Volume 42 Issue 3
Apr.  2021
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JIANG Nan, WANG Shuang, WU Chang. Analysis of serum uric acid levels and associated factors among primary and middle school students in Tongzhou District, Beijing[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(3): 436-439,453. doi: 10.16835/j.cnki.1000-9817.2021.03.028
Citation: JIANG Nan, WANG Shuang, WU Chang. Analysis of serum uric acid levels and associated factors among primary and middle school students in Tongzhou District, Beijing[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(3): 436-439,453. doi: 10.16835/j.cnki.1000-9817.2021.03.028

Analysis of serum uric acid levels and associated factors among primary and middle school students in Tongzhou District, Beijing

doi: 10.16835/j.cnki.1000-9817.2021.03.028
  • Received Date: 2020-12-22
  • Rev Recd Date: 2021-01-20
  • Available Online: 2021-04-20
  • Publish Date: 2021-03-25
  •   Objective  To examine uric acid (UA) levels and their influencing factors among primary and middle school students in the Tongzhou District of Beijing, and to provide referential guidance for the prevention and control of hyperuricemia in teenagers.  Methods  A total of 1 483 students from four middle schools and four primary schools in three cities and three towns in Tongzhou District were selected for a questionnaire survey, physical examination, and blood examination using a multi-stage stratified cluster sampling method. The results of the serum uric acid (SUA) examinations were statistically analyzed and the influencing factors were evaluated.  Results  The UA level of the students was skewed, with a median value of 296.0 mol/L and an interquartile distance of 96.0 mol/L. The overall detection rate of hyperuricemia was 14.83% (220/1 483). Middle school students (342 μmol/L), students from villages and towns (307 μmol/L), males (309 μmol/L), family dining students (298 μmol/L), students with high levels of triglyceride (TG) (318 μmol/L), students with low levels of high-density lipoprotein cholesterol (HDL-C) (329 μmol/L), and obese students (303 μmol/L) all had statistically higher SUA levels(H/U value was 119 938, 229 525, 212 043, 156 347, 42 052, 63 375, 33.49, P < 0.05). The univariate analysis showed that the HUA detection rate was higher in older age groups, middle school students, township students, overweight or obese students, and low HDL-C students(χ2=614.55, 73.20, 6.16, 30.56, 14.50, P < 0.05). Multivariate Logistic regression showed that older age, being male, low HDL-C, high LDL-C, overweight, and obesity were risk factors for HUA(P < 0.05).  Conclusion  The SUA level and the detection rate of hyperuricemia among primary and middle school students in Tongzhou District were high, and the risk of disease and influencing factors had significant characteristics. Therefore, targeted prevention and control measures should be strengthened.
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  • [1]
    莫文秋, 李双蕾, 陈文辉, 等. 无症状高尿酸血症危险因素的调查与研究[J]. 医学综述, 2020, 26(23): 4745-4748, 4753. https://www.cnki.com.cn/Article/CJFDTOTAL-YXZS202023031.htm

    MO W Q, LI S L, CHEN W H, et al. Investigation and study of risk factors of asymptomatic hyperuricemia[J]. Med Recap, 2020, 26(23): 4745-4748, 4753. https://www.cnki.com.cn/Article/CJFDTOTAL-YXZS202023031.htm
    [2]
    王茜, 朱小霞, 邹和建. 青少年高尿酸血症病因及发病机制研究进展[J]. 中华风湿病学杂志, 2019, 23(11): 781-782, 785.

    WANG Q, ZHU X X, ZOU H J. Research progress on etiology and pathogenesis of hyperuricemia in adolescents[J]. Chin J Rheumatol, 2019, 23(11): 781-782, 785.
    [3]
    MALIAVSKAIA S I, LEBEDEV A V, TERNOVSKAIA V A. Chronic asymptomatic hyperuricemia as a marker of atherogenic risk in children[J]. Kardiologiia, 2007, 47(3): 62-66. http://europepmc.org/abstract/med/17495850
    [4]
    于丽华, 刘英, 王菁. 青岛市7至15岁少年儿童高尿酸血症发生率调查[J]. 标记免疫分析与临床, 2013, 20(2): 116-117. https://www.cnki.com.cn/Article/CJFDTOTAL-BJMY201302022.htm

    YU L H, LIU Y, WANG J. Investigation on the incidence of hyperuricemia in children aged 7 to 15 in Qingdao[J]. Labeled Immunoassays Clin Med, 2013, 20(2): 116-117. https://www.cnki.com.cn/Article/CJFDTOTAL-BJMY201302022.htm
    [5]
    国家卫生计生委. 学生健康检查技术规范GB/T 26343—2010[S]. 北京: 中国标准出版社, 2011.

