Analysis of thyroid hormone level and its influencing factors among pubertal girls in Minhang District of Shanghai

HE Dandan; WEN Xiaosa; FU Ye; XU Xiaoli; TAO Shiji; SU Hualin; XU Dongli; WANG Na

doi:10.16835/j.cnki.1000-9817.2021.03.027

Volume 42 Issue 3

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HE Dandan, WEN Xiaosa, FU Ye, XU Xiaoli, TAO Shiji, SU Hualin, XU Dongli, WANG Na. Analysis of thyroid hormone level and its influencing factors among pubertal girls in Minhang District of Shanghai[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(3): 430-435. doi: 10.16835/j.cnki.1000-9817.2021.03.027

Citation:

HE Dandan, WEN Xiaosa, FU Ye, XU Xiaoli, TAO Shiji, SU Hualin, XU Dongli, WANG Na. Analysis of thyroid hormone level and its influencing factors among pubertal girls in Minhang District of Shanghai[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(3): 430-435. doi: 10.16835/j.cnki.1000-9817.2021.03.027

Citation:

HE Dandan, WEN Xiaosa, FU Ye, XU Xiaoli, TAO Shiji, SU Hualin, XU Dongli, WANG Na. Analysis of thyroid hormone level and its influencing factors among pubertal girls in Minhang District of Shanghai[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(3): 430-435. doi: 10.16835/j.cnki.1000-9817.2021.03.027

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Analysis of thyroid hormone level and its influencing factors among pubertal girls in Minhang District of Shanghai

doi: 10.16835/j.cnki.1000-9817.2021.03.027

HE Dandan^{1, 2},
WEN Xiaosa^{1, 2},
FU Ye^{1, 2},
XU Xiaoli^{1, 2},
TAO Shiji^{1, 2},
SU Hualin^{1, 2
,
,},
XU Dongli^{1, 2},
WANG Na³

1.
Department of Public Health Managemet, Shanghai Minhang District Center for Disease Control and Prevention, Shanghai(201101), China

Received Date: 2020-07-29
Rev Recd Date: 2020-12-15

Available Online: 2021-04-20

Publish Date: 2021-03-25

Abstract

Abstract

Objective To investigate thyroid hormone concentration and associated factors among pubertal girls in Minhang District of Shanghai. Methods From January to March 2019, a stratified sampling method was used to select junior high schools from the east, south, north, and middle areas in Minhang district. A total of 386 girls of grade 6 in selected schools were included in the study. Physical examination was conducted, and their urine and blood samples were collected to determine urinary iodine concentration (UIC) and thyroid function. Puberty Development Self-rating Scale (PDS) was used to define the pubertal stage. Logistic regression models were conducted to analyze the associations between pubertal stage and thyroid function. Results The median urinary iodine concentration was 163.57(106.57, 232.96) μg/L. The geometric mean values of TSH, TT3, FT3 and FT4 were 0.29 mU/L, 0.26 nmol/L, 0.68 pmol/L and 1.18 pmol/L.The mean value of TT4 was 91.64 nmol / L. The abnormal rates of TGAb and TPOAb were 6.22% and 4.15%. The rate of abnormal TGAb combined with abnormal TPOAb was 3.68%. Girls in puberty and post-puberty had the lower level of TT4 (OR=0.47, 0.43) as compared with girls in pre-puberty stage. Obese girls had higher level of TT3(OR=9.08, 95%CI=1.52-54.07). With the increase of exercise time(0.5-1, >1 h/d), FT4 level was increased (OR=2.45, 2.19). TSH levels were significantly higher in girls with higher TGAb and TPOAb. Girls had higher TT4 or FT4 levels if their TGAb levels were higher and TPOAb levels were normal. Conclusion There is an association between pubertal stage, obesity, exercise and thyroid function in school-aged girls during puberty in iodine sufficient areas. TSH, FT4 and TT4 levels are correlated with TGAb and TPOAb levels.
- Puberty,
- Thyroid hormones,
- Growth and development,
- Regression analysis,
- Students,
- Female

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References(27)

