Risk factors for bronchial asthma in children with allergic rhinitis

YE Maoxin; LIU Chuanhe; SHA Li; GU Qinglong; ZHAO Jing

doi:10.16835/j.cnki.1000-9817.2021.09.007

Volume 42 Issue 9

Sep. 2021

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Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2021 > 42(9): 1302-1305,1310

YE Maoxin, LIU Chuanhe, SHA Li, GU Qinglong, ZHAO Jing. Risk factors for bronchial asthma in children with allergic rhinitis[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(9): 1302-1305,1310. doi: 10.16835/j.cnki.1000-9817.2021.09.007

Citation:

YE Maoxin, LIU Chuanhe, SHA Li, GU Qinglong, ZHAO Jing. Risk factors for bronchial asthma in children with allergic rhinitis[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(9): 1302-1305,1310. doi: 10.16835/j.cnki.1000-9817.2021.09.007

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Risk factors for bronchial asthma in children with allergic rhinitis

doi: 10.16835/j.cnki.1000-9817.2021.09.007

YE Maoxin^{1, 2},
LIU Chuanhe^{2
,
,},
SHA Li²,
GU Qinglong²,
ZHAO Jing²

1.
Clinical College of Weifang Medical University, Weifang(261000), Shandong Province, China

Received Date: 2021-01-05
Rev Recd Date: 2021-03-30

Available Online: 2021-09-24

Publish Date: 2021-09-24

Abstract

Abstract

Objective To explore the risk factors of bronchial asthma in children with allergic rhinitis, and to provide evidence for the early diagnosis, treatment and prevention of asthma in children with allergic rhinitis. Methods Children with allergic rhinitis and children with allergic rhinitis and asthma, who attended the Allergy Clinic of the Capital Institute of Pediatrics from November 2019 to October 2020, were recruited for the study. Medical history, clinical characteristics, allergen types and risk factors were collected and analyzed. Results A total of 117 children with allergic rhinitis and 111 children with allergic rhinitis that subsequently developed into asthma were included. The results of the univariate analysis showed that the occurrence of asthma in children with allergic rhinitis was associated with the course of rhinitis, severity of rhinitis, type of rhinitis, seasonal onset, history of pet contact, family history of allergic diseases, mold, ragweed, dermatophagoides culinae and dust mite sensitization(χ²=6.15, 8.79, 3.99, 9.44, 5.17, 4.43, 8.48, 10.38, 6.18, 5.31, P < 0.05). The Logistic regression analysis showed that rhinitis severity(OR=7.03), family history of allergic diseases(OR=8.24), mold(OR=5.19), and household dust mite sensitization (OR=25.25) were positively correlated with the occurrence of asthma in children with allergic rhinitis(P < 0.05), and dust mite sensitization was the strongest risk factor. Conclusion The development of asthma in children with allergic rhinitis is affected by many factors, among which the severity of rhinitis, family history of allergic diseases and dust mite sensitization are the most important factors.
- Rhinitis,
- Asthma,
- Allergens,
- Regression analysis,
- Child

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References(27)