    National Health and Family Planning Commission. Technical standard for physical examination for students GB/T 26343-2010[S]. Beijing: Standards Press of China, 2011.
    [6]
    胡亚美, 江载芳, 申昆玲, 等. 诸福棠实用儿科学[M]. 8版. 北京: 人民卫生出版社, 2015: 2885.

    HU Y M, JIANG Z F, SHEN K L, et al. Zhu futang practice of pediatrics[M]. 8th. Beijing: People's Med Publishing House, 2015: 2885.
    [7]
    向伟, 杜军保. 儿童青少年血脂异常防治专家共识[J]. 中华儿科杂志, 2009, 47(6): 426-428. https://www.cnki.com.cn/Article/CJFDTOTAL-XCYS201031009.htm

    XIANG W, DU J B. Experts consensus for prevention and treatment of dyslipidemia in children and adolescents[J]. Chin J Pediatr, 2009, 47(6): 426-428. https://www.cnki.com.cn/Article/CJFDTOTAL-XCYS201031009.htm
    [8]
    陈旭东, 王银会, 巴蕾, 等. 朝阳区557名中小学生血尿酸状况及相关因素分析[J]. 中国学校卫生, 2018, 39(12): 1848-1850, 1854. doi: 10.16835/j.cnki.1000-9817.2018.12.024

    CHEN X D, WANG Y H, BA L, et al. Serum uric acid concentration and related factor among 579 primary and middle school students in Chaoyang district of Beijing[J]. Chin J Sch Health, 2018, 39(12): 1848-1850, 1854. doi: 10.16835/j.cnki.1000-9817.2018.12.024
    [9]
    陈新春, 寇永妹, 谷小娜, 等. 唐山地区儿童青少年血尿酸分布特征及相关危险因素分析[J]. 中国全科医学, 2019, 22(26): 3227-3232. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX201926020.htm

    CHEN X C, KOU Y M, GU X N, et al. Distribution of serum uric acid and risk factors of hyperuricemia in children and adolescents in Tangshan[J]. Chin Gener Pract, 2019, 22(26): 3227-3232. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX201926020.htm
    [10]
    郭丹丹, 喻颖杰, 余晓辉, 等. 北京市3 566名中小学生高尿酸血症患病情况及相关因素[J]. 首都公共卫生, 2018, 12(2): 77-80. https://www.cnki.com.cn/Article/CJFDTOTAL-SDGW201802006.htm

    GUO D D, YU Y J, YU X H, et al. Analysis on prevalence and related factors of hyperuricemia among 3566 primary and middle school students in Beijing[J]. Capit J Public Health, 2018, 12(2): 77-80. https://www.cnki.com.cn/Article/CJFDTOTAL-SDGW201802006.htm
    [11]
    庄婧誉, 徐滨华, 段滨红, 等. 青少年血尿酸水平与心血管代谢危险因子的相关性分析[J]. 中国学校卫生, 2016, 37(3): 425-427, 431. doi: 10.16835/j.cnki.1000-9817.2016.03.031

    ZHUANG J Y, XU B H, DUAN B H, et al. Association between serum uric acid level and cardiovascular metabolism risk factors in adolescents[J]. Chin J Sch Health, 2016, 37(3): 425-427, 431. doi: 10.16835/j.cnki.1000-9817.2016.03.031
    [12]
    马巧兰, 蒋卓勤, 邓亮. 生活方式和膳食因素与高尿酸血症关系的病例对照研究[J]. 公共卫生与预防医学, 2012, 23(2): 29-32. https://www.cnki.com.cn/Article/CJFDTOTAL-FBYF201202010.htm

    MA Q L, JIANG Z Q, DENG L. Case control study of the influence of diet and lifestyle on hyperuricemia[J]. J Public Health Prev, 2012, 23(2): 29-32. https://www.cnki.com.cn/Article/CJFDTOTAL-FBYF201202010.htm
    [13]
    张帆, 胡小琪, 张倩, 等. 国内外学生营养餐的膳食模式与供餐方式[J]. 中国食物与营养, 2016, 22(3): 76-79. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWY201603019.htm

    ZHANG F, HU X Q, ZHANG Q, et al. Dietary patters and catering modes of school meal program worldwide[J]. Food Nutr China, 2016, 22(3): 76-79. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWY201603019.htm
    [14]
    张春华, 丁贤彬, 冯连贵, 等. 家庭喂养方式与饮食习惯对儿童肥胖的影响[J]. 中国学校卫生, 2013, 34(9): 1056-1058. http://www.cjsh.org.cn/article/id/zgxxws201309012