References

[1]	LARSEN P R, DAVIS T F, HAY I D. The thyroid gland[M]//WILSON J D, FOSTER D W, KRONENBERG H M, et al. Williams textbook of endocrinology. 9th ed. Philadelphia: WB Saunders, 1998: 389-515.
[2]	BURGI H. The thyroid gland[M]//LABHART A. Clinical endocrinology. 2nd ed. Heidelberg: Springer, 1986.
[3]	BVLOW PEDERSEN I, KNUDSEN N, JØRGENSEN T, et al. Large differences in incidences of overt hyper-and hypothyroidism associated with a small difference in iodine intake: a prospective comparative register-based population survey[J]. J Clin Endocrinol Metab, 2002, 87(10): 4462-4469. doi: 10.1210/jc.2002-020750
[4]	STOCKLING J R. Serum thyrotropin and thyroid hormone measurements and assessment of thyroid hormone transport[M]//BRAVERMAN L F, UTIGER R D. The thyroid. 7th ed. PA: JB Lippincott, 1996: 377.
[5]	MANJI N, BOELAERT K, SHEPPARD M C, et al. Lack of association between serum TSH or free T4 and body mass index in euthyroid subjects[J]. Clin Endocrinol(Oxf), 2006, 64(2): 125-128. doi: 10.1111/j.1365-2265.2006.02433.x
[6]	SOLDIN O P, TRACTENBERG R E, PEZZULLO J C. Do Thyroxine and thyroid-stimulating hormone levels reflect urinary iodine concentrations?[J]. Therapeut Drug Monit, 2005, 27(2): 178-185. doi: 10.1097/01.ftd.0000149954.20089.0b
[7]	SAGGIORATO E, MUSSA A, SACERDOTE C, et al. Thyroid volume and urinary iodine excretion in the schoolchild population of a Northwestern Italian sub-Alp metropolitan area[J]. J Endocrinol Invest, 2004, 27(6): 516-522. doi: 10.1007/BF03347472
[8]	王莹莹, 徐芊, 徐东丽, 等. 青春发育与女性甲状腺形态及功能状况的关联研究[J]. 中华流行病学杂志, 2020, 41(6): 89-95. WANG Y Y, XU Q, XU D L, et al. Association between puberty with thyroid morphology and function in women[J]. Chin J Epidemiol, 2020, 41(6): 89-95.
[9]	中华人民共和国国家卫生和计划生育委员会. 学龄儿童青少年营养不良筛查WS/T 456—2014[S]. 北京: 中国标准出版社, 2014. National Health and Family Planning Commission of the People's Republic of China. Screening standard for malnutrition of school-age children and adolescents WS/T 456-2014[S]. Beijing: Standards Press of China, 2014.
[10]	中华人民共和国国家卫生和计划生育委员会. 学龄儿童青少年超重与肥胖筛查WS/T 586—2018[S]. 2018-08-01. National Health and Family Planning Commission of the Peoples Republic of China. Screening for overweight and obesity among school-age children and adolescents WS/T 586-2018[S]. 2018-08-01.
[11]	PETERSEN A C, CROCKETT L, RICHARDS M, et al. A self-report measure of pubertal status: reliability, validity and initial norms[J]. J Youth Adolesc, 1988, 17(2): 117-133. doi: 10.1007/BF01537962
[12]	WHO, UNICEF, ICCIDD. Assessment of iodine deficiency disorders and monitoring their elimination. A guide for programme managers[M]. 3rd ed. Geneva: WHO Press, 2007: 32-33.
[13]	BRAVERMAN L E, UTIGER R D, WERNER S C, et al. The Thyroid. A fundamental and clinical text[M]. Philadelphia: Lippincott-Raven, 2000: 103-120.
[14]	范义兵, 陈海婴, 凌军, 等. 尿碘作为碘缺乏病监测指标的意义[J]. 中国地方病学杂志, 2005, 24(3): 346-348. doi: 10.3760/cma.j.issn.1000-4955.2005.03.044 FAN Y B, CHEN H Y, LING J, et al. Significance of urinary iodine as a monitoring index of iodine deficiency disorders[J]. Chin J Endemiol, 2005, 24(3): 346-348. doi: 10.3760/cma.j.issn.1000-4955.2005.03.044