References

[1]	BROZEK J L, BOUSQUET J, AGACHE I, et al. Allergic Rhinits and its Impact on Asthma (ARIA) Guidelines-2016 revision[J]. J Allergy Clin Immunol, 2017, 140(4): 950-958. doi: 10.1016/j.jaci.2017.03.050
[2]	LEYNAERT B, BOUSQUET J, NEUKIRCH C, et al. Perennial rhinitis: an independent risk factor for asthma in nonatopic subjects: results from the european community respiratory health survey[J]. J Allergy Clin Immunol, 1999, 104(2Pt1): 301-304. http://www.sciencedirect.com/science/article/pii/S0091674999703702
[3]	TESTA D, DIBARI M, NUNZIATA M, et al. Allergic rhinitis and asthma assessment of risk factors in pediatric patients: a systematic review[J]. Int J Pediatr Otorhinolaryngol, 2020, 129(10): 1-11. http://www.ncbi.nlm.nih.gov/pubmed/31734564
[4]	刘传合, 邵明军, 王强, 等. 北京市城区0~14岁儿童哮喘流行病学调查[J]. 中华医学杂志, 2013, 93(8): 574-578. doi: 10.3760/cma.j.issn.0376-2491.2013.08.004 LIU C H, SHAO M J, WANG Q, et al. Epidemiological survey of children asthma prevalence in Beijing urban area[J]. Chin Med J, 2013, 93(8): 574-578. doi: 10.3760/cma.j.issn.0376-2491.2013.08.004
[5]	罗向前, 刘大波. 儿童过敏性鼻炎的流行病学[J]. 中国实用儿科杂志, 2019, 34(3): 197-199. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK201903009.htm LUO X Q, LIU D B. Epidemiology of allergic rhinitis in children[J]. Chin J Pract Pediatr, 2019, 34(3): 197-199. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK201903009.htm
[6]	中华耳鼻咽喉头颈外科杂志编委会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组、小儿学组. 儿童变应性鼻炎诊断和治疗指南[J]. 中华耳咽喉头颈外科杂志, 2011, 46(1): 7-8. Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery editorial board, Rhinology Group and Pediatrics Group of Chinese Medical Association of Otorhinolaryngology, Head and Neck Surgery. Guidelines for diagnosis and treatment of pediatric allergic rhinitis[J]. Chin J Otorhinolaryngol Head Neck Surg, 2011, 46(1): 7-8.
[7]	中华医学会儿科学分会呼吸学组, 《中华儿科杂志》编辑委员会. 儿童支气管哮喘诊断防治指南(2016年版)[J]. 中华儿科杂志, 2016, 54(3): 167-181. doi: 10.3760/cma.j.issn.0578-1310.2016.03.003 Paediatrics Society of Chinese Medical Association, Editorial Board of Chinese Journal of Pediatrics. Guidebooks for the diagnosis and optimal management of asthma in children(2016)[J]. Chin J Pediatr, 2016, 54(3): 167-181. doi: 10.3760/cma.j.issn.0578-1310.2016.03.003
[8]	ASHER M, KEIL U, ANDERSON H R, et al. International Study of Asthma and Allergies in Childhood(ISAAC): rationale and methods[J]. Eur Respir J, 1995, 8(3): 483-491. doi: 10.1183/09031936.95.08030483
[9]	YANG L, FU J, ZHOU Y. Research progress in Atopic March[J]. Front Immunol, 2020, 27(11): 1-11.
[10]	ACCORDINI S, CORSICO A G, CALCIANO L, et al. The impact of asthma chronic bronchitis and allergic. rhinitis on all-cause hospitalizations and limitations in daily activities: a population-based observational study[J]. BMC Pulm Med, 2015, 15(1): 8. doi: 10.1186/s12890-015-0006-2
[11]	OWENS L, LAING I A, ZHANG G C, et al. Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort[J]. J Asthma Allergy, 2018, 13(11): 173-180. http://www.researchgate.net/publication/326994004_Prevalence_of_allergic_sensitization_hay_fever_eczema_and_asthma_in_a_longitudinal_birth_cohort
[12]	BUELO A, MCLEAN S, JULIOUS S, et al. At-risk children with asthma(ARC): a systematic review[J]. Thorax, 2018, 73(9): 813-824. doi: 10.1136/thoraxjnl-2017-210939
[13]	洪海裕, 许光福, 杨烁伟, 等. 探究广东地区变应性鼻炎合并支气管哮喘的危险因素[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 94-98. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYU201901020.htm HONG H Y, XU G F, YANG S W, et al. The prevalence and risk factors of bronchial asthma in patients with allergic rhinitis in Guangdong Province[J]. J Otolaryngol Ophthalmol Shandong Univ, 2019, 33(1): 94-98. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYU201901020.htm
