Association between visceral adiposity index and non-alcoholic fatty liver among overweight and obese children in Beijing

LI Yindong; LI Menglong; DUAN Junwei; SHU Wen; LI Ziang; ZHEN Guoxin; ZHAO Ruilan; HU Yifei

doi:10.16835/j.cnki.1000-9817.2021.05.005

Volume 42 Issue 5

May 2021

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF SCHOOL HEALTH > 2021 > 42(5): 659-662

LI Yindong, LI Menglong, DUAN Junwei, SHU Wen, LI Ziang, ZHEN Guoxin, ZHAO Ruilan, HU Yifei. Association between visceral adiposity index and non-alcoholic fatty liver among overweight and obese children in Beijing[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(5): 659-662. doi: 10.16835/j.cnki.1000-9817.2021.05.005

Citation:

LI Yindong, LI Menglong, DUAN Junwei, SHU Wen, LI Ziang, ZHEN Guoxin, ZHAO Ruilan, HU Yifei. Association between visceral adiposity index and non-alcoholic fatty liver among overweight and obese children in Beijing[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(5): 659-662. doi: 10.16835/j.cnki.1000-9817.2021.05.005

Citation:

LI Yindong, LI Menglong, DUAN Junwei, SHU Wen, LI Ziang, ZHEN Guoxin, ZHAO Ruilan, HU Yifei. Association between visceral adiposity index and non-alcoholic fatty liver among overweight and obese children in Beijing[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(5): 659-662. doi: 10.16835/j.cnki.1000-9817.2021.05.005

PDF( 917 KB)

Association between visceral adiposity index and non-alcoholic fatty liver among overweight and obese children in Beijing

doi: 10.16835/j.cnki.1000-9817.2021.05.005

1.
Department of School Health, Shunyi District Center for Disease Control and Prevention, Beijing(101300), China

Received Date: 2021-01-17
Rev Recd Date: 2021-04-09

Available Online: 2021-05-20

Publish Date: 2021-05-25

Abstract

Abstract

Objective To examine the association between the visceral adiposity index (VAI) and nonalcoholic fatty liver disease (NAFLD) in the pediatric population in order to improve risk stratification and prevention systems for chronic liver disease. Methods A total of 510 overweight/obese children aged 6-8 years old were enrolled from the child cohort which was designed to study puberty, obesity, and cardiovascular risk (PROC), and complete data from liver ultrasounds and the VAI were obtained. Used Spearman's rank correlation coefficient, Chi-square tests, and Logistic regression analyses to explore the association between the VAI and NAFLD. Results The detection rates of NAFLD for boys and girls were 25.9% and 11.1%, respectively. VAI for normal group and the NAFLD group were 0.43(0.31, 0.61) and 0.61(0.44, 0.87) in boys, and 0.74(0.56, 1.07) and 1.08(0.67, 1.51) in girls, respectively. Spearman's correlation coefficient analysis showed that triglycerides(TG), VAI, and the third quintile VAI group were positively correlated with NAFLD in both boys and girls(r=0.19, 0.26, 0.29;0.16, 0.16, 1.18, P < 0.05), and high-density lipoprotein-cholesterol (HDL-C) was negatively correlated with NAFLD in boys (r=-0.21, P < 0.05). With advancing tertiles of VAI, the increasing trend in the NAFLD detection rate was statistically significant in boys and girls(Chi-square for trend were 21.77, 7.66, P < 0.01). The results of univariate and multivariable Logistic regression showed that, by taking the first tertile of VAI as a reference, the risk of NAFLD among boys was higher in the second tertile (cOR=2.59, 95%CI=1.15-5.86; aOR=2.33, 95%CI=1.01-5.36) and in the third tertile(cOR=5.73, 95%CI=2.62-12.53; aOR=4.87, 95%CI=2.15-11.03), where as the risk among girls was higher in the third tertile(cOR=4.43, 95%CI=1.40-14.00). Conclusion VAI is positively correlated with pediatric NAFLD. Higher tertiles of VAI were associated with an increased risk of NAFLD in overweight and obese children, which indicates that VAI can be used as an early predictor of NAFLD.
- Overweight,
- Obesity,
- Viscera,
- Adipose tissue,
- Fatty liver,
- Regression analysis,
- Child

FullText(HTML)

References(18)

