Case-control study of early life-related risk factors associated with type 1 diabetes mellitus in children

LIU Hezuo; SUN Qi; WEI Wei; ZHAI Lingling; BAI Yinglong; JIA Lihong.

doi:10.16835/j.cnki.1000-9817.2021.01.031

Volume 42 Issue 1

Apr. 2021

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LIU Hezuo, SUN Qi, WEI Wei, ZHAI Lingling, BAI Yinglong, JIA Lihong.. Case-control study of early life-related risk factors associated with type 1 diabetes mellitus in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(1): 128-131. doi: 10.16835/j.cnki.1000-9817.2021.01.031

Citation:

LIU Hezuo, SUN Qi, WEI Wei, ZHAI Lingling, BAI Yinglong, JIA Lihong.. Case-control study of early life-related risk factors associated with type 1 diabetes mellitus in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(1): 128-131. doi: 10.16835/j.cnki.1000-9817.2021.01.031

Citation:

LIU Hezuo, SUN Qi, WEI Wei, ZHAI Lingling, BAI Yinglong, JIA Lihong.. Case-control study of early life-related risk factors associated with type 1 diabetes mellitus in children[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(1): 128-131. doi: 10.16835/j.cnki.1000-9817.2021.01.031

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Case-control study of early life-related risk factors associated with type 1 diabetes mellitus in children

doi: 10.16835/j.cnki.1000-9817.2021.01.031

Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang(110122), China

Received Date: 2020-05-07
Rev Recd Date: 2020-06-30

Available Online: 2021-04-01

Publish Date: 2021-01-25

Abstract

Abstract

Objective To investigate the affecting factors of type 1 diabetes mellitus(T1DM) in children, and to provide reference for the prevention and treatment measures in the future. Methods A case-control study was carried out among 106 children diagnosed with T1DM in a hospital in Shenyang. At the same time, 106 healthy children were selected as the control group by 1∶1 matching of age, gender and living area. The early life-related factors that may affect the development of T1DM in two groups were investigated by questionnaire. Results The average age of diagnosis in 106 cases with T1DM was(8.02±3.49) years, girls accounted for 60.4% and boys 39.6%. Multi-factor Logistic regression analysis showed that high family socioeconomic status and higher education of fathers were associated with lower odds of development of T1DM. Family member smoking(OR=2.51, 95%CI=1.19-5.29), family history of diabetes(OR=2.56, 95%CI=1.18-5.55), maternal obesity(OR=5.42, 95%CI=2.49-11.83) and infection during pregnancy(OR=3.45, 95%CI=1.04-11.46) were associated with higher risk of T1DM(P < 0.05). Conclusion The occurrence of T1DM in children is affected by many factors including heredity, maternal health during pregnancy and family economy, highlighting the importance of early life prevention of T1DM.
- Diabetes mellitus, tpye 1,
- Case-control studies,
- Regression analysis,
- Child

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References(25)

