Comparison of the effect of screening test for different tuberculin dosage forms for close contacts of tuberculosis in colleges and universities in Nanning

LI Xiaoyuan; YANG Shaohu; HUANG Hongyu; DENG Chunli; XIE Liuyuan; SHI Jian

doi:10.16835/j.cnki.1000-9817.2021.05.030

Volume 42 Issue 5

May 2021

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Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2021 > 42(5): 768-771, 775

LI Xiaoyuan, YANG Shaohu, HUANG Hongyu, DENG Chunli, XIE Liuyuan, SHI Jian. Comparison of the effect of screening test for different tuberculin dosage forms for close contacts of tuberculosis in colleges and universities in Nanning[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(5): 768-771, 775. doi: 10.16835/j.cnki.1000-9817.2021.05.030

Citation:

LI Xiaoyuan, YANG Shaohu, HUANG Hongyu, DENG Chunli, XIE Liuyuan, SHI Jian. Comparison of the effect of screening test for different tuberculin dosage forms for close contacts of tuberculosis in colleges and universities in Nanning[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(5): 768-771, 775. doi: 10.16835/j.cnki.1000-9817.2021.05.030

Citation:

LI Xiaoyuan, YANG Shaohu, HUANG Hongyu, DENG Chunli, XIE Liuyuan, SHI Jian. Comparison of the effect of screening test for different tuberculin dosage forms for close contacts of tuberculosis in colleges and universities in Nanning[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(5): 768-771, 775. doi: 10.16835/j.cnki.1000-9817.2021.05.030

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Comparison of the effect of screening test for different tuberculin dosage forms for close contacts of tuberculosis in colleges and universities in Nanning

doi: 10.16835/j.cnki.1000-9817.2021.05.030

Department of Tuberculosis Control, Nanning Center for Disease Control and Prevention, Nanning(530023), China

Received Date: 2020-11-22
Rev Recd Date: 2020-12-28

Available Online: 2021-05-20

Publish Date: 2021-05-25

Abstract

Abstract

Objective To understand the similarities and differences in different dosage forms of tuberculin test for college students having close contact with tuberculosis in Nanning colleges and universities in order to provide reference for the prevention and control of tuberculosis. Methods A total of 7 771 students were screened for symptoms and tuberculin skin test(TST)、X radiographs from 2018 to 2019 in Nanning.The used doses of Purified Protein Derivative of Tuberculin (TB-PPD) in 2018 and 2019 were 2 IU and 5 IU respectively. Results A total of 916 positive cases were detected in 2 years, with the total positive rate of 11.79%. Total strong positive number was 184 and the strong positive rate was 2.37%. The number of tuberculosis patients was 17. Positive rate of the students from grade one to grade four was 13.88%, 8.57%, 10.59%, 10.29%, respectively. The difference was statistically significant(χ²=46.30, P < 0.01). The positive rates of male and female in the past two years were 13.24%(500/3 777) and 10.42%(416/3 994), respectively (χ²=17.84, P < 0.01), and there was no significant difference in the diagnosis of pulmonary tuberculosis among TST positive patients (χ²=0.29, P=0.59). The positive and strong positive rates of 2 IU dose and 5 IU dose were 7.57%, 15.04%, respectively, the difference in dosage forms were statistically significant (χ²=114.41, P < 0.01). The tuberculosis case detection rate (CDR) of moderate & above positive subjects of 2 IU and 5 IU dose was 6.92% and 2.07%, respectively, the difference was statistically significant(χ²=6.60, P=0.02). Conclusion More positive tuberculosis cases (including moderate & strong positive) can be detected by using 5 IU dose, though it is may not have advantage over discovering tuberculosis patients comparing to 2 IU dose. However, it is more critical to minimize the following cases and control the outbreak in university.
- Tuberculosis,
- Tuberculin test,
- Prevalence,
- Students

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References(17)