    ZHANG C H, DING X B, FENG L G, et al. Influences of family feeding and dietary habits on childhood obesity[J]. Chin J Sch Health, 2013, 34(9): 1056-1058. http://www.cjsh.org.cn/article/id/zgxxws201309012
    [15]
    杨静, 赵艳杰, 咸亚静, 等. 家庭因素对学龄前儿童挑食偏食行为的影响研究[J]. 实用预防医学, 2020, 27(4): 433-437. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYY202004014.htm

    YANG J, ZHAO Y J, XIAN Y J, et al. Influence of family factors on picky eating behavior of preschool children[J]. Pract Prev Med, 2020, 27(4): 433-437. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYY202004014.htm
    [16]
    卢雪婷, 于祥远, 秦林原, 等. 13675例体检者高尿酸血症的检出率及其与体重指数、血脂、血糖的相关性研究[J]. 现代预防医学, 2015, 42(4): 713-716. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201504045.htm

    LU X T, YU X Y, QIN L Y, et al. Detection rate of hyperuricemia in 13675 people conducted physical examination and its correlation with body mass index, blood lipid and blood glucose[J]. Modern Prev Med, 2015, 42(4): 713-716. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201504045.htm
    [17]
    林曦阳, 袁雪, 刘俊田, 等. 天津地区45229名健康体检者男女性尿酸水平差别及高尿酸血症影响因素[J]. 中国慢性病预防与控制, 2016, 24(12): 904-908. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMXB201612006.htm

    LIN X Y, YUAN X, LIU J T, et al. The uric acid level difference between males and females and the influencing factor of hyperuricemia in 45229 residents with the physical examination of Tianjin area[J]. Chin J Prev Contr Chron Dis, 2016, 24(12): 904-908. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMXB201612006.htm
    [18]
    吴琴, 周行, 周蓓蓓, 等. 江苏省扬州市邗江区青少年尿酸情况及相关因素调查研究[J]. 中华风湿病学杂志, 2019(11): 731-734.

    WU Q, ZHOU X, ZHOU B B, et al. Serum uric acid level and its correlation among adolescents in Hangjiang district Yangzhou city[J]. Chin J Rheumatol, 2019, 23(11): 731-734.
    [19]
    钟声宇, 刘淑歌, 陈东. 深圳宝安区青少年高尿酸血症发病率特点和遗传因素对发病情况的影响[J]. 黑龙江医药科学, 2020, 43(4): 29-31. https://www.cnki.com.cn/Article/CJFDTOTAL-KXJY202004012.htm

    ZHONG S Y, LIU S G, CHEN D. The characteristics of hyperuricemia incidence and the influence of genetic factors on the incidence of hyperuricemia among adolescents in Baoan District, Shenzhen[J]. Heilongjiang Med Pharmacy, 2020, 43(4): 29-31. https://www.cnki.com.cn/Article/CJFDTOTAL-KXJY202004012.htm
    [20]
    王彤, 刘戈力, 郑荣秀, 等. 儿童代谢综合征尿酸变化及其与心血管危险因素的关系[J]. 临床儿科杂志, 2009, 27(12): 1126-1130. https://www.cnki.com.cn/Article/CJFDTOTAL-LCAK200912008.htm

    WANG T, LIU G L, ZHENG R X, et al. Serum uric acid its correlation with cardiovascular risk factors in children with metabolic syndrome[J]. J Clin Pediatr, 2009, 27(12): 1126-1130. https://www.cnki.com.cn/Article/CJFDTOTAL-LCAK200912008.htm
    [21]
    SILVA H A, CARRARO J C, BRESSAN J, et al. Relation between uric acid and metabolic syndrome in subjects with cardiometabolic risk[J]. Einstein(Sao Paulo), 2015, 13(2): 202-208. http://www.ncbi.nlm.nih.gov/pubmed/26018145
    [22]
    TANG L, KUBOTA M, NAGAI A, et al. Hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome[J]. Pediatr Rep, 2010, 2(1): 12. http://pubmedcentralcanada.ca/pmcc/articles/PMC3094014/
    [23]
    吴汝香, 林珊. 儿童肥胖与高尿酸血症的相关性分析[J]. 国际检验医学杂志, 2015, 36(3): 322-323. https://www.cnki.com.cn/Article/CJFDTOTAL-GWSQ201503017.htm

    WU R X, LIN S. The correlation between serum uric acid concentration and obesity in children[J]. Int J Lab Med, 2015, 36(3): 322-323. https://www.cnki.com.cn/Article/CJFDTOTAL-GWSQ201503017.htm
    [24]
    方启宇, 万燕萍. 肥胖儿童高尿酸血症的研究进展[J]. 中国妇幼健康研究, 2009, 20(5): 588-591.

    FANG Q Y, WAN Y P. Advances in study on hyperuricemia of obese children[J]. Chin J Woman Child Health Res, 2009, 20(5): 588-591.
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