References

[1]	FITZPATRICK E. Understanding susceptibility and targeting treatment in non-alcoholic fatty liver disease in children; moving the fulcrum[J]. Proc Nutr Soc, 2019, 78(3): 362-371. doi: 10.1017/S0029665118002914
[2]	YOUNOSSI Z, TACKE F, ARRESE M, et al. Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis[J]. Hepatology, 2019, 69(6): 2672-2682. doi: 10.1002/hep.30251
[3]	CIMINI F A, BARCHETTA I, CICCARELLI G, et al. Adipose tissue remodelling in obese subjects is a determinant of presence and severity of fatty liver disease[J]. Diabet Metab Res Rev, 2021, 37(1): e3358. http://www.researchgate.net/publication/341743045_Adipose_tissue_remodelling_in_obese_subjects_is_a_determinant_of_presence_and_severity_of_fatty_liver_disease
[4]	CALCATERRA V, REGALBUTO C, PORRI D, et al. Inflammation in obesity-related complications in children: the protective effect of diet and its potential role as a therapeutic agent[J]. Biomolecules, 2020, 10(9): 1324. doi: 10.3390/biom10091324
[5]	杨琴, 曾祥士, 代东伶. 儿童非酒精性脂肪性肝病相关的脂质代谢基因变异及生物学信息分析[J]. 中华实用儿科临床杂志, 2019, 34(19): 1458-1461. YANG Q, ZENG X S, DAI D L. Genetic variation and biological information analysis of lipid metabolism associated with non-alcoholic fatty liver disease in children[J]. Chin J Appl Clin Pediatr, 2019, 34(19): 1458-1461.
[6]	SCHETZ M, DE JONG A, DEANE A M, et al. Obesity in the critically ill: a narrative review[J]. Inten Care Med, 2019, 45(6): 757-769. doi: 10.1007/s00134-019-05594-1
[7]	KWAK J H, JUN D W, LEE S M, et al. Lifestyle predictors of obese and non-obese patients with nonalcoholic fatty liver disease: a cross-sectional study[J]. Clin Nutr, 2018, 37(5): 1550-1557. doi: 10.1016/j.clnu.2017.08.018
[8]	OOI G J, BURTON P R, BAYLISS J, et al. Effect of body mass index, metabolic health and adipose tissue inflammation on the severity of non-alcoholic fatty liver disease in bariatric surgical patients: a prospective study[J]. Obes Surg, 2019, 29(1): 99-108. doi: 10.1007/s11695-018-3479-2
[9]	AMATO M C, GIORDANO C, GALIA M, et al. Visceral adiposity index: a reliable indicator of visceral fat function associated with cardiometabolic risk[J]. Diabetes Care, 2010, 33(4): 920-922. doi: 10.2337/dc09-1825
[10]	XU C, MA Z, WANG Y, et al. Visceral adiposity index as a predictor of NAFLD: a prospective study with 4-year follow-up[J]. Liver Int, 2018, 38(12): 2294-2300. doi: 10.1111/liv.13941
[11]	OKAMURA T, HASHIMOTO Y, HAMAGUCHI M, et al. The visceral adiposity index is a predictor of incident nonalcoholic fatty liver disease: a population-based longitudinal study[J]. Clin Res Hepatol Gastroenterol, 2020, 44(3): 375-383. doi: 10.1016/j.clinre.2019.04.002
[12]	国家卫生和计划生育委员会. 学龄儿童青少年超重与肥胖筛查WS/T 586—2018[S]. 北京: 中国标准出版社, 2018. National Health Commission of the People's Republic of China. Screening for overweight and obesity among school-age children and adolescents WS/T 586-2018[S]. Beijing: China Standards Press, 2018.
[13]	周雪莲, 傅君芬. 儿童非酒精性脂肪肝病诊断与治疗专家共识[J]. 中国实用儿科杂志, 2018, 33(7): 12-17. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK201807002.htm ZHOU X L, FU J F. Expert consensus on the diagnosis and treatment of non-alcoholic fatty liver disease in children[J]. Chin J Pract Pediatr, 2018, 33(7): 12-17. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK201807002.htm
[14]	范歆, 陈少科, 唐晴, 等. 南宁市超重、肥胖儿童非酒精性脂肪肝患病情况分析[J]. 中国儿童保健杂志, 2012, 20(2): 124-126. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO201202010.htm FAN X, CHEN S K, TANG Q, et al. Analysis of incidence of non-alcoholic fatty liver disease in overweight and obesity children in Nanning[J]. Chin J Child Health Care, 2012, 20(2): 124-126. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO201202010.htm
[15]	LONARDO A, NASCIMBENI F, BALLESTRI S, et al. Sex differences in nonalcoholic fatty liver disease: state of the art and identification of research gaps[J]. Hepatology, 2019, 70(4): 1457-1469. doi: 10.1002/hep.30626
[16]	DRAIJER L G, FROON-TORENSTRA D, VAN WEEGHEL M, et al. Lipidomics in nonalcoholic fatty liver disease: exploring serum lipids as biomarkers for pediatric nonalcoholic fatty liver disease[J]. J Pediatr Gastroenterol Nutr, 2020, 71(4): 433-439. doi: 10.1097/MPG.0000000000002875
[17]	OZSU E, YAZICIOGLU B. Obese boys with low concentrations of high-density lipoprotein cholesterol are at greater risk of hepatosteatosis[J]. Hormones(Athens), 2019, 18(4): 477-484. doi: 10.1007/s42000-019-00152-2
[18]	张云飞, 杨丽丽, 席波, 等. 代谢异常指标聚集性与高血压儿童青少年非酒精性脂肪肝的关系[J]. 中国学校卫生, 2019, 40(6): 809-811. https://www.cnki.com.cn/Article/CJFDTOTAL-XIWS201906007.htm ZHANG Y F, YANG L L, XI B, et al. Association of clustering of metabolic abnormalities with non-alcoholic fatty liver disease in hypertensive children and adolescents[J]. Chin J Sch Health, 2019, 40(6): 809-811. https://www.cnki.com.cn/Article/CJFDTOTAL-XIWS201906007.htm