Clustering of Staphylococcus aureus carriage among kindergarten children in Liuzhou

LI Wenyu; CHEN Minqi; WANG Xulin; FU Jinjian; XU Shaolin; YE Xiaohua

doi:10.16835/j.cnki.1000-9817.2021.06.024

Volume 42 Issue 6

Jun. 2021

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2021 > 42(6): 902-905

LI Wenyu, CHEN Minqi, WANG Xulin, FU Jinjian, XU Shaolin, YE Xiaohua. Clustering of Staphylococcus aureus carriage among kindergarten children in Liuzhou[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(6): 902-905. doi: 10.16835/j.cnki.1000-9817.2021.06.024

Citation:

LI Wenyu, CHEN Minqi, WANG Xulin, FU Jinjian, XU Shaolin, YE Xiaohua. Clustering of Staphylococcus aureus carriage among kindergarten children in Liuzhou[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(6): 902-905. doi: 10.16835/j.cnki.1000-9817.2021.06.024

Citation:

PDF( 994 KB)

Clustering of Staphylococcus aureus carriage among kindergarten children in Liuzhou

doi: 10.16835/j.cnki.1000-9817.2021.06.024

1.
Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou(510310), China

Received Date: 2020-11-05
Rev Recd Date: 2021-01-03

Available Online: 2021-06-22

Publish Date: 2021-06-25

Abstract

Abstract

Objective To explore clustering and risk factors of Staphylococcus aureus (S. aureus) carriage among kindergarten children in Liuzhou. Methods Two-sided nasal swabs were collected from 1 702 children in Liuzhou from April to June 2018. Parents of all the children were investigated by questionnaires. The random-effect Logistic regression was used to analyze the clustering and risk factors of S. aureus carriage. Results The carriage rate of S. aureus among kindergarten children was 16.3%. The random-effect Logistic regression model indicated that the class-level random effect of S. aureus carriage among children was statistically significant(Z=2.12, P<0.01). Children aged 6 to 7 years (OR=2.18, 95%CI=1.45-3.27) and 5 years (OR=1.65, 95%CI=1.08-2.50) had higher carriage rates of S. aureus than those aged 3-4 years. The history of antibiotic using (OR=1.45, 95%CI=1.05-2.01) and skin and soft tissue infections (OR=1.36, 95%CI=1.04-1.79) in the previous year were risk factors of S. aureus carriage among children. Conclusion The class-level clustering of S. aureus carriage is observed in healthy children. Age, history of antibiotic usage and history of skin and soft tissue infections are associated with risk of S. aureus carriage among preschool children.
- Staphylococcus aureus,
- Regression analysis,
- Child,
- Infection

FullText(HTML)

References(19)