[14]	SETTIPANE R J, HAGY G W, SETTIPANE G A. Long-term risk factors for developing asthma and allergic rhinitis: a 23-year follow-up study of college students[J]. Allergy Proc, 1994, 15(1): 21-25. doi: 10.2500/108854194778816634
[15]	LI J, ZHANG Y, ZHANG L. Discovering susceptibility genes for allergic rhinitis and allergy using: a genome-wide association study strategy[J]. Curr Opin Allergy Clin Immunol, 2015, 15(1): 33-40. doi: 10.1097/ACI.0000000000000124
[16]	全国儿科哮喘协作组, 中国疾病预防控制中心环境与健康相关产品安全所. 第三次中国城市儿童哮喘流行病学调查[J]. 中华儿科杂志, 2013, 51(10): 729-735. doi: 10.3760/cma.j.issn.0578-1310.2013.10.003 The National Cooperative Group on Childhood Asthma, Institute for Environmental and Health Related Product Safety of Chinese Center for Disease Control and Prevention. Third nationwide survey of childhood asthma in urban areas of China[J]. Chin J Pediatr, 2013, 51(10): 729-735. doi: 10.3760/cma.j.issn.0578-1310.2013.10.003
[17]	LI J, SUN B, HUANG Y, China Alliance of Research on Respiratory Allergic Disease. A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China[J]. Allergy, 2009, 64(7): 1083-1092. doi: 10.1111/j.1398-9995.2009.01967.x
[18]	LUO S, SUN Y, HOU J, et al. Pet keeping in childhood and asthma and allergy among children in Tianjin area, China[J]. PLoS One, 2018, 13(5): 1-9. http://europepmc.org/abstract/MED/29768461
[19]	ALSHATTI K A, ZIYAB A H. Pet-keeping in relation to asthma, rhinitis, and eczema symptoms among adolescents in Kuwait: a cross-sectional study[J]. Front Pediatr, 2020, 23(8): 1-10. http://www.researchgate.net/publication/342383171_Pet-Keeping_in_Relation_to_Asthma_Rhinitis_and_Eczema_Symptoms_Among_Adolescents_in_Kuwait_A_Cross-Sectional_Study/download
[20]	MILLER J D. The role of dust mites in allergy[J]. Clin Rev Allergy Immunol, 2019, 57(3): 312-329. doi: 10.1007/s12016-018-8693-0
[21]	RUDERT A, PORTNOY J. Mold allergy: is it real and what do we do about it?[J]. Expert Rev Clin Immunol, 2017, 13(8): 823-835. doi: 10.1080/1744666X.2017.1324298
[22]	BORDAS-LE FLOCH V, GROEME R, CHABRE H, et al. New insights into ragweed pollen allergens[J]. Curr Allergy Asthma Rep, 2015, 15(11): 63. doi: 10.1007/s11882-015-0565-6
[23]	王晓艳, 丁佳琪, 陈艳蕾, 等. 豚草花粉在夏秋季花粉症中的致敏特点分析[J]. 中国耳鼻咽喉头颈外科, 2020, 27(4): 180-183. https://www.cnki.com.cn/Article/CJFDTOTAL-EBYT202004003.htm WANG X Y, DING J Q, CHEN Y L, et al. Sensitization characteristics of ragweed pollen allergy among patients with hay fever during summer and autumn season[J]. Chin Arch Otolaryngol Head Neck Surg, 2020, 27(4): 180-183. https://www.cnki.com.cn/Article/CJFDTOTAL-EBYT202004003.htm
[24]	王子熹, 曲辉, 王瑞琦, 等. 青岛及北京地区五年间空气中豚草花粉的调查与分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 73-76. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYU201901016.htm WANG Z X, QU H, WANG R Q, et al. Investigation and analysis of airborne ragweed pollen in Qingdao and Beijing areas from 2010 to 2015[J]. J Otolaryngol Ophthalmol Shandong Univ, 2019, 33(1): 73-76. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYU201901016.htm
[25]	BURGESS J A, LOWE A J, MATHESON M C, et al. Does eczema lead to asthma?[J]. J Asthma, 2009, 46(5): 429-436. doi: 10.1080/02770900902846356
[26]	CIPRANDI G, CIRILLO I, TOSCA M A, et al. Bronchial hyperreactivity and spirometric impairment in patients with seasonal allergic rhinitis[J]. Respir Med, 2004, 98(9): 826-831. doi: 10.1016/j.rmed.2004.02.021
[27]	CIPRANDI G, CIRILLO I, TOSCA M A, et al. Bronchial hyperreactivity and spirometric impairment in patients with perennial allergic rhinitis[J]. Int Arch Allergy Immunol, 2004, 133(1): 14-18. doi: 10.1159/000075249