References

[1]	HARREITER J, RODEN M. Diabetes mellitus-definition, classification, diagnosis, screening and prevention (update 2019)[J]. Wien Klin Wochenschr, 2019, 131(Suppl 1): 6-15. doi: 10.1007/s00508-019-1450-4
[2]	PATTERSON C, GUARIGUATA L, DAHLQUIST G, et al. Diabetes in the young-a global view and worldwide estimates of numbers of children with type 1 diabetes[J]. Diabetes Res Clin Pract, 2014, 103(2): 161-175. doi: 10.1016/j.diabres.2013.11.005
[3]	GROUP D P. Incidence and trends of childhood type 1 diabetes worldwide 1990-1999[J]. Diab Med, 2006, 23(8): 857-866. doi: 10.1111/j.1464-5491.2006.01925.x
[4]	WENG J, ZHOU Z, GUO L, et al. Incidence of type 1 diabetes in China, 2010-13: population based study[J]. BMJ, 2018, 360(3): j5295. http://europepmc.org/articles/PMC5750780/
[5]	GUNGOR D, NADAUD P, LAPERGOLA C C, et al. Infant milk-feeding practices and diabetes outcomes in offspring: a systematic review[J]. Am J Clin Nutr, 2019, 109(Suppl 7): 817S-837S. http://www.researchgate.net/publication/332873081_Infant_milk-feeding_practices_and_diabetes_outcomes_in_offspring_a_systematic_review
[6]	VEHIK K, LYNCH K F, WONG M C, et al. Prospective virome analyses in young children at increased genetic risk for type 1 diabetes[J]. Nat Med, 2019, 25(12): 1865-1872. doi: 10.1038/s41591-019-0667-0
[7]	AWADALLA N J, HEGAZY A A, ABD E M, et al. Environmental factors associated with type 1 diabetes development: a case control study in egypt[J]. Int J Environ Res Public Health, 2017, 14(6): 615. doi: 10.3390/ijerph14060615
[8]	AHADI M, TABATABAEIYAN M, MOAZZAMI K. Association between environmental factors and risk of type 1 diabetes-a case-control study[J]. Endokrynol Pol, 2011, 62(2): 134-137. http://www.ncbi.nlm.nih.gov/pubmed/21528475
[9]	AL-RAEES G Y, AL-AMER M A, MUSAIGER, et al. Prevalence of overwight and obesity among children aged 2-5 years in Bahrain: a comparison between two reference standards[J]. Int J Pediatr Obes, 2009, 4(4): 414-416. doi: 10.3109/17477160902763325
[10]	DESAI S, DESHMUKH A. Mapping of type 1 diabetes mellitus[J]. Curr Diabetes Rev, 2020, 16(5): 438-441. doi: 10.2174/1573399815666191004112647
[11]	卓越. 儿童初发1型糖尿病相关危险因素分析[D]. 沈阳: 中国医科大学, 2019. ZHUO Y. Risk factors associated with type 1 mellitus in children[D]. Shengyang: China Medical University, 2019.
[12]	任宏, 欧阳凤秀, 罗飞宏, 等. 儿童1型糖尿病环境危险因素病例对照研究[J]. 中国公共卫生, 2005, 21(2): 129-130. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGW200502000.htm REN H, OUYANG F X, LUO F H, et al. Case-control study on environmental risk factors of type 1 diabetes in Shanghai population[J]. Chin J Public Health, 2005, 21(2): 129-130. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGW200502000.htm
[13]	BRUIN J E, PETRE M A, RAHA S, et al. Fetal and neonatal nicotine exposure in wistar rats causes progressive pancreatic mitochondrial damage and beta cell dysfunction[J]. PLoS One, 2008, 3(10): e3371. doi: 10.1371/journal.pone.0003371
[14]	LINDELL N, CARLSSON A, JOSEFSSON A, et al. Maternal obesity as a risk factor for early childhood type 1 diabetes: a nationwide, prospective, population-based case-control study[J]. Diabetologia, 2018, 61(1): 130-137. doi: 10.1007/s00125-017-4481-2
[15]	王兰英, 郝冬荣, 厉红, 等. 儿童1型糖尿病发病的高危因素分析[J]. 中国妇幼保健, 2014, 29(8): 1204-1206. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201408024.htm WANG L Y, HAO D R, LI H, et al. Analysis of risk factors for type 1 diabetes in children[J]. Matern Child Health Care China, 2014, 29(8): 1204-1206. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201408024.htm
[16]	BOLJAT A, GUNJACA I, KONSTANTINOVIC I, et al. Environmental risk factors for type 1 diabetes mellitus development[J]. Exp Clin Endocrinol Diabetes, 2017, 125(8): 563-570. doi: 10.1055/s-0043-109000
[17]	MILLER K M, HART P H, DE KLERK N H, et al. Are low sun exposure and/or vitamin D risk factors for type 1 diabetes?[J]. Photochem Photobiol Sci, 2017, 16(3): 381-398. doi: 10.1039/C6PP00294C
[18]	王吉顺, 王兰英, 安美静, 等. 儿童1型糖尿病相关危险因素的病例对照研究[J]. 现代预防医学, 2016, 43(24): 4428-4431. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201624004.htm WANG J S, WANG L Y, AN M J, et al. The investigation and analysis of risk factors of children type 1 diabetes mellitus[J]. Modern Prevent Med, 2016, 43(24): 4428-4431. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201624004.htm
[19]	GREER R M, PORTELLI S L, HUNG B S, et al. Serum vitamin D levels are lower in Australian children and adolescents with type 1 diabetes than in children without diabetes[J]. Pediatr Diabetes, 2013, 14(1): 31-41. doi: 10.1111/j.1399-5448.2012.00890.x
[20]	GRANFORS M, AUGUSTIN H, LUDVIGSSON J, et al. No association between use of multivitamin supplement containing vitamin D during pregnancy and risk of type 1 diabetes in the child[J]. Pediatr Diabetes, 2016, 17(7): 525-530. doi: 10.1111/pedi.12334
[21]	热衣兰木·包尔汉, 米热古丽·买买提. 新疆维吾尔族儿童1型糖尿病危险因素探讨[J]. 中国当代儿科杂志, 2015, 17(3): 266-269. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201503018.htm REYILANMU B R H, MIREGULI M M T. Risk factors for type 1 diabetes among Uyghur children in Xinjiang, China[J]. Chin J Contemp Pediatr, 2015, 17(3): 266-269. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201503018.htm
[22]	BARUAH M P, AMMINI A C, KHURANA M L. Demographic, breast-feeding, and nutritional trends among children with type 1 diabetes mellitus[J]. Indian J Endocrinol Metab, 2011, 15(1): 38-42. doi: 10.4103/2230-8210.77583
[23]	DAHLQUIST G G, PATTERSON C, SOLTESZ G. Perinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group[J]. Diabetes Care, 1999, 22(10): 1698-1702. doi: 10.2337/diacare.22.10.1698
[24]	ZINKERNAGEL R M. Maternal antibodies, childhood infections, and autoimmune diseases[J]. N Engl J Med, 2001, 345(18): 1331-1335. doi: 10.1056/NEJMra012493
[25]	YUE Y, TANG Y, TANG J, et al. Maternal infection during pregnancy and type 1 diabetes mellitus in offspring: a systematic review and meta-analysis[J]. Epidemiol Infect, 2018, 146(16): 2131-2138. doi: 10.1017/S0950268818002455