References

[1]	COBOS-CARRASCOSA E, SOLER-PALACÍN P, NIEVES LARROSA M, et al. Staphylococcus aureus bacteremia in children: changes during eighteen years[J]. Pediatr Infect Dis J, 2015, 34(12): 1329-1334. doi: 10.1097/INF.0000000000000907
[2]	傅锦坚, 叶小华, 樊燕平, 等. 广州健康儿童鼻前庭定植金黄色葡萄球菌危险因素研究[J]. 重庆医学, 2015, 44(26): 3669-3671. doi: 10.3969/j.issn.1671-8348.2015.26.022 FU J J, YE X H, FAN Y P, et al. Analysis on risk factors of staphylococcus aureus nasal vestibule colonization Among Guangzhou healthy children[J]. Chongqing Med, 2015, 44(26): 3669-3671. doi: 10.3969/j.issn.1671-8348.2015.26.022
[3]	徐境, 晏丹. 学龄前儿童呼吸道感染的鼻咽部细菌携带及危险因素分析[J]. 中国医药导报, 2018, 15(6): 102-105. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201806025.htm XU J, YAN D. Analysis of nasopharyngeal bacteria carrying and risk factors in preschool children with respiratory infection[J]. China Med Herald, 2018, 15(6): 102-105. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201806025.htm
[4]	PAN H H, HUANG Y C, CHEN C J, et al. Prevalence of and risk factors for nasal methicillin-resistant Staphylococcus aureus colonization among children in central Taiwan[J]. J Microbiol Immunol Infect, 2019, 52(1): 45-53. doi: 10.1016/j.jmii.2016.08.020
[5]	钱莎莎, 邢健男, 王璐. 多水平统计模型分析方法及其应用[J]. 中国公共卫生, 2017, 33(9): 1414-1416. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGW201709030.htm QIAN S S, XING J N, WANG L. Multilevel statistical model analysis and its application[J]. Chin J Public Health, 2017, 33(9): 1414-1416. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGW201709030.htm
[6]	WERTHEIM H F, MELLES D C, VOS M C, et al. The role of nasal carriage in Staphylococcus aureus infections[J]. Lancet Infect Dis, 2005, 5(12): 751-762. doi: 10.1016/S1473-3099(05)70295-4
[7]	MILLER M B, WEBER D J, GOODRICH J S, et al. Prevalence and risk factor analysis for methicillin-resistant Staphylococcus aureus nasal colonization in children attending child care centers[J]. J Clin Microbiol, 2011, 49(3): 1041-1047. doi: 10.1128/JCM.02235-10
[8]	KOVÁCS E, SAHIM-TÓTH J, TÓTHPÁL A, et al. Co-carriage of staphylococcus aureus, streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis among three different age categories of children in Hungary[J]. PLoS One, 2020, 15(2): e0229021. doi: 10.1371/journal.pone.0229021
[9]	SINGH A K, AGARWAL L, KUMAR A, et al. Prevalence of nasal colonization of methicillin-resistant staphylococcus aureus among school children of barabanki district, uttar pradesh, India[J]. J Fam Med Prim Care, 2018, 7(1): 162-166. doi: 10.4103/jfmpc.jfmpc_345_16
[10]	HO P L, CHIU S S, CHAN M Y, et al. Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong[J]. J Infect, 2012, 64(5): 500-506. doi: 10.1016/j.jinf.2012.02.018
[11]	PAN H, CUI B L, HUANG Y C, et al. Nasal carriage of common bacterial pathogens among healthy kindergarten children in Chaoshan region, southern China: a cross-sectional study[J]. BMC Pediatr, 2016, 16(1): 161. doi: 10.1186/s12887-016-0703-x
[12]	叶小华, 傅锦坚, 周俊立, 等. 儿童携带耐甲氧西林金黄色葡萄球菌及影响因素[J]. 中国妇幼保健, 2014, 29(9): 1359-1361. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201409018.htm YE X H, FU J J, ZHOU J L, et al. Influencing factors of methicillin-resistant Staphylococcus aureus carried by children[J]. Matern Child Health Care China, 2014, 29(9): 1359-1361. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201409018.htm
[13]	范娟, 周伟, 舒敏, 等. 成都地区健康儿童鼻腔社区获得性耐甲氧西林金黄色葡萄球菌的携带研究[J]. 中国当代儿科杂志, 2011, 13(1): 16-19. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201101007.htm FAN J, ZHOU W, SHU M, et al. Nasal carriage of community-acquired methicillin-resistant Staphylococcus aureus in healthy children from Chengdu[J]. Chin J Contemp Pediatr, 2011, 13(1): 16-19. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201101007.htm
[14]	LEBON A, LABOUT J A, VERBRUGH H A, et al. Dynamics and determinants of staphylococcus aureus carriage in infancy: the generation R study[J]. J Clin Microbiol, 2008, 46(10): 3517-3521. doi: 10.1128/JCM.00641-08
[15]	SOLLID J U, FURBERG A S, HANSSEN A M, et al. Staphylococcus aureus: determinants of human carriage[J]. Infect Genet Evol, 2014, 21(1): 531-541.
[16]	TSAI M S, CHEN C J, LIN T Y, et al. Nasal methicillinresistant staphylococcus aureus colonization among otherwise healthy children aged between 2 months and 5 years in northern Taiwan 2005-2010[J]. J Microbiol Immunol Infect, 2018, 51(6): 756-762. doi: 10.1016/j.jmii.2017.07.014
[17]	李云珠, 马琳, 孔繁荣. 脓疱疮患儿鼻腔与皮损分离金黄色葡萄球菌的同源性[J]. 中国医学科学院学报, 2009, 31(1): 10-12. doi: 10.3881/j.issn.1000-503X.2009.01.004 LI Y Z, MA L, KONG F R. Homology of Staphylococcus aureus isolated from skin lesions and nose of patients with impetigo[J]. Acta Academ Med Sinic, 2009, 31(1): 10-12. doi: 10.3881/j.issn.1000-503X.2009.01.004
[18]	SANTOSANINGSIH D, SANTOSO S, SETIJOWATI N, et al. Prevalence and characterisation of Staphylococcus aureus causing community-acquired skin and soft tissue infections on Java and Bali, Indonesia[J]. Trop Med Int Health, 2018, 23(1): 34-44. doi: 10.1111/tmi.13000
[19]	JAUNEIKAITE E, FERGUSON T, MOSAVIE M, et al. Staphylococcus aureus colonization and acquisition of skin and soft tissue infection among royal Marines recruits: a prospective cohort study[J]. Clin Microbiol Infect, 2020, 26(3): e1-e6. http://www.ncbi.nlm.nih.gov/pubmed/31357012