Research progress of the role of microRNAs in puberty initiation

SHI Mengmeng; LIU Li; LI Xuesi; ZHAI Lingling

doi:10.16835/j.cnki.1000-9817.2021.05.035

Volume 42 Issue 5

May 2021

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SHI Mengmeng, LIU Li, LI Xuesi, ZHAI Lingling. Research progress of the role of microRNAs in puberty initiation[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(5): 788-791. doi: 10.16835/j.cnki.1000-9817.2021.05.035

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SHI Mengmeng, LIU Li, LI Xuesi, ZHAI Lingling. Research progress of the role of microRNAs in puberty initiation[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(5): 788-791. doi: 10.16835/j.cnki.1000-9817.2021.05.035

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Research progress of the role of microRNAs in puberty initiation

doi: 10.16835/j.cnki.1000-9817.2021.05.035

Department of Maternal, Child & Adolescent Health, School of Public Health, China Medical University, Shenyang(110122), China

Received Date: 2020-08-13
Rev Recd Date: 2020-09-04

Available Online: 2021-05-20

Publish Date: 2021-05-25

Abstract

Abstract

MiRNAs are a type of single-stranded, endogenous, non-coding small RNAs, which can regulate the post-transcriptional expression of genes and a variety of biological functions. Puberty development involves a complex regulatory network, among which the the hypothalamic-pituitary-gonad axis may play the key role. Studies have found that there was a relationship between the miRNAs and puberty development. The absence and abnormal expression of miRNAs can affect the initiation of puberty. But the mechanism is not clear. It may be related to the secretion of GnRH in the hypothalamus. This article mainly introduced several miRNAs which were currently closely related to the initiation of puberty, and reviewed their role and possible mechanisms in the initiation of puberty.
- RNA,
- Adolescent development,
- Animal experimentation,
- Hypothalamo-hypophyseal system

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References(43)

References

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