015-0198-z
[6]	DURÁN W N, BRESLIN J W, SÁNCHEZ F A. The NO cascade, eNOS location, and microvascular permeability[J]. Cardiovasc Res, 2010, 87(2): 254-261. doi: 10.1093/cvr/cvq139
[7]	中国肥胖问题工作组. 中国学龄儿童青少年超重、肥胖筛查体重指数值分类标准[J]. 中华流行病学杂志, 2004, 25(2): 97-102. doi: 10.3760/j.issn:0254-6450.2004.02.003 Group of China Obesity Task Force. Body mass index reference norm for screening overweight and obesity in Chinese children and adolescents[J]. Chin J Epidemiol, 2004, 25(2): 97-102. doi: 10.3760/j.issn:0254-6450.2004.02.003
[8]	唐东辉, 侯玉洁, 白爽, 等. 运动结合饮食控制通过降低RAAS系统活性改善男性肥胖男性青少年血管内皮功能[J]. 体育科学, 2017, 37(9): 48-54. TANG D H, HOU Y J, BAI S, et al. Exercise combined with diet control improving male obese adolescents' vascular endothelial function through reducing the activity of RAAS system[J]. Chin Sport Sci, 2017, 37(9): 48-54.
[9]	XU Y, ARORA R C, HIEBERT B M, et al. Non-invasive endothelial function testing and the risk of adverse outcomes: a systematic review and meta-analysis[J]. Eur Heart J Cardiovasc Imag, 2014, 15(7): 736-737. doi: 10.1093/ehjci/jet256
[10]	YANO S, TOBITA H, UNO C, et al. Reactive hyperemia index is suitable for screening endothelial dysfunction especially in obese subjects with non-alcoholic hepatitis[J]. Atherosclerosis, 2018, 275: e191-197.
[11]	TANG D H, BAI S, LI X L, et al. Improvement of microvascular endothelial dysfunction induced by exercise and diet is associated with microRNA-126 in obese adolescents[J]. Microvasc Res, 2018, 123: 86-91.
[12]	李娟, 唐东辉, 陈巍. 有氧运动结合抗阻训练对男性肥胖男性青少年心血管功能的改善及可能机制[J]. 体育科学, 2013, 33(8): 37-42. doi: 10.3969/j.issn.1000-677X.2013.08.005 LI J, TANG D H, CHEN W, et al. The Effects of aerobic combined with resistance exercise on cardiovascular efficiency in male obese adolescents and related mechanisms[J]. Chin Sport Sci, 2013, 33(8): 37-42. doi: 10.3969/j.issn.1000-677X.2013.08.005
[13]	ALEXOPOULOS N, KATRITSIS D, RAGGI P. Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis[J]. Atherosclerosis, 2014, 233(1): 104-112. doi: 10.1016/j.atherosclerosis.2013.12.023
[14]	SASAKI Y, OHTA M, DESAI D, et al. Angiopoietin-likeprotein 2 (ANGPTL2) promotes adipose tissue macrophage and T lymphocyte accumulation and leads to insulin resistance[J]. PLoS One, 2015, 10(7): 35.
[15]	TABATA M, KADOMATSU T, FUKUHARA S, et al. Angiopoietin-likeprotein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance[J]. Cell Metab, 2009, 10(3): 178-188. doi: 10.1016/j.cmet.2009.08.003
[16]	HORIO E, KADOMATSU T, MIYATA K, et al. Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression[J]. Arterioscler Thromb Vasc Biol, 2014, 34(4): 790-800. doi: 10.1161/ATVBAHA.113.303116