References

[1]	鲁建民, 鲁滨, 刘晚霞. 某高校6534名新生结核菌素试验结果分析[J]. 中国学校卫生, 2009, 30(3): 254-255. https://www.cnki.com.cn/Article/CJFDTOTAL-XIWS200903034.htm LU J M, LU B, LIU W X. Result of purified protein derivative test among 6534 college freshmen[J]. Chin J Sch Health, 2009, 30(3): 254-255. https://www.cnki.com.cn/Article/CJFDTOTAL-XIWS200903034.htm
[2]	卫生部, 中国疾病预防控制中心. 中国结核病防治规划实施工作指南[M]. 北京: 中国协和医科大学出版社, 2008: 21-26. Ministry of Health of the People's Republic of China, China Centers for Disease Control and Prevention. Guidelines for the implementation of China's tuberculosis control programme[M]. Beijing: Peking Union Medical College's Publishing House, 2008: 21-26.
[3]	王黎霞, 成诗明, 周林, 等. 结核病化学预防及预防接种手册[M]. 北京: 人民卫生出版社, 2012: 88-91. WANG L X, CHENG S M, ZHOU L, et al. Tuberculosis chemoprevention and vaccination handbook[M]. Beijing: People's Medical Publishing House, 2012: 88-91.
[4]	张晓龙, 王斐娴, 傅颖, 等. 2015—2017年苏州市学校结核病聚集性疫情调查[J]. 现代预防医学, 2019, 46(14): 2634-2637. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201914036.htm ZHANG X L, WANG F X, FU Y, et al. Epidemic analysis of school tuberculosis outbreak in Suzhou city between 2015 and 2017[J]. Modern Prev Med, 2019, 46(14): 2634-2637. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201914036.htm
[5]	沈丽燕. 2015—2017年河源市学校结核病聚集性疫情危险因素调查[J]. 河南预防医学杂志, 2019, 30(1): 35-37. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYF201901012.htm SHEN L Y. Study on risk factors of school-based tuberculosis clustering in Heyuan from 2015 to 2017[J]. Henan J Prev Med, 2019, 30(1): 35-37. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYF201901012.htm
[6]	国家卫生和计划生育委员会办公厅, 教育部办公厅. 关于印发学校结核病防控工作规范(2017版)的通知》(国卫办疾控发[2017]22号)[A/OL]. [2017-06-29]. http://www.moe.gov.cn/srcsite/A17/moe_943/s3285/201707/t20170727_310182.html. Office of the State Health and Family Planning Commission of the People's Republic of China, General Office of the Ministry of Education of the People's Republic of China. Standard for the prevention and control of tuberculosis in schools(2017edition)[A/OL]. [2017-06-29]. http://www.moe.gov.cn/srcsite/A17/moe_943/s3285/201707/t20170727_310182.html.
[7]	国家卫生和计划生育委员会. 肺结核诊断WS 288—2017[EB/OL]. [2018-05-01]. http://www.gxcdc.com/ywzd/2018/0326/9358.html. National Health and Family Planning Commission of the People's Republic of China. Diagnosis for pulmonary tuberculosis (WS 288-2017)[EB/OL]. [2018-05-01]. http://www.gxcdc.com/ywzd/2018/0326/9358.html.
[8]	张敦熔. 现代结核病学[M]. 北京: 人民军医出版社, 2000: 766-768. ZHANG D R. Modern Tuberculosis[M]. Beijing: People's Military Medical Publishing House, 2000: 766-768.
[9]	屠德华. 结核菌素试验的应用[J]. 中国防痨杂志, 2000, 23(2): 123-125. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFLZ200102022.htm TU D H. Application of tuberculin test[J]. Chin J Antituberc, 2000, 23(2): 123-125. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFLZ200102022.htm
[10]	刘春燕, 肖利力, 刘翌. 不同类型及剂量结核菌素试剂皮肤试验结果分析[J]. 中国国境卫生检疫杂志, 2015, 38(4): 276-278. https://www.cnki.com.cn/Article/CJFDTOTAL-GJWJ201504014.htm LIU C Y, XIAO L L, LIU Y. Analysis on the results of tuberculin skin test using different types and doses of purified protein derivative of tuberculin[J]. Chin Front Health Quaran, 2015, 38(4): 276-278. https://www.cnki.com.cn/Article/CJFDTOTAL-GJWJ201504014.htm
[11]	赵学刚, 郭付爱, 朱建良, 等. 石家庄市2015—2016年学生结核菌素试验分析[J]. 中国学校卫生, 2018, 39(7): 1090-1092. doi: 10.16835/j.cnki.1000-9817.2018.07.039 ZHAO X G, GUO F A, ZHU J L, et al. Analysis of tuberculin test results of students in Shijiazhuang from 2015 to 2016[J]. Chin J Sch Health, 2018, 39(7): 1090-1092. doi: 10.16835/j.cnki.1000-9817.2018.07.039
[12]	何树梅, 梁贵年, 马丽霞, 等. 西藏民族大学新生2016—2017年结核菌素试验结果分析[J]. 中国学校卫生, 2018, 39(4): 627-629. doi: 10.16835/j.cnki.1000-9817.2018.04.045 HE S M, LIANG G N, MA L X, et al. Analysis of tuberculin test results among freshmen in the university of Tibet from 2016 to 2017[J]. Chin J Sch Health, 2018, 39(4): 627-629. doi: 10.16835/j.cnki.1000-9817.2018.04.045
[13]	张进国, 王彦辉, 李燕广, 等. 易县入学新生结核菌素试验结果分析[J]. 中国学校卫生, 2012, 33(11): 1384-1385. https://www.cnki.com.cn/Article/CJFDTOTAL-XIWS201211041.htm ZHANG J G, WANG Y H, LI Y G, et al. Analysis of tuberculin test results of Incoming Freshman in Yixian[J]. Chin J Sch Health, 2012, 33(11): 1384-1385. https://www.cnki.com.cn/Article/CJFDTOTAL-XIWS201211041.htm
[14]	国家卫生健康委员会. 中国结核病预防控制工作技术规范(2020年版)[EB/OL]. [2020-11-01]. http://www.guide.medlive.cn/guideline/21035.html. National Health Commission of the People's Republic of China. Technical Standard for tuberculosis prevention and control in China(2020edition)[EB/OL]. [2020-11-01]. http://www.guide.medlive.cn/guideline/21035.html.
[15]	刘玉清, 屠德华, 安燕生, 等. 大学生结核病控制的研究: (二)结核感染者的预防性治疗[J]. 中国防痨杂志, 2005, 27(3): 139-142. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFLZ200503000.htm LIU Y Q, TU D H, AN Y S, et al. Control in university students in Beijing: preventive therapy for uberculosis-infected persons[J]. Chin J Antituberc, 2005, 27(3): 139-142. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFLZ200503000.htm
[16]	杨运亭, 赵清芳, 宁海燕, 等. 家庭密切接触者结核感染的预防性治疗效果观察[J]. 中国现代药物应用, 2009, 3(14): 209-210. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY200914175.htm YANG Y T, ZHAO Q F, NING H Y, et al. Effect of preventive treatment of Mycobacterium tuberculosis infection in Close family contacts[J]. Chin J Mod Drug Appl, 2009, 3(14): 209-210. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY200914175.htm
[17]	DUARTE R, CARVALHO A, CORREUA A. Two-moth regimen of isoniazd, rifampin and pirazinamid for latent tuberculosis infection[J]. Public Health, 2012, 126(9): 760-762. http://www.ncbi.nlm.nih.gov/pubmed/22633080/