[15]	SKEAFF S A, THOMSON C D, WILSON N, et al. A comprehensive assessment of urinary iodineconcentration and thyroid hormones in NewZealand schoolchildren: a cross-sectional study[J]. Nutr J, 2012, 11(31): 1-7.
[16]	DJEMLI A, VAN VLIET G, BELGUDI J, et al. Reference intervals for free thyroxine, total triiodothyronine, thyrotropin and thyroglobulin for Quebec newborns, children and teenagers[J]. Clin Biochem, 2004, 37(4): 328-330. doi: 10.1016/j.clinbiochem.2003.12.006
[17]	ZURAKOWSKI D, DICANZIO J, MAJZOUB J A. Pediatric reference values forserum thyroxine, tri-iodothyronine, thyrotropin, and free thyroxine[J]. Clin Chemistry, 1999, 45(7): 1087-1091. doi: 10.1093/clinchem/45.7.1087
[18]	TAYLOR P N, SAYERS A, OKOSIEME O, et al. Maturation in serum thyroid function parameters over childhood and puberty: results of a longitudinal study[J]. J Clin Endocrinol Metab, 2017, 102(7): 2508-2515. doi: 10.1210/jc.2016-3605
[19]	MARWAHA R K, TANDON N, DESAI A K, et al. The evolution of thyroid function with puberty[J]. Clin Endocrinol, 2012, 76(6): 899-904. doi: 10.1111/j.1365-2265.2011.04305.x
[20]	KALOUMENOU I, MASTORAKOS G, ALEVIZAKI M, et al. Thyroid autoimmunity in schoolchildren in an areawith long-standing iodine sufficiency: correlation with gender, pubertal stage, and maternal thyroid autoimmunity[J]. Thyroid, 2008, 18(7): 747-754. DOI: 10.1089/thy.2007.0370.
[21]	FONTENELLE L C, FEITOSA M M, SEVERO J S, et al. Thyroid function in human obesity: underlying mechanisms[J]. Horm Metab Res, 2016, 48(12): 787-794. doi: 10.1055/s-0042-121421
[22]	TERJUNG R L, TIPTON C M. Plasma thyroxine and thyroid stimulating hormone levls during submaxinal exercise in humans[J]. Am J Physiol, 1971, 220(6): 1840-1845. doi: 10.1152/ajplegacy.1971.220.6.1840
[23]	朱亚林, 王国庆. 递增负荷的力竭性运动对血清甲状腺激素的影响[J], 标记免疫分析与临床, 2003, 10(1): 51-52. doi: 10.3969/j.issn.1006-1703.2003.01.020 ZHU Y L, WANG G Q. Effects of incremental-load exhaustive exercise on serum thyroid hormones[J]. Lab Immun Clin Med, 2003, 10(1): 51-52. doi: 10.3969/j.issn.1006-1703.2003.01.020
[24]	平龙玉, 杜立树, 张曼俐. 甲状腺疾病诊治中血清TPOAb、TGAb的变化及其价值[J]. 临床和实验医学杂志, 2016, 15(13): 1278-1281. doi: 10.3969/j.issn.1671-4695.2016.13.013 PING L Y, DU L S, ZHANG M L. Thyroid disease diagnosis and treatment of TpoAb, serum TGAb change and its value[J]. J Clin Exp Med, 2016, 15(13): 1278-1281. doi: 10.3969/j.issn.1671-4695.2016.13.013
[25]	LOVISELLI A, VELLUZZI F, MOSSA P, et al. The sardinian autoimmunity study: 3 studies on circulating antithyroid antibodies in Sardinian schoolchildren: relationship to goiter prevalence and thyroid function[J]. Thyroid, 2001, 11(9): 849-857. doi: 10.1089/105072501316973109
[26]	KABELITZ M, LIESENKOTTER K P, STACH B, et al. The prevalence of anti-thyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area[J]. Eur J Endocrinol, 2003, 148(3): 301-307. http://www.ncbi.nlm.nih.gov/pubmed/12611610/
[27]	MOORE D C. Natural course of subclinical hypothyroidism in childhood and adolescence[J]. Arch Pediatr Adolesc Med, 1996, 150(3): 293-297. doi: 10.1001/archpedi.1996.